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The map label for this gene is rmlA1 [H]

Identifier: 86748690

GI number: 86748690

Start: 1763766

End: 1764644

Strand: Direct

Name: rmlA1 [H]

Synonym: RPB_1565

Alternate gene names: 86748690

Gene position: 1763766-1764644 (Clockwise)

Preceding gene: 86748689

Following gene: 162138522

Centisome position: 33.08

GC content: 64.51

Gene sequence:

>879_bases
ATGACCACCGTTTCCAAGGGCATCATTCTCGCAGGCGGCAGTGGGACGCGGCTGTATCCGATGACGGTGTCGGCCTCTAA
GCAGCTGCTGCCGATCTACGACAAGCCGCTGATCTACTACCCGCTGTCGACGCTGATGATGGCGGGCATCCGCGACATCC
TGGTGATCTCGACCCCGGCGGACCTGCCGCGATTCCAGCAATTGCTCGGCGACGGCGCGCGCTGGGGGATGTCGTTCAGC
TACGCCGAGCAGCCGCGCCCCGAAGGGCTGGCGCAGGCCTACATCATCGGCGCCGATTTCGTCGCCGGCGGGCCCTCCGC
GCTCGTGCTCGGCGACAATCTGTTTTACGGCCACGATCTGATTCCGCTGCTGCGGAAGGCGGCGGGCCAGTGCGACGGCG
CCACCGTGTTCGCCTATCAGGTGCGCGATCCGCAGGCCTACGGCGTCGTCGAATTCGACGACAACCAGACCGCGCTCTCG
ATCGAGGAGAAGCCGGCGACCCCGCGATCCAACTGGGCGGTGACCGGCGTGTACTTCTACGATTCACAGGCCGTCGAAAT
CGCCGCCGGGCTGAAACCGTCGGCGCGCGGCGAACTCGAGATCACCGATCTCAACCGGGCCTATCTCGAACGCGGTCAAC
TCCGCGTCGAAAAGATGGGGCGCGGTTTCGCTTGGCTCGATACTGGGACGCCGGACAGTCTGCTGGAGGCGGCCGAGTTC
GTGCGCATCCTGGAAAAGCGGCAGGGCCTCAAGATCTGCTGCCCCGAAGAGATCGCCTTCCATATGAAGTGGATCGACGC
CGATCAGCTCGAAGCTTTGGCGAAGCCGATCGCGAACAGCGGCTATGGCCGCTATTTGCTCGCTATCGCGCAACGCTGA

Upstream 100 bases:

>100_bases
CGCCACGGCGTGCGGCTGCCGGATTGGCGGGACTCGCTGCCCTCCTGCGTCGACCGGCTGCTGGCGGCGCGGCGCGTCCA
CCATTGAGACAGGCATCGCC

Downstream 100 bases:

>100_bases
GCCGCAGCGCGCCCGCAGCCGCCTCAGCGCCGCCGCCAGATCGTCGCCTGCGCCTGTTGGTCCGGCAGGTCGTAGCTCGG
TCCACGGGCGTAGCGGGTCT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTTVSKGIILAGGSGTRLYPMTVSASKQLLPIYDKPLIYYPLSTLMMAGIRDILVISTPADLPRFQQLLGDGARWGMSFS
YAEQPRPEGLAQAYIIGADFVAGGPSALVLGDNLFYGHDLIPLLRKAAGQCDGATVFAYQVRDPQAYGVVEFDDNQTALS
IEEKPATPRSNWAVTGVYFYDSQAVEIAAGLKPSARGELEITDLNRAYLERGQLRVEKMGRGFAWLDTGTPDSLLEAAEF
VRILEKRQGLKICCPEEIAFHMKWIDADQLEALAKPIANSGYGRYLLAIAQR

Sequences:

>Translated_292_residues
MTTVSKGIILAGGSGTRLYPMTVSASKQLLPIYDKPLIYYPLSTLMMAGIRDILVISTPADLPRFQQLLGDGARWGMSFS
YAEQPRPEGLAQAYIIGADFVAGGPSALVLGDNLFYGHDLIPLLRKAAGQCDGATVFAYQVRDPQAYGVVEFDDNQTALS
IEEKPATPRSNWAVTGVYFYDSQAVEIAAGLKPSARGELEITDLNRAYLERGQLRVEKMGRGFAWLDTGTPDSLLEAAEF
VRILEKRQGLKICCPEEIAFHMKWIDADQLEALAKPIANSGYGRYLLAIAQR
>Mature_291_residues
TTVSKGIILAGGSGTRLYPMTVSASKQLLPIYDKPLIYYPLSTLMMAGIRDILVISTPADLPRFQQLLGDGARWGMSFSY
AEQPRPEGLAQAYIIGADFVAGGPSALVLGDNLFYGHDLIPLLRKAAGQCDGATVFAYQVRDPQAYGVVEFDDNQTALSI
EEKPATPRSNWAVTGVYFYDSQAVEIAAGLKPSARGELEITDLNRAYLERGQLRVEKMGRGFAWLDTGTPDSLLEAAEFV
RILEKRQGLKICCPEEIAFHMKWIDADQLEALAKPIANSGYGRYLLAIAQR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=251, Percent_Identity=25.4980079681275, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI11761619, Length=251, Percent_Identity=25.4980079681275, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=64.9305555555556, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1790224, Length=284, Percent_Identity=63.3802816901408, Blast_Score=379, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI133931050, Length=234, Percent_Identity=26.0683760683761, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=25.296442687747, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355443, Length=252, Percent_Identity=23.4126984126984, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644084, Length=252, Percent_Identity=23.4126984126984, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 31974; Mature: 31843

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVSKGIILAGGSGTRLYPMTVSASKQLLPIYDKPLIYYPLSTLMMAGIRDILVISTPA
CCCCCCCEEEECCCCCEEEEEEECCCCCEEEECCCCEEEECHHHHHHHCCCEEEEEECCC
DLPRFQQLLGDGARWGMSFSYAEQPRPEGLAQAYIIGADFVAGGPSALVLGDNLFYGHDL
CCHHHHHHHCCCHHCCCEECCCCCCCCCCCEEEEEEECHHHCCCCCEEEEECCEEECCCH
IPLLRKAAGQCDGATVFAYQVRDPQAYGVVEFDDNQTALSIEEKPATPRSNWAVTGVYFY
HHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCCCEEEEEEEEE
DSQAVEIAAGLKPSARGELEITDLNRAYLERGQLRVEKMGRGFAWLDTGTPDSLLEAAEF
CCCEEEEEECCCCCCCCCEEEEECCHHHHHHCCEEEEHHCCCEEEEECCCCHHHHHHHHH
VRILEKRQGLKICCPEEIAFHMKWIDADQLEALAKPIANSGYGRYLLAIAQR
HHHHHHHCCCEEECHHHHEEEEEECCHHHHHHHHHHHCCCCCCEEEEEEECC
>Mature Secondary Structure 
TTVSKGIILAGGSGTRLYPMTVSASKQLLPIYDKPLIYYPLSTLMMAGIRDILVISTPA
CCCCCCEEEECCCCCEEEEEEECCCCCEEEECCCCEEEECHHHHHHHCCCEEEEEECCC
DLPRFQQLLGDGARWGMSFSYAEQPRPEGLAQAYIIGADFVAGGPSALVLGDNLFYGHDL
CCHHHHHHHCCCHHCCCEECCCCCCCCCCCEEEEEEECHHHCCCCCEEEEECCEEECCCH
IPLLRKAAGQCDGATVFAYQVRDPQAYGVVEFDDNQTALSIEEKPATPRSNWAVTGVYFY
HHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCCCEEEEEEEEE
DSQAVEIAAGLKPSARGELEITDLNRAYLERGQLRVEKMGRGFAWLDTGTPDSLLEAAEF
CCCEEEEEECCCCCCCCCEEEEECCHHHHHHCCEEEEHHCCCEEEEECCCCHHHHHHHHH
VRILEKRQGLKICCPEEIAFHMKWIDADQLEALAKPIANSGYGRYLLAIAQR
HHHHHHHCCCEEECHHHHEEEEEECCHHHHHHHHHHHCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]