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The map label for this gene is hemE

Identifier: 86751122

GI number: 86751122

Start: 4580766

End: 4581812

Strand: Direct

Name: hemE

Synonym: RPB_4014

Alternate gene names: 86751122

Gene position: 4580766-4581812 (Clockwise)

Preceding gene: 86751114

Following gene: 86751123

Centisome position: 85.92

GC content: 66.0

Gene sequence:

>1047_bases
TTGACACAGAAACTCGTGACGAAACCGTTCATTGAGGTGCTTTCCGGAAATCGGCAGGCATCTCCCCCGATGTGGATGAT
GCGGCAGGCCGGCCGTTACCTGCCGGAATACCGCGCGACCCGCGCCGAAGCCGGCAGCTTCCTCGATCTGTGCTTCAACG
CCAAGCTCGCCGCCGAGGTGACGTTGCAGCCGATCCGGCGCTTCGGCTTCGACGCCGCGATCATCTTTTCGGATATTCTG
GTCGTGCCTTACGCGCTCGGACGCGCGGTGCGCTTCGAGGTCGGCGAAGGCCCGCGGCTCGATCCGTTGAATTCGCCGGA
CCTGGTCGGCACGCTGAATGGCGCGATCGACCTGTCGAAGCTCGAGCCGGTGTTCGAAGCGCTGCGCATCGTGCGCAGCG
AGCTCGCCCCGGAGACGACGCTGATCGGCTTCTGTGGCGCGCCGTTCACCGTCGCGACCTACATGGTCGCGGGTCAGGGC
ACGTCGGATCAGCACCCGGCGCGACTGATGGCGTATCAGCACCCCGGCGCGTTCGCCAGGATCATCGACGTGCTGGTCGA
GAGTTCGATCCAGTATCTGTTGAAGCAGCTCGAGGCCGGCGCCGACGTGCTGCAGATCTTCGACACCTGGGGCGGCATCC
TGCCGCCCCGCGAATTCGAGAAGTGGTGCATCGAGCCGACCCGCCGCATCGTCGAGGGTGTCCGCAAGGTGAGCCCCGGC
GCCAAGATCATCGGCTTCCCGCGCGGCGCCGGCGCGATGCTGCCGGACTTCATCGCGCGCACCGGCGTCGACGCCGTGAG
CATCGACTGGACGGCCGAGCCGAACATGATCCGCGAACGGGTGCAGAGCAAGGTCGCGGTTCAGGGCAACCTCGATCCGC
TGCTGCTGATCGCCGGCGGTTCGGCGCTCGATCAAGGCGTCGACGACGTGCTGAAGAACTTCTCGGCCGGACGCCACATC
TTCAATCTCGGCCACGGCATCACGCCGGACGCGCCGGTGGCGCATGTCGAGCAGATGGTGAAACGGGTCCGCGCCTACAA
AGGCTGA

Upstream 100 bases:

>100_bases
TGTTCGCGGCCACTCCGGCCGCATCTCGACGTGGCCAAGACGGTGTGCGCAGTGTATCAGACCGTCAAGAACGCTTGTCG
TATAACAATGGGTATGTCTC

Downstream 100 bases:

>100_bases
GATCTTCGGTATCAACGATCGAAGCCGGTGCGCAAGCGCCGGCTTTTTTCGTGCCGACGTGAAGCGGGGCCAAGTGTCGT
TGATATGACGCGCTCCGGCC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTQKLVTKPFIEVLSGNRQASPPMWMMRQAGRYLPEYRATRAEAGSFLDLCFNAKLAAEVTLQPIRRFGFDAAIIFSDIL
VVPYALGRAVRFEVGEGPRLDPLNSPDLVGTLNGAIDLSKLEPVFEALRIVRSELAPETTLIGFCGAPFTVATYMVAGQG
TSDQHPARLMAYQHPGAFARIIDVLVESSIQYLLKQLEAGADVLQIFDTWGGILPPREFEKWCIEPTRRIVEGVRKVSPG
AKIIGFPRGAGAMLPDFIARTGVDAVSIDWTAEPNMIRERVQSKVAVQGNLDPLLLIAGGSALDQGVDDVLKNFSAGRHI
FNLGHGITPDAPVAHVEQMVKRVRAYKG

Sequences:

>Translated_348_residues
MTQKLVTKPFIEVLSGNRQASPPMWMMRQAGRYLPEYRATRAEAGSFLDLCFNAKLAAEVTLQPIRRFGFDAAIIFSDIL
VVPYALGRAVRFEVGEGPRLDPLNSPDLVGTLNGAIDLSKLEPVFEALRIVRSELAPETTLIGFCGAPFTVATYMVAGQG
TSDQHPARLMAYQHPGAFARIIDVLVESSIQYLLKQLEAGADVLQIFDTWGGILPPREFEKWCIEPTRRIVEGVRKVSPG
AKIIGFPRGAGAMLPDFIARTGVDAVSIDWTAEPNMIRERVQSKVAVQGNLDPLLLIAGGSALDQGVDDVLKNFSAGRHI
FNLGHGITPDAPVAHVEQMVKRVRAYKG
>Mature_347_residues
TQKLVTKPFIEVLSGNRQASPPMWMMRQAGRYLPEYRATRAEAGSFLDLCFNAKLAAEVTLQPIRRFGFDAAIIFSDILV
VPYALGRAVRFEVGEGPRLDPLNSPDLVGTLNGAIDLSKLEPVFEALRIVRSELAPETTLIGFCGAPFTVATYMVAGQGT
SDQHPARLMAYQHPGAFARIIDVLVESSIQYLLKQLEAGADVLQIFDTWGGILPPREFEKWCIEPTRRIVEGVRKVSPGA
KIIGFPRGAGAMLPDFIARTGVDAVSIDWTAEPNMIRERVQSKVAVQGNLDPLLLIAGGSALDQGVDDVLKNFSAGRHIF
NLGHGITPDAPVAHVEQMVKRVRAYKG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=352, Percent_Identity=39.7727272727273, Blast_Score=228, Evalue=4e-60,
Organism=Escherichia coli, GI2367337, Length=326, Percent_Identity=45.0920245398773, Blast_Score=270, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6320252, Length=328, Percent_Identity=35.6707317073171, Blast_Score=206, Evalue=4e-54,
Organism=Drosophila melanogaster, GI19921920, Length=328, Percent_Identity=37.1951219512195, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI221330099, Length=328, Percent_Identity=37.1951219512195, Blast_Score=220, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_RHOP2 (Q2ISV3)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_487618.1
- ProteinModelPortal:   Q2ISV3
- SMR:   Q2ISV3
- STRING:   Q2ISV3
- GeneID:   3911821
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_4014
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   RPAL316058:RPB_4014-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38022; Mature: 37890

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 78-78 BINDING 154-154 BINDING 209-209 BINDING 325-325

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKLVTKPFIEVLSGNRQASPPMWMMRQAGRYLPEYRATRAEAGSFLDLCFNAKLAAEV
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHCCHHHHHH
TLQPIRRFGFDAAIIFSDILVVPYALGRAVRFEVGEGPRLDPLNSPDLVGTLNGAIDLSK
HHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEECCCCEEHHH
LEPVFEALRIVRSELAPETTLIGFCGAPFTVATYMVAGQGTSDQHPARLMAYQHPGAFAR
HHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCHHHEEECCCCHHHH
IIDVLVESSIQYLLKQLEAGADVLQIFDTWGGILPPREFEKWCIEPTRRIVEGVRKVSPG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
AKIIGFPRGAGAMLPDFIARTGVDAVSIDWTAEPNMIRERVQSKVAVQGNLDPLLLIAGG
CEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHEEECCCCCEEEEEECC
SALDQGVDDVLKNFSAGRHIFNLGHGITPDAPVAHVEQMVKRVRAYKG
CHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQKLVTKPFIEVLSGNRQASPPMWMMRQAGRYLPEYRATRAEAGSFLDLCFNAKLAAEV
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHCCHHHHHH
TLQPIRRFGFDAAIIFSDILVVPYALGRAVRFEVGEGPRLDPLNSPDLVGTLNGAIDLSK
HHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEECCCCEEHHH
LEPVFEALRIVRSELAPETTLIGFCGAPFTVATYMVAGQGTSDQHPARLMAYQHPGAFAR
HHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCHHHEEECCCCHHHH
IIDVLVESSIQYLLKQLEAGADVLQIFDTWGGILPPREFEKWCIEPTRRIVEGVRKVSPG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
AKIIGFPRGAGAMLPDFIARTGVDAVSIDWTAEPNMIRERVQSKVAVQGNLDPLLLIAGG
CEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHEEECCCCCEEEEEECC
SALDQGVDDVLKNFSAGRHIFNLGHGITPDAPVAHVEQMVKRVRAYKG
CHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA