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The map label for this gene is livH [H]

Identifier: 86606569

GI number: 86606569

Start: 1933911

End: 1935068

Strand: Reverse

Name: livH [H]

Synonym: CYA_1923

Alternate gene names: 86606569

Gene position: 1935068-1933911 (Counterclockwise)

Preceding gene: 86606570

Following gene: 86606568

Centisome position: 65.98

GC content: 60.02

Gene sequence:

>1158_bases
ATGACCTTGCTCCTGGACAGCTTGTTCAACGGCCTTAGCATTGGCACCGTCTTGCTGATAGCCGCCTTGGGCTTGGCTAT
TGTTTTCGGCCTCATGGGGGTCATCAACATGGCCCATGGGGAGCTGATGATGTTGGGGGCCTACACCACTTTTGTGGTTC
AAAATGCCTTTCGTCCCCTAGGGGATCCCTGGCGGGATCTGTACATCTTTCCAGCTTTGGTAGCTGCCTTTGCCGTCACG
GCTCTGGTGGGACTAGCCCTGGAGCGGGGGGTGATCCGCTTTTTGTATGGCCGACCGCTGGAAACCCTTCTGGCCACTTG
GGGTGTGAGCCTGATCCTGCAGCAGTTTGTGCGCAGCGTCAATTGGGTGCTGGCTTTCCGCTTGGGGGCCTTCGCGGTGC
TCTTTTTCGGCGGCTGGTGGCTTTTGTCCAGGCGGGCGGATTGGCCGCGTCTCAAGGGGTGGACGCTGGCGCTGCTGTTG
GTGCTCTCCACGGCCATTGCATCGGTGGGGGGGCGGGTGCTGGCGCAAACCTATGCTTTGGCGGTTACCCAGCCTTGGTT
CGGCGCCCAGAACAAAGACGTGACGGCTCCCCGGTGGCTGGGGGGTGGGATCCCGGTGGGCAACCTGTTTTTGCCCAATA
CCCGCCTGTTTATCATCGCCCTCACCATCCTCTGCATCCTGGGGCTGTACTTCTTCTTGCAACGCACCCGCTGGGGGCTG
CGCATCCGGGCGGTTACCCAGAATCGGGCCATGAGCGCCTGTGTAGGGATCCCCACGCAAAAGGTGGATGCCCTTACCTT
TGCCGTCGGCTCGGGTCTGGCGGGAGTAGCCGGCGTGGCGGTCAGCCTGCTGGGATCCGTGGGGCCGAACACCGGCCAGA
ACTACATCGTGGATACCTTTATGGTGGTCGTCGTGGGGGGTGTTGGTAAGCTCTTAGGCAGTATTGTGGCGGCGCTTGGG
ATCGGGATTGCCAACTTTGTCATCGGCTCAGGGACGCTGGCTTTGATTTTTCCCAACGTGCCCATCCTGACCGATACCCT
CAACTTTTTTGCCACCACGAGCATGGCCAAGGTGATGGTCTTTGCTTTGATCGTGGCCTTTTTGCAGGTGCGACCTCGGG
GCCTTTTCCCCGAAAAAGGTCGTATGGTGGATGCCTAG

Upstream 100 bases:

>100_bases
GGCCAGGGCTGGGATCCCTTGCCGTTTGGATAGGGTCGGGGATCCCGCCTAGATGCTCGGTTAGCCTCCCTAGTTTAGTT
GGAAGGAGGATCCCCTGCCC

Downstream 100 bases:

>100_bases
GGAATGATCTCGCTTGGCGAAAACTCTAGGACCAGACTCTCCATCTTCTACTCCCTCACAAAGCCTATGAAACTGGTTCA
TTCCCCCCGTGCTGATCATG

Product: urea ABC transporter, permease protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTLLLDSLFNGLSIGTVLLIAALGLAIVFGLMGVINMAHGELMMLGAYTTFVVQNAFRPLGDPWRDLYIFPALVAAFAVT
ALVGLALERGVIRFLYGRPLETLLATWGVSLILQQFVRSVNWVLAFRLGAFAVLFFGGWWLLSRRADWPRLKGWTLALLL
VLSTAIASVGGRVLAQTYALAVTQPWFGAQNKDVTAPRWLGGGIPVGNLFLPNTRLFIIALTILCILGLYFFLQRTRWGL
RIRAVTQNRAMSACVGIPTQKVDALTFAVGSGLAGVAGVAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLLGSIVAALG
IGIANFVIGSGTLALIFPNVPILTDTLNFFATTSMAKVMVFALIVAFLQVRPRGLFPEKGRMVDA

Sequences:

>Translated_385_residues
MTLLLDSLFNGLSIGTVLLIAALGLAIVFGLMGVINMAHGELMMLGAYTTFVVQNAFRPLGDPWRDLYIFPALVAAFAVT
ALVGLALERGVIRFLYGRPLETLLATWGVSLILQQFVRSVNWVLAFRLGAFAVLFFGGWWLLSRRADWPRLKGWTLALLL
VLSTAIASVGGRVLAQTYALAVTQPWFGAQNKDVTAPRWLGGGIPVGNLFLPNTRLFIIALTILCILGLYFFLQRTRWGL
RIRAVTQNRAMSACVGIPTQKVDALTFAVGSGLAGVAGVAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLLGSIVAALG
IGIANFVIGSGTLALIFPNVPILTDTLNFFATTSMAKVMVFALIVAFLQVRPRGLFPEKGRMVDA
>Mature_384_residues
TLLLDSLFNGLSIGTVLLIAALGLAIVFGLMGVINMAHGELMMLGAYTTFVVQNAFRPLGDPWRDLYIFPALVAAFAVTA
LVGLALERGVIRFLYGRPLETLLATWGVSLILQQFVRSVNWVLAFRLGAFAVLFFGGWWLLSRRADWPRLKGWTLALLLV
LSTAIASVGGRVLAQTYALAVTQPWFGAQNKDVTAPRWLGGGIPVGNLFLPNTRLFIIALTILCILGLYFFLQRTRWGLR
IRAVTQNRAMSACVGIPTQKVDALTFAVGSGLAGVAGVAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLLGSIVAALGI
GIANFVIGSGTLALIFPNVPILTDTLNFFATTSMAKVMVFALIVAFLQVRPRGLFPEKGRMVDA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=378, Percent_Identity=24.8677248677249, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 41218; Mature: 41087

Theoretical pI: Translated: 11.23; Mature: 11.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLLDSLFNGLSIGTVLLIAALGLAIVFGLMGVINMAHGELMMLGAYTTFVVQNAFRPL
CEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCC
GDPWRDLYIFPALVAAFAVTALVGLALERGVIRFLYGRPLETLLATWGVSLILQQFVRSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NWVLAFRLGAFAVLFFGGWWLLSRRADWPRLKGWTLALLLVLSTAIASVGGRVLAQTYAL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
AVTQPWFGAQNKDVTAPRWLGGGIPVGNLFLPNTRLFIIALTILCILGLYFFLQRTRWGL
HEECCCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCE
RIRAVTQNRAMSACVGIPTQKVDALTFAVGSGLAGVAGVAVSLLGSVGPNTGQNYIVDTF
EEEEECCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHH
MVVVVGGVGKLLGSIVAALGIGIANFVIGSGTLALIFPNVPILTDTLNFFATTSMAKVMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
FALIVAFLQVRPRGLFPEKGRMVDA
HHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TLLLDSLFNGLSIGTVLLIAALGLAIVFGLMGVINMAHGELMMLGAYTTFVVQNAFRPL
EEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCC
GDPWRDLYIFPALVAAFAVTALVGLALERGVIRFLYGRPLETLLATWGVSLILQQFVRSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NWVLAFRLGAFAVLFFGGWWLLSRRADWPRLKGWTLALLLVLSTAIASVGGRVLAQTYAL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
AVTQPWFGAQNKDVTAPRWLGGGIPVGNLFLPNTRLFIIALTILCILGLYFFLQRTRWGL
HEECCCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCE
RIRAVTQNRAMSACVGIPTQKVDALTFAVGSGLAGVAGVAVSLLGSVGPNTGQNYIVDTF
EEEEECCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHH
MVVVVGGVGKLLGSIVAALGIGIANFVIGSGTLALIFPNVPILTDTLNFFATTSMAKVMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
FALIVAFLQVRPRGLFPEKGRMVDA
HHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]