Click here to switch to the map view.

The map label for this gene is lpxA [H]

Identifier: 86749934

GI number: 86749934

Start: 3210407

End: 3211249

Strand: Reverse

Name: lpxA [H]

Synonym: RPB_2817

Alternate gene names: 86749934

Gene position: 3211249-3210407 (Counterclockwise)

Preceding gene: 86749935

Following gene: 86749933

Centisome position: 60.23

GC content: 66.9

Gene sequence:

>843_bases
ATGAGCAGAATCGACCCAACCGCGCGAGTTGAAGACGGCGCCGTGATCGGCGACGAGGTATCGATCGGGCCGTTCTGCAC
TGTCGGTCCGAATGTCAGCATCGGCGCCGGCACCCGGCTGATCAGCCACGTCAACCTCACCGGCCACACCACCATCGGCG
AGAGCTGCACGATCCACCCGTTCGCCTCGCTCGGCGGCGCACCGCAATCGACCGGCTACAAGGGTGAGCCGACGCAGCTC
TTGATCGGCAGCGGCTGCACCATCCGCGAGAACGTGACGATGAACACCGGCACGGTCGGCGGCGGCGGCGTCACCCGTGT
CGGCGACCGCGGCTTCTTCATGGCGGCGAGCCATGTCGGCCACGACTGCATCGTCGGCAACGACGTGATCTTCGCCAATG
CGGCGACGCTCGGCGGGCATTGCGAGATCGGCGATTTTACCTTCATCGGCGGCATGACGGTGTTGCAGCAATTCACCCGC
GTCGGCGCCCAGGTCATGCTCGGCGGCATCAGCGGCGTGCGCGACGACGTCATTCCCTACGCGCTCGCCGCCGGCATCTA
TGCGAAGCTCTCGGGGTTGAATATCGTCGGCATGCGCCGGCGCAAATTCACCAGGGAGCGGCTCAACCTTGTTCGCTCGT
TCTTCAACGACCTGTTCTACAGCGAGGGCGCGCTCGCCGAACGGCTCGAACGGGTGCGACCGCGCACCGTCGAGGATCCC
GCCATCGCCGAGATCGTCGCCTTCATCGACGACGGCAAGCGCCTCGGCCGGCGTCGCCGGCCGCTGTGCTCGGTGGCGGA
GGGAGCTCGCGCCGACGACGACAACGCTGAGACCGACGCCTAG

Upstream 100 bases:

>100_bases
CGCAAGACCATGTGGTGGTTCCACGGCGATGCGATCGTCGACGGCCAGACCGTCGCGGAAGCCGACGTCGGCGCAATGCT
GACCGATTGAACCGGATTTC

Downstream 100 bases:

>100_bases
GCTGGCGGCGGCCGCGCCATGACCGGTCCCGTCCCGCAGATCGACTCGCCTGTCGGTGTCATCGCCGGCGGAGGTGTGTT
GCCGTTCGCGGTCGCGGACG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSRIDPTARVEDGAVIGDEVSIGPFCTVGPNVSIGAGTRLISHVNLTGHTTIGESCTIHPFASLGGAPQSTGYKGEPTQL
LIGSGCTIRENVTMNTGTVGGGGVTRVGDRGFFMAASHVGHDCIVGNDVIFANAATLGGHCEIGDFTFIGGMTVLQQFTR
VGAQVMLGGISGVRDDVIPYALAAGIYAKLSGLNIVGMRRRKFTRERLNLVRSFFNDLFYSEGALAERLERVRPRTVEDP
AIAEIVAFIDDGKRLGRRRRPLCSVAEGARADDDNAETDA

Sequences:

>Translated_280_residues
MSRIDPTARVEDGAVIGDEVSIGPFCTVGPNVSIGAGTRLISHVNLTGHTTIGESCTIHPFASLGGAPQSTGYKGEPTQL
LIGSGCTIRENVTMNTGTVGGGGVTRVGDRGFFMAASHVGHDCIVGNDVIFANAATLGGHCEIGDFTFIGGMTVLQQFTR
VGAQVMLGGISGVRDDVIPYALAAGIYAKLSGLNIVGMRRRKFTRERLNLVRSFFNDLFYSEGALAERLERVRPRTVEDP
AIAEIVAFIDDGKRLGRRRRPLCSVAEGARADDDNAETDA
>Mature_279_residues
SRIDPTARVEDGAVIGDEVSIGPFCTVGPNVSIGAGTRLISHVNLTGHTTIGESCTIHPFASLGGAPQSTGYKGEPTQLL
IGSGCTIRENVTMNTGTVGGGGVTRVGDRGFFMAASHVGHDCIVGNDVIFANAATLGGHCEIGDFTFIGGMTVLQQFTRV
GAQVMLGGISGVRDDVIPYALAAGIYAKLSGLNIVGMRRRKFTRERLNLVRSFFNDLFYSEGALAERLERVRPRTVEDPA
IAEIVAFIDDGKRLGRRRRPLCSVAEGARADDDNAETDA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=248, Percent_Identity=48.3870967741936, Blast_Score=221, Evalue=4e-59,
Organism=Escherichia coli, GI1786376, Length=221, Percent_Identity=27.1493212669683, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: NA

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 29615; Mature: 29484

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIDPTARVEDGAVIGDEVSIGPFCTVGPNVSIGAGTRLISHVNLTGHTTIGESCTIHP
CCCCCCCCCCCCCCEECCCCCCCCEEECCCCCEECCCHHEEEEECCCCCCCCCCCCEECC
FASLGGAPQSTGYKGEPTQLLIGSGCTIRENVTMNTGTVGGGGVTRVGDRGFFMAASHVG
HHHCCCCCCCCCCCCCCCEEEEECCCEEECCCEECCCCCCCCCCEEECCCCEEEEHHHCC
HDCIVGNDVIFANAATLGGHCEIGDFTFIGGMTVLQQFTRVGAQVMLGGISGVRDDVIPY
CEEEECCCEEEEECCCCCCEEEECCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ALAAGIYAKLSGLNIVGMRRRKFTRERLNLVRSFFNDLFYSEGALAERLERVRPRTVEDP
HHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCH
AIAEIVAFIDDGKRLGRRRRPLCSVAEGARADDDNAETDA
HHHHHHHHHHCHHHHHHHCCCHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRIDPTARVEDGAVIGDEVSIGPFCTVGPNVSIGAGTRLISHVNLTGHTTIGESCTIHP
CCCCCCCCCCCCCEECCCCCCCCEEECCCCCEECCCHHEEEEECCCCCCCCCCCCEECC
FASLGGAPQSTGYKGEPTQLLIGSGCTIRENVTMNTGTVGGGGVTRVGDRGFFMAASHVG
HHHCCCCCCCCCCCCCCCEEEEECCCEEECCCEECCCCCCCCCCEEECCCCEEEEHHHCC
HDCIVGNDVIFANAATLGGHCEIGDFTFIGGMTVLQQFTRVGAQVMLGGISGVRDDVIPY
CEEEECCCEEEEECCCCCCEEEECCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ALAAGIYAKLSGLNIVGMRRRKFTRERLNLVRSFFNDLFYSEGALAERLERVRPRTVEDP
HHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCH
AIAEIVAFIDDGKRLGRRRRPLCSVAEGARADDDNAETDA
HHHHHHHHHHCHHHHHHHCCCHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA