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The map label for this gene is lysA [H]

Identifier: 86749199

GI number: 86749199

Start: 2361791

End: 2363077

Strand: Direct

Name: lysA [H]

Synonym: RPB_2078

Alternate gene names: 86749199

Gene position: 2361791-2363077 (Clockwise)

Preceding gene: 86749198

Following gene: 86749200

Centisome position: 44.3

GC content: 72.26

Gene sequence:

>1287_bases
ATGAGCGCCCCGGCCGCGTTCGATCCCGATCGGGTCGCGACGCTCGCCGCGCGCCACGGCACGCCGCTGTTCATCTACGA
CGCGCCGGCGATGCGCGCCGCCGCGGCGCGATTGCAGGAGGCGCTGCCGCCGGGCGCGCGATTGTTCTTCGCGGTGAAGG
CCAATCCCGCGCCCGATGTGATCCGGCTGTTCGCCGGCGAGGGCCTCGGCGCCGAAGTGGCGTCGGGCGGCGAATTGCGG
CTCGCGCTCGCCTGCGGCGTCGCGCCGGATCGCATCGTGTTCTCCGGCCCGGCGAAGACCGCGCCGGAGCTGCGCTGCGC
GATCGAGGCCTGCATCTTCGCGGTGCAGGCGGAATCCGTCGCCGAGCTCGACACGCTGCAGGCGCTGTGCGTCGCGCGCG
GCGCGACGGTGCGCGTCGCCCTGCGCGTCAATCTCGGGCCGGGCGGCGAACGCCGCGGCGGCTGGGGCGGGCCTTCGCCG
TTCGGCATGGATACCGACGCGCTGGACGAGGTCACAGCGCGCGCCGCGCGGCTCGATCGTCTGCGCATTGTCGGCCTGCA
CAATCACCAGGCGTCGCAGACGCTCGATCCGGCGAAGCTGATCGCGCGGTTCGACGCCTTTGCGCGCGTGGCGGCGTCGC
TCGGGTCGCGCTTCGATCTGCAGTTCGTCAATTTCGGCGGCGGCTTCGGTGCGCCGTTCTACGCCGACGACGCGCCGCTC
GATCTCGCGCCGGTCCGCGCGTGTTTCGCCGCGCTCGCCGGCGTGTTCGGCGACCGGCCGCTGCAGTTCGCCGCCGAATC
CGGGCGCTATCTCGTCGGGCCCGCGGGCTGCTACGTCGCGCGCGTGGTCGATGTGAAGCGGTCGTTCGGCGTGCGCTACG
CGCTGCTCGACGGCGGCATTCATCACGTGCTCGGCCTGTCCGGAACGATGCGGTCGCTGCGCCGGCCGGTGGCGGTGGCG
CGGGTCGGCGCGCGATCGGGGGAGCCTTGCGAGCCGACCGAAATCGCCGGGCCGCTGTGCACGCCGATCGATCGCCTCGC
CGGCGCCGCCGAGCTGCCGTGCGATCTCGCCGCCGGCGACCTGCTGGCGTTCGCCAATTGCGGAGCCTATGCCAAGCACG
CGAGCCCGCTGAACTTCCTCGGCCACGACTGGCCGGCCGAACTGATGATCGACGGCGCGCGCGTCATCGTCCTGTCGCCG
CAAATTGCATTCGGGCCGGCGCTGTGGCAATCACGCGAGGTACTCCAGCGATTTCGATGCGATGGCAAAATCCCCACGAG
CTCCTGA

Upstream 100 bases:

>100_bases
GGCCGTATCCGTCCGAAGTCGCGGTCGTGGTCGCCGCCGGCCTCGACATCGCCGTGCTGGCGCGCACGCTGCGGCTGCGG
CCCGGCGACGAGCCACCGCG

Downstream 100 bases:

>100_bases
TCGCGGCGCGGTCATCTACAAGGCGTTGTGGCACGCCATCATCGAGCAGGCGCTGCAGCCCGGCGCCAAGCTTCCCGAAG
ACGCGATCGGCGAGAAATTC

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSAPAAFDPDRVATLAARHGTPLFIYDAPAMRAAAARLQEALPPGARLFFAVKANPAPDVIRLFAGEGLGAEVASGGELR
LALACGVAPDRIVFSGPAKTAPELRCAIEACIFAVQAESVAELDTLQALCVARGATVRVALRVNLGPGGERRGGWGGPSP
FGMDTDALDEVTARAARLDRLRIVGLHNHQASQTLDPAKLIARFDAFARVAASLGSRFDLQFVNFGGGFGAPFYADDAPL
DLAPVRACFAALAGVFGDRPLQFAAESGRYLVGPAGCYVARVVDVKRSFGVRYALLDGGIHHVLGLSGTMRSLRRPVAVA
RVGARSGEPCEPTEIAGPLCTPIDRLAGAAELPCDLAAGDLLAFANCGAYAKHASPLNFLGHDWPAELMIDGARVIVLSP
QIAFGPALWQSREVLQRFRCDGKIPTSS

Sequences:

