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The map label for this gene is purC [H]

Identifier: 86609242

GI number: 86609242

Start: 1870499

End: 1871242

Strand: Direct

Name: purC [H]

Synonym: CYB_1784

Alternate gene names: 86609242

Gene position: 1870499-1871242 (Clockwise)

Preceding gene: 86609241

Following gene: 86609243

Centisome position: 61.39

GC content: 60.08

Gene sequence:

>744_bases
ATGCCATTCTCCCCCCAAGAGCTGCTCTACGAGGGCAAGGCCAAGCGCATCTACCGCACTGCCGATCCCAGGGTTTATCT
TTGCCAATACAAAGACGACGCCACCGCCTTCAACGCCCAAAAGCGGGGATCCATCGCCGGCAAGGGAGAGGTGAATTGCA
CCGTCTCCAGCCATGTGTTTGCCTACCTGGCGCAGCAAGGGATCCCCAACCATTTCTTGGCCCAGACCGGCCCCACCGAG
ATGCAGGTGCGAGCCTTGCACATCCTGCCTTTGGAAGTGGTGGTGCGCAACCGCACCGCCGGCAGCCTCTGCAAGCGCCT
GGGCCTGGAGCAGGGGCTTCCTATCCAGCCGCCGCTGGTGGAGTTCTATTACAAAAACGATGCCTTGGGGGATCCCTTGG
TAACCCCCGACCACATCCGCCTATTGCAGCTGGCCACGCCGGAGCAGGTGGAGCGCCTCGGATCCCTGGCTTTGGCCATC
AACAACCATCTGCAGGCTTTCTGGCGAAGCTGCCGCCTAGAGTTGGTGGACTTTAAGCTGGAGTTTGGCCTGGACGAGAA
GGGAGAGATCCTGCTAGCCGACGAGATTAGCCCCGATACCTGCCGTCTTTGGGATCGGGGGGGATCTGAGCCGCGGGTGC
TGGATAAAGATCTCTTTCGCTTTGATCTGGGGGATCCGGTGGCTGGCTATCAAGAGGTGTTGCAGCGGGTGCTTCAGGCA
GTGGGATCCCAATTCCTTCTCTGA

Upstream 100 bases:

>100_bases
TATGTGCAAAACTGGTCGCTGTGGCTGGATCTGCGCATCCTGGCCATCACCTTCTGGCAAGGGATCCGCGGACGGCTGGC
CGGATACTAGGGGTTAGCGT

Downstream 100 bases:

>100_bases
TACATTTACGCTGAACACTGCTGAACATCACTGTTCAACTATGCAGCGATAGCATTCTGTTTGTTTCCATTCGCGTTAGC
GGGACGGAGTCCAAACAGAA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MPFSPQELLYEGKAKRIYRTADPRVYLCQYKDDATAFNAQKRGSIAGKGEVNCTVSSHVFAYLAQQGIPNHFLAQTGPTE
MQVRALHILPLEVVVRNRTAGSLCKRLGLEQGLPIQPPLVEFYYKNDALGDPLVTPDHIRLLQLATPEQVERLGSLALAI
NNHLQAFWRSCRLELVDFKLEFGLDEKGEILLADEISPDTCRLWDRGGSEPRVLDKDLFRFDLGDPVAGYQEVLQRVLQA
VGSQFLL

Sequences:

>Translated_247_residues
MPFSPQELLYEGKAKRIYRTADPRVYLCQYKDDATAFNAQKRGSIAGKGEVNCTVSSHVFAYLAQQGIPNHFLAQTGPTE
MQVRALHILPLEVVVRNRTAGSLCKRLGLEQGLPIQPPLVEFYYKNDALGDPLVTPDHIRLLQLATPEQVERLGSLALAI
NNHLQAFWRSCRLELVDFKLEFGLDEKGEILLADEISPDTCRLWDRGGSEPRVLDKDLFRFDLGDPVAGYQEVLQRVLQA
VGSQFLL
>Mature_246_residues
PFSPQELLYEGKAKRIYRTADPRVYLCQYKDDATAFNAQKRGSIAGKGEVNCTVSSHVFAYLAQQGIPNHFLAQTGPTEM
QVRALHILPLEVVVRNRTAGSLCKRLGLEQGLPIQPPLVEFYYKNDALGDPLVTPDHIRLLQLATPEQVERLGSLALAIN
NHLQAFWRSCRLELVDFKLEFGLDEKGEILLADEISPDTCRLWDRGGSEPRVLDKDLFRFDLGDPVAGYQEVLQRVLQAV
GSQFLL

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=246, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI5453539, Length=246, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI119220559, Length=253, Percent_Identity=32.0158102766798, Blast_Score=101, Evalue=8e-22,
Organism=Escherichia coli, GI1788820, Length=232, Percent_Identity=39.6551724137931, Blast_Score=174, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17531275, Length=226, Percent_Identity=32.7433628318584, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI18860083, Length=247, Percent_Identity=29.5546558704453, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24583917, Length=221, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27749; Mature: 27618

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFSPQELLYEGKAKRIYRTADPRVYLCQYKDDATAFNAQKRGSIAGKGEVNCTVSSHVF
CCCCHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCCCCHHCCCCCCCCCEEEEEHHHHH
AYLAQQGIPNHFLAQTGPTEMQVRALHILPLEVVVRNRTAGSLCKRLGLEQGLPIQPPLV
HHHHHCCCCCCHHCCCCCCCEEEEEEEEEEEEHEEECCCHHHHHHHHCCCCCCCCCCCCE
EFYYKNDALGDPLVTPDHIRLLQLATPEQVERLGSLALAINNHLQAFWRSCRLELVDFKL
EEEECCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEE
EFGLDEKGEILLADEISPDTCRLWDRGGSEPRVLDKDLFRFDLGDPVAGYQEVLQRVLQA
ECCCCCCCCEEEECCCCCCHHHHCCCCCCCCCHHCHHHHHCCCCCCCHHHHHHHHHHHHH
VGSQFLL
HHHHCCC
>Mature Secondary Structure 
PFSPQELLYEGKAKRIYRTADPRVYLCQYKDDATAFNAQKRGSIAGKGEVNCTVSSHVF
CCCHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCCCCHHCCCCCCCCCEEEEEHHHHH
AYLAQQGIPNHFLAQTGPTEMQVRALHILPLEVVVRNRTAGSLCKRLGLEQGLPIQPPLV
HHHHHCCCCCCHHCCCCCCCEEEEEEEEEEEEHEEECCCHHHHHHHHCCCCCCCCCCCCE
EFYYKNDALGDPLVTPDHIRLLQLATPEQVERLGSLALAINNHLQAFWRSCRLELVDFKL
EEEECCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEE
EFGLDEKGEILLADEISPDTCRLWDRGGSEPRVLDKDLFRFDLGDPVAGYQEVLQRVLQA
ECCCCCCCCEEEECCCCCCHHHHCCCCCCCCCHHCHHHHHCCCCCCCHHHHHHHHHHHHH
VGSQFLL
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA