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The map label for this gene is hemE [H]

Identifier: 86609317

GI number: 86609317

Start: 1942420

End: 1943460

Strand: Direct

Name: hemE [H]

Synonym: CYB_1861

Alternate gene names: 86609317

Gene position: 1942420-1943460 (Clockwise)

Preceding gene: 86609311

Following gene: 86609318

Centisome position: 63.76

GC content: 59.85

Gene sequence:

>1041_bases
TTGGGTGACCGTTTGCTGCGGGCGGCCCGAGGGGAAGTGCTGGATCGCCCTCCAGTTTGGATGATGCGCCAGGCGGGTCG
CTACATGGCGGCCTACCGCGAGCTGCAAAGCAAGTACACCTTTAAGCAGCGTTGCGAGATCCCGGAGCTGGCCGTCGAGA
TCTCGTTGCAACCGTTTCGGGCCTTTGCCCCTGATGGAGTGATCCTGTTCAGCGATATCCTCACCCCCCTTGAGGGCATG
GGCATCCCCTTTGAGCTGGTGGAGCATCAGGGGCCGATCATCGACCCGCCGATTCGTTCGCAAGCCCAAATTGAACGCAT
CCGCCTCCTGGAACCGGAAGAAAGTCTGCCCTTTATCAAGACCATTCTCAGCACCCTGCGCCGCGAGGTGGAAGGGAAAG
CAACGCTGCTGGGGTTTGTCGGCTCCCCCTGGACTCTGGCCTGCTATGCTGTGGAAGGGCGCAGCTCCAAAGATTACGCC
CACATCAAGAGCTTGGCCTTCGCGCAGCCGCCATTGCTGCATCAGTTGCTGAGCAAGCTGGCCGACAGCATTGCCCGCTA
CGTGATCTACCAGATCGAGGGCGGTGCCCAGGTGGTGCAGTTGTTCGATACTTGGGCCGGACAGCTCAGCCCAGTCGATT
ACGAGTGTTGGGCCTTGCCCTACCAAAAGCAAATTGTGGATCAGGTGAAAGCTCGCTATCCGCAGGTGCCGCTGATCCTC
TACATCAACGGCAGCGCCGCTTTGCTGGAGCGGGTGGGCAAAGCCGGCATCGACGTGTTCAGCCTCGATTGGATGAGCGA
CATGGCAGAGGCCAGGGCTCGCCTGGGATCCCTAGCGGTGCAGGGCAATCTGGATCCGATGGTGTTGCTGGGATCCCCGG
AGTTCATCCGGCAGCGCACCCTAGAGGTGATTCGAAAAGCCGGATCCCGTGGGCATATCATGAACCTGGGCCACGGCATT
CACCCAAGCACTCCAGAGGCCAATGTCCATTACTTTTTCGAGACGGTGCGCCAGTCGGCAGAGCTGATACATTTACGCTG
A

Upstream 100 bases:

>100_bases
TGTCAGGATTCATAAGGATCTTTAGCCGGATTGCCCTCCTATGTCCCACTCGCCTGTTCAGCTCAGCGCCACCTCCTCCA
CCGCCAGCGGTGCGGAGCAC

Downstream 100 bases:

>100_bases
ACACTGCTGAACATCACTGTTCAACTATGCAGCGATAGCATTCTGTTTGTTTCCATTCGCGTTAGCGGGACGGAGTCCAA
ACAGAATGGCGGTATCCCGC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MGDRLLRAARGEVLDRPPVWMMRQAGRYMAAYRELQSKYTFKQRCEIPELAVEISLQPFRAFAPDGVILFSDILTPLEGM
GIPFELVEHQGPIIDPPIRSQAQIERIRLLEPEESLPFIKTILSTLRREVEGKATLLGFVGSPWTLACYAVEGRSSKDYA
HIKSLAFAQPPLLHQLLSKLADSIARYVIYQIEGGAQVVQLFDTWAGQLSPVDYECWALPYQKQIVDQVKARYPQVPLIL
YINGSAALLERVGKAGIDVFSLDWMSDMAEARARLGSLAVQGNLDPMVLLGSPEFIRQRTLEVIRKAGSRGHIMNLGHGI
HPSTPEANVHYFFETVRQSAELIHLR

Sequences:

>Translated_346_residues
MGDRLLRAARGEVLDRPPVWMMRQAGRYMAAYRELQSKYTFKQRCEIPELAVEISLQPFRAFAPDGVILFSDILTPLEGM
GIPFELVEHQGPIIDPPIRSQAQIERIRLLEPEESLPFIKTILSTLRREVEGKATLLGFVGSPWTLACYAVEGRSSKDYA
HIKSLAFAQPPLLHQLLSKLADSIARYVIYQIEGGAQVVQLFDTWAGQLSPVDYECWALPYQKQIVDQVKARYPQVPLIL
YINGSAALLERVGKAGIDVFSLDWMSDMAEARARLGSLAVQGNLDPMVLLGSPEFIRQRTLEVIRKAGSRGHIMNLGHGI
HPSTPEANVHYFFETVRQSAELIHLR
>Mature_345_residues
GDRLLRAARGEVLDRPPVWMMRQAGRYMAAYRELQSKYTFKQRCEIPELAVEISLQPFRAFAPDGVILFSDILTPLEGMG
IPFELVEHQGPIIDPPIRSQAQIERIRLLEPEESLPFIKTILSTLRREVEGKATLLGFVGSPWTLACYAVEGRSSKDYAH
IKSLAFAQPPLLHQLLSKLADSIARYVIYQIEGGAQVVQLFDTWAGQLSPVDYECWALPYQKQIVDQVKARYPQVPLILY
INGSAALLERVGKAGIDVFSLDWMSDMAEARARLGSLAVQGNLDPMVLLGSPEFIRQRTLEVIRKAGSRGHIMNLGHGIH
PSTPEANVHYFFETVRQSAELIHLR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=351, Percent_Identity=37.3219373219373, Blast_Score=235, Evalue=4e-62,
Organism=Escherichia coli, GI2367337, Length=347, Percent_Identity=40.9221902017291, Blast_Score=273, Evalue=9e-75,
Organism=Saccharomyces cerevisiae, GI6320252, Length=346, Percent_Identity=36.1271676300578, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=37.7906976744186, Blast_Score=246, Evalue=1e-65,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=37.7906976744186, Blast_Score=246, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38904; Mature: 38772

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDRLLRAARGEVLDRPPVWMMRQAGRYMAAYRELQSKYTFKQRCEIPELAVEISLQPFR
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHEEEEEECHHH
AFAPDGVILFSDILTPLEGMGIPFELVEHQGPIIDPPIRSQAQIERIRLLEPEESLPFIK
HCCCCCEEHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHH
TILSTLRREVEGKATLLGFVGSPWTLACYAVEGRSSKDYAHIKSLAFAQPPLLHQLLSKL
HHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHH
ADSIARYVIYQIEGGAQVVQLFDTWAGQLSPVDYECWALPYQKQIVDQVKARYPQVPLIL
HHHHHHHEEEEECCCHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCCEEE
YINGSAALLERVGKAGIDVFSLDWMSDMAEARARLGSLAVQGNLDPMVLLGSPEFIRQRT
EECCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCEEEECCCCCEEEECCHHHHHHHH
LEVIRKAGSRGHIMNLGHGIHPSTPEANVHYFFETVRQSAELIHLR
HHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
GDRLLRAARGEVLDRPPVWMMRQAGRYMAAYRELQSKYTFKQRCEIPELAVEISLQPFR
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHEEEEEECHHH
AFAPDGVILFSDILTPLEGMGIPFELVEHQGPIIDPPIRSQAQIERIRLLEPEESLPFIK
HCCCCCEEHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHH
TILSTLRREVEGKATLLGFVGSPWTLACYAVEGRSSKDYAHIKSLAFAQPPLLHQLLSKL
HHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHH
ADSIARYVIYQIEGGAQVVQLFDTWAGQLSPVDYECWALPYQKQIVDQVKARYPQVPLIL
HHHHHHHEEEEECCCHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCCEEE
YINGSAALLERVGKAGIDVFSLDWMSDMAEARARLGSLAVQGNLDPMVLLGSPEFIRQRT
EECCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCEEEECCCCCEEEECCHHHHHHHH
LEVIRKAGSRGHIMNLGHGIHPSTPEANVHYFFETVRQSAELIHLR
HHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA