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The map label for this gene is hemF [H]

Identifier: 86751117

GI number: 86751117

Start: 4574992

End: 4575903

Strand: Reverse

Name: hemF [H]

Synonym: RPB_4009

Alternate gene names: 86751117

Gene position: 4575903-4574992 (Counterclockwise)

Preceding gene: 86751118

Following gene: 86751116

Centisome position: 85.83

GC content: 67.11

Gene sequence:

>912_bases
ATGACCATCGACACCGACCTCGACCGCACGCCCGCTGTTTCCGATGACCCGGTGGAAGCCCGACGGACGCAGGCACGCGC
CTGGTTCGAGGGCCTGCGCGATCGGATCTGCGCCGAGATCGAAACGCTGGAACGCGAGGCGCCGGCCGCATTGTTTCCCG
GCGAGCCCGCGACCTTCAGCTACAAGCCGTGGCAGCGCAAAACCGGCGCCGGCGGCGGCGTCGGCGGTTTCCTCTCGGGC
GGCCGGCTGTTCGAGAAGATCGGCATCCACACCTCGTCGGCCAACGGCACGCTGACGCCGGAGATGGCGAAGAATCTGCC
CGGCGACGGCGTCACGCGCGACTACGTCTCGACCAGCATCAGCCTGATCATGCATCCGCGCAGTCCGCGGGTCCCCACCG
TGCACATGAACACCCGGTTCCTGTCGACGTCGCAGGGCTGGTTCGGCGGCGGCGCCGATCTGACGCCGATGCTGCCCGAG
CAGCGCAGCCAGGACGCCGAGGACGCGGTGATGTTCCACGCCGCCATGAAGGCCGCCTGCGACGCCCACGATCCGGCTTA
CTACGCGAAATTCAAGCCCTGGGCCGACACTTACTTCTTCCTGCCGCATCGCGGCACCGCGCGCGGCGTCGGCGGCATCT
TCTACGATCACCTGAACAGCGGCGATTTCGAGCGCGACTTTGCCTTCACCCGCGACGTCGGCGCGGCATTGCTCGAGATC
TATCCGAGGATCGTGCGCAAGCGCATGGTCGAGCCGTGGACCGAGCAGGAGCGGGCGCAGCAACTCGCCTGCCGCGGGCT
CTATGTCGAGTTCAACCTGTTGTACGACAAGGGCACGATGTTCGGCCTGCAGACCGGCGGCAACACCGAGACCATCATGA
GCTCGATGCCGCCGCTGGTGAGCTGGAGCTGA

Upstream 100 bases:

>100_bases
CGCTAAAGGCAGCGTCTCAACCGCCACCCATTTGCAAAAACTCTCGAAGACGCCACACTGGCGTGATACCGATGCTGACC
TTGCGCAACGGATCACGGCC

Downstream 100 bases:

>100_bases
GGCGTACGTCAAGGCAGAATTGGCTTGAGACGACTGTGGGCGTCATCCTGAGGTGCTCGCCCGAAAGGGCGAGCCTCGAA
GGATGCGCGACACGCGCGGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTIDTDLDRTPAVSDDPVEARRTQARAWFEGLRDRICAEIETLEREAPAALFPGEPATFSYKPWQRKTGAGGGVGGFLSG
GRLFEKIGIHTSSANGTLTPEMAKNLPGDGVTRDYVSTSISLIMHPRSPRVPTVHMNTRFLSTSQGWFGGGADLTPMLPE
QRSQDAEDAVMFHAAMKAACDAHDPAYYAKFKPWADTYFFLPHRGTARGVGGIFYDHLNSGDFERDFAFTRDVGAALLEI
YPRIVRKRMVEPWTEQERAQQLACRGLYVEFNLLYDKGTMFGLQTGGNTETIMSSMPPLVSWS

Sequences:

>Translated_303_residues
MTIDTDLDRTPAVSDDPVEARRTQARAWFEGLRDRICAEIETLEREAPAALFPGEPATFSYKPWQRKTGAGGGVGGFLSG
GRLFEKIGIHTSSANGTLTPEMAKNLPGDGVTRDYVSTSISLIMHPRSPRVPTVHMNTRFLSTSQGWFGGGADLTPMLPE
QRSQDAEDAVMFHAAMKAACDAHDPAYYAKFKPWADTYFFLPHRGTARGVGGIFYDHLNSGDFERDFAFTRDVGAALLEI
YPRIVRKRMVEPWTEQERAQQLACRGLYVEFNLLYDKGTMFGLQTGGNTETIMSSMPPLVSWS
>Mature_302_residues
TIDTDLDRTPAVSDDPVEARRTQARAWFEGLRDRICAEIETLEREAPAALFPGEPATFSYKPWQRKTGAGGGVGGFLSGG
RLFEKIGIHTSSANGTLTPEMAKNLPGDGVTRDYVSTSISLIMHPRSPRVPTVHMNTRFLSTSQGWFGGGADLTPMLPEQ
RSQDAEDAVMFHAAMKAACDAHDPAYYAKFKPWADTYFFLPHRGTARGVGGIFYDHLNSGDFERDFAFTRDVGAALLEIY
PRIVRKRMVEPWTEQERAQQLACRGLYVEFNLLYDKGTMFGLQTGGNTETIMSSMPPLVSWS

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=260, Percent_Identity=43.0769230769231, Blast_Score=204, Evalue=9e-53,
Organism=Escherichia coli, GI1788777, Length=286, Percent_Identity=39.1608391608392, Blast_Score=204, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6320249, Length=295, Percent_Identity=36.271186440678, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17864388, Length=289, Percent_Identity=39.1003460207612, Blast_Score=200, Evalue=8e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 33600; Mature: 33469

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDTDLDRTPAVSDDPVEARRTQARAWFEGLRDRICAEIETLEREAPAALFPGEPATFS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCC
YKPWQRKTGAGGGVGGFLSGGRLFEKIGIHTSSANGTLTPEMAKNLPGDGVTRDYVSTSI
CCCCCCCCCCCCCCCHHCCCCHHHHHHCCEECCCCCEECHHHHHCCCCCCCHHHHHHHEE
SLIMHPRSPRVPTVHMNTRFLSTSQGWFGGGADLTPMLPEQRSQDAEDAVMFHAAMKAAC
EEEECCCCCCCCEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
DAHDPAYYAKFKPWADTYFFLPHRGTARGVGGIFYDHLNSGDFERDFAFTRDVGAALLEI
CCCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
YPRIVRKRMVEPWTEQERAQQLACRGLYVEFNLLYDKGTMFGLQTGGNTETIMSSMPPLV
HHHHHHHHHCCCCHHHHHHHHHHHCEEEEEEEEEEECCEEEEEECCCCHHHHHHHCCCCC
SWS
CCC
>Mature Secondary Structure 
TIDTDLDRTPAVSDDPVEARRTQARAWFEGLRDRICAEIETLEREAPAALFPGEPATFS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCC
YKPWQRKTGAGGGVGGFLSGGRLFEKIGIHTSSANGTLTPEMAKNLPGDGVTRDYVSTSI
CCCCCCCCCCCCCCCHHCCCCHHHHHHCCEECCCCCEECHHHHHCCCCCCCHHHHHHHEE
SLIMHPRSPRVPTVHMNTRFLSTSQGWFGGGADLTPMLPEQRSQDAEDAVMFHAAMKAAC
EEEECCCCCCCCEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
DAHDPAYYAKFKPWADTYFFLPHRGTARGVGGIFYDHLNSGDFERDFAFTRDVGAALLEI
CCCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
YPRIVRKRMVEPWTEQERAQQLACRGLYVEFNLLYDKGTMFGLQTGGNTETIMSSMPPLV
HHHHHHHHHCCCCHHHHHHHHHHHCEEEEEEEEEEECCEEEEEECCCCHHHHHHHCCCCC
SWS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA