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The map label for this gene is fadA [H]

Identifier: 86748871

GI number: 86748871

Start: 1997586

End: 1998773

Strand: Direct

Name: fadA [H]

Synonym: RPB_1748

Alternate gene names: 86748871

Gene position: 1997586-1998773 (Clockwise)

Preceding gene: 86748870

Following gene: 86748872

Centisome position: 37.47

GC content: 69.53

Gene sequence:

>1188_bases
ATGACCGACGCCGTAATCGTTTCCACCGCGCGCACGCCGATCGGCAAGGCCTATCGCGGCGCCCTCAACGCCACCGAGGG
CGCGACCTTGCTGGGCCATGCGATCGAGCACGCCGTCAAGCGTGCCGGCATCGACCCGAAGGAGGTCGAGGACGTGGTGA
TGGGCGCCGCGATGCAGCAGGGCGCCACCGGCGGCAACATCGCCCGCAAGGCGCTGCTGCGCGCCGGCCTGCCGGTCTCC
ACCGCCGGTACCACGATCGACCGGCAATGCGCCTCCGGCCTGCAGGCGATCGCGCTCGCCGCGCGCTCGGTGCTGTTCGA
TGGCGTCGAGATCGCGGTCGGCGGCGGCGGCGAGTCGATCAGCTTGGTGCAGAACGACAAGATGAACGGCTTCCACGCCG
TCGATCCGGCGCTGCAGGCGATCAAGGGCGACGTCTACATGGCGATGCTCGACACCGCCGAAACGGTGGCGAAGCGCTAC
GGCATCTCGCGCGAGCGCCAGGACGAGTATTCGCTGGAGAGCCAGCGCCGCACCGCTGCGGCGCAGCAGGGCGGCAAGTT
CGCCGACGAGATCGCGCCGATCGCGACCAAGATGGGCGTCGTCGACAAGGCCACCGGCGAGGTATCGTTCAAGGACATCA
CGCTGTCGCAAGACGAGGGCCCGCGGCCCGAGACCTCCGCTGAAGGTCTCGCCAGCCTGAAGGCGGTGCGCGGCGAGGGC
TTCACCATCACCGCCGGCAACGCCAGCCAGCTCTCCGACGGCGCCTCCGCCACGGTGATCATGAGCGACAAGACCGCGGC
GGCGAAGGGCCTGAAGCCGCTCGGCATCTTCCGCGGCATGGTCTCGCACGGCTGCGAGCCGGACGAGATGGGCATCGGCC
CGGTGTTCGCGGTGCCGCGTCTGTTGAAGCGCCACGGCCTGACCGTCGACGACATCGGCGTCTGGGAGCTCAACGAAGCC
TTCGCCGTGCAGGTGCTGTACTGCCGCGACAAGCTCGGCATCGATCCGGAGAAGCTCAACGTCAATGGCGGCGCGATCTC
GGTCGGCCACCCCTACGGCATGTCGGGCGCCCGCCTCGCCGGCCACGCCCTGATCGAAGGCCGTCGCCGCAAGGCGAAGT
ACGCGGTGGTGACGATGTGCGTCGGCGGCGGCATGGGCTCGGCCGGCCTGTTCGAGATCGTGCACTGA

Upstream 100 bases:

>100_bases
CGCGCACCCCGGTCGGCAAACTCTCGCGCCACGAACTGCGCAATCAGCTACCCAAATCCACCAACCAGAGCCAACAGCAA
ACCGCACAGGGAGTCCGCCC

Downstream 100 bases:

>100_bases
GGAAGTAACAACGGGCACCGACTAAACCTCTCCCCGCGTGCGGGGAGAGGTCGACCGGCGAAGCCGGTCGGGTGAGGGGG
CGTTTCAACAAGGCCGAGCG

Product: Acetyl-CoA C-acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTDAVIVSTARTPIGKAYRGALNATEGATLLGHAIEHAVKRAGIDPKEVEDVVMGAAMQQGATGGNIARKALLRAGLPVS
TAGTTIDRQCASGLQAIALAARSVLFDGVEIAVGGGGESISLVQNDKMNGFHAVDPALQAIKGDVYMAMLDTAETVAKRY
GISRERQDEYSLESQRRTAAAQQGGKFADEIAPIATKMGVVDKATGEVSFKDITLSQDEGPRPETSAEGLASLKAVRGEG
FTITAGNASQLSDGASATVIMSDKTAAAKGLKPLGIFRGMVSHGCEPDEMGIGPVFAVPRLLKRHGLTVDDIGVWELNEA
FAVQVLYCRDKLGIDPEKLNVNGGAISVGHPYGMSGARLAGHALIEGRRRKAKYAVVTMCVGGGMGSAGLFEIVH

Sequences:

>Translated_395_residues
MTDAVIVSTARTPIGKAYRGALNATEGATLLGHAIEHAVKRAGIDPKEVEDVVMGAAMQQGATGGNIARKALLRAGLPVS
TAGTTIDRQCASGLQAIALAARSVLFDGVEIAVGGGGESISLVQNDKMNGFHAVDPALQAIKGDVYMAMLDTAETVAKRY
GISRERQDEYSLESQRRTAAAQQGGKFADEIAPIATKMGVVDKATGEVSFKDITLSQDEGPRPETSAEGLASLKAVRGEG
FTITAGNASQLSDGASATVIMSDKTAAAKGLKPLGIFRGMVSHGCEPDEMGIGPVFAVPRLLKRHGLTVDDIGVWELNEA
FAVQVLYCRDKLGIDPEKLNVNGGAISVGHPYGMSGARLAGHALIEGRRRKAKYAVVTMCVGGGMGSAGLFEIVH
>Mature_394_residues
TDAVIVSTARTPIGKAYRGALNATEGATLLGHAIEHAVKRAGIDPKEVEDVVMGAAMQQGATGGNIARKALLRAGLPVST
AGTTIDRQCASGLQAIALAARSVLFDGVEIAVGGGGESISLVQNDKMNGFHAVDPALQAIKGDVYMAMLDTAETVAKRYG
ISRERQDEYSLESQRRTAAAQQGGKFADEIAPIATKMGVVDKATGEVSFKDITLSQDEGPRPETSAEGLASLKAVRGEGF
TITAGNASQLSDGASATVIMSDKTAAAKGLKPLGIFRGMVSHGCEPDEMGIGPVFAVPRLLKRHGLTVDDIGVWELNEAF
AVQVLYCRDKLGIDPEKLNVNGGAISVGHPYGMSGARLAGHALIEGRRRKAKYAVVTMCVGGGMGSAGLFEIVH

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=41.5816326530612, Blast_Score=271, Evalue=9e-73,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=37.7833753148615, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI4557237, Length=401, Percent_Identity=37.4064837905237, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=36.4321608040201, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI4504327, Length=442, Percent_Identity=29.8642533936652, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI194353979, Length=244, Percent_Identity=35.2459016393443, Blast_Score=118, Evalue=9e-27,
Organism=Escherichia coli, GI1787663, Length=416, Percent_Identity=42.3076923076923, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1788554, Length=410, Percent_Identity=40.4878048780488, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=37.3762376237624, Blast_Score=235, Evalue=3e-63,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=38.5, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788683, Length=424, Percent_Identity=29.4811320754717, Blast_Score=157, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=37.0927318295739, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI25147385, Length=395, Percent_Identity=35.1898734177215, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17535921, Length=413, Percent_Identity=36.0774818401937, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=442, Percent_Identity=31.2217194570136, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=390, Percent_Identity=29.7435897435897, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322031, Length=404, Percent_Identity=36.1386138613861, Blast_Score=226, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6325229, Length=404, Percent_Identity=33.4158415841584, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24655093, Length=399, Percent_Identity=39.5989974937343, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=36.9077306733167, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI17648125, Length=400, Percent_Identity=38.25, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI17137578, Length=438, Percent_Identity=29.9086757990868, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41042; Mature: 40911

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAVIVSTARTPIGKAYRGALNATEGATLLGHAIEHAVKRAGIDPKEVEDVVMGAAMQQ
CCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GATGGNIARKALLRAGLPVSTAGTTIDRQCASGLQAIALAARSVLFDGVEIAVGGGGESI
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEE
SLVQNDKMNGFHAVDPALQAIKGDVYMAMLDTAETVAKRYGISRERQDEYSLESQRRTAA
EEEECCCCCCEEHHHHHHHHHCCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
AQQGGKFADEIAPIATKMGVVDKATGEVSFKDITLSQDEGPRPETSAEGLASLKAVRGEG
HHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCC
FTITAGNASQLSDGASATVIMSDKTAAAKGLKPLGIFRGMVSHGCEPDEMGIGPVFAVPR
EEEECCCHHHCCCCCCEEEEEECCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LLKRHGLTVDDIGVWELNEAFAVQVLYCRDKLGIDPEKLNVNGGAISVGHPYGMSGARLA
HHHHCCCCEECCCCEECCHHHEEEEEEEHHHCCCCHHHEECCCCEEECCCCCCCCCCHHH
GHALIEGRRRKAKYAVVTMCVGGGMGSAGLFEIVH
HHHHHHCHHHHCCEEEEEEEECCCCCCCCHHEECC
>Mature Secondary Structure 
TDAVIVSTARTPIGKAYRGALNATEGATLLGHAIEHAVKRAGIDPKEVEDVVMGAAMQQ
CCCEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GATGGNIARKALLRAGLPVSTAGTTIDRQCASGLQAIALAARSVLFDGVEIAVGGGGESI
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEE
SLVQNDKMNGFHAVDPALQAIKGDVYMAMLDTAETVAKRYGISRERQDEYSLESQRRTAA
EEEECCCCCCEEHHHHHHHHHCCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
AQQGGKFADEIAPIATKMGVVDKATGEVSFKDITLSQDEGPRPETSAEGLASLKAVRGEG
HHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCC
FTITAGNASQLSDGASATVIMSDKTAAAKGLKPLGIFRGMVSHGCEPDEMGIGPVFAVPR
EEEECCCHHHCCCCCCEEEEEECCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LLKRHGLTVDDIGVWELNEAFAVQVLYCRDKLGIDPEKLNVNGGAISVGHPYGMSGARLA
HHHHCCCCEECCCCEECCHHHEEEEEEEHHHCCCCHHHEECCCCEEECCCCCCCCCCHHH
GHALIEGRRRKAKYAVVTMCVGGGMGSAGLFEIVH
HHHHHHCHHHHCCEEEEEEEECCCCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]