>Translated_428_residues
MSAPAAFDPDRVATLAARHGTPLFIYDAPAMRAAAARLQEALPPGARLFFAVKANPAPDVIRLFAGEGLGAEVASGGELR
LALACGVAPDRIVFSGPAKTAPELRCAIEACIFAVQAESVAELDTLQALCVARGATVRVALRVNLGPGGERRGGWGGPSP
FGMDTDALDEVTARAARLDRLRIVGLHNHQASQTLDPAKLIARFDAFARVAASLGSRFDLQFVNFGGGFGAPFYADDAPL
DLAPVRACFAALAGVFGDRPLQFAAESGRYLVGPAGCYVARVVDVKRSFGVRYALLDGGIHHVLGLSGTMRSLRRPVAVA
RVGARSGEPCEPTEIAGPLCTPIDRLAGAAELPCDLAAGDLLAFANCGAYAKHASPLNFLGHDWPAELMIDGARVIVLSP
QIAFGPALWQSREVLQRFRCDGKIPTSS
>Mature_427_residues
SAPAAFDPDRVATLAARHGTPLFIYDAPAMRAAAARLQEALPPGARLFFAVKANPAPDVIRLFAGEGLGAEVASGGELRL
ALACGVAPDRIVFSGPAKTAPELRCAIEACIFAVQAESVAELDTLQALCVARGATVRVALRVNLGPGGERRGGWGGPSPF
GMDTDALDEVTARAARLDRLRIVGLHNHQASQTLDPAKLIARFDAFARVAASLGSRFDLQFVNFGGGFGAPFYADDAPLD
LAPVRACFAALAGVFGDRPLQFAAESGRYLVGPAGCYVARVVDVKRSFGVRYALLDGGIHHVLGLSGTMRSLRRPVAVAR
VGARSGEPCEPTEIAGPLCTPIDRLAGAAELPCDLAAGDLLAFANCGAYAKHASPLNFLGHDWPAELMIDGARVIVLSPQ
IAFGPALWQSREVLQRFRCDGKIPTSS

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=402, Percent_Identity=28.8557213930348, Blast_Score=99, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24586472, Length=347, Percent_Identity=27.6657060518732, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24586474, Length=362, Percent_Identity=27.9005524861878, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44844; Mature: 44713

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPAAFDPDRVATLAARHGTPLFIYDAPAMRAAAARLQEALPPGARLFFAVKANPAPDV
CCCCCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHH
IRLFAGEGLGAEVASGGELRLALACGVAPDRIVFSGPAKTAPELRCAIEACIFAVQAESV
HHHHCCCCCCCHHCCCCCEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AELDTLQALCVARGATVRVALRVNLGPGGERRGGWGGPSPFGMDTDALDEVTARAARLDR
HHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
LRIVGLHNHQASQTLDPAKLIARFDAFARVAASLGSRFDLQFVNFGGGFGAPFYADDAPL
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCC
DLAPVRACFAALAGVFGDRPLQFAAESGRYLVGPAGCYVARVVDVKRSFGVRYALLDGGI
CHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCEEEEECCCH
HHVLGLSGTMRSLRRPVAVARVGARSGEPCEPTEIAGPLCTPIDRLAGAAELPCDLAAGD
HHHHCCCHHHHHHHCCHHHHHHCCCCCCCCCCHHCCCCCCCCHHHHCCCCCCCCCHHHCH
LLAFANCGAYAKHASPLNFLGHDWPAELMIDGARVIVLSPQIAFGPALWQSREVLQRFRC
HHHHHCCCCHHHCCCCCHHCCCCCCHHEEECCCEEEEECCCHHCCHHHHHHHHHHHHHCC
DGKIPTSS
CCCCCCCC
>Mature Secondary Structure 
SAPAAFDPDRVATLAARHGTPLFIYDAPAMRAAAARLQEALPPGARLFFAVKANPAPDV
CCCCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHH
IRLFAGEGLGAEVASGGELRLALACGVAPDRIVFSGPAKTAPELRCAIEACIFAVQAESV
HHHHCCCCCCCHHCCCCCEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AELDTLQALCVARGATVRVALRVNLGPGGERRGGWGGPSPFGMDTDALDEVTARAARLDR
HHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
LRIVGLHNHQASQTLDPAKLIARFDAFARVAASLGSRFDLQFVNFGGGFGAPFYADDAPL
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCC
DLAPVRACFAALAGVFGDRPLQFAAESGRYLVGPAGCYVARVVDVKRSFGVRYALLDGGI
CHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCEEEEECCCH
HHVLGLSGTMRSLRRPVAVARVGARSGEPCEPTEIAGPLCTPIDRLAGAAELPCDLAAGD
HHHHCCCHHHHHHHCCHHHHHHCCCCCCCCCCHHCCCCCCCCHHHHCCCCCCCCCHHHCH
LLAFANCGAYAKHASPLNFLGHDWPAELMIDGARVIVLSPQIAFGPALWQSREVLQRFRC
HHHHHCCCCHHHCCCCCHHCCCCCCHHEEECCCEEEEECCCHHCCHHHHHHHHHHHHHCC
DGKIPTSS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]