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The map label for this gene is ycdW [C]

Identifier: 86606135

GI number: 86606135

Start: 1476143

End: 1477069

Strand: Reverse

Name: ycdW [C]

Synonym: CYA_1468

Alternate gene names: 86606135

Gene position: 1477069-1476143 (Counterclockwise)

Preceding gene: 86606138

Following gene: 86606131

Centisome position: 50.36

GC content: 65.8

Gene sequence:

>927_bases
ATGGGCATCCAAGGCAGACGCATAGCCGTCGAACCCGACCACCTCCGACCCTGGTTAAAAGAGGCAGTCCTGGCGGGGGG
TGGCGAACTGGTGCCGCTGGCGGAAGCGGAGGCTCTGGTGTGGGCCGATGCCTTTGACGTGCCCAAGCTCAAGCAGTGTC
TTGCCGAAGGAAAGGGGATCCGCTGGGTGCAGTTGCCCTGGGCGGGCGTGGAGCCTTTTGCCCAGGCAGGGATCCTGGAT
CCCGCCTATGTGTGGACCTGCGGCAAGGGGGTCTATGCCCAAGCGGTGGCCGAGCATGCCCTGGCCCTCACCTTGGCCGG
CCTGCGGGATCTCAAGCACCGCGCTCTGGCCCAGACTTGGCAGCCGGGATCCGGCACCAGCCTCTGGGGCAGCCGCGTGG
TCATCTTCGGGGCGGGGGGCATTGCCCAGGCCCTGATCCGCTTGTTGCAGCCCTTCCAGTGTTCCGTTGAGGTGGTGCGG
CGCAGGGCGGATCCCTTGCCGGGAGCCAGCCGGGTGGTGACGTTGGCGGAGCGGCAGGCAGTGCTGGCAGGAGCGGATGT
GGTGATCCTGGCCTTGGCCCTCACCCCCGAGACAGAGGGGATCATCGCCTGGCCAGAGCTGGAGCAGATGGGATCCGGCT
GTTGGTTGGTCAATGTGGCGCGCGGCAAACATATCGTCACCCCTGACCTGGTGGCCGCCTTGCAGGAGGGGATCATCCGG
GGTGCCGCCCTGGATGTTACGGATCCAGAACCGCTGCCCGATGGACATCCCCTCTGGCGCTTGCCCAATTGCCTAATTAC
CCCCCACACGGCCATCACCGACGCCATGATTGTCCCTGCCCTCTCCGAGCGGGTGCGGGAAAATGTGAGCCGCTTTCGGC
TGGGAGAACCCTTGCTGGGGGTGGTGGATCCGGTTCTAGGTTACTGA

Upstream 100 bases:

>100_bases
CCCATCCTCCCTTTGGGATCCCTTAACAGTTCTGAGGCTTTTCCCACCCCCTTCTGCCAGCGATATCCTGGCAAAGGGGA
AGTCATCTTCGAGAGCTCTG

Downstream 100 bases:

>100_bases
GCCCTCACCCTCTCCCGAGGGAAGCAGGGATCTAGGACTCGATGGGAATAGGATCCTGGGGAGGAGCCATCTCCTGGACG
CGGGCGGCGATGGCCTCGGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MGIQGRRIAVEPDHLRPWLKEAVLAGGGELVPLAEAEALVWADAFDVPKLKQCLAEGKGIRWVQLPWAGVEPFAQAGILD
PAYVWTCGKGVYAQAVAEHALALTLAGLRDLKHRALAQTWQPGSGTSLWGSRVVIFGAGGIAQALIRLLQPFQCSVEVVR
RRADPLPGASRVVTLAERQAVLAGADVVILALALTPETEGIIAWPELEQMGSGCWLVNVARGKHIVTPDLVAALQEGIIR
GAALDVTDPEPLPDGHPLWRLPNCLITPHTAITDAMIVPALSERVRENVSRFRLGEPLLGVVDPVLGY

Sequences:

>Translated_308_residues
MGIQGRRIAVEPDHLRPWLKEAVLAGGGELVPLAEAEALVWADAFDVPKLKQCLAEGKGIRWVQLPWAGVEPFAQAGILD
PAYVWTCGKGVYAQAVAEHALALTLAGLRDLKHRALAQTWQPGSGTSLWGSRVVIFGAGGIAQALIRLLQPFQCSVEVVR
RRADPLPGASRVVTLAERQAVLAGADVVILALALTPETEGIIAWPELEQMGSGCWLVNVARGKHIVTPDLVAALQEGIIR
GAALDVTDPEPLPDGHPLWRLPNCLITPHTAITDAMIVPALSERVRENVSRFRLGEPLLGVVDPVLGY
>Mature_307_residues
GIQGRRIAVEPDHLRPWLKEAVLAGGGELVPLAEAEALVWADAFDVPKLKQCLAEGKGIRWVQLPWAGVEPFAQAGILDP
AYVWTCGKGVYAQAVAEHALALTLAGLRDLKHRALAQTWQPGSGTSLWGSRVVIFGAGGIAQALIRLLQPFQCSVEVVRR
RADPLPGASRVVTLAERQAVLAGADVVILALALTPETEGIIAWPELEQMGSGCWLVNVARGKHIVTPDLVAALQEGIIRG
AALDVTDPEPLPDGHPLWRLPNCLITPHTAITDAMIVPALSERVRENVSRFRLGEPLLGVVDPVLGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=218, Percent_Identity=32.5688073394495, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI145580578, Length=223, Percent_Identity=31.390134529148, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4557499, Length=223, Percent_Identity=31.390134529148, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI145580575, Length=105, Percent_Identity=42.8571428571429, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081824, Length=219, Percent_Identity=34.2465753424658, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787645, Length=225, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI87082289, Length=188, Percent_Identity=29.7872340425532, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320925, Length=217, Percent_Identity=29.4930875576037, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322116, Length=217, Percent_Identity=29.0322580645161, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574284, Length=292, Percent_Identity=30.4794520547945, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24585514, Length=292, Percent_Identity=30.4794520547945, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28574282, Length=292, Percent_Identity=30.4794520547945, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI45552429, Length=292, Percent_Identity=30.4794520547945, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45551003, Length=292, Percent_Identity=30.4794520547945, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571528, Length=189, Percent_Identity=31.2169312169312, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28574286, Length=216, Percent_Identity=30.0925925925926, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585516, Length=188, Percent_Identity=32.4468085106383, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 32996; Mature: 32865

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIQGRRIAVEPDHLRPWLKEAVLAGGGELVPLAEAEALVWADAFDVPKLKQCLAEGKGI
CCCCCCEEECCCHHHHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCHHHHHHHHCCCCC
RWVQLPWAGVEPFAQAGILDPAYVWTCGKGVYAQAVAEHALALTLAGLRDLKHRALAQTW
EEEECCCCCCCHHHHCCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPGSGTSLWGSRVVIFGAGGIAQALIRLLQPFQCSVEVVRRRADPLPGASRVVTLAERQA
CCCCCCCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHEEHHHHHHH
VLAGADVVILALALTPETEGIIAWPELEQMGSGCWLVNVARGKHIVTPDLVAALQEGIIR
HHCCCCEEEEEEEECCCCCCEEECCCHHHHCCCEEEEEECCCCEECCHHHHHHHHHHHHC
GAALDVTDPEPLPDGHPLWRLPNCLITPHTAITDAMIVPALSERVRENVSRFRLGEPLLG
CCEECCCCCCCCCCCCCHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VVDPVLGY
HHHHHHCC
>Mature Secondary Structure 
GIQGRRIAVEPDHLRPWLKEAVLAGGGELVPLAEAEALVWADAFDVPKLKQCLAEGKGI
CCCCCEEECCCHHHHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCHHHHHHHHCCCCC
RWVQLPWAGVEPFAQAGILDPAYVWTCGKGVYAQAVAEHALALTLAGLRDLKHRALAQTW
EEEECCCCCCCHHHHCCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPGSGTSLWGSRVVIFGAGGIAQALIRLLQPFQCSVEVVRRRADPLPGASRVVTLAERQA
CCCCCCCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHEEHHHHHHH
VLAGADVVILALALTPETEGIIAWPELEQMGSGCWLVNVARGKHIVTPDLVAALQEGIIR
HHCCCCEEEEEEEECCCCCCEEECCCHHHHCCCEEEEEECCCCEECCHHHHHHHHHHHHC
GAALDVTDPEPLPDGHPLWRLPNCLITPHTAITDAMIVPALSERVRENVSRFRLGEPLLG
CCEECCCCCCCCCCCCCHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VVDPVLGY
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]