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The map label for this gene is fabF [H]

Identifier: 86609126

GI number: 86609126

Start: 1744648

End: 1745928

Strand: Direct

Name: fabF [H]

Synonym: CYB_1666

Alternate gene names: 86609126

Gene position: 1744648-1745928 (Clockwise)

Preceding gene: 86609125

Following gene: 86609127

Centisome position: 57.26

GC content: 62.69

Gene sequence:

>1281_bases
ATGGCTACCACAGATCCCGCCACTGCTTACAGACCAACCCGCCGCGTTGTGATTACGGGCCTGGGTGCGGTCACCCCTAT
CGGCAACTCTCCTGCCGAGTTTTGGCAGAGCTTGCTGGCAGGGCGCTCCGGCATTGGGCCGATTACCCATTTCGATGCCT
CCCGCCACGACTGCCGTATTGCCGGAGAGGTGAAGGGATTTGATCCCCTCGACTACTTGGATCGCAAGGATGTCAAGCGC
ACCGACCGCTTTGTGCACCTGGCGATGGCGGCCACCCGGCAAGCCTTGGAGGACGCTGACTTTCGCATCACCGCTCTCAA
CGCCGAGCAAGTGGGGGTGATCTTGGGCACCGGCATCGGCGGCATCCGCGTCTTGGAAGAGCAGCAGACCATCTATCTGC
AGAAAGGGCCGGATCGCTGTAGCCCCTTCATGGTGCCCATGATGATTGCCAATATGGCTGCGGGTCACCTGGCCATTCAT
TTTGGCGCCAAAGGCCCCAATTCCTGCACAGTTACGGCCTGTGCCTCTGGCTCCAACGCCATTGGCGATGCCTTTCGGCT
CATCCAGAGGGGAGAGGTGCAAGCGGCGATTACAGGTGGCACGGAAGCGGCGGTTACCCCTTTGTCCATGGCGGGGTTCA
GTGCCATGAAGGCCCTTTCCACCCGCAACGACACCCCGGAGCAAGCCTGTAGGCCCTTTGATCGGGATCGGGATGGCTTT
GTCATGGGGGAAGGAGCAGGGATCCTGGTGCTGGAGGAGTTGGAGCACGCCCGCGCCCGCGGGGCCAAGATCTATGCGGA
GATAGTCGGCTATGGCCTCACCTGCGATGCCCACCACATGACCAACCCTGCCCCCGGCGGCGAGGGAGCGGCCCGGGCGA
TGCGGCTGGCCCTCAAGGATGCCGGGCTTCAGCCTGGGGATGTGCAACACATCAATGCCCATGCCACCAGCACCCCTGTA
GGGGATATCGCCGAGGTCCAGGCCATCAAGTCGGTCTTTGGCGAGCATGCCCCCCGTTTGGCCATCAGCGCCACCAAGTC
CATGACCGGCCACCTGTTGGGGGGAGCGGGCGGCATTGCCACGGTGGCCACAGCTTTGGCCATCCACCACGGCTGGGTTC
CTCCCACCCTCAACTTGGACAACCCCGATCCCGAGTGCGAAGGGCTGGATTTTGTACCCCACAAGGGGCGGCAGATGGCT
GTCGGGGCCGCTTTGGTCAATGCCTTTGGATTTGGTGGGCACAACGTCACGCTGGCTTTGCGCCGCTACTCTCCCGATTG
A

Upstream 100 bases:

>100_bases
GATCGCCACCGTGCAAGACGCTGTTAACTACATCCTCTCGAAGAAAGCTGCCTAGTCTGCCCCCAGTTCTGACTCTATAC
CCCCGGGCTAACACCGGACG

Downstream 100 bases:

>100_bases
AAGGCTTGGCCTATGTCTTCTCCCGAAAGTTCGTCGCCCTCAGTTCGTCAACAAGCCTTGGCCGCTTTGACGGCGGAGCT
GGCGCAGCAAGGCCACCCGC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MATTDPATAYRPTRRVVITGLGAVTPIGNSPAEFWQSLLAGRSGIGPITHFDASRHDCRIAGEVKGFDPLDYLDRKDVKR
TDRFVHLAMAATRQALEDADFRITALNAEQVGVILGTGIGGIRVLEEQQTIYLQKGPDRCSPFMVPMMIANMAAGHLAIH
FGAKGPNSCTVTACASGSNAIGDAFRLIQRGEVQAAITGGTEAAVTPLSMAGFSAMKALSTRNDTPEQACRPFDRDRDGF
VMGEGAGILVLEELEHARARGAKIYAEIVGYGLTCDAHHMTNPAPGGEGAARAMRLALKDAGLQPGDVQHINAHATSTPV
GDIAEVQAIKSVFGEHAPRLAISATKSMTGHLLGGAGGIATVATALAIHHGWVPPTLNLDNPDPECEGLDFVPHKGRQMA
VGAALVNAFGFGGHNVTLALRRYSPD

Sequences:

>Translated_426_residues
MATTDPATAYRPTRRVVITGLGAVTPIGNSPAEFWQSLLAGRSGIGPITHFDASRHDCRIAGEVKGFDPLDYLDRKDVKR
TDRFVHLAMAATRQALEDADFRITALNAEQVGVILGTGIGGIRVLEEQQTIYLQKGPDRCSPFMVPMMIANMAAGHLAIH
FGAKGPNSCTVTACASGSNAIGDAFRLIQRGEVQAAITGGTEAAVTPLSMAGFSAMKALSTRNDTPEQACRPFDRDRDGF
VMGEGAGILVLEELEHARARGAKIYAEIVGYGLTCDAHHMTNPAPGGEGAARAMRLALKDAGLQPGDVQHINAHATSTPV
GDIAEVQAIKSVFGEHAPRLAISATKSMTGHLLGGAGGIATVATALAIHHGWVPPTLNLDNPDPECEGLDFVPHKGRQMA
VGAALVNAFGFGGHNVTLALRRYSPD
>Mature_425_residues
ATTDPATAYRPTRRVVITGLGAVTPIGNSPAEFWQSLLAGRSGIGPITHFDASRHDCRIAGEVKGFDPLDYLDRKDVKRT
DRFVHLAMAATRQALEDADFRITALNAEQVGVILGTGIGGIRVLEEQQTIYLQKGPDRCSPFMVPMMIANMAAGHLAIHF
GAKGPNSCTVTACASGSNAIGDAFRLIQRGEVQAAITGGTEAAVTPLSMAGFSAMKALSTRNDTPEQACRPFDRDRDGFV
MGEGAGILVLEELEHARARGAKIYAEIVGYGLTCDAHHMTNPAPGGEGAARAMRLALKDAGLQPGDVQHINAHATSTPVG
DIAEVQAIKSVFGEHAPRLAISATKSMTGHLLGGAGGIATVATALAIHHGWVPPTLNLDNPDPECEGLDFVPHKGRQMAV
GAALVNAFGFGGHNVTLALRRYSPD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=421, Percent_Identity=45.8432304038005, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=52.7027027027027, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI41872631, Length=428, Percent_Identity=27.5700934579439, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=50.9756097560976, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=40.4358353510896, Blast_Score=258, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71983541, Length=421, Percent_Identity=36.104513064133, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=41.5094339622642, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=437, Percent_Identity=26.0869565217391, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17550940, Length=287, Percent_Identity=24.7386759581882, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=39.3736017897092, Blast_Score=295, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=42.3809523809524, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI221330659, Length=429, Percent_Identity=25.6410256410256, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19920632, Length=429, Percent_Identity=25.6410256410256, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24581345, Length=428, Percent_Identity=23.3644859813084, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44778; Mature: 44647

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTDPATAYRPTRRVVITGLGAVTPIGNSPAEFWQSLLAGRSGIGPITHFDASRHDCRI
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCEECCCCCCCEEE
AGEVKGFDPLDYLDRKDVKRTDRFVHLAMAATRQALEDADFRITALNAEQVGVILGTGIG
ECCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCC
GIRVLEEQQTIYLQKGPDRCSPFMVPMMIANMAAGHLAIHFGAKGPNSCTVTACASGSNA
CEEEEECCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCCCH
IGDAFRLIQRGEVQAAITGGTEAAVTPLSMAGFSAMKALSTRNDTPEQACRPFDRDRDGF
HHHHHHHHHCCCEEEEEECCCCHHCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCE
VMGEGAGILVLEELEHARARGAKIYAEIVGYGLTCDAHHMTNPAPGGEGAARAMRLALKD
EEECCCCEEEEHHHHHHHHCCCEEEEHHHCCCCEECCCCCCCCCCCCCHHHHHHHHHHHH
AGLQPGDVQHINAHATSTPVGDIAEVQAIKSVFGEHAPRLAISATKSMTGHLLGGAGGIA
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEECCCCHHH
TVATALAIHHGWVPPTLNLDNPDPECEGLDFVPHKGRQMAVGAALVNAFGFGGHNVTLAL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEE
RRYSPD
EECCCC
>Mature Secondary Structure 
ATTDPATAYRPTRRVVITGLGAVTPIGNSPAEFWQSLLAGRSGIGPITHFDASRHDCRI
CCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCEECCCCCCCEEE
AGEVKGFDPLDYLDRKDVKRTDRFVHLAMAATRQALEDADFRITALNAEQVGVILGTGIG
ECCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCC
GIRVLEEQQTIYLQKGPDRCSPFMVPMMIANMAAGHLAIHFGAKGPNSCTVTACASGSNA
CEEEEECCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCCCH
IGDAFRLIQRGEVQAAITGGTEAAVTPLSMAGFSAMKALSTRNDTPEQACRPFDRDRDGF
HHHHHHHHHCCCEEEEEECCCCHHCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCE
VMGEGAGILVLEELEHARARGAKIYAEIVGYGLTCDAHHMTNPAPGGEGAARAMRLALKD
EEECCCCEEEEHHHHHHHHCCCEEEEHHHCCCCEECCCCCCCCCCCCCHHHHHHHHHHHH
AGLQPGDVQHINAHATSTPVGDIAEVQAIKSVFGEHAPRLAISATKSMTGHLLGGAGGIA
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEECCCCHHH
TVATALAIHHGWVPPTLNLDNPDPECEGLDFVPHKGRQMAVGAALVNAFGFGGHNVTLAL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEE
RRYSPD
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]