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The map label for this gene is purK [H]

Identifier: 86608690

GI number: 86608690

Start: 1260496

End: 1261680

Strand: Reverse

Name: purK [H]

Synonym: CYB_1214

Alternate gene names: 86608690

Gene position: 1261680-1260496 (Counterclockwise)

Preceding gene: 86608701

Following gene: 86608689

Centisome position: 41.41

GC content: 62.78

Gene sequence:

>1185_bases
GTGGAAACCCAGGTATCCTCAAAAGACCAGAGATCCCAACCTGTGGGGGTGATTGGCGGCGGGCAGTTGGCGCAGATGTT
GGCCTTGGCAGCTCGCCAGATGGGGATCCCGCTGGTGGTGCAGGCTGCTGCTCCCACCGATCCGGCGGTGGCAGTGGCCG
ATGGGGTGGTTTGGGGATCCACAGCCGACAGCCAGGCCACGGCCCAGTTGTTGGAGCGCTGCCCGGTGGTTACTTTTGAA
AACGAGTTTATCCCTCTGCCGGAGCTGAAAAAACTGGATCCGGAGGGATCCCGCTTTCGTCCCAGCCTCAGCACGCTAGA
GCCGCTGCTGGACAAGTTGCACCAACGGCAGTTCCTGGCGCGGTTGGGGTTGCCGGTGCCGACTTTTTTTCCGCTGGAGG
CGGTGTTGGATTCGGCAGACCTGGCTGGACTGGGCTTTCCGGTGGTGCTCAAGCGACGGCGGCAGGGCTACGATGGGCAG
GGCACCCGCATCTTGCACGAGCGAGCGGCTTTGCAGCAGGCCCTTAGCCAATCTGAGGGGATCCCGCTATTGCTGGAGGA
ATGGATCCCGTTCGAGCGGGAGCTGGCGGTGATGGTAGCGCGGGGGCTGAAGGGAGAGATCCGGGTTTACCCGGTGGTGG
AAACTGTGCAGATTGAGCAAATCTGCCGCCACGTCCTGGTGCCTGCCCGCATCCCCCCAACCACCGAGGCGGAGATCCGG
CGCTTAGCAGCCGATCTGATGGAAAAATTGGGTGCAGTTGGCGTGTTTGGCATCGAGCTGTTCTGGGTGCCGCCGCCCCA
CCCCAAGGCCGGGATCTGGATCAACGAAATCTCGCCGCGGGTCCACAATTCCGGCCACTACACCCTAGAAGCCTGCCGCA
CCTCACAATTCGAGCAACACCTGCGGGCCATCCTCGGCCTGCCCTTGGGGGATCCCTCCCTCAAGTGTGGGGGGGCAGTG
ATGGTGAACCTCTTGGGCTATGAGCATTCCACCGGCGATTACCCAGAAAAGCGGCAGCGCCTGGCCCAGCTCCCCAATGC
CACGGTGCATTGGTACCACAAAACCCCTGCCCGCCCAGGGCGGAAACTGGGCCATGTAACCGTCTGTCTGCCGACTGCTC
CCTCTCCTTTCGAAGCAGCAGCCCTTGTCCGCACCCTCGAATCCCTCTGGTACCCCCAGCCATGA

Upstream 100 bases:

>100_bases
CGTTTTTCTCCTAGCGCTGGAGGGCAAGGGATCCCATAATGGGGTTCTGGATCCCAGAAGCAATGGACAGCGGCCCACCA
CCCAGTATAACGGTACGGCT

Downstream 100 bases:

>100_bases
GCCAAGTGTCGGATCCCTCCTTCTCCCCAGACATTCAAGCCCTGATCCAGGCCATGCAACGGCGGGATGTGCCCGCGGTA
GCCCAGCAGGTCAACCGCCT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
METQVSSKDQRSQPVGVIGGGQLAQMLALAARQMGIPLVVQAAAPTDPAVAVADGVVWGSTADSQATAQLLERCPVVTFE
NEFIPLPELKKLDPEGSRFRPSLSTLEPLLDKLHQRQFLARLGLPVPTFFPLEAVLDSADLAGLGFPVVLKRRRQGYDGQ
GTRILHERAALQQALSQSEGIPLLLEEWIPFERELAVMVARGLKGEIRVYPVVETVQIEQICRHVLVPARIPPTTEAEIR
RLAADLMEKLGAVGVFGIELFWVPPPHPKAGIWINEISPRVHNSGHYTLEACRTSQFEQHLRAILGLPLGDPSLKCGGAV
MVNLLGYEHSTGDYPEKRQRLAQLPNATVHWYHKTPARPGRKLGHVTVCLPTAPSPFEAAALVRTLESLWYPQP

Sequences:

>Translated_394_residues
METQVSSKDQRSQPVGVIGGGQLAQMLALAARQMGIPLVVQAAAPTDPAVAVADGVVWGSTADSQATAQLLERCPVVTFE
NEFIPLPELKKLDPEGSRFRPSLSTLEPLLDKLHQRQFLARLGLPVPTFFPLEAVLDSADLAGLGFPVVLKRRRQGYDGQ
GTRILHERAALQQALSQSEGIPLLLEEWIPFERELAVMVARGLKGEIRVYPVVETVQIEQICRHVLVPARIPPTTEAEIR
RLAADLMEKLGAVGVFGIELFWVPPPHPKAGIWINEISPRVHNSGHYTLEACRTSQFEQHLRAILGLPLGDPSLKCGGAV
MVNLLGYEHSTGDYPEKRQRLAQLPNATVHWYHKTPARPGRKLGHVTVCLPTAPSPFEAAALVRTLESLWYPQP
>Mature_394_residues
METQVSSKDQRSQPVGVIGGGQLAQMLALAARQMGIPLVVQAAAPTDPAVAVADGVVWGSTADSQATAQLLERCPVVTFE
NEFIPLPELKKLDPEGSRFRPSLSTLEPLLDKLHQRQFLARLGLPVPTFFPLEAVLDSADLAGLGFPVVLKRRRQGYDGQ
GTRILHERAALQQALSQSEGIPLLLEEWIPFERELAVMVARGLKGEIRVYPVVETVQIEQICRHVLVPARIPPTTEAEIR
RLAADLMEKLGAVGVFGIELFWVPPPHPKAGIWINEISPRVHNSGHYTLEACRTSQFEQHLRAILGLPLGDPSLKCGGAV
MVNLLGYEHSTGDYPEKRQRLAQLPNATVHWYHKTPARPGRKLGHVTVCLPTAPSPFEAAALVRTLESLWYPQP

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=381, Percent_Identity=31.496062992126, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1788155, Length=377, Percent_Identity=24.9336870026525, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324702, Length=368, Percent_Identity=36.1413043478261, Blast_Score=239, Evalue=8e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 43262; Mature: 43262

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS50975 ATP_GRASP ; PS00046 HISTONE_H2A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METQVSSKDQRSQPVGVIGGGQLAQMLALAARQMGIPLVVQAAAPTDPAVAVADGVVWGS
CCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHCCCEEECC
TADSQATAQLLERCPVVTFENEFIPLPELKKLDPEGSRFRPSLSTLEPLLDKLHQRQFLA
CCCHHHHHHHHHHCCEEEECCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RLGLPVPTFFPLEAVLDSADLAGLGFPVVLKRRRQGYDGQGTRILHERAALQQALSQSEG
HHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
IPLLLEEWIPFERELAVMVARGLKGEIRVYPVVETVQIEQICRHVLVPARIPPTTEAEIR
CCCHHHHCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHH
RLAADLMEKLGAVGVFGIELFWVPPPHPKAGIWINEISPRVHNSGHYTLEACRTSQFEQH
HHHHHHHHHHCCCEEEEEEEEEECCCCCCCCEEEECCCCCEECCCCEEEHHHHHHHHHHH
LRAILGLPLGDPSLKCGGAVMVNLLGYEHSTGDYPEKRQRLAQLPNATVHWYHKTPARPG
HHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCC
RKLGHVTVCLPTAPSPFEAAALVRTLESLWYPQP
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
METQVSSKDQRSQPVGVIGGGQLAQMLALAARQMGIPLVVQAAAPTDPAVAVADGVVWGS
CCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHCCCEEECC
TADSQATAQLLERCPVVTFENEFIPLPELKKLDPEGSRFRPSLSTLEPLLDKLHQRQFLA
CCCHHHHHHHHHHCCEEEECCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RLGLPVPTFFPLEAVLDSADLAGLGFPVVLKRRRQGYDGQGTRILHERAALQQALSQSEG
HHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
IPLLLEEWIPFERELAVMVARGLKGEIRVYPVVETVQIEQICRHVLVPARIPPTTEAEIR
CCCHHHHCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHH
RLAADLMEKLGAVGVFGIELFWVPPPHPKAGIWINEISPRVHNSGHYTLEACRTSQFEQH
HHHHHHHHHHCCCEEEEEEEEEECCCCCCCCEEEECCCCCEECCCCEEEHHHHHHHHHHH
LRAILGLPLGDPSLKCGGAVMVNLLGYEHSTGDYPEKRQRLAQLPNATVHWYHKTPARPG
HHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCC
RKLGHVTVCLPTAPSPFEAAALVRTLESLWYPQP
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA