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The map label for this gene is argG

Identifier: 86605422

GI number: 86605422

Start: 717300

End: 718511

Strand: Reverse

Name: argG

Synonym: CYA_0710

Alternate gene names: 86605422

Gene position: 718511-717300 (Counterclockwise)

Preceding gene: 86605423

Following gene: 86605420

Centisome position: 24.5

GC content: 65.84

Gene sequence:

>1212_bases
ATGGGACGGGCAAAGAAAGTGGTATTGGCCTATTCGGGGGGCGTCGATACTTCCGTCTGCATCCCCTATCTCAAGCACGA
GTGGGGGGTGGAATCGGTGGTCACCCTGGCGGTGGACTTGGGTCAGGGGGCGGAGCTGGAGGCCATTCAAGCCAAGGCCC
TGAGGGCCGGGGCCGAGCAATCCCTGGTGCGGGAGGCCGTCCAGACCCTGATTGCCGACTACGCCTTCCCCGCTATCCAG
GCCAATGCCCTCTACGAGCAGCGCTACCCTCTCTCCACTGCCCTGGCCCGGCCCCTGATCGCCCAGCTGTTGGTGGAGGT
GGCCGAAGAGGTGGGCGCCGACGCCGTGGCCCACGGCTGCACCGGCAAGGGCAATGACCAAGTCCGCTTCGACCTGGCCA
TCGCCGCCTTGAACCCCAAGCTCAAGGTGCTGGCCCCGGCGCGCGAGTGGGGCATGACCCGCGAGGAGACCATCGCCTAC
GGCGAGCGCTACGGCATCCCTATGCCAGTACAAAAATCCAGCCCCTACAGCATCGACCTCAACATCCTGGGCCGCAGCGT
CGAAGCCGGGATCCTGGAGGACGCCGACCAAGAGCCGCCGGAGGAAGTCTACGCCCTCACCCGCTCTATTGCTCAAACCC
CCGACGAGCCCGCCTACGTGGAGATCGCCTTTGAAGAGGGGATCCCGGTGGAGCTGGACGGGCAGCGCCTCGGCCCCAGA
GCCCTCