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The map label for this gene is gnd [H]

Identifier: 86609914

GI number: 86609914

Start: 2576049

End: 2577467

Strand: Direct

Name: gnd [H]

Synonym: CYB_2481

Alternate gene names: 86609914

Gene position: 2576049-2577467 (Clockwise)

Preceding gene: 86609913

Following gene: 86609918

Centisome position: 84.55

GC content: 60.39

Gene sequence:

>1419_bases
ATGAGCAAGCCCAGCTTTGCGGTGATCGGCCTGGCGGTGATGGGGGAAAACTTGGCCCTCAACGTCGAGCGCAATGGCTT
CCCGGTTGCCGTCTACAACCGCACCAGCTCCAAAACCGACCAGTTCATGCGGGAGCGAGCCCAAGGCAAACGGATCACCC
CCGCCTACAGCCTGCCGGAATTGGTGCAACTGATGGAGCGGCCCCGCAAATTCTTGATCATGGTCAAGGCGGGTGCGCCG
GTAGACGCGGTGATTGACGAGCTTAAACCCCTGCTGGATCCGGGGGATATCATCATCGACGGCGGCAACTCCCTCTACAC
CGACACCGATCGCCGTGCCGAAGCCCTCGCCCCCACCGGGATCCACTTTGTCGGCATGGGAGTGAGCGGCGGGGAAGAGG
GAGCCCTGAACGGCCCCAGCCTCATGCCCGGCTGCAGCCCAGAGGCCTACCAACAACTGGAGCCCATCTTGGCCAAAATT
GCCGCTCAAGTGCCAGACGGCCCCTGTGTCACCTACCTGGGGCCCAAAGGGGGCGGGCACTACGTGAAGATGGTACACAA
CGGCATCGAATACGGCGATATGCAGCTGATCGCCGAGGTCTACGACCTAATGCGCAGGGCTTTGAAGCTGTCGGCCTCGC
AGATGCAGGAGATTTTTCAGGCTTGGAATGAAACAGAGCTGGAATCTTTCCTAATTGAAATTACCGCCAAGATTTTCCAA
ACCCTGGATCCGGAAACCGGCAAGCCGTTGGTGGATCTCATTCTGGATAAGGCTGGGCAAAAAGGCACCGGTTTGTGGAC
AGTCAAGGACGCTCTAGATCTGGGGGTACCAGTGCCCACCATTGAAGCGGCGGTGCAAGCTCGCATCCTCTCGTCGATGA
AAGAGGAACGGGTGGCTGCCTCTGCCCAGTTGAAGGGGCCCGACGCAACTTTTGCAGGGGATCCCGACTGCTTTATCCAA
GATCTGCGCGCCGCCCTCTACTGCTCCAAAATCTGCTCCTATGCGCAGGGGATGGCCCTGCTCAAAAGAGCCACTGTTGC
CCACGGCTACGTCTACACCTTCAGTGAGATTCCGCGGATTTGGAAGGGGGGCTGTATCATCCGCGCCCGCTTCCTGGGCG
AGATCCAGTCGGCCTACAAACGGGATCCAGAGCTGGTGAACCTGCTGTTGGATGAGGAATTCGAGCAGGCCATCCGGGAG
CGGCAGGGATCCTGGCGGCGGGTGGTGTCCACGGCGGCTGCGCTGGGGATCCCGATCCCGGCCATCAGCGCTTCTTTGGC
CTACTACGACAGCTACCGTACCGCCAACCTGCCCCAGAACCTCACCCAAGCCCAGCGGGACTTCTTCGGGGCCCACACCT
TCGAGCGCATCGACAGGCCGGGCGTCTTTCACCATGAGTGGAATGCCTGTTGCCGTTAG

Upstream 100 bases:

>100_bases
CCCTTGAATCAGGGCCGGCAAAGGTGAAGAAAACAGGATCCCTGAGCCCCGTCGGTCAGATTGGCCTCTAGATTGGGTGA
GGTGTCGATAGTGCCCAACT

Downstream 100 bases:

>100_bases
CAATGCGTAGCATCAAGAGGTCTCCGGAAAAAAGTTGAACCGCGCACCTCCGTATGGAAAGGCTCCCCTTCCTGAGGAAA
ATCCTCGCGGAAATGGGCCC

Product: 6-phosphogluconate dehydrogenase, decarboxylating

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSKPSFAVIGLAVMGENLALNVERNGFPVAVYNRTSSKTDQFMRERAQGKRITPAYSLPELVQLMERPRKFLIMVKAGAP
VDAVIDELKPLLDPGDIIIDGGNSLYTDTDRRAEALAPTGIHFVGMGVSGGEEGALNGPSLMPGCSPEAYQQLEPILAKI
AAQVPDGPCVTYLGPKGGGHYVKMVHNGIEYGDMQLIAEVYDLMRRALKLSASQMQEIFQAWNETELESFLIEITAKIFQ
TLDPETGKPLVDLILDKAGQKGTGLWTVKDALDLGVPVPTIEAAVQARILSSMKEERVAASAQLKGPDATFAGDPDCFIQ
DLRAALYCSKICSYAQGMALLKRATVAHGYVYTFSEIPRIWKGGCIIRARFLGEIQSAYKRDPELVNLLLDEEFEQAIRE
RQGSWRRVVSTAAALGIPIPAISASLAYYDSYRTANLPQNLTQAQRDFFGAHTFERIDRPGVFHHEWNACCR

Sequences:

>Translated_472_residues
MSKPSFAVIGLAVMGENLALNVERNGFPVAVYNRTSSKTDQFMRERAQGKRITPAYSLPELVQLMERPRKFLIMVKAGAP
VDAVIDELKPLLDPGDIIIDGGNSLYTDTDRRAEALAPTGIHFVGMGVSGGEEGALNGPSLMPGCSPEAYQQLEPILAKI
AAQVPDGPCVTYLGPKGGGHYVKMVHNGIEYGDMQLIAEVYDLMRRALKLSASQMQEIFQAWNETELESFLIEITAKIFQ
TLDPETGKPLVDLILDKAGQKGTGLWTVKDALDLGVPVPTIEAAVQARILSSMKEERVAASAQLKGPDATFAGDPDCFIQ
DLRAALYCSKICSYAQGMALLKRATVAHGYVYTFSEIPRIWKGGCIIRARFLGEIQSAYKRDPELVNLLLDEEFEQAIRE
RQGSWRRVVSTAAALGIPIPAISASLAYYDSYRTANLPQNLTQAQRDFFGAHTFERIDRPGVFHHEWNACCR
>Mature_471_residues
SKPSFAVIGLAVMGENLALNVERNGFPVAVYNRTSSKTDQFMRERAQGKRITPAYSLPELVQLMERPRKFLIMVKAGAPV
DAVIDELKPLLDPGDIIIDGGNSLYTDTDRRAEALAPTGIHFVGMGVSGGEEGALNGPSLMPGCSPEAYQQLEPILAKIA
AQVPDGPCVTYLGPKGGGHYVKMVHNGIEYGDMQLIAEVYDLMRRALKLSASQMQEIFQAWNETELESFLIEITAKIFQT
LDPETGKPLVDLILDKAGQKGTGLWTVKDALDLGVPVPTIEAAVQARILSSMKEERVAASAQLKGPDATFAGDPDCFIQD
LRAALYCSKICSYAQGMALLKRATVAHGYVYTFSEIPRIWKGGCIIRARFLGEIQSAYKRDPELVNLLLDEEFEQAIRER
QGSWRRVVSTAAALGIPIPAISASLAYYDSYRTANLPQNLTQAQRDFFGAHTFERIDRPGVFHHEWNACCR

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=53.1779661016949, Blast_Score=480, Evalue=1e-135,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=54.4871794871795, Blast_Score=519, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=53.0785562632696, Blast_Score=500, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6321695, Length=460, Percent_Identity=53.9130434782609, Blast_Score=486, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6321977, Length=451, Percent_Identity=52.3281596452328, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24639279, Length=465, Percent_Identity=51.8279569892473, Blast_Score=449, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51844; Mature: 51713

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPSFAVIGLAVMGENLALNVERNGFPVAVYNRTSSKTDQFMRERAQGKRITPAYSLPE
CCCCCEEEEEHEEECCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHH
LVQLMERPRKFLIMVKAGAPVDAVIDELKPLLDPGDIIIDGGNSLYTDTDRRAEALAPTG
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHCCCCC
IHFVGMGVSGGEEGALNGPSLMPGCSPEAYQQLEPILAKIAAQVPDGPCVTYLGPKGGGH
CEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
YVKMVHNGIEYGDMQLIAEVYDLMRRALKLSASQMQEIFQAWNETELESFLIEITAKIFQ
CHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
TLDPETGKPLVDLILDKAGQKGTGLWTVKDALDLGVPVPTIEAAVQARILSSMKEERVAA
HCCCCCCCHHHHHHHHHCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SAQLKGPDATFAGDPDCFIQDLRAALYCSKICSYAQGMALLKRATVAHGYVYTFSEIPRI
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
WKGGCIIRARFLGEIQSAYKRDPELVNLLLDEEFEQAIRERQGSWRRVVSTAAALGIPIP
HCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCH
AISASLAYYDSYRTANLPQNLTQAQRDFFGAHTFERIDRPGVFHHEWNACCR
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCC
>Mature Secondary Structure 
SKPSFAVIGLAVMGENLALNVERNGFPVAVYNRTSSKTDQFMRERAQGKRITPAYSLPE
CCCCEEEEEHEEECCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHH
LVQLMERPRKFLIMVKAGAPVDAVIDELKPLLDPGDIIIDGGNSLYTDTDRRAEALAPTG
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHCCCCC
IHFVGMGVSGGEEGALNGPSLMPGCSPEAYQQLEPILAKIAAQVPDGPCVTYLGPKGGGH
CEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
YVKMVHNGIEYGDMQLIAEVYDLMRRALKLSASQMQEIFQAWNETELESFLIEITAKIFQ
CHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
TLDPETGKPLVDLILDKAGQKGTGLWTVKDALDLGVPVPTIEAAVQARILSSMKEERVAA
HCCCCCCCHHHHHHHHHCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SAQLKGPDATFAGDPDCFIQDLRAALYCSKICSYAQGMALLKRATVAHGYVYTFSEIPRI
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
WKGGCIIRARFLGEIQSAYKRDPELVNLLLDEEFEQAIRERQGSWRRVVSTAAALGIPIP
HCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCH
AISASLAYYDSYRTANLPQNLTQAQRDFFGAHTFERIDRPGVFHHEWNACCR
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]