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The map label for this gene is 86747440

Identifier: 86747440

GI number: 86747440

Start: 357590

End: 358387

Strand: Reverse

Name: 86747440

Synonym: RPB_0314

Alternate gene names: NA

Gene position: 358387-357590 (Counterclockwise)

Preceding gene: 86747447

Following gene: 86747439

Centisome position: 6.72

GC content: 70.05

Gene sequence:

>798_bases
GTGCCGGCGGCCGCAACGGCTCCTGTTTCCCTCTCACAGGCGAGGACGTCAGGCGTGGCACTGCTTGTCACCCGCCCGCA
ACCCGACAACGACGCCACCGCCGCCGCGCTGCGCGCGAAGGGCTACGACGTGCTGCTGGCGCCGATGCTGCGGTTCGAGC
CGGCGCCGTTTCCGGACGATCAGGACACCGACTATACGGGCGTGATCGTCACCAGCGCCAATGCGCTGCGGGCGATCGCC
GATCAGCCCGGTTTCGCGCGGCTGCTGAAGCTGCCGCTGTTCGCGGTCGGCAAGCACACCGCGCGCGCGGCCCGCGACGC
CGGCTTCAAGGACGTCATCGTCGCCGAGGGCGACGCCGCCAGACTGCGGCTGAAGGTCGCCGATAGCGTCAAAGGGAAAA
AGAAGGCGGCCGGCGCGTTGCTGTATCTGGCCGGCGCCGATCTGTCGCGCGACCTCGCCGGCGAATTGCGCGAGGACGGC
TTCCACGTGGTGATGCAGACGACCTACAGGATGCTGCCGGTGCAGACGCTGCCGGCGACCATCTGCGACGAATTTGCGGC
CAATCGGATCGAGGCGGTGCTGCATTACTCGCGGCGCAGCGCGCGCGCCTTCATCGACGCGACGCGGGCGTCCGGGATCG
AGATCTCGGCGCTGGCGATTCCGCAATGCTGCCTGTCGGACTCGGTGTCCGACGTGGTGCGCGAGGCCGGCGCGACGCAG
GTGATGGTGGCGCGCACGCCCGACGAGAAGGCGCTGTTCGAGGCGCTGGACCGTGCGGTCGGTGCGCCCGCGCGCTGA

Upstream 100 bases:

>100_bases
CGAACCGGCGTTCTCCTTGCCTCGCGTAGCATTGCGGGGTCTCGGAATGCAATCATCCGGTCGGCTCCCCGCGGCTCCGG
CAAGGTCCGACGGCCCGCTG

Downstream 100 bases:

>100_bases
ACGAACAACGCGCCGGGCCGGCAACGGATTCGGCAGGAGTGACGAGGAACGATTGCGGATGGTCGAGAACAGGCCCGGAC
ACGAGGATACGCAGCACGGA

Product: uroporphyrinogen III synthase HEM4

Products: uroporphyrinogen III; H2O

Alternate protein names: Uroporphyrinogen III Synthase

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MPAAATAPVSLSQARTSGVALLVTRPQPDNDATAAALRAKGYDVLLAPMLRFEPAPFPDDQDTDYTGVIVTSANALRAIA
DQPGFARLLKLPLFAVGKHTARAARDAGFKDVIVAEGDAARLRLKVADSVKGKKKAAGALLYLAGADLSRDLAGELREDG
FHVVMQTTYRMLPVQTLPATICDEFAANRIEAVLHYSRRSARAFIDATRASGIEISALAIPQCCLSDSVSDVVREAGATQ
VMVARTPDEKALFEALDRAVGAPAR

Sequences:

>Translated_265_residues
MPAAATAPVSLSQARTSGVALLVTRPQPDNDATAAALRAKGYDVLLAPMLRFEPAPFPDDQDTDYTGVIVTSANALRAIA
DQPGFARLLKLPLFAVGKHTARAARDAGFKDVIVAEGDAARLRLKVADSVKGKKKAAGALLYLAGADLSRDLAGELREDG
FHVVMQTTYRMLPVQTLPATICDEFAANRIEAVLHYSRRSARAFIDATRASGIEISALAIPQCCLSDSVSDVVREAGATQ
VMVARTPDEKALFEALDRAVGAPAR
>Mature_264_residues
PAAATAPVSLSQARTSGVALLVTRPQPDNDATAAALRAKGYDVLLAPMLRFEPAPFPDDQDTDYTGVIVTSANALRAIAD
QPGFARLLKLPLFAVGKHTARAARDAGFKDVIVAEGDAARLRLKVADSVKGKKKAAGALLYLAGADLSRDLAGELREDGF
HVVMQTTYRMLPVQTLPATICDEFAANRIEAVLHYSRRSARAFIDATRASGIEISALAIPQCCLSDSVSDVVREAGATQV
MVARTPDEKALFEALDRAVGAPAR

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 28070; Mature: 27939

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAAATAPVSLSQARTSGVALLVTRPQPDNDATAAALRAKGYDVLLAPMLRFEPAPFPDD
CCCCCCCCCCHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEHHHHHCCCCCCCCC
QDTDYTGVIVTSANALRAIADQPGFARLLKLPLFAVGKHTARAARDAGFKDVIVAEGDAA
CCCCEEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCEEEEECCCCC
RLRLKVADSVKGKKKAAGALLYLAGADLSRDLAGELREDGFHVVMQTTYRMLPVQTLPAT
EEEEEECCCCCCCHHHCCEEEEEECCCCCHHHHHHHHHCCEEEEEEHHHHHCCHHHHHHH
ICDEFAANRIEAVLHYSRRSARAFIDATRASGIEISALAIPQCCLSDSVSDVVREAGATQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHCCHHHHHHHHCCCCE
VMVARTPDEKALFEALDRAVGAPAR
EEEEECCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PAAATAPVSLSQARTSGVALLVTRPQPDNDATAAALRAKGYDVLLAPMLRFEPAPFPDD
CCCCCCCCCHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEHHHHHCCCCCCCCC
QDTDYTGVIVTSANALRAIADQPGFARLLKLPLFAVGKHTARAARDAGFKDVIVAEGDAA
CCCCEEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCEEEEECCCCC
RLRLKVADSVKGKKKAAGALLYLAGADLSRDLAGELREDGFHVVMQTTYRMLPVQTLPAT
EEEEEECCCCCCCHHHCCEEEEEECCCCCHHHHHHHHHCCEEEEEEHHHHHCCHHHHHHH
ICDEFAANRIEAVLHYSRRSARAFIDATRASGIEISALAIPQCCLSDSVSDVVREAGATQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHCCHHHHHHHHCCCCE
VMVARTPDEKALFEALDRAVGAPAR
EEEEECCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA