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The map label for this gene is yvaG [H]

Identifier: 86750957

GI number: 86750957

Start: 4401947

End: 4402729

Strand: Direct

Name: yvaG [H]

Synonym: RPB_3849

Alternate gene names: 86750957

Gene position: 4401947-4402729 (Clockwise)

Preceding gene: 86750955

Following gene: 86750959

Centisome position: 82.56

GC content: 68.45

Gene sequence:

>783_bases
GTGGATCTGGGAATCAAGGGCCGCCGCGCGCTGGTCTGCGCATCGAGCAAGGGACTGGGCCGCGCCTGCGCCGCGGCGCT
CGCAGCCGAAGGCGTGCATGTGACGATGACGGCGCGCGGCGCGGAAGCGCTGGCCCAGGCTGCGGCCGATCTGCGAAAGG
CCTATCCGGATGTCGAGATCATCGAAGTGGCCGGAGACATCACCACGCCCGAAGGGCGCGCCGCCGCGCTGCAGGCCTGC
CCGGAGCCCGACATTCTGGTGAACAATGCCGGCGGTCCGCCGCCCGGCGATTTCCGCAACTGGACCCGCGACGACTGGAT
CAAGGCGCTCGACGCCAACATGCTGACGCCGATCGAACTGATCAAGGCGACCGTCGACCAGATGATCGCGCGAAAATTCG
GCCGGATCGTCAACATCACCTCGGCCGCAGTCAAGGCGCCAATCGACGTGCTCGGCCTGTCCAATGGCGCGCGCACCGGG
CTGACCGGCTTCGTCGCCGGGCTGTCGCGCAAGACCGTGCGGCACAATGTGACGATCAACGCGCTGCTGCCGGGCCCGTT
CGACACCGACCGGCTGCGCGGCGTGTCCGCCGGCCAGGCTAAAGCCTCCGGCGTGCCGGTGGAGCAGATCCTGCAGACGC
GGATGAACGAGAACCCGGCCGGCCGGTTCGGCGATCCGGAAGAGTTCGGACTCGCCTGCGCATTCTTGTGCGGCGCAAAA
TCCGGCTACATCACCGGCCAGAACATCCTGCTCGACGGCGGCGCCTTCCCCGGCACGCTGTGA

Upstream 100 bases:

>100_bases
TCCCGTTGATGCGTTATGCGTTGCCCTCCCCTTATCATGCCGGGCCGGGTTGGCTAGAGTGCCGGCCTCACCGACATCGC
CATCCATTCGGGAGTGAAAC

Downstream 100 bases:

>100_bases
CGGGGGCGGCCCGCGCCGCCGTCAGGCCTTGGGCGCGGTCATCACGATCCGAACCAGGTCGGTGGCGTTGCGCGCGCCGA
GCTTCTTCATGATGTTGGCG

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MDLGIKGRRALVCASSKGLGRACAAALAAEGVHVTMTARGAEALAQAAADLRKAYPDVEIIEVAGDITTPEGRAAALQAC
PEPDILVNNAGGPPPGDFRNWTRDDWIKALDANMLTPIELIKATVDQMIARKFGRIVNITSAAVKAPIDVLGLSNGARTG
LTGFVAGLSRKTVRHNVTINALLPGPFDTDRLRGVSAGQAKASGVPVEQILQTRMNENPAGRFGDPEEFGLACAFLCGAK
SGYITGQNILLDGGAFPGTL

Sequences:

>Translated_260_residues
MDLGIKGRRALVCASSKGLGRACAAALAAEGVHVTMTARGAEALAQAAADLRKAYPDVEIIEVAGDITTPEGRAAALQAC
PEPDILVNNAGGPPPGDFRNWTRDDWIKALDANMLTPIELIKATVDQMIARKFGRIVNITSAAVKAPIDVLGLSNGARTG
LTGFVAGLSRKTVRHNVTINALLPGPFDTDRLRGVSAGQAKASGVPVEQILQTRMNENPAGRFGDPEEFGLACAFLCGAK
SGYITGQNILLDGGAFPGTL
>Mature_260_residues
MDLGIKGRRALVCASSKGLGRACAAALAAEGVHVTMTARGAEALAQAAADLRKAYPDVEIIEVAGDITTPEGRAAALQAC
PEPDILVNNAGGPPPGDFRNWTRDDWIKALDANMLTPIELIKATVDQMIARKFGRIVNITSAAVKAPIDVLGLSNGARTG
LTGFVAGLSRKTVRHNVTINALLPGPFDTDRLRGVSAGQAKASGVPVEQILQTRMNENPAGRFGDPEEFGLACAFLCGAK
SGYITGQNILLDGGAFPGTL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=31.2252964426877, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI5031737, Length=254, Percent_Identity=28.3464566929134, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI66933014, Length=233, Percent_Identity=27.4678111587983, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=28.0487804878049, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI7705925, Length=258, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI15277342, Length=273, Percent_Identity=27.1062271062271, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=25.2918287937743, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI33667109, Length=191, Percent_Identity=30.3664921465969, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1787335, Length=260, Percent_Identity=31.5384615384615, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788459, Length=251, Percent_Identity=28.2868525896414, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=23.046875, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082160, Length=259, Percent_Identity=27.027027027027, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=28.3018867924528, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1789208, Length=260, Percent_Identity=25.7692307692308, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787905, Length=257, Percent_Identity=23.7354085603113, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=27.0916334661355, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786812, Length=261, Percent_Identity=24.5210727969349, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=31.3725490196078, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193204405, Length=271, Percent_Identity=30.9963099630996, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=31.9391634980989, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562908, Length=269, Percent_Identity=29.368029739777, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=28.8389513108614, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17560220, Length=266, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=28.8973384030418, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=30.4511278195489, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI72000259, Length=268, Percent_Identity=31.3432835820896, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=30.0380228136882, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=29.4339622641509, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=29.4339622641509, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=29.1666666666667, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565030, Length=256, Percent_Identity=31.25, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=30.0380228136882, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=271, Percent_Identity=30.6273062730627, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=27.3764258555133, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=267, Percent_Identity=31.4606741573034, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=28.1853281853282, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=26.4, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=26.7657992565056, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17508651, Length=253, Percent_Identity=26.4822134387352, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=264, Percent_Identity=25.7575757575758, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=24.7011952191235, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=27.4131274131274, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24639444, Length=260, Percent_Identity=27.6923076923077, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=26.8774703557312, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644339, Length=257, Percent_Identity=24.5136186770428, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 27014; Mature: 27014

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLGIKGRRALVCASSKGLGRACAAALAAEGVHVTMTARGAEALAQAAADLRKAYPDVEI
CCCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHCCCCEE
IEVAGDITTPEGRAAALQACPEPDILVNNAGGPPPGDFRNWTRDDWIKALDANMLTPIEL
EEECCCCCCCCCCHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHH
IKATVDQMIARKFGRIVNITSAAVKAPIDVLGLSNGARTGLTGFVAGLSRKTVRHNVTIN
HHHHHHHHHHHHHHCEEEHHHHHHHCCHHEEECCCCCCCCHHHHHHHHHHHHEEECEEEE
ALLPGPFDTDRLRGVSAGQAKASGVPVEQILQTRMNENPAGRFGDPEEFGLACAFLCGAK
EEECCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCC
SGYITGQNILLDGGAFPGTL
CCCEECCEEEEECCCCCCCC
>Mature Secondary Structure
MDLGIKGRRALVCASSKGLGRACAAALAAEGVHVTMTARGAEALAQAAADLRKAYPDVEI
CCCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHCCCCEE
IEVAGDITTPEGRAAALQACPEPDILVNNAGGPPPGDFRNWTRDDWIKALDANMLTPIEL
EEECCCCCCCCCCHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHH
IKATVDQMIARKFGRIVNITSAAVKAPIDVLGLSNGARTGLTGFVAGLSRKTVRHNVTIN
HHHHHHHHHHHHHHCEEEHHHHHHHCCHHEEECCCCCCCCHHHHHHHHHHHHEEECEEEE
ALLPGPFDTDRLRGVSAGQAKASGVPVEQILQTRMNENPAGRFGDPEEFGLACAFLCGAK
EEECCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCC
SGYITGQNILLDGGAFPGTL
CCCEECCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]