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The map label for this gene is trpF

Identifier: 86607695

GI number: 86607695

Start: 207847

End: 208548

Strand: Direct

Name: trpF

Synonym: CYB_0194

Alternate gene names: 86607695

Gene position: 207847-208548 (Clockwise)

Preceding gene: 86607694

Following gene: 86607698

Centisome position: 6.82

GC content: 62.54

Gene sequence:

>702_bases
ATGGGCCGGTTGTTTGTCAAAATCTGCGGCATCACCCGTCAGGATCAGGCGGAGGCCATCGCCGCGCTGGGGGTGAGTGC
CCTTGGGTTCATCGCGGTGCCCAATACCCCCCGCTATTTGCCCCTCTCGGAAATGGCTCGTTGGGTGGGATCCCTGCCCG
GCCCTGTGGAAAAGGTGGGGGTCTTCCTGGATCAGGATCCCCGCGCCATCGCCGCCTGGGTGGAAACGGTGGGCCTCACG
GCTGTCCAGTTGCATGGCCAAGAATCCCCGCAGGATTGTCAGCAATTGGGGGAATGGCTTCCCGGGATCCGCCGCATCAA
GGCCCTGCGCGTCCGCCAGCCGCAAGATCTGGAAGTGGCCAATCTCTACCGAGACTGTGTGGAGATGCTGCTTTTGGATG
CTTATCACCCCCAACAGGCGGGGGGAACGGGGCGAACCCTGAATTGGCCAGAACTTGCTCGCCTTTCGCGTGAGCGGGCT
CTGCCCTTGCCTTGGCTACTGGCCGGTGGTCTGAACCCGGACAATGTTCTGCAGGCGCTCAGCCACCTGCAGCCAAGCGG
CATCGACCTCTCCAGTGGTGTGGAACGTCGGCCAGGCGATAAAGACATCGACAAAGTCCGGCACCTGCTGCAGCAGCTTG
GCTCCCAAGGGTGGGAGATTGCTCCTACTCTGCCGCCGATAACGCCAAGCGCAACGGGATGA

Upstream 100 bases:

>100_bases
AGCCGGATCCTCTGCAAATGCGCCCTGAACAAAAGTAGATGTATCAGCGCTCTCAGAACCATCCAAGAACCAGCAGCCAA
TTGTTTTGGTGGTGCTCCCA

Downstream 100 bases:

>100_bases
TCATTTGGCTGGGTTCCTACTGCAGCGACTGAATATCCAACCCCGGCTCGAACATCAGCTCTTTCACTTCCCCAAATCGG
CCCATCACTCCAAGCTCCCG

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MGRLFVKICGITRQDQAEAIAALGVSALGFIAVPNTPRYLPLSEMARWVGSLPGPVEKVGVFLDQDPRAIAAWVETVGLT
AVQLHGQESPQDCQQLGEWLPGIRRIKALRVRQPQDLEVANLYRDCVEMLLLDAYHPQQAGGTGRTLNWPELARLSRERA
LPLPWLLAGGLNPDNVLQALSHLQPSGIDLSSGVERRPGDKDIDKVRHLLQQLGSQGWEIAPTLPPITPSATG

Sequences:

>Translated_233_residues
MGRLFVKICGITRQDQAEAIAALGVSALGFIAVPNTPRYLPLSEMARWVGSLPGPVEKVGVFLDQDPRAIAAWVETVGLT
AVQLHGQESPQDCQQLGEWLPGIRRIKALRVRQPQDLEVANLYRDCVEMLLLDAYHPQQAGGTGRTLNWPELARLSRERA
LPLPWLLAGGLNPDNVLQALSHLQPSGIDLSSGVERRPGDKDIDKVRHLLQQLGSQGWEIAPTLPPITPSATG
>Mature_232_residues
GRLFVKICGITRQDQAEAIAALGVSALGFIAVPNTPRYLPLSEMARWVGSLPGPVEKVGVFLDQDPRAIAAWVETVGLTA
VQLHGQESPQDCQQLGEWLPGIRRIKALRVRQPQDLEVANLYRDCVEMLLLDAYHPQQAGGTGRTLNWPELARLSRERAL
PLPWLLAGGLNPDNVLQALSHLQPSGIDLSSGVERRPGDKDIDKVRHLLQQLGSQGWEIAPTLPPITPSATG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=214, Percent_Identity=31.3084112149533, Blast_Score=74, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320210, Length=226, Percent_Identity=31.858407079646, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_SYNJB (Q2JPT2)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_476457.1
- ProteinModelPortal:   Q2JPT2
- SMR:   Q2JPT2
- STRING:   Q2JPT2
- GeneID:   3902235
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_0194
- TIGR:   CYB_0194
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- PhylomeDB:   Q2JPT2
- ProtClustDB:   PRK01222
- BioCyc:   SSP321332:CYB_0194-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 25417; Mature: 25285

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLFVKICGITRQDQAEAIAALGVSALGFIAVPNTPRYLPLSEMARWVGSLPGPVEKVG
CCCEEEEECCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHCCCCCCHHHHH
VFLDQDPRAIAAWVETVGLTAVQLHGQESPQDCQQLGEWLPGIRRIKALRVRQPQDLEVA
HHHCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
NLYRDCVEMLLLDAYHPQQAGGTGRTLNWPELARLSRERALPLPWLLAGGLNPDNVLQAL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHH
SHLQPSGIDLSSGVERRPGDKDIDKVRHLLQQLGSQGWEIAPTLPPITPSATG
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCC
>Mature Secondary Structure 
GRLFVKICGITRQDQAEAIAALGVSALGFIAVPNTPRYLPLSEMARWVGSLPGPVEKVG
CCEEEEECCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHCCCCCCHHHHH
VFLDQDPRAIAAWVETVGLTAVQLHGQESPQDCQQLGEWLPGIRRIKALRVRQPQDLEVA
HHHCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
NLYRDCVEMLLLDAYHPQQAGGTGRTLNWPELARLSRERALPLPWLLAGGLNPDNVLQAL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHH
SHLQPSGIDLSSGVERRPGDKDIDKVRHLLQQLGSQGWEIAPTLPPITPSATG
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA