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The map label for this gene is livM [H]

Identifier: 86606568

GI number: 86606568

Start: 1932699

End: 1933907

Strand: Reverse

Name: livM [H]

Synonym: CYA_1922

Alternate gene names: 86606568

Gene position: 1933907-1932699 (Counterclockwise)

Preceding gene: 86606569

Following gene: 86606567

Centisome position: 65.94

GC content: 54.51

Gene sequence:

>1209_bases
ATGATCTCGCTTGGCGAAAACTCTAGGACCAGACTCTCCATCTTCTACTCCCTCACAAAGCCTATGAAACTGGTTCATTC
CCCCCGTGCTGATCATGAAGTGGCTGCTCCCGCCGCGGGTGGGGATCCCAATTCTTCTCGCAAGCTTCTGTGGGAGGCCG
GGATCCTCATCGTTTTGGTGCTGGCCTTGATCTTTGTGGCCCCAACTGTGCTGTCTGGCTTTCGGCTCAACTTGTTGGGG
CGGTTTCTGGCCCTCAGCATTGTAGCTTTGGGGATCGACCTCATCTGGGGCTATACCGGCATGCTCAGCCTGGGGCATGG
GGTGTTCTTCGCCTTGGGGGGCTACGCTCTGGGGATGCACCTGAAATTGCAATTGCCGGAAGGTCAGATACCAGAGTTTT
TCAGCCTCTACGGGGTAACGGAATTGCCCTGGTTTTGGTATCCCTTTTATTCGTTTCCGTTTACGGCTGTTGCTGTTGTC
TTGATCCCGGCTTTGGTGGCGGCAGCCCTGGGGTATTTGGTGGTGAGAAATCGCATCCGAGGGGTTTATTTTTCCATTTT
AACTCAGGCCACCACGATCATTTTCTTTAACTTCTTCAACGGCCAACAGCGCTTAATTAACGGCACCAACGGCCTGACCA
ACTTCCAGACTTTGTTTGGCCTAGATGTCAACTCGTCCGAAATGCGCTTTGCTGTCTATGTCACTACAGTTCTGGCGGTG
GTTTTGGCTTACCTTCTCTGTCGTTGGCTGACCAGCGGCCTATTCGGTCGGATCCTGGTAGCCATTCGAGATGACGAGCC
GCGGGTTCGTTTTTCCGGCTACGATCCCACCGGCTTTAAAGTTCTGGTGTTTGCCGTGTCTGCTGCCCTGGCGGGTGTTG
CCGGAGCTTTGTTTACCTTGCAAACTGGGATCATCTCTCCCAATGCGATGGCCGTTCCCTTTTCCATTGAGATGGTAATC
TGGGTGGCGGTGGGCGGTCGGGCCAGTTTGGTGGGGGCGGTGCTGGGGGCTCTGTTGGTTAACTTTGCCAAGAGCTTGCT
GAGCGAAAATTTTCCGGAGATTTGGCTGTTTTTCCAGGGGGGATTGTTCCTGCTGGTGGTGCTGGTGTTGCCGGATGGAC
TGGTGGGTTGGGTGCGCACCCAAGGCAGGCAACTTTGGGTCACCGTTCAGCTTTGGCGCAGGCGTTTGGCAAATACTTCT
CCAGCCTAA

Upstream 100 bases:

>100_bases
CATGGCCAAGGTGATGGTCTTTGCTTTGATCGTGGCCTTTTTGCAGGTGCGACCTCGGGGCCTTTTCCCCGAAAAAGGTC
GTATGGTGGATGCCTAGGGA

Downstream 100 bases:

>100_bases
ATCTGGCTTTCTCTTGAGGATGTCAGTTATGTGCAAGATATAAGTTTAAGGTAAGAGGATCCCATGGGTGAGCCAGCGAT
GCCAAGTTTCCTCTCCTATT

Product: urea ABC transporter, permease protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MISLGENSRTRLSIFYSLTKPMKLVHSPRADHEVAAPAAGGDPNSSRKLLWEAGILIVLVLALIFVAPTVLSGFRLNLLG
RFLALSIVALGIDLIWGYTGMLSLGHGVFFALGGYALGMHLKLQLPEGQIPEFFSLYGVTELPWFWYPFYSFPFTAVAVV
LIPALVAAALGYLVVRNRIRGVYFSILTQATTIIFFNFFNGQQRLINGTNGLTNFQTLFGLDVNSSEMRFAVYVTTVLAV
VLAYLLCRWLTSGLFGRILVAIRDDEPRVRFSGYDPTGFKVLVFAVSAALAGVAGALFTLQTGIISPNAMAVPFSIEMVI
WVAVGGRASLVGAVLGALLVNFAKSLLSENFPEIWLFFQGGLFLLVVLVLPDGLVGWVRTQGRQLWVTVQLWRRRLANTS
PA

Sequences:

>Translated_402_residues
MISLGENSRTRLSIFYSLTKPMKLVHSPRADHEVAAPAAGGDPNSSRKLLWEAGILIVLVLALIFVAPTVLSGFRLNLLG
RFLALSIVALGIDLIWGYTGMLSLGHGVFFALGGYALGMHLKLQLPEGQIPEFFSLYGVTELPWFWYPFYSFPFTAVAVV
LIPALVAAALGYLVVRNRIRGVYFSILTQATTIIFFNFFNGQQRLINGTNGLTNFQTLFGLDVNSSEMRFAVYVTTVLAV
VLAYLLCRWLTSGLFGRILVAIRDDEPRVRFSGYDPTGFKVLVFAVSAALAGVAGALFTLQTGIISPNAMAVPFSIEMVI
WVAVGGRASLVGAVLGALLVNFAKSLLSENFPEIWLFFQGGLFLLVVLVLPDGLVGWVRTQGRQLWVTVQLWRRRLANTS
PA
>Mature_402_residues
MISLGENSRTRLSIFYSLTKPMKLVHSPRADHEVAAPAAGGDPNSSRKLLWEAGILIVLVLALIFVAPTVLSGFRLNLLG
RFLALSIVALGIDLIWGYTGMLSLGHGVFFALGGYALGMHLKLQLPEGQIPEFFSLYGVTELPWFWYPFYSFPFTAVAVV
LIPALVAAALGYLVVRNRIRGVYFSILTQATTIIFFNFFNGQQRLINGTNGLTNFQTLFGLDVNSSEMRFAVYVTTVLAV
VLAYLLCRWLTSGLFGRILVAIRDDEPRVRFSGYDPTGFKVLVFAVSAALAGVAGALFTLQTGIISPNAMAVPFSIEMVI
WVAVGGRASLVGAVLGALLVNFAKSLLSENFPEIWLFFQGGLFLLVVLVLPDGLVGWVRTQGRQLWVTVQLWRRRLANTS
PA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=320, Percent_Identity=28.125, Blast_Score=85, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 43974; Mature: 43974

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLGENSRTRLSIFYSLTKPMKLVHSPRADHEVAAPAAGGDPNSSRKLLWEAGILIVLV
CCCCCCCCCEEEEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LALIFVAPTVLSGFRLNLLGRFLALSIVALGIDLIWGYTGMLSLGHGVFFALGGYALGMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEEE
LKLQLPEGQIPEFFSLYGVTELPWFWYPFYSFPFTAVAVVLIPALVAAALGYLVVRNRIR
EEEECCCCCCCHHHHHCCCCCCCHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVYFSILTQATTIIFFNFFNGQQRLINGTNGLTNFQTLFGLDVNSSEMRFAVYVTTVLAV
HHHHHHHHHHHHEEEEEEECCCHHEECCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHH
VLAYLLCRWLTSGLFGRILVAIRDDEPRVRFSGYDPTGFKVLVFAVSAALAGVAGALFTL
HHHHHHHHHHHHCHHHEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QTGIISPNAMAVPFSIEMVIWVAVGGRASLVGAVLGALLVNFAKSLLSENFPEIWLFFQG
HHCCCCCCCEEECEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
GLFLLVVLVLPDGLVGWVRTQGRQLWVTVQLWRRRLANTSPA
HHHHHHHHHHCCCCEEHHCCCCCEEEEEHHHHHHHHCCCCCC
>Mature Secondary Structure
MISLGENSRTRLSIFYSLTKPMKLVHSPRADHEVAAPAAGGDPNSSRKLLWEAGILIVLV
CCCCCCCCCEEEEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LALIFVAPTVLSGFRLNLLGRFLALSIVALGIDLIWGYTGMLSLGHGVFFALGGYALGMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEEE
LKLQLPEGQIPEFFSLYGVTELPWFWYPFYSFPFTAVAVVLIPALVAAALGYLVVRNRIR
EEEECCCCCCCHHHHHCCCCCCCHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVYFSILTQATTIIFFNFFNGQQRLINGTNGLTNFQTLFGLDVNSSEMRFAVYVTTVLAV
HHHHHHHHHHHHEEEEEEECCCHHEECCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHH
VLAYLLCRWLTSGLFGRILVAIRDDEPRVRFSGYDPTGFKVLVFAVSAALAGVAGALFTL
HHHHHHHHHHHHCHHHEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QTGIISPNAMAVPFSIEMVIWVAVGGRASLVGAVLGALLVNFAKSLLSENFPEIWLFFQG
HHCCCCCCCEEECEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
GLFLLVVLVLPDGLVGWVRTQGRQLWVTVQLWRRRLANTSPA
HHHHHHHHHHCCCCEEHHCCCCCEEEEEHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]