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The map label for this gene is pyrD

Identifier: 86609722

GI number: 86609722

Start: 2386225

End: 2387370

Strand: Reverse

Name: pyrD

Synonym: CYB_2280

Alternate gene names: 86609722

Gene position: 2387370-2386225 (Counterclockwise)

Preceding gene: 86609723

Following gene: 86609721

Centisome position: 78.36

GC content: 61.61

Gene sequence:

>1146_bases
GTGAACCTGTACCGAGATGTGTTGTGGCCTCTGCTTTTTTCTGGGCTGAGAGCCGACCCGGAAGCGGTCAAGATGGGCCT
GCTGCGCGCCTTGCATTGGATCGATGCCACCCAGGCCACCGGGATCCTATCGGCTCTGGAGCGACTGTTTTGCTACCGGG
ATCCCCGGCTAGCGGTGTCGCTGTGGGGCCTTACCTTTCCCAATCCCCTTGGATTGGCTGCGGGCTTCGACAAAGATGGC
CTGGCTCTGGGCGTCTGGCCCAGCCTAGGATTTGGTTTTGTAGAGGTGGGCACCATCACTCCTCAGCCCCAACCGGGCAA
CCCCAAACCTCGCCTGTTTCAACTGCCCCAAGATCGCGCCGCCCTCAACCGCATGGGCTTTAACAACCAAGGGGCGGCGG
CTCTGGCGGAACGGTTGCGCCGGCTACAGCAACGTCCCATCCCCATTGGAATTAACCTGGGCAAAGCCAAAATCACCCCT
CTGGAAGAAGCGGCTGCCGATTACCTGGCCAGCTTCCGGCTGCTCCAGGATCTGGGGGACTACTTTGTGGTCAACGTCAG
CTCCCCCAACACGCCGGGGCTGCGATCCCTGCAGGCTGCTGAGCAACTGGAGCCCATCCTATCTGCCTTACAGCGGGAAA
ATCAGAAGCGAAAACCCCTCCTGGTGAAGATCGCCCCCGATCTGGACTGGCCCGACATCGACAGCATCCTGGAGCTGGCC
CAAGACCATCAACTGGCCGGGATCGTGGCCACCAACACCACCCTCCGCCGCGATAACCTGAAAACCCGTTTCCTGCCTGG
CCGCGGGATCCCCTTCGCACCAGCGGAGTCTAGGCCAATCCTTGCAGAAGCCGGCGGGATCAGCGGTGCCCCCTTGCGGG
AGCGTTCCACCCAAGTCATCCGCTACATCCACCGCTCCACCCAAGGAAAATTGCCCATCATCGGAGTGGGGGGCATCTTC
ACCTTGGCCGACGCCTTGGAGAAACTGGAAGCGGGAGCCAGCCTGCTGCAGGTCTACACCGGCTGGGTTTACGAAGGGCC
GGGTATGGTGCCGCAATTGCTCCGAGGCCTAGCCCGCTCTTCTCCCCCCAGCCCTGATGTTACACTTCCCCCAGAGAATA
CCCCTGTGGGTCAGATCCAGGCGTAA

Upstream 100 bases:

>100_bases
CCCCACCATGGGCGTCGGCGCTGCCTGGCAATAGGGAATGACTCTTGACCTAGCAGTAAATCCAAAATCCATGGGTTCCC
ACCCGTAGGAAATCCTTGTG

Downstream 100 bases:

>100_bases
GATCGTTAGGGATCCCTGAGGAAGCTTGCCGGTGAACCTGCTGCAACACCTCTTCAAAACCCCCCATCCGGTCATTGGGG
TGGTTCATTTGTTGCCGCTG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MNLYRDVLWPLLFSGLRADPEAVKMGLLRALHWIDATQATGILSALERLFCYRDPRLAVSLWGLTFPNPLGLAAGFDKDG
LALGVWPSLGFGFVEVGTITPQPQPGNPKPRLFQLPQDRAALNRMGFNNQGAAALAERLRRLQQRPIPIGINLGKAKITP
LEEAAADYLASFRLLQDLGDYFVVNVSSPNTPGLRSLQAAEQLEPILSALQRENQKRKPLLVKIAPDLDWPDIDSILELA
QDHQLAGIVATNTTLRRDNLKTRFLPGRGIPFAPAESRPILAEAGGISGAPLRERSTQVIRYIHRSTQGKLPIIGVGGIF
TLADALEKLEAGASLLQVYTGWVYEGPGMVPQLLRGLARSSPPSPDVTLPPENTPVGQIQA

Sequences:

>Translated_381_residues
MNLYRDVLWPLLFSGLRADPEAVKMGLLRALHWIDATQATGILSALERLFCYRDPRLAVSLWGLTFPNPLGLAAGFDKDG
LALGVWPSLGFGFVEVGTITPQPQPGNPKPRLFQLPQDRAALNRMGFNNQGAAALAERLRRLQQRPIPIGINLGKAKITP
LEEAAADYLASFRLLQDLGDYFVVNVSSPNTPGLRSLQAAEQLEPILSALQRENQKRKPLLVKIAPDLDWPDIDSILELA
QDHQLAGIVATNTTLRRDNLKTRFLPGRGIPFAPAESRPILAEAGGISGAPLRERSTQVIRYIHRSTQGKLPIIGVGGIF
TLADALEKLEAGASLLQVYTGWVYEGPGMVPQLLRGLARSSPPSPDVTLPPENTPVGQIQA
>Mature_381_residues
MNLYRDVLWPLLFSGLRADPEAVKMGLLRALHWIDATQATGILSALERLFCYRDPRLAVSLWGLTFPNPLGLAAGFDKDG
LALGVWPSLGFGFVEVGTITPQPQPGNPKPRLFQLPQDRAALNRMGFNNQGAAALAERLRRLQQRPIPIGINLGKAKITP
LEEAAADYLASFRLLQDLGDYFVVNVSSPNTPGLRSLQAAEQLEPILSALQRENQKRKPLLVKIAPDLDWPDIDSILELA
QDHQLAGIVATNTTLRRDNLKTRFLPGRGIPFAPAESRPILAEAGGISGAPLRERSTQVIRYIHRSTQGKLPIIGVGGIF
TLADALEKLEAGASLLQVYTGWVYEGPGMVPQLLRGLARSSPPSPDVTLPPENTPVGQIQA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=314, Percent_Identity=45.2229299363057, Blast_Score=251, Evalue=9e-67,
Organism=Escherichia coli, GI1787177, Length=356, Percent_Identity=39.0449438202247, Blast_Score=248, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17509475, Length=316, Percent_Identity=41.7721518987342, Blast_Score=239, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322633, Length=270, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281361352, Length=334, Percent_Identity=40.1197604790419, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI17137316, Length=334, Percent_Identity=40.1197604790419, Blast_Score=248, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_SYNJB (Q2JJF3)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_478484.1
- ProteinModelPortal:   Q2JJF3
- SMR:   Q2JJF3
- STRING:   Q2JJF3
- GeneID:   3902659
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_2280
- TIGR:   CYB_2280
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- PhylomeDB:   Q2JJF3
- ProtClustDB:   PRK05286
- BioCyc:   SSP321332:CYB_2280-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 41462; Mature: 41462

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 188-188

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLYRDVLWPLLFSGLRADPEAVKMGLLRALHWIDATQATGILSALERLFCYRDPRLAVS
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
LWGLTFPNPLGLAAGFDKDGLALGVWPSLGFGFVEVGTITPQPQPGNPKPRLFQLPQDRA
EECCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEECCCCCCCCCCCCCCCEEECCHHHH
ALNRMGFNNQGAAALAERLRRLQQRPIPIGINLGKAKITPLEEAAADYLASFRLLQDLGD
HHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
YFVVNVSSPNTPGLRSLQAAEQLEPILSALQRENQKRKPLLVKIAPDLDWPDIDSILELA
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHH
QDHQLAGIVATNTTLRRDNLKTRFLPGRGIPFAPAESRPILAEAGGISGAPLRERSTQVI
HCCCEEEEEECCCEEECCCCCEEECCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHH
RYIHRSTQGKLPIIGVGGIFTLADALEKLEAGASLLQVYTGWVYEGPGMVPQLLRGLARS
HHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHC
SPPSPDVTLPPENTPVGQIQA
CCCCCCEECCCCCCCCCCCCC
>Mature Secondary Structure
MNLYRDVLWPLLFSGLRADPEAVKMGLLRALHWIDATQATGILSALERLFCYRDPRLAVS
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
LWGLTFPNPLGLAAGFDKDGLALGVWPSLGFGFVEVGTITPQPQPGNPKPRLFQLPQDRA
EECCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEECCCCCCCCCCCCCCCEEECCHHHH
ALNRMGFNNQGAAALAERLRRLQQRPIPIGINLGKAKITPLEEAAADYLASFRLLQDLGD
HHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
YFVVNVSSPNTPGLRSLQAAEQLEPILSALQRENQKRKPLLVKIAPDLDWPDIDSILELA
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHH
QDHQLAGIVATNTTLRRDNLKTRFLPGRGIPFAPAESRPILAEAGGISGAPLRERSTQVI
HCCCEEEEEECCCEEECCCCCEEECCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHH
RYIHRSTQGKLPIIGVGGIFTLADALEKLEAGASLLQVYTGWVYEGPGMVPQLLRGLARS
HHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHC
SPPSPDVTLPPENTPVGQIQA
CCCCCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA