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The map label for this gene is mcpA [H]

Identifier: 86748539

GI number: 86748539

Start: 1603635

End: 1604957

Strand: Direct

Name: mcpA [H]

Synonym: RPB_1414

Alternate gene names: 86748539

Gene position: 1603635-1604957 (Clockwise)

Preceding gene: 86748538

Following gene: 86748540

Centisome position: 30.08

GC content: 68.1

Gene sequence:

>1323_bases
ATGATCAACTCGTCTTCTCTCTCTAACGCGGCCGTTTGTCTCGGCGGCGTCGTCGTTTCCGCGCTGGCGGCGGCGGCGGG
CTTGCTGGCCGATATGCCGCTGTTGCTGGCGGTCGGACTCGTCGCGACGCTCGCATGTGCCGGACTGCTCGGCCTGATGC
TGCTGCGGCTGGACCGGACCTTGGCGAATCTGGGCGCGATCTGTCAGCGCATCGCCGATGGCGATTTCGAGGCGCGGGTC
ATCGGCAGCCGCGAGGGCGGCCGGATCGGTGCGCTGCATCACGCCTTCAACGATATGATCGACCGCTGCGACGCCTTCGT
GCGCGAGGCCAGCGCGGCGATGGGCGCCATCCGCGACGACAAATATTATCGCCACATTCTGCCGGCGGGCTTGCGCGGCT
CGCTGTTGATCGCGAGCCGGACGATCAATGAGGCGATGCAGGCGATCGAGACGCGGGTCGCCGCCTTCAACGCCAACACC
GCGGAATTCGAAGGCACGATCGGCGCGGTGATCGACACGGTGTCGTCGGCGTCGAACAATATGGGCACCACCGCCGGCAG
CCTCAACCGCGGCGTCGCCGCGACGCGCGAACGCACGCTCGCCGTGTCGGCGGCCTCGGAACAGGCCTCGACCAATATGG
AGACGGTGGCGGCGGCGACGACGGAACTCACCGCGTCGGCCAACGAGATTCTCGGCAGCGTCAATCGCTCGGCCATGATC
GCGAAAACCGCGGTCGGCGCCTCGGACCATGCGCGCGAGACGGTCGGCAGCCTGTCGACCGCGACCGAGCGGATCGGCAC
CATCGTTCAACTGATCGAGGAGATCGCCTCGCAGACCAATCTGCTGGCGCTGAACGCCACGATCGAGGCCGCGCGCGCCG
GCGAAGCGGGCAGGGGCTTTTCGGTGGTGGCGCAGGAGGTCAAATCGCTCGCCGCGCAGACCGCCAAGGCGACCCACGAC
ATCTCCGTCAGCATCGCCGAAGTGCAGGAAACCACCCGCGCCGCGGTCGACGCCATCTCCGGCATCGGCCGGAGCATCGG
CGAAGTCGACGCCATCACCCGTCAGGTCGCGGTCGCGGTCGAAGCGCAGACCGCGGCGACCAGCGAGGTGGCGCGCAACA
TCGAGCAGGCCTTCGCCGGCATCCGCGACATTTCGTTCAACATCCAGAGCGTGAGCGTCAACGTCGCTGAAACCGAGGAG
CACGCCGGAACCACCTTGACCGCTTCCGGCTCGCTGGCGCAGCAAGCCACCACGCTCGGCGACGCGGTGCGCGATTTCCT
GCGATCGCTGCGCCGGGACGAGGCCTCGCGCCGCGCCGCTTGA

Upstream 100 bases:

>100_bases
GAGTTGAGCGAGGTGGAAAAGCGTCATCGCAACGGCAAGGACGGGCTCGCCGCCGGCACGCAGCACCTGATCGATTTCGT
CAAAGCCAAGAATGTGCCCT

Downstream 100 bases:

>100_bases
TGGGTCCACGGATCGCCGAGGAGCGAAGGCGCGGGCGAGATGGGGCCGCCCTGCAGCTTACCGAAATGTCACGAAGATGA
ACCTCTCCGTCAGCCCTCGT

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: Methyl-accepting chemotaxis protein [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MINSSSLSNAAVCLGGVVVSALAAAAGLLADMPLLLAVGLVATLACAGLLGLMLLRLDRTLANLGAICQRIADGDFEARV
IGSREGGRIGALHHAFNDMIDRCDAFVREASAAMGAIRDDKYYRHILPAGLRGSLLIASRTINEAMQAIETRVAAFNANT
AEFEGTIGAVIDTVSSASNNMGTTAGSLNRGVAATRERTLAVSAASEQASTNMETVAAATTELTASANEILGSVNRSAMI
AKTAVGASDHARETVGSLSTATERIGTIVQLIEEIASQTNLLALNATIEAARAGEAGRGFSVVAQEVKSLAAQTAKATHD
ISVSIAEVQETTRAAVDAISGIGRSIGEVDAITRQVAVAVEAQTAATSEVARNIEQAFAGIRDISFNIQSVSVNVAETEE
HAGTTLTASGSLAQQATTLGDAVRDFLRSLRRDEASRRAA

Sequences:

>Translated_440_residues
MINSSSLSNAAVCLGGVVVSALAAAAGLLADMPLLLAVGLVATLACAGLLGLMLLRLDRTLANLGAICQRIADGDFEARV
IGSREGGRIGALHHAFNDMIDRCDAFVREASAAMGAIRDDKYYRHILPAGLRGSLLIASRTINEAMQAIETRVAAFNANT
AEFEGTIGAVIDTVSSASNNMGTTAGSLNRGVAATRERTLAVSAASEQASTNMETVAAATTELTASANEILGSVNRSAMI
AKTAVGASDHARETVGSLSTATERIGTIVQLIEEIASQTNLLALNATIEAARAGEAGRGFSVVAQEVKSLAAQTAKATHD
ISVSIAEVQETTRAAVDAISGIGRSIGEVDAITRQVAVAVEAQTAATSEVARNIEQAFAGIRDISFNIQSVSVNVAETEE
HAGTTLTASGSLAQQATTLGDAVRDFLRSLRRDEASRRAA
>Mature_440_residues
MINSSSLSNAAVCLGGVVVSALAAAAGLLADMPLLLAVGLVATLACAGLLGLMLLRLDRTLANLGAICQRIADGDFEARV
IGSREGGRIGALHHAFNDMIDRCDAFVREASAAMGAIRDDKYYRHILPAGLRGSLLIASRTINEAMQAIETRVAAFNANT
AEFEGTIGAVIDTVSSASNNMGTTAGSLNRGVAATRERTLAVSAASEQASTNMETVAAATTELTASANEILGSVNRSAMI
AKTAVGASDHARETVGSLSTATERIGTIVQLIEEIASQTNLLALNATIEAARAGEAGRGFSVVAQEVKSLAAQTAKATHD
ISVSIAEVQETTRAAVDAISGIGRSIGEVDAITRQVAVAVEAQTAATSEVARNIEQAFAGIRDISFNIQSVSVNVAETEE
HAGTTLTASGSLAQQATTLGDAVRDFLRSLRRDEASRRAA

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein. Note=Localized at the flagellum-bearing pole of the swarmer cell [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=275, Percent_Identity=31.6363636363636, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788195, Length=240, Percent_Identity=32.5, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI2367378, Length=187, Percent_Identity=35.8288770053476, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788194, Length=196, Percent_Identity=33.6734693877551, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789453, Length=104, Percent_Identity=43.2692307692308, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 45263; Mature: 45263

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2 ; PS50192 T_SNARE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSSSLSNAAVCLGGVVVSALAAAAGLLADMPLLLAVGLVATLACAGLLGLMLLRLDRT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LANLGAICQRIADGDFEARVIGSREGGRIGALHHAFNDMIDRCDAFVREASAAMGAIRDD
HHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KYYRHILPAGLRGSLLIASRTINEAMQAIETRVAAFNANTAEFEGTIGAVIDTVSSASNN
HHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCCC
MGTTAGSLNRGVAATRERTLAVSAASEQASTNMETVAAATTELTASANEILGSVNRSAMI
CCCCCCCHHCCHHHHHHHHEEEECHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AKTAVGASDHARETVGSLSTATERIGTIVQLIEEIASQTNLLALNATIEAARAGEAGRGF
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCH
SVVAQEVKSLAAQTAKATHDISVSIAEVQETTRAAVDAISGIGRSIGEVDAITRQVAVAV
HHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAQTAATSEVARNIEQAFAGIRDISFNIQSVSVNVAETEEHAGTTLTASGSLAQQATTLG
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEHHHHHCCCEEEECCCHHHHHHHHH
DAVRDFLRSLRRDEASRRAA
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MINSSSLSNAAVCLGGVVVSALAAAAGLLADMPLLLAVGLVATLACAGLLGLMLLRLDRT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LANLGAICQRIADGDFEARVIGSREGGRIGALHHAFNDMIDRCDAFVREASAAMGAIRDD
HHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KYYRHILPAGLRGSLLIASRTINEAMQAIETRVAAFNANTAEFEGTIGAVIDTVSSASNN
HHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCCC
MGTTAGSLNRGVAATRERTLAVSAASEQASTNMETVAAATTELTASANEILGSVNRSAMI
CCCCCCCHHCCHHHHHHHHEEEECHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AKTAVGASDHARETVGSLSTATERIGTIVQLIEEIASQTNLLALNATIEAARAGEAGRGF
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCH
SVVAQEVKSLAAQTAKATHDISVSIAEVQETTRAAVDAISGIGRSIGEVDAITRQVAVAV
HHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAQTAATSEVARNIEQAFAGIRDISFNIQSVSVNVAETEEHAGTTLTASGSLAQQATTLG
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEHHHHHCCCEEEECCCHHHHHHHHH
DAVRDFLRSLRRDEASRRAA
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1577276; 11259647 [H]