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The map label for this gene is relA [H]

Identifier: 86748925

GI number: 86748925

Start: 2062707

End: 2063243

Strand: Direct

Name: relA [H]

Synonym: RPB_1802

Alternate gene names: 86748925

Gene position: 2062707-2063243 (Clockwise)

Preceding gene: 86748924

Following gene: 86748926

Centisome position: 38.69

GC content: 67.78

Gene sequence:

>537_bases
ATGACCGACCTCGTTCTCGTCTCCCGCGCCGCCGATTTCGCCGCGCGGTGCCATGCCGGGCAGCGCCGCAAGGGCGCGGC
GAAGGAGCCCTACGTCAATCATCTCGCCGAAGTCGCCGAGCTGCTGGCGGTGGCGACCGACGGCTCCGACGCAGCGCTGG
TCGCGGCCGGCTGGCTGCACGACACCGTCGAGGATTCCGGCACGACCCGCGACGAATTGATCGAGCAGTTCGGCGACGAC
GTCGCCGCGCTGGTGATCGAATGCACCGACGACAAGACGTTGCCGAAGGCCGAGCGCAAGCGGCTGCAGATCGAGCACGC
GCCGCATCTGAGCGGCCGGGCGCGGATGGTCAAGCTCGCCGACAAGATCAGCAATCTGCGTTCGCTGATCTTCTCGCCGC
CCGACGATTGGGAGCGCGAGCGGCTGATCGACTATCTCGATTGGGCCGACCGGGTCGTCGCCGGCTGCCGCGGCGTCAAC
GGTTATCTCGAACGCATCTACGACGAAACCGCCTCGTCCGGGAGGGCCGTGTTGTGA

Upstream 100 bases:

>100_bases
CCGCTTCGAGCCCGGCCAGACCCGCGACGTGCAACTCGTGGCGCTCGCGGGCAAGCGCGTCGTCTACGGCTTCCGCGGCG
ACGTGATGGGCAAGCTGTAG

Downstream 100 bases:

>100_bases
GCACCAGAATCTCGCGTTCCGTCTATGCCGACATGTTCGGTCCGACCACCGGCGACCGCGTCCGGCTCGCCGACACCGAT
CTGATCATCGAGGTCGAGAA

Product: metal dependent phosphohydrolase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MTDLVLVSRAADFAARCHAGQRRKGAAKEPYVNHLAEVAELLAVATDGSDAALVAAGWLHDTVEDSGTTRDELIEQFGDD
VAALVIECTDDKTLPKAERKRLQIEHAPHLSGRARMVKLADKISNLRSLIFSPPDDWERERLIDYLDWADRVVAGCRGVN
GYLERIYDETASSGRAVL

Sequences:

>Translated_178_residues
MTDLVLVSRAADFAARCHAGQRRKGAAKEPYVNHLAEVAELLAVATDGSDAALVAAGWLHDTVEDSGTTRDELIEQFGDD
VAALVIECTDDKTLPKAERKRLQIEHAPHLSGRARMVKLADKISNLRSLIFSPPDDWERERLIDYLDWADRVVAGCRGVN
GYLERIYDETASSGRAVL
>Mature_177_residues
TDLVLVSRAADFAARCHAGQRRKGAAKEPYVNHLAEVAELLAVATDGSDAALVAAGWLHDTVEDSGTTRDELIEQFGDDV
AALVIECTDDKTLPKAERKRLQIEHAPHLSGRARMVKLADKISNLRSLIFSPPDDWERERLIDYLDWADRVVAGCRGVNG
YLERIYDETASSGRAVL

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=126, Percent_Identity=54.7619047619048, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25143118, Length=172, Percent_Identity=43.0232558139535, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24650996, Length=157, Percent_Identity=46.4968152866242, Blast_Score=137, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 19614; Mature: 19483

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLVLVSRAADFAARCHAGQRRKGAAKEPYVNHLAEVAELLAVATDGSDAALVAAGWLH
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHH
DTVEDSGTTRDELIEQFGDDVAALVIECTDDKTLPKAERKRLQIEHAPHLSGRARMVKLA
HHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHH
DKISNLRSLIFSPPDDWERERLIDYLDWADRVVAGCRGVNGYLERIYDETASSGRAVL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TDLVLVSRAADFAARCHAGQRRKGAAKEPYVNHLAEVAELLAVATDGSDAALVAAGWLH
CCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHH
DTVEDSGTTRDELIEQFGDDVAALVIECTDDKTLPKAERKRLQIEHAPHLSGRARMVKLA
HHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHH
DKISNLRSLIFSPPDDWERERLIDYLDWADRVVAGCRGVNGYLERIYDETASSGRAVL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]