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The map label for this gene is yhdN [H]

Identifier: 86606144

GI number: 86606144

Start: 1485217

End: 1486212

Strand: Reverse

Name: yhdN [H]

Synonym: CYA_1477

Alternate gene names: 86606144

Gene position: 1486212-1485217 (Counterclockwise)

Preceding gene: 86606147

Following gene: 86606143

Centisome position: 50.68

GC content: 63.35

Gene sequence:

>996_bases
ATGGAGTTTGTTACGCTTGCCGAGACGAGGCTAAAACTTAGCCGCGTGGGGCTGGGCACCTGGAGCATGACCGGGGATTG
GTGGGGGCCAGCGGATCCCCAGGAAGCGTATGCCACCCTCCGCAAGGCTATTGACCTGGGCATTACGCTCTTTGACACGG
CTCCGGCCTATGGCCGCGGCCTTTCGGAAGAGCTCTTGGGACGGGCCATCCGGGATGCCGGCTGTCGGGATCGCGTAGTC
ATTGCCACCAAGGCCGGCCTGCAGTGGACTAACAGCAAGGTGGTGCGCAACTGCAGCCTAAGTTGGCTGGCTCAGGATCT
GGAAAACTCCCTCCGCCGCCTGCAGACGGATGTGATCGACATCTACCAGGTGCATTGGCCGGATCCCTTGGAGCCCCTGG
AGGAGACGGCTGCCTTTTTCGGCCGCTTGCTGCAGCAGGGCAAGATCCGCGCCATTGGGGTGAGCAACTTTTCTCCTCCG
CAGATGGAGCGTTTCCGTCAGGTGGCTCCCCTGCATACCGTCCAGCCGCCCTATAACCTGTTTGAGCGCCAGATCGAAGC
AGATGTCCTGCCCTACTGTCGTGCCAACGGTATTGCCACGCTGATCTACAGCCCCCTCTGTCGAGGGCTGTTGGGGGGAC
GGCTGACGCCGCAAACCCAGTTTCCGCCTGGAGATCTGCGCGGCGGCATCGATCCCAAGTTTGCGGAGCCTCGCTACTCC
CACTACTTGCAAGCAGCGGAAGAGCTGAGCCGGCTGGCGCGAGAGCGCTACGGCAAAACCCTGCCCCAGTTGGCGGTGCG
CTGGCTCTTGGATCAGCCGGGAGTAAGTGCAATCCTGTGGGGAGCGCGCAAGCGCCAGCAGTTGGAGGACCTAGCCGGCG
TGTGGGGCTGGTCGCTGGAGGCGGAGGCAATGCAGGCCATCGACGCGATCCTGCAAAGGCATGTCCCCGAACCCATCCCC
CCCAGCTTCATGGCCCCCCCTGCCCGTGCTGCCTAG

Upstream 100 bases:

>100_bases
CCACCAGCAGCTAGGCACGTGGGTTGTCTGCGCAACCGGCTTTGTCCTCCCCTGGCGCCTGTTAGCATCCTGAAACGGGA
TCCTGTCTGCAGACGTTGCC

Downstream 100 bases:

>100_bases
AGCAAGGAGTGGGGGGTAAGGCTGTCCAATGGCGCTGCAAGGGGTGATCCTAAGCTGGAGCGGTGTGGTGGCCGACGACG
AGGGGCTGCACCTCCACGCC

Product: aldo/keto reductase family oxidoreductase

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MEFVTLAETRLKLSRVGLGTWSMTGDWWGPADPQEAYATLRKAIDLGITLFDTAPAYGRGLSEELLGRAIRDAGCRDRVV
IATKAGLQWTNSKVVRNCSLSWLAQDLENSLRRLQTDVIDIYQVHWPDPLEPLEETAAFFGRLLQQGKIRAIGVSNFSPP
QMERFRQVAPLHTVQPPYNLFERQIEADVLPYCRANGIATLIYSPLCRGLLGGRLTPQTQFPPGDLRGGIDPKFAEPRYS
HYLQAAEELSRLARERYGKTLPQLAVRWLLDQPGVSAILWGARKRQQLEDLAGVWGWSLEAEAMQAIDAILQRHVPEPIP
PSFMAPPARAA

Sequences:

>Translated_331_residues
MEFVTLAETRLKLSRVGLGTWSMTGDWWGPADPQEAYATLRKAIDLGITLFDTAPAYGRGLSEELLGRAIRDAGCRDRVV
IATKAGLQWTNSKVVRNCSLSWLAQDLENSLRRLQTDVIDIYQVHWPDPLEPLEETAAFFGRLLQQGKIRAIGVSNFSPP
QMERFRQVAPLHTVQPPYNLFERQIEADVLPYCRANGIATLIYSPLCRGLLGGRLTPQTQFPPGDLRGGIDPKFAEPRYS
HYLQAAEELSRLARERYGKTLPQLAVRWLLDQPGVSAILWGARKRQQLEDLAGVWGWSLEAEAMQAIDAILQRHVPEPIP
PSFMAPPARAA
>Mature_331_residues
MEFVTLAETRLKLSRVGLGTWSMTGDWWGPADPQEAYATLRKAIDLGITLFDTAPAYGRGLSEELLGRAIRDAGCRDRVV
IATKAGLQWTNSKVVRNCSLSWLAQDLENSLRRLQTDVIDIYQVHWPDPLEPLEETAAFFGRLLQQGKIRAIGVSNFSPP
QMERFRQVAPLHTVQPPYNLFERQIEADVLPYCRANGIATLIYSPLCRGLLGGRLTPQTQFPPGDLRGGIDPKFAEPRYS
HYLQAAEELSRLARERYGKTLPQLAVRWLLDQPGVSAILWGARKRQQLEDLAGVWGWSLEAEAMQAIDAILQRHVPEPIP
PSFMAPPARAA

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=325, Percent_Identity=30.1538461538462, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4504825, Length=323, Percent_Identity=30.030959752322, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI27436964, Length=326, Percent_Identity=29.4478527607362, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI27436962, Length=326, Percent_Identity=29.4478527607362, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI27436966, Length=322, Percent_Identity=29.5031055900621, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI27436971, Length=333, Percent_Identity=26.1261261261261, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI223718702, Length=278, Percent_Identity=28.7769784172662, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI41152114, Length=298, Percent_Identity=29.1946308724832, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI41327764, Length=286, Percent_Identity=30.0699300699301, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI223468663, Length=289, Percent_Identity=26.2975778546713, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI223718708, Length=128, Percent_Identity=35.9375, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1788070, Length=334, Percent_Identity=33.8323353293413, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI87081735, Length=325, Percent_Identity=30.1538461538462, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789375, Length=306, Percent_Identity=32.3529411764706, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789199, Length=346, Percent_Identity=28.9017341040462, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1788081, Length=315, Percent_Identity=31.1111111111111, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI48994888, Length=284, Percent_Identity=28.169014084507, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082198, Length=320, Percent_Identity=26.875, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787674, Length=315, Percent_Identity=25.3968253968254, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786400, Length=203, Percent_Identity=30.0492610837438, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17564128, Length=335, Percent_Identity=24.7761194029851, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538386, Length=219, Percent_Identity=29.2237442922374, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17550248, Length=222, Percent_Identity=27.4774774774775, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323998, Length=327, Percent_Identity=25.3822629969419, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319958, Length=296, Percent_Identity=23.9864864864865, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6325169, Length=302, Percent_Identity=24.8344370860927, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319951, Length=286, Percent_Identity=25.5244755244755, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322615, Length=251, Percent_Identity=25.0996015936255, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646155, Length=297, Percent_Identity=28.6195286195286, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24646159, Length=161, Percent_Identity=34.1614906832298, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24640980, Length=315, Percent_Identity=27.3015873015873, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45549126, Length=315, Percent_Identity=27.3015873015873, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644950, Length=335, Percent_Identity=25.9701492537313, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 37063; Mature: 37063

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFVTLAETRLKLSRVGLGTWSMTGDWWGPADPQEAYATLRKAIDLGITLFDTAPAYGRG
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCHHCCC
LSEELLGRAIRDAGCRDRVVIATKAGLQWTNSKVVRNCSLSWLAQDLENSLRRLQTDVID
CHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYQVHWPDPLEPLEETAAFFGRLLQQGKIRAIGVSNFSPPQMERFRQVAPLHTVQPPYNL
HHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHH
FERQIEADVLPYCRANGIATLIYSPLCRGLLGGRLTPQTQFPPGDLRGGIDPKFAEPRYS
HHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
HYLQAAEELSRLARERYGKTLPQLAVRWLLDQPGVSAILWGARKRQQLEDLAGVWGWSLE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
AEAMQAIDAILQRHVPEPIPPSFMAPPARAA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEFVTLAETRLKLSRVGLGTWSMTGDWWGPADPQEAYATLRKAIDLGITLFDTAPAYGRG
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCHHCCC
LSEELLGRAIRDAGCRDRVVIATKAGLQWTNSKVVRNCSLSWLAQDLENSLRRLQTDVID
CHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYQVHWPDPLEPLEETAAFFGRLLQQGKIRAIGVSNFSPPQMERFRQVAPLHTVQPPYNL
HHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHH
FERQIEADVLPYCRANGIATLIYSPLCRGLLGGRLTPQTQFPPGDLRGGIDPKFAEPRYS
HHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
HYLQAAEELSRLARERYGKTLPQLAVRWLLDQPGVSAILWGARKRQQLEDLAGVWGWSLE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
AEAMQAIDAILQRHVPEPIPPSFMAPPARAA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]