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The map label for this gene is accB

Identifier: 86605953

GI number: 86605953

Start: 1286275

End: 1286754

Strand: Reverse

Name: accB

Synonym: CYA_1271

Alternate gene names: 86605953

Gene position: 1286754-1286275 (Counterclockwise)

Preceding gene: 86605954

Following gene: 86605952

Centisome position: 43.88

GC content: 60.62

Gene sequence:

>480_bases
TTGGATGTTGTCAATTGGCAGGAAGTTCGCCTTCTGCTGGCCGCTCTGCAGGAGAGCGACGTTACCGAGCTAATCCTGGA
GTACAAGGATTTCCGCCTCACCCTGCGCAAAGGGATCCCGGCTGGCCTTGCTGCTGCTGCCGCTGCTCCGCCCGCTGCCC
CGCCGCCAGAACCCCCCCCTGCTTCCCCTGCAGAAGCTCCCCCTCCTGAGAGCGCTCCTAAGCCTGCCCCCAGCCACTGG
GTGGAGGTGACGGCGCCGATGGTGGGCACCTTCTACAGCGCTCCTGCCCCTGGAGAAACGGATTTTGTGCAGGTTGGCCA
ACGGGTGAACAAGGGCCAAACTCTCTGCATTATCGAAGCCATGAAGCTGATGAACGAGATAGAAGCTGAAACGGCGGGCG
TGGTGAGGGAGATTTTGGTGAGCAACGGCCAGCCGGTGGAATTTGGCCAAGTTTTAATGCGACTGGATCCCACCGGCTAA

Upstream 100 bases:

>100_bases
ACTCGCACCGACACCTATATAGGCCGCGAGTGATGGCTCCCCCTCTTCTTGCCGCTGGGCTGCCGTTGTGGACAGGTGAT
GCATCAGGAGTAATCTTCCC

Downstream 100 bases:

>100_bases
CAACAAGGCTGGGGCAGAGATAGGGAGGGATCCCTTGGTGGAGGAGGGGCTGTGGCAATTTCTCTTGCCGACCTTTGCCT
GCGACTAGGCAACTTTGCCG

Product: acetyl-CoA carboxylase, biotin carboxyl carrier protein

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MDVVNWQEVRLLLAALQESDVTELILEYKDFRLTLRKGIPAGLAAAAAAPPAAPPPEPPPASPAEAPPPESAPKPAPSHW
VEVTAPMVGTFYSAPAPGETDFVQVGQRVNKGQTLCIIEAMKLMNEIEAETAGVVREILVSNGQPVEFGQVLMRLDPTG

Sequences:

>Translated_159_residues
MDVVNWQEVRLLLAALQESDVTELILEYKDFRLTLRKGIPAGLAAAAAAPPAAPPPEPPPASPAEAPPPESAPKPAPSHW
VEVTAPMVGTFYSAPAPGETDFVQVGQRVNKGQTLCIIEAMKLMNEIEAETAGVVREILVSNGQPVEFGQVLMRLDPTG
>Mature_159_residues
MDVVNWQEVRLLLAALQESDVTELILEYKDFRLTLRKGIPAGLAAAAAAPPAAPPPEPPPASPAEAPPPESAPKPAPSHW
VEVTAPMVGTFYSAPAPGETDFVQVGQRVNKGQTLCIIEAMKLMNEIEAETAGVVREILVSNGQPVEFGQVLMRLDPTG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=157, Percent_Identity=39.4904458598726, Blast_Score=110, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 16901; Mature: 16901

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVVNWQEVRLLLAALQESDVTELILEYKDFRLTLRKGIPAGLAAAAAAPPAAPPPEPPP
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCC
ASPAEAPPPESAPKPAPSHWVEVTAPMVGTFYSAPAPGETDFVQVGQRVNKGQTLCIIEA
CCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHH
MKLMNEIEAETAGVVREILVSNGQPVEFGQVLMRLDPTG
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MDVVNWQEVRLLLAALQESDVTELILEYKDFRLTLRKGIPAGLAAAAAAPPAAPPPEPPP
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCC
ASPAEAPPPESAPKPAPSHWVEVTAPMVGTFYSAPAPGETDFVQVGQRVNKGQTLCIIEA
CCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHH
MKLMNEIEAETAGVVREILVSNGQPVEFGQVLMRLDPTG
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]