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The map label for this gene is gltA [H]

Identifier: 86609364

GI number: 86609364

Start: 1992540

End: 1993676

Strand: Direct

Name: gltA [H]

Synonym: CYB_1908

Alternate gene names: 86609364

Gene position: 1992540-1993676 (Clockwise)

Preceding gene: 86609361

Following gene: 86609365

Centisome position: 65.4

GC content: 58.31

Gene sequence:

>1137_bases
ATGGCGGATGGCGAATACAGACCAGGCTTGGAAGGCGTTCCGGCCACACGCTCCAACATTAGTTTTGTGGATGGCCAGGC
GGGGATCCTGGAATATCGGGGCATCCCCATCGAGGAATTGACCGCCCACAGTACCTTTCTGGAGACAGCCTACTTGCTGA
TCTTTGGAAAGCTGCCGACCCAATCGGAGCTGGACAACTTTGATCAGGCAATCCGCAGTCATCGACGGGTGAAATACCGC
ATCCGCGACATGATCAAGTCGTTTCCGGAGTCGGGCCACCCGATGGATGCTCTGCAAACCTGTGTGGCGGGCTTGGGGCT
GTTTTACCCGCTGCGGGAGATGGATCCCGACTATGTGTTCGGCACCGTCACCCGCTTGCTCTCCAAGCTGCCGACCATGG
TGGCCATGTTCCACCAGATGCGACAGGGCAATGATCCCATTCCCCCGGACGACAACCTGGATCATGCTGCCAATTTCCTA
TACATGCTCTCGGGCAAGAAGCCGGATCCCTGGTTGGCCCGCATTTTTGACATCTGCCTGATCCTGCACGCCGAGCACAC
GGTCAATGCCTCTACGTTTGCCCTTCTGGTGAGCGCTTCCACGCTGGCTAACCCCTACAGCAGCCTGGCCACGGCGGTGG
GTACCCTTTCGGGGCTGTTGCACGGGGGGGCCAACCAACAGGTGATGATGCTGCTGCGGCAAATCGGCTCGGTGGAAAAT
GTGCGCTCGTTTATCGAGGAGAAGCTGGCCAAAAAACAGCGCATCATGGGCATGGGCCACCGAGTCTACAAGGTGAAGGA
TCCGCGGGCCACCATCCTGCAGCGGCTGGCCGAAGAGCTATTTGAGCGCTACGGCCACGACAAGTACTACGACATTGCCC
TGGAGGTGGAGCGGGTGTGTGAGGAGTTGTTAGGGCCGAAGGGGATCTACCCGAATGTGGACTTCTACTCAGGGTTGGTC
TACGCCAAGTTGGGGATCCCAGAAGATTTGTTTACACCGGTGTTTGCCATTGCCCGAGCGGCGGGTTGGCTGGCCCATTG
GCGGGAGCAGTTGTCCGATAATCGGCTTTTCCGACCCACCCAGGTGTACACAGGTGAACGCCAGCAACGCTACATCCCTA
TAGAAGAGCGGGGTTGA

Upstream 100 bases:

>100_bases
GTCAGTACTGCCCGAGGGGAGCAAGGGGTTGGGTTCCAGGCACCTTTGGCAACCCTTGATTCATCATTATCTAGGAAATA
CTTGCTCTAAGGATCCGACC

Downstream 100 bases:

>100_bases
GAGCCGTTTGACAGGGCGCTGGGCCGGGATCCAAACTCAGTAAGGCCCAAGTCGTGCGTGAGGTGGTGTGTTGAGCCTCT
TGGACTCTCCCCTTTGGCGA

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MADGEYRPGLEGVPATRSNISFVDGQAGILEYRGIPIEELTAHSTFLETAYLLIFGKLPTQSELDNFDQAIRSHRRVKYR
IRDMIKSFPESGHPMDALQTCVAGLGLFYPLREMDPDYVFGTVTRLLSKLPTMVAMFHQMRQGNDPIPPDDNLDHAANFL
YMLSGKKPDPWLARIFDICLILHAEHTVNASTFALLVSASTLANPYSSLATAVGTLSGLLHGGANQQVMMLLRQIGSVEN
VRSFIEEKLAKKQRIMGMGHRVYKVKDPRATILQRLAEELFERYGHDKYYDIALEVERVCEELLGPKGIYPNVDFYSGLV
YAKLGIPEDLFTPVFAIARAAGWLAHWREQLSDNRLFRPTQVYTGERQQRYIPIEERG

Sequences:

>Translated_378_residues
MADGEYRPGLEGVPATRSNISFVDGQAGILEYRGIPIEELTAHSTFLETAYLLIFGKLPTQSELDNFDQAIRSHRRVKYR
IRDMIKSFPESGHPMDALQTCVAGLGLFYPLREMDPDYVFGTVTRLLSKLPTMVAMFHQMRQGNDPIPPDDNLDHAANFL
YMLSGKKPDPWLARIFDICLILHAEHTVNASTFALLVSASTLANPYSSLATAVGTLSGLLHGGANQQVMMLLRQIGSVEN
VRSFIEEKLAKKQRIMGMGHRVYKVKDPRATILQRLAEELFERYGHDKYYDIALEVERVCEELLGPKGIYPNVDFYSGLV
YAKLGIPEDLFTPVFAIARAAGWLAHWREQLSDNRLFRPTQVYTGERQQRYIPIEERG
>Mature_377_residues
ADGEYRPGLEGVPATRSNISFVDGQAGILEYRGIPIEELTAHSTFLETAYLLIFGKLPTQSELDNFDQAIRSHRRVKYRI
RDMIKSFPESGHPMDALQTCVAGLGLFYPLREMDPDYVFGTVTRLLSKLPTMVAMFHQMRQGNDPIPPDDNLDHAANFLY
MLSGKKPDPWLARIFDICLILHAEHTVNASTFALLVSASTLANPYSSLATAVGTLSGLLHGGANQQVMMLLRQIGSVENV
RSFIEEKLAKKQRIMGMGHRVYKVKDPRATILQRLAEELFERYGHDKYYDIALEVERVCEELLGPKGIYPNVDFYSGLVY
AKLGIPEDLFTPVFAIARAAGWLAHWREQLSDNRLFRPTQVYTGERQQRYIPIEERG

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=383, Percent_Identity=26.8929503916449, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1786939, Length=379, Percent_Identity=36.9393139841689, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1786527, Length=374, Percent_Identity=33.4224598930481, Blast_Score=231, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17555174, Length=322, Percent_Identity=27.0186335403727, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319850, Length=369, Percent_Identity=27.9132791327913, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324328, Length=367, Percent_Identity=25.8855585831063, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=374, Percent_Identity=24.8663101604278, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640124, Length=371, Percent_Identity=27.7628032345013, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24640126, Length=371, Percent_Identity=27.7628032345013, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI21356863, Length=387, Percent_Identity=27.906976744186, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 42742; Mature: 42610

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADGEYRPGLEGVPATRSNISFVDGQAGILEYRGIPIEELTAHSTFLETAYLLIFGKLPT
CCCCCCCCCCCCCCCCCCCCEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
QSELDNFDQAIRSHRRVKYRIRDMIKSFPESGHPMDALQTCVAGLGLFYPLREMDPDYVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
GTVTRLLSKLPTMVAMFHQMRQGNDPIPPDDNLDHAANFLYMLSGKKPDPWLARIFDICL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHH
ILHAEHTVNASTFALLVSASTLANPYSSLATAVGTLSGLLHGGANQQVMMLLRQIGSVEN
HHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
VRSFIEEKLAKKQRIMGMGHRVYKVKDPRATILQRLAEELFERYGHDKYYDIALEVERVC
HHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHH
EELLGPKGIYPNVDFYSGLVYAKLGIPEDLFTPVFAIARAAGWLAHWREQLSDNRLFRPT
HHHCCCCCCCCCCHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
QVYTGERQQRYIPIEERG
HHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADGEYRPGLEGVPATRSNISFVDGQAGILEYRGIPIEELTAHSTFLETAYLLIFGKLPT
CCCCCCCCCCCCCCCCCCCEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
QSELDNFDQAIRSHRRVKYRIRDMIKSFPESGHPMDALQTCVAGLGLFYPLREMDPDYVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
GTVTRLLSKLPTMVAMFHQMRQGNDPIPPDDNLDHAANFLYMLSGKKPDPWLARIFDICL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHH
ILHAEHTVNASTFALLVSASTLANPYSSLATAVGTLSGLLHGGANQQVMMLLRQIGSVEN
HHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
VRSFIEEKLAKKQRIMGMGHRVYKVKDPRATILQRLAEELFERYGHDKYYDIALEVERVC
HHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHH
EELLGPKGIYPNVDFYSGLVYAKLGIPEDLFTPVFAIARAAGWLAHWREQLSDNRLFRPT
HHHCCCCCCCCCCHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
QVYTGERQQRYIPIEERG
HHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]