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The map label for this gene is gmk

Identifier: 86607558

GI number: 86607558

Start: 68551

End: 69216

Strand: Direct

Name: gmk

Synonym: CYB_0056

Alternate gene names: 86607558

Gene position: 68551-69216 (Clockwise)

Preceding gene: 86607557

Following gene: 86607559

Centisome position: 2.25

GC content: 59.46

Gene sequence:

>666_bases
TTGCGTCGGTCTCTGTCTATGCCAACCTCTCCTACCCCGGTTTCCTCTGAGTGTACGCAGCAGCAGGGATCCCTTCCGGC
TCCTACCCCGCGCGGTCGCTTGGTGGTTTTGACAGGGCCCAGCGGAGTGGGTAAGGGTACGCTGGTCAACCAGTTGCGCC
AGCGCCACCCCGAGCTGTATCTCTCGGTTTCGGTCACCACCCGCCCCCCCCGCCCCAGCGAACAGGAAGGTGTCAACTAC
TACTTTCGCAGCCGGGAGGAATTTCTCAACTTGATTGAAGCCAACGAGCTGTTGGAATGGGCACAGTATGCGGGCAACTT
TTACGGCACTCCCCGCGAGATCGTGTTCCAAAAACTTAACCAGGGTCAGGATGTGCTGCTGGAAATTGAGCTGGCGGGGG
CCCGTCAGGTGAGGCAGCAGTACCCAGATGCCATTCGCATCTTTCTTTGTCCCCCTTCTCTGGAAGAGCTGGAACGTCGC
ATCCGCGAGCGCGGACAAGACTCAGAGGCCAGCATCGAGCGCCGCCTGGAGCAGGCCCGCAAGGAATTGGATGCCCAAGA
CGAATTTGACTACGTGATTGTCAACGACAACCTGGAGCAAGCGCTGCAGGAGCTGGAAGCCCTGCTCTATCCCCCCTCTC
CCTCTTCAAAGGAGCAGCAGCCCTAG

Upstream 100 bases:

>100_bases
TCAGAGGAGACCGAGTGAAAGCCCATCGCTGTGAGCCGTTTGAGAAACCAGAAGTGAGATATCCTAAAACCAACCCAAAC
AAGTCAATTGCCCAGCCGTC

Downstream 100 bases:

>100_bases
CTTCTCCAGCCCCTTCCCGGAACGCTGGTGTCGGTGGTGCAGTGGCTCCAGATTGGGCCTAGGGTTAACTTTCGGTTAAG
AAAAAAGCTGCTGGGGAGGG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRRSLSMPTSPTPVSSECTQQQGSLPAPTPRGRLVVLTGPSGVGKGTLVNQLRQRHPELYLSVSVTTRPPRPSEQEGVNY
YFRSREEFLNLIEANELLEWAQYAGNFYGTPREIVFQKLNQGQDVLLEIELAGARQVRQQYPDAIRIFLCPPSLEELERR
IRERGQDSEASIERRLEQARKELDAQDEFDYVIVNDNLEQALQELEALLYPPSPSSKEQQP

Sequences:

>Translated_221_residues
MRRSLSMPTSPTPVSSECTQQQGSLPAPTPRGRLVVLTGPSGVGKGTLVNQLRQRHPELYLSVSVTTRPPRPSEQEGVNY
YFRSREEFLNLIEANELLEWAQYAGNFYGTPREIVFQKLNQGQDVLLEIELAGARQVRQQYPDAIRIFLCPPSLEELERR
IRERGQDSEASIERRLEQARKELDAQDEFDYVIVNDNLEQALQELEALLYPPSPSSKEQQP
>Mature_221_residues
MRRSLSMPTSPTPVSSECTQQQGSLPAPTPRGRLVVLTGPSGVGKGTLVNQLRQRHPELYLSVSVTTRPPRPSEQEGVNY
YFRSREEFLNLIEANELLEWAQYAGNFYGTPREIVFQKLNQGQDVLLEIELAGARQVRQQYPDAIRIFLCPPSLEELERR
IRERGQDSEASIERRLEQARKELDAQDEFDYVIVNDNLEQALQELEALLYPPSPSSKEQQP

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=181, Percent_Identity=40.8839779005525, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI226874833, Length=181, Percent_Identity=40.8839779005525, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI4504221, Length=181, Percent_Identity=40.8839779005525, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI262118259, Length=185, Percent_Identity=33.5135135135135, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI4505237, Length=185, Percent_Identity=33.5135135135135, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI262118255, Length=185, Percent_Identity=33.5135135135135, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI262118263, Length=185, Percent_Identity=33.5135135135135, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI14780902, Length=193, Percent_Identity=30.5699481865285, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI38570142, Length=185, Percent_Identity=30.8108108108108, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI21361598, Length=186, Percent_Identity=28.494623655914, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI186972120, Length=185, Percent_Identity=27.5675675675676, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI186700627, Length=185, Percent_Identity=27.5675675675676, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI186700629, Length=185, Percent_Identity=27.5675675675676, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI52630447, Length=191, Percent_Identity=31.413612565445, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI21389483, Length=191, Percent_Identity=28.7958115183246, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI111154074, Length=166, Percent_Identity=27.710843373494, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI21536464, Length=198, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI192447426, Length=190, Percent_Identity=27.8947368421053, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4557529, Length=190, Percent_Identity=27.8947368421053, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=183, Percent_Identity=45.3551912568306, Blast_Score=164, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=41.6666666666667, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17508835, Length=182, Percent_Identity=41.7582417582418, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71988048, Length=181, Percent_Identity=29.2817679558011, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71988041, Length=181, Percent_Identity=29.2817679558011, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17557440, Length=194, Percent_Identity=28.3505154639175, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17556244, Length=124, Percent_Identity=33.8709677419355, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=40.4371584699454, Blast_Score=144, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21356141, Length=195, Percent_Identity=38.4615384615385, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI281362232, Length=180, Percent_Identity=28.3333333333333, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI161078485, Length=180, Percent_Identity=28.3333333333333, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24648810, Length=180, Percent_Identity=28.3333333333333, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161078487, Length=185, Percent_Identity=28.1081081081081, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24648808, Length=185, Percent_Identity=28.1081081081081, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI281362230, Length=185, Percent_Identity=28.1081081081081, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI85816281, Length=152, Percent_Identity=30.9210526315789, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85816106, Length=152, Percent_Identity=30.9210526315789, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45551002, Length=152, Percent_Identity=30.9210526315789, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221330162, Length=162, Percent_Identity=31.4814814814815, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221330166, Length=162, Percent_Identity=31.4814814814815, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24640542, Length=177, Percent_Identity=25.4237288135593, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45554489, Length=177, Percent_Identity=25.4237288135593, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330164, Length=162, Percent_Identity=31.4814814814815, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161077626, Length=177, Percent_Identity=25.4237288135593, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007136, Length=177, Percent_Identity=25.4237288135593, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI85724806, Length=177, Percent_Identity=25.4237288135593, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45554481, Length=177, Percent_Identity=25.4237288135593, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_SYNJB (Q2JQ59)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_476320.1
- ProteinModelPortal:   Q2JQ59
- SMR:   Q2JQ59
- STRING:   Q2JQ59
- GeneID:   3899981
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_0056
- TIGR:   CYB_0056
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   SSP321332:CYB_0056-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 25210; Mature: 25210

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSLSMPTSPTPVSSECTQQQGSLPAPTPRGRLVVLTGPSGVGKGTLVNQLRQRHPELY
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEE
LSVSVTTRPPRPSEQEGVNYYFRSREEFLNLIEANELLEWAQYAGNFYGTPREIVFQKLN
EEEEEEECCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
QGQDVLLEIELAGARQVRQQYPDAIRIFLCPPSLEELERRIRERGQDSEASIERRLEQAR
CCCEEEEEEEECCHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
KELDAQDEFDYVIVNDNLEQALQELEALLYPPSPSSKEQQP
HHCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRRSLSMPTSPTPVSSECTQQQGSLPAPTPRGRLVVLTGPSGVGKGTLVNQLRQRHPELY
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEE
LSVSVTTRPPRPSEQEGVNYYFRSREEFLNLIEANELLEWAQYAGNFYGTPREIVFQKLN
EEEEEEECCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
QGQDVLLEIELAGARQVRQQYPDAIRIFLCPPSLEELERRIRERGQDSEASIERRLEQAR
CCCEEEEEEEECCHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
KELDAQDEFDYVIVNDNLEQALQELEALLYPPSPSSKEQQP
HHCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA