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The map label for this gene is thiD [H]

Identifier: 86610257

GI number: 86610257

Start: 2931711

End: 2932577

Strand: Direct

Name: thiD [H]

Synonym: CYB_2833

Alternate gene names: 86610257

Gene position: 2931711-2932577 (Clockwise)

Preceding gene: 86610256

Following gene: 86610258

Centisome position: 96.23

GC content: 63.09

Gene sequence:

>867_bases
ATGTCTGTCTCTGCATCTGAACCAACTCCGGCTCCACTGCTGGCCGAGCAGCACCCCCCTGTCGCCCTCACCATCGCTGG
ATCCGACAGTGGTGGGGGAGCAGGGATCCAAGCGGATCTGCGCACCTTTGCTTTCCAACGGGTACACGGTACCTCTGCCC
TGACCTGCGTGACCGCCCAGAATACCCTTGGGGTGAGCCGGGTGGATGCGCTGCCCCCCGAAGCCGTAGCCGCCCAAATC
GAGGCCGTGGTGCAGGACATTGGGGTGCAAGGGATCAAGACGGGCATGTTGCTGAATGCCGAGATCGTGCTGGAGGTAGC
CCGTCAGGTGGAGCGCTGGGCGTTGCGGCCTCTGGTGGTGGATCCGGTGATGGTGTCCCGCACGGGAGCAAAGTTGCTGG
CAGATGAGGCCATTCAGGCCATCCGCGAGCAGCTGATCCCCTTGGCTCAGGTGCTGACCCCCAACCGCTATGAGGCGCAA
ATTTTAACGGGGCTGGAGCTGCAGTCCCTGGCAGATATGCAAACGGCGGCCCAGCAGATTCACGCCTTAGGCTGTGGAGC
GGTGTTGGTTAAAGGCGGAGGCATGCCGGGGGAACTGCAGGGGGTGGATGTGTGGTTCGATGGCGAGCGACTGGAAGTGC
TGAAAACAGAGCGGATCCCCACCCGCCACACCCACGGCACCGGCTGTACCCTCTCGGCGGCCATTGCAGCACAGATGGCC
TGGGGCAGGGATCCCTTGGCGGCCACAGTGGCGGCCAAAGCCTATGTAACAGAAGCGCTGCGACATCCTTTGGCCATCGG
GTCAGGGCAGGGGCCAGTGGGGCACTTCTACCCGCTTCTGTCCGGGATTGGCAAACCTGTGCCATAA

Upstream 100 bases:

>100_bases
AATCGAGAACCAACAGTTTCATTGCTACGTTAAAGAGATGGTTCATATTGATTGATGGAAATGGCTATCGGTACCCTTGC
CCATTTTTGTCGTTTGGCCA

Downstream 100 bases:

>100_bases
GAGAGAGGTCACTCTCTCTGGCTGCTATGGCTAGCCCGTCGAATCTTTCTCAGAAGGGATCCCTGCCCAAATGGCGGTTT
TGGCTACCCCTACTGCTGCA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSVSASEPTPAPLLAEQHPPVALTIAGSDSGGGAGIQADLRTFAFQRVHGTSALTCVTAQNTLGVSRVDALPPEAVAAQI
EAVVQDIGVQGIKTGMLLNAEIVLEVARQVERWALRPLVVDPVMVSRTGAKLLADEAIQAIREQLIPLAQVLTPNRYEAQ
ILTGLELQSLADMQTAAQQIHALGCGAVLVKGGGMPGELQGVDVWFDGERLEVLKTERIPTRHTHGTGCTLSAAIAAQMA
WGRDPLAATVAAKAYVTEALRHPLAIGSGQGPVGHFYPLLSGIGKPVP

Sequences:

>Translated_288_residues
MSVSASEPTPAPLLAEQHPPVALTIAGSDSGGGAGIQADLRTFAFQRVHGTSALTCVTAQNTLGVSRVDALPPEAVAAQI
EAVVQDIGVQGIKTGMLLNAEIVLEVARQVERWALRPLVVDPVMVSRTGAKLLADEAIQAIREQLIPLAQVLTPNRYEAQ
ILTGLELQSLADMQTAAQQIHALGCGAVLVKGGGMPGELQGVDVWFDGERLEVLKTERIPTRHTHGTGCTLSAAIAAQMA
WGRDPLAATVAAKAYVTEALRHPLAIGSGQGPVGHFYPLLSGIGKPVP
>Mature_287_residues
SVSASEPTPAPLLAEQHPPVALTIAGSDSGGGAGIQADLRTFAFQRVHGTSALTCVTAQNTLGVSRVDALPPEAVAAQIE
AVVQDIGVQGIKTGMLLNAEIVLEVARQVERWALRPLVVDPVMVSRTGAKLLADEAIQAIREQLIPLAQVLTPNRYEAQI
LTGLELQSLADMQTAAQQIHALGCGAVLVKGGGMPGELQGVDVWFDGERLEVLKTERIPTRHTHGTGCTLSAAIAAQMAW
GRDPLAATVAAKAYVTEALRHPLAIGSGQGPVGHFYPLLSGIGKPVP

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=259, Percent_Identity=40.5405405405405, Blast_Score=176, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6325378, Length=294, Percent_Identity=31.9727891156463, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324517, Length=295, Percent_Identity=34.5762711864407, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6324997, Length=292, Percent_Identity=34.5890410958904, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 30036; Mature: 29905

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSASEPTPAPLLAEQHPPVALTIAGSDSGGGAGIQADLRTFAFQRVHGTSALTCVTAQ
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEC
NTLGVSRVDALPPEAVAAQIEAVVQDIGVQGIKTGMLLNAEIVLEVARQVERWALRPLVV
CCCCCHHHCCCCHHHHHHHHHHHHHHHCCCHHCCCEEEHHHHHHHHHHHHHHHHCCCEEE
DPVMVSRTGAKLLADEAIQAIREQLIPLAQVLTPNRYEAQILTGLELQSLADMQTAAQQI
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCHHHHHHHHHHHHHHH
HALGCGAVLVKGGGMPGELQGVDVWFDGERLEVLKTERIPTRHTHGTGCTLSAAIAAQMA
HHHCCCEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
WGRDPLAATVAAKAYVTEALRHPLAIGSGQGPVGHFYPLLSGIGKPVP
CCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SVSASEPTPAPLLAEQHPPVALTIAGSDSGGGAGIQADLRTFAFQRVHGTSALTCVTAQ
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEC
NTLGVSRVDALPPEAVAAQIEAVVQDIGVQGIKTGMLLNAEIVLEVARQVERWALRPLVV
CCCCCHHHCCCCHHHHHHHHHHHHHHHCCCHHCCCEEEHHHHHHHHHHHHHHHHCCCEEE
DPVMVSRTGAKLLADEAIQAIREQLIPLAQVLTPNRYEAQILTGLELQSLADMQTAAQQI
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCHHHHHHHHHHHHHHH
HALGCGAVLVKGGGMPGELQGVDVWFDGERLEVLKTERIPTRHTHGTGCTLSAAIAAQMA
HHHCCCEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
WGRDPLAATVAAKAYVTEALRHPLAIGSGQGPVGHFYPLLSGIGKPVP
CCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA