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The map label for this gene is cyoE

Identifier: 86608147

GI number: 86608147

Start: 673292

End: 674284

Strand: Reverse

Name: cyoE

Synonym: CYB_0660

Alternate gene names: 86608147

Gene position: 674284-673292 (Counterclockwise)

Preceding gene: 86608148

Following gene: 86608146

Centisome position: 22.13

GC content: 60.02

Gene sequence:

>993_bases
ATGGGGGGGATCCCCTCTGAGCAGAGCCCATGTGCTCTGGGGTGCGAGCGCCAGGCGCTTGTCCAGGTTTTGCGCAGCTA
CAGCCAGTTGGTGAAGCCCAAGATCATCGCCCTCTTGCTGATGACGACGGCTGGGGCCATGTGGATGGCAGGCAACACCG
ACCCGTTCAGGTTTTTCATCACCCTTTTGGGGGGAGGAATAGCGGCGGCGGCAGCCAACGTCATCAACATGGTGTATGAC
ACCGATATCGATCGGATGATGGAGCGAACCCGCCATCGTCCCCTGCCTTCCGGTCGAATCCGGGCGCGGGATGCTCTGAT
TTTTTCGGGGATCCTGGCTTTGGCTGCCTTTGGGTTGTTGGCTATTTTCACCAACCTGCTGGCTGCCGGTTTGGCCATGT
CGGGGATCCTGGTGTATGTGGGGGTCTATACCCACTGGCTGAAGCGTTCCAGCACGCAAAATATTGTCATCGGTGGAGCG
GCAGGAGCGATCCCACCTTTGGTGGGCTGGGCAGCAACCACAGGCGAGCTCAGCTGGGCCGCGTGGGTGATGTTCGCCAT
CATCTTTTTGTGGACTCCACCCCACTTCTGGGCTTTGGCCATTCTGAAGCGGGAAGACTATGCCCGTGCCGGGGTGCCGA
TGCTGCCGGTGGTAGCGGGCGAAAGGATCACTGCCGCGCAGATTTTGCTCTACGCGCTGCTGATGGTTCCGGTCAGTCTG
TTGCTGGTTTACCCCTTAGGGATGCTGGGATCCTTTTATCTGAGCGCGGCGGCGCTGCTGGGATCCCTCTTGGTTTGGAA
GGCGGTGCAGTTGCTGCAGGATCCCTGCGACCGAGATCGGGCGGCCTCGCTCTTCACGTTTGCCAACCTGTATCTGCTGC
TGTTGTGCGGGGCCATGGGTCTGGATAGGTGGTCGTTAACCCACATCCTCTGGAGCCAGGCCACTGCGTCCCTCCAAGGG
ATTTACACCACCCTCATAGCGCTGGCCAGCTGA

Upstream 100 bases:

>100_bases
AAGAAGGCCAGTGGATGGCCATGACCGCAGAAATGACTGGTGAGTGAATTTCATGCAAGATAGCGTTTTAGTCGACCGTC
AGGCTTCCTACCAGAACCCG

Downstream 100 bases:

>100_bases
CTTGCGCGAATGGGGGATCCCTGGGTTGATAACCCCCGTTGGCCAGCCGGTTTTTCCTCAAAATTGCGGCCCATTCTCAG
AGAGCATGACTCTAGTCAAT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MGGIPSEQSPCALGCERQALVQVLRSYSQLVKPKIIALLLMTTAGAMWMAGNTDPFRFFITLLGGGIAAAAANVINMVYD
TDIDRMMERTRHRPLPSGRIRARDALIFSGILALAAFGLLAIFTNLLAAGLAMSGILVYVGVYTHWLKRSSTQNIVIGGA
AGAIPPLVGWAATTGELSWAAWVMFAIIFLWTPPHFWALAILKREDYARAGVPMLPVVAGERITAAQILLYALLMVPVSL
LLVYPLGMLGSFYLSAAALLGSLLVWKAVQLLQDPCDRDRAASLFTFANLYLLLLCGAMGLDRWSLTHILWSQATASLQG
IYTTLIALAS

Sequences:

>Translated_330_residues
MGGIPSEQSPCALGCERQALVQVLRSYSQLVKPKIIALLLMTTAGAMWMAGNTDPFRFFITLLGGGIAAAAANVINMVYD
TDIDRMMERTRHRPLPSGRIRARDALIFSGILALAAFGLLAIFTNLLAAGLAMSGILVYVGVYTHWLKRSSTQNIVIGGA
AGAIPPLVGWAATTGELSWAAWVMFAIIFLWTPPHFWALAILKREDYARAGVPMLPVVAGERITAAQILLYALLMVPVSL
LLVYPLGMLGSFYLSAAALLGSLLVWKAVQLLQDPCDRDRAASLFTFANLYLLLLCGAMGLDRWSLTHILWSQATASLQG
IYTTLIALAS
>Mature_329_residues
GGIPSEQSPCALGCERQALVQVLRSYSQLVKPKIIALLLMTTAGAMWMAGNTDPFRFFITLLGGGIAAAAANVINMVYDT
DIDRMMERTRHRPLPSGRIRARDALIFSGILALAAFGLLAIFTNLLAAGLAMSGILVYVGVYTHWLKRSSTQNIVIGGAA
GAIPPLVGWAATTGELSWAAWVMFAIIFLWTPPHFWALAILKREDYARAGVPMLPVVAGERITAAQILLYALLMVPVSLL
LVYPLGMLGSFYLSAAALLGSLLVWKAVQLLQDPCDRDRAASLFTFANLYLLLLCGAMGLDRWSLTHILWSQATASLQGI
YTTLIALAS

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=192, Percent_Identity=38.5416666666667, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1786631, Length=281, Percent_Identity=36.2989323843416, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71998235, Length=265, Percent_Identity=30.5660377358491, Blast_Score=107, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6325085, Length=251, Percent_Identity=27.4900398406374, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI19921064, Length=198, Percent_Identity=35.8585858585859, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_SYNJB (Q2JNL3)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_476909.1
- STRING:   Q2JNL3
- GeneID:   3902315
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_0660
- TIGR:   CYB_0660
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   MALTEGW
- PhylomeDB:   Q2JNL3
- ProtClustDB:   PRK04375
- BioCyc:   SSP321332:CYB_0660-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 35613; Mature: 35482

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12148440)-; HASH(0x119bb180)-; HASH(0x129289a0)-; HASH(0x11a47a44)-; HASH(0xe4fd070)-; HASH(0x1110db28)-; HASH(0x125c5ac8)-; HASH(0x1291f80c)-; HASH(0x115213b4)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGIPSEQSPCALGCERQALVQVLRSYSQLVKPKIIALLLMTTAGAMWMAGNTDPFRFFI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHH
TLLGGGIAAAAANVINMVYDTDIDRMMERTRHRPLPSGRIRARDALIFSGILALAAFGLL
HHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AIFTNLLAAGLAMSGILVYVGVYTHWLKRSSTQNIVIGGAAGAIPPLVGWAATTGELSWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHCCCCCCCHHHH
AWVMFAIIFLWTPPHFWALAILKREDYARAGVPMLPVVAGERITAAQILLYALLMVPVSL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHH
LLVYPLGMLGSFYLSAAALLGSLLVWKAVQLLQDPCDRDRAASLFTFANLYLLLLCGAMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
LDRWSLTHILWSQATASLQGIYTTLIALAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
GGIPSEQSPCALGCERQALVQVLRSYSQLVKPKIIALLLMTTAGAMWMAGNTDPFRFFI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHH
TLLGGGIAAAAANVINMVYDTDIDRMMERTRHRPLPSGRIRARDALIFSGILALAAFGLL
HHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AIFTNLLAAGLAMSGILVYVGVYTHWLKRSSTQNIVIGGAAGAIPPLVGWAATTGELSWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHCCCCCCCHHHH
AWVMFAIIFLWTPPHFWALAILKREDYARAGVPMLPVVAGERITAAQILLYALLMVPVSL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHH
LLVYPLGMLGSFYLSAAALLGSLLVWKAVQLLQDPCDRDRAASLFTFANLYLLLLCGAMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
LDRWSLTHILWSQATASLQGIYTTLIALAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA