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The map label for this gene is lpxB [H]

Identifier: 86610213

GI number: 86610213

Start: 2884124

End: 2885332

Strand: Direct

Name: lpxB [H]

Synonym: CYB_2789

Alternate gene names: 86610213

Gene position: 2884124-2885332 (Clockwise)

Preceding gene: 86610212

Following gene: 86610215

Centisome position: 94.66

GC content: 63.36

Gene sequence:

>1209_bases
GTGAGCCACCTGTTCATCTGCACGGGCGAGGTCTCAGGGGATCTGCAGGCCGGCCATCTGATTGAAGAATTGCTGCGCCA
GCGCCCTCAACTGCGCATCACAGCGGTCGGGGGAGAGCGCATGGCTGCTGCCGGGGCCCGTTTATTGCACCGCACTACCG
AGATCAGCTCCGTTGGCATTTTAGAGGCTCTTCCCTTTATCGGCCCCGCCCTCTGGACGGAATGGAAGATTCGCCGCTTT
TTGGCCCAAGACCCGCCAGATGTGGCTGTGCTGGTGGACTACATCGGCGTCAACAGCCGCATTGCCCGTCTGCTGCAACG
GCGGCAGATCCCTGCTGTCTATTACATTGCCCCCCAAGAGTGGGTGTGGTCGCAGGACGCCCGCCTCACCTACCAACTGG
CCCAGCAGATGCGGCTGATGTTGGCAATTTTCCCTGAGGAAGCCCGCTACTACGCGGCGGCAGGAGCCCATGTCCAGTAT
GTGGGCCATCCCCTGTTGGATATTTTGGCCGCTGTGCCCAGCCGTGCTGCCGCCAGAGCCCAGTTGGGGATCCCTGCCGA
AGCCACGGTGGTGGTGGTGGTGCCGGCTTCGCGTCGGCAAGAGCTGCGCTCGGTTCTGCCTGTCTTGCTCAAGGCGGCTC
AGTTGTTGCAAGCTCACCTGCCTCAGGCACAGTTTTGGGTGCCCCTGGCCTCGCCCCGTTTTGCTGCCCCGATTGCGCGG
GCTGCCCGCCGCCTTGGGCTCAACCTCACCCTTTTGGATCCCCAAGCTCTGCCCTTCTTCTCCCCCCACAAAGCTCATCA
CCTCGCCTTGGCAGCGGCTGATTTGGTGTTGGCCAAGTCGGGCACGGTGAACTTGGAGACGGCCATCTTGGGGATCCCCC
AGGTGGTGATCTATCGCCTCAACCCCCTCACCTTCTGGATCGCCCGCCATTGGCTGAGGGTGTCGGTGCCCTTCATGTCT
CCGCCCAACCTGGTGCAGATGCGCCCCATTGTCCCGGAGTTGCTGCAGGAGCAGGCCCAGCCAGAGAAGATTGCCCAACT
GGCGCTGGAGTTGCTAACTCGGCCCGAACGCAAAGCCCAACTGCAAGCCGACTACGCCGCGATGCGGGCAGCCCTGGGAG
AACCCGGCGTTCTGGCTCGCGCTGCCAAGGCCATCCTAGAGGTGTTGGATGGCGCAGCCGGCCCCCAGCGGCATCCCTTT
TGCCGCTAG

Upstream 100 bases:

>100_bases
TGCCGGCCCTGCGCGGGAGGGGGGAAGATTCCTTATCGACAGCGATGCAGAGCACTTCAGAGCTGGATGACTAAAGATTG
GGGTCGGGAGCGTAGCTCTG

Downstream 100 bases:

>100_bases
CTCCGGTGACCCAGGGCCCGGGGCACCGCCCGTCCTCCCGCCAGGGCTGCCGTTGAATCTTCCTCTTCCAGATACTCAGC
ATCTTGGTTGACGCGCCACC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MSHLFICTGEVSGDLQAGHLIEELLRQRPQLRITAVGGERMAAAGARLLHRTTEISSVGILEALPFIGPALWTEWKIRRF
LAQDPPDVAVLVDYIGVNSRIARLLQRRQIPAVYYIAPQEWVWSQDARLTYQLAQQMRLMLAIFPEEARYYAAAGAHVQY
VGHPLLDILAAVPSRAAARAQLGIPAEATVVVVVPASRRQELRSVLPVLLKAAQLLQAHLPQAQFWVPLASPRFAAPIAR
AARRLGLNLTLLDPQALPFFSPHKAHHLALAAADLVLAKSGTVNLETAILGIPQVVIYRLNPLTFWIARHWLRVSVPFMS
PPNLVQMRPIVPELLQEQAQPEKIAQLALELLTRPERKAQLQADYAAMRAALGEPGVLARAAKAILEVLDGAAGPQRHPF
CR

Sequences:

>Translated_402_residues
MSHLFICTGEVSGDLQAGHLIEELLRQRPQLRITAVGGERMAAAGARLLHRTTEISSVGILEALPFIGPALWTEWKIRRF
LAQDPPDVAVLVDYIGVNSRIARLLQRRQIPAVYYIAPQEWVWSQDARLTYQLAQQMRLMLAIFPEEARYYAAAGAHVQY
VGHPLLDILAAVPSRAAARAQLGIPAEATVVVVVPASRRQELRSVLPVLLKAAQLLQAHLPQAQFWVPLASPRFAAPIAR
AARRLGLNLTLLDPQALPFFSPHKAHHLALAAADLVLAKSGTVNLETAILGIPQVVIYRLNPLTFWIARHWLRVSVPFMS
PPNLVQMRPIVPELLQEQAQPEKIAQLALELLTRPERKAQLQADYAAMRAALGEPGVLARAAKAILEVLDGAAGPQRHPF
CR
>Mature_401_residues
SHLFICTGEVSGDLQAGHLIEELLRQRPQLRITAVGGERMAAAGARLLHRTTEISSVGILEALPFIGPALWTEWKIRRFL
AQDPPDVAVLVDYIGVNSRIARLLQRRQIPAVYYIAPQEWVWSQDARLTYQLAQQMRLMLAIFPEEARYYAAAGAHVQYV
GHPLLDILAAVPSRAAARAQLGIPAEATVVVVVPASRRQELRSVLPVLLKAAQLLQAHLPQAQFWVPLASPRFAAPIARA
ARRLGLNLTLLDPQALPFFSPHKAHHLALAAADLVLAKSGTVNLETAILGIPQVVIYRLNPLTFWIARHWLRVSVPFMSP
PNLVQMRPIVPELLQEQAQPEKIAQLALELLTRPERKAQLQADYAAMRAALGEPGVLARAAKAILEVLDGAAGPQRHPFC
R

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=337, Percent_Identity=30.8605341246291, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 44342; Mature: 44210

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLFICTGEVSGDLQAGHLIEELLRQRPQLRITAVGGERMAAAGARLLHRTTEISSVGI
CCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LEALPFIGPALWTEWKIRRFLAQDPPDVAVLVDYIGVNSRIARLLQRRQIPAVYYIAPQE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCHHHHHHHHHCCCCEEEEECCCH
WVWSQDARLTYQLAQQMRLMLAIFPEEARYYAAAGAHVQYVGHPLLDILAAVPSRAAARA
HCCCCCCHHHHHHHHHHHHHHHCCCCHHHEEHCCCCCHHHHCCHHHHHHHHCCCHHHHHH
QLGIPAEATVVVVVPASRRQELRSVLPVLLKAAQLLQAHLPQAQFWVPLASPRFAAPIAR
HCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHH
AARRLGLNLTLLDPQALPFFSPHKAHHLALAAADLVLAKSGTVNLETAILGIPQVVIYRL
HHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHEECCCCCEEHHHHHCCCCEEEEEC
NPLTFWIARHWLRVSVPFMSPPNLVQMRPIVPELLQEQAQPEKIAQLALELLTRPERKAQ
CHHHHHHHHHHHHEECCCCCCCCCEEECCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHH
LQADYAAMRAALGEPGVLARAAKAILEVLDGAAGPQRHPFCR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SHLFICTGEVSGDLQAGHLIEELLRQRPQLRITAVGGERMAAAGARLLHRTTEISSVGI
CEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LEALPFIGPALWTEWKIRRFLAQDPPDVAVLVDYIGVNSRIARLLQRRQIPAVYYIAPQE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCHHHHHHHHHCCCCEEEEECCCH
WVWSQDARLTYQLAQQMRLMLAIFPEEARYYAAAGAHVQYVGHPLLDILAAVPSRAAARA
HCCCCCCHHHHHHHHHHHHHHHCCCCHHHEEHCCCCCHHHHCCHHHHHHHHCCCHHHHHH
QLGIPAEATVVVVVPASRRQELRSVLPVLLKAAQLLQAHLPQAQFWVPLASPRFAAPIAR
HCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHH
AARRLGLNLTLLDPQALPFFSPHKAHHLALAAADLVLAKSGTVNLETAILGIPQVVIYRL
HHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHEECCCCCEEHHHHHCCCCEEEEEC
NPLTFWIARHWLRVSVPFMSPPNLVQMRPIVPELLQEQAQPEKIAQLALELLTRPERKAQ
CHHHHHHHHHHHHEECCCCCCCCCEEECCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHH
LQADYAAMRAALGEPGVLARAAKAILEVLDGAAGPQRHPFCR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA