Click here to switch to the map view.

The map label for this gene is groEL [H]

Identifier: 86609172

GI number: 86609172

Start: 1794624

End: 1796243

Strand: Direct

Name: groEL [H]

Synonym: CYB_1712

Alternate gene names: 86609172

Gene position: 1794624-1796243 (Clockwise)

Preceding gene: 86609171

Following gene: 86609174

Centisome position: 58.9

GC content: 57.35

Gene sequence:

>1620_bases
ATGGCAAAGCGGATTCTGTTTAGAGAAGAGGCCCGCAAGGCATTGGAGCAGGGCATCAACCAACTGGCGGATGCAATCAA
GGTTACGATTGGCCCCAAAGGACGCAACGTGGTCTTGGAGAAGAAGTTTGGTGCCCCCCAAATCGTCAACGACGGGGTCA
CGATTGCCAAGGAAATTGAGTTGGCCGATCCTTTGGAGAACACAGGCGCCCAGTTGATGCGGGAAGTGGCCTCTAAGACC
AACGATGTGGCCGGAGATGGTACCACCACAGCCACCATCCTGGCCCAAAGCATGGTGCGGGAAGGGCTCAAAAACATCTC
GGCGGGCGCCAACCCTGTGGCTCTGCGGCGCGGCATTGAAAAGACCACTGCCTACTTGGTGGAGCAAATTGCAGCTCATG
CCAAGCCTGTGGAAGGCCGTAAAACCATCGCCGAAGTAGCCACTATCTCTGCCGGCAATGACAGCGAAGTGGGAGAGATG
ATCGCCAAGGCCATGGATGCTGTAGGGCGAGATGGGGTGATCACGGTCGAAGAATCCAAGTCGCTGGAAACCGAGTTGGA
CGTGGTGGAGGGGATGCAGTTTGACCGCGGCTACATTTCCCCCTATTTCGTCACAGACTCGGAGCGGATGGTGGCCGAGT
ATGAGAATGCTTATCTGCTGATTACCAGCAACAAGATCTCCAGCCTGCAAGATCTGGTGCCCATCCTAGAGCGGGTGGCC
CGCGAGGGTCGGCCTCTTCTGGTCATTGCGGAGGATGTGGAGGGAGAGGCTCTGGCCACATTGGTGGTGAACCGCCTGCG
GGGGGTACTCAATGCGGTGGCGGTCAAGGCTCCGGCTTTTGGGGATCGGCGCAAAGCCATGCTGGAAGATATCGCCATTC
TCACCGGCGGGCAGCTCATCTCTGAGGATGTGGGCATCAAGTTGGATAAGGTCACTCTGGACATGATGGGGGTAGCCCGC
AAGATCACCGTCACCAAAGACAAGACCACCATCGTGACCGATGGCAGCACCAAAGCGGCGGTGGAAAAGCGAGTGGCTCA
AATTCGCAAGCAACTGGAAACCACCGATTCCGAGTACGACCGCGAAAAATTGCAAGAACGCATCGCCAAGTTAGCCGGGG
GAGTGGCGGTGATCAAAGTGGGGGCTGCCACTGAAACCGAACTCAAAGATCGCAAGCTGCGCATTGAGGATGCCCTGAAT
GCCACCCGAGCTGCGGTGGAAGAAGGGATCGTCCCTGGCGGCGGGGCGACGCTATTGCACCTCTCCAAAGGGATCCCGGC
TTTCAAGGCCAAGTTGAATGCCGAAGAACAGGTGGGGGCAGAAATTGTTTACCGAGCCTTGCAGGCCCCTCTCTTTCAGA
TTGCCCACAATGCCGGTCTGGAAGGGTCAGTGGTGGTGGAAAAGGTTTTGGAGAAGGAGATGCCCTTTGGCTTCGATGCC
CTGACCGGAACCTATGTGGATATGTTTGCCCAGGGGATCGTGGATCCGGCCAAAGTGGTGCGCTCAGCGCTGCAAAACGC
GGCTTCCATAGCCGGAATGTACCTCACAACCGAAGCGATTGTGGTGGAAAAGCCTGAGCCCAAGCCGGCGGCTGGCTCTG
CACCTAAGGGGATGATGTAG

Upstream 100 bases:

>100_bases
AACTCCCTGCTAGCCGAGCCGGAGGATTCCTGGGAACCCCACTCCGCCTGGCAGTACCCAAAGTAGGAGCCCAGTCAGAC
TTACGAGGATCGCGGATTCT

Downstream 100 bases:

>100_bases
TCTTGCGAAAGTGAGCTTTCTGGGAAGGGATCAGTCTTGGATGTACTCCTCGCCGGAGATCAGGGCAGCTTCAGCTTTTT
GAAACTCCCTGCCCAAGTAG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MAKRILFREEARKALEQGINQLADAIKVTIGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELADPLENTGAQLMREVASKT
NDVAGDGTTTATILAQSMVREGLKNISAGANPVALRRGIEKTTAYLVEQIAAHAKPVEGRKTIAEVATISAGNDSEVGEM
IAKAMDAVGRDGVITVEESKSLETELDVVEGMQFDRGYISPYFVTDSERMVAEYENAYLLITSNKISSLQDLVPILERVA
REGRPLLVIAEDVEGEALATLVVNRLRGVLNAVAVKAPAFGDRRKAMLEDIAILTGGQLISEDVGIKLDKVTLDMMGVAR
KITVTKDKTTIVTDGSTKAAVEKRVAQIRKQLETTDSEYDREKLQERIAKLAGGVAVIKVGAATETELKDRKLRIEDALN
ATRAAVEEGIVPGGGATLLHLSKGIPAFKAKLNAEEQVGAEIVYRALQAPLFQIAHNAGLEGSVVVEKVLEKEMPFGFDA
LTGTYVDMFAQGIVDPAKVVRSALQNAASIAGMYLTTEAIVVEKPEPKPAAGSAPKGMM

Sequences:

>Translated_539_residues
MAKRILFREEARKALEQGINQLADAIKVTIGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELADPLENTGAQLMREVASKT
NDVAGDGTTTATILAQSMVREGLKNISAGANPVALRRGIEKTTAYLVEQIAAHAKPVEGRKTIAEVATISAGNDSEVGEM
IAKAMDAVGRDGVITVEESKSLETELDVVEGMQFDRGYISPYFVTDSERMVAEYENAYLLITSNKISSLQDLVPILERVA
REGRPLLVIAEDVEGEALATLVVNRLRGVLNAVAVKAPAFGDRRKAMLEDIAILTGGQLISEDVGIKLDKVTLDMMGVAR
KITVTKDKTTIVTDGSTKAAVEKRVAQIRKQLETTDSEYDREKLQERIAKLAGGVAVIKVGAATETELKDRKLRIEDALN
ATRAAVEEGIVPGGGATLLHLSKGIPAFKAKLNAEEQVGAEIVYRALQAPLFQIAHNAGLEGSVVVEKVLEKEMPFGFDA
LTGTYVDMFAQGIVDPAKVVRSALQNAASIAGMYLTTEAIVVEKPEPKPAAGSAPKGMM
>Mature_538_residues
AKRILFREEARKALEQGINQLADAIKVTIGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELADPLENTGAQLMREVASKTN
DVAGDGTTTATILAQSMVREGLKNISAGANPVALRRGIEKTTAYLVEQIAAHAKPVEGRKTIAEVATISAGNDSEVGEMI
AKAMDAVGRDGVITVEESKSLETELDVVEGMQFDRGYISPYFVTDSERMVAEYENAYLLITSNKISSLQDLVPILERVAR
EGRPLLVIAEDVEGEALATLVVNRLRGVLNAVAVKAPAFGDRRKAMLEDIAILTGGQLISEDVGIKLDKVTLDMMGVARK
ITVTKDKTTIVTDGSTKAAVEKRVAQIRKQLETTDSEYDREKLQERIAKLAGGVAVIKVGAATETELKDRKLRIEDALNA
TRAAVEEGIVPGGGATLLHLSKGIPAFKAKLNAEEQVGAEIVYRALQAPLFQIAHNAGLEGSVVVEKVLEKEMPFGFDAL
TGTYVDMFAQGIVDPAKVVRSALQNAASIAGMYLTTEAIVVEKPEPKPAAGSAPKGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=48.8636363636364, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=48.8636363636364, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI38455427, Length=525, Percent_Identity=22.6666666666667, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=55.765595463138, Blast_Score=591, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI17555558, Length=527, Percent_Identity=47.8178368121442, Blast_Score=495, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI193210679, Length=217, Percent_Identity=45.1612903225806, Blast_Score=195, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=48.3809523809524, Blast_Score=503, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=48.4790874524715, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=48.4790874524715, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=46.8571428571429, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=46.8571428571429, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=46.8571428571429, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17864606, Length=524, Percent_Identity=40.8396946564886, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=35.2830188679245, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=35.2830188679245, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI17647245, Length=523, Percent_Identity=22.9445506692161, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24652903, Length=523, Percent_Identity=22.9445506692161, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24645179, Length=500, Percent_Identity=22.4, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24583944, Length=537, Percent_Identity=22.1601489757914, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57665; Mature: 57534

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRILFREEARKALEQGINQLADAIKVTIGPKGRNVVLEKKFGAPQIVNDGVTIAKEIE
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCEEEHHCC
LADPLENTGAQLMREVASKTNDVAGDGTTTATILAQSMVREGLKNISAGANPVALRRGIE
CCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KTTAYLVEQIAAHAKPVEGRKTIAEVATISAGNDSEVGEMIAKAMDAVGRDGVITVEESK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
SLETELDVVEGMQFDRGYISPYFVTDSERMVAEYENAYLLITSNKISSLQDLVPILERVA
CHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHH
REGRPLLVIAEDVEGEALATLVVNRLRGVLNAVAVKAPAFGDRRKAMLEDIAILTGGQLI
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHH
SEDVGIKLDKVTLDMMGVARKITVTKDKTTIVTDGSTKAAVEKRVAQIRKQLETTDSEYD
HHCCCCEEEHHHHHHHCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHH
REKLQERIAKLAGGVAVIKVGAATETELKDRKLRIEDALNATRAAVEEGIVPGGGATLLH
HHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
LSKGIPAFKAKLNAEEQVGAEIVYRALQAPLFQIAHNAGLEGSVVVEKVLEKEMPFGFDA
ECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHH
LTGTYVDMFAQGIVDPAKVVRSALQNAASIAGMYLTTEAIVVEKPEPKPAAGSAPKGMM
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKRILFREEARKALEQGINQLADAIKVTIGPKGRNVVLEKKFGAPQIVNDGVTIAKEIE
CCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCEEEHHCC
LADPLENTGAQLMREVASKTNDVAGDGTTTATILAQSMVREGLKNISAGANPVALRRGIE
CCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KTTAYLVEQIAAHAKPVEGRKTIAEVATISAGNDSEVGEMIAKAMDAVGRDGVITVEESK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
SLETELDVVEGMQFDRGYISPYFVTDSERMVAEYENAYLLITSNKISSLQDLVPILERVA
CHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHH
REGRPLLVIAEDVEGEALATLVVNRLRGVLNAVAVKAPAFGDRRKAMLEDIAILTGGQLI
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHH
SEDVGIKLDKVTLDMMGVARKITVTKDKTTIVTDGSTKAAVEKRVAQIRKQLETTDSEYD
HHCCCCEEEHHHHHHHCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHH
REKLQERIAKLAGGVAVIKVGAATETELKDRKLRIEDALNATRAAVEEGIVPGGGATLLH
HHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
LSKGIPAFKAKLNAEEQVGAEIVYRALQAPLFQIAHNAGLEGSVVVEKVLEKEMPFGFDA
ECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHH
LTGTYVDMFAQGIVDPAKVVRSALQNAASIAGMYLTTEAIVVEKPEPKPAAGSAPKGMM
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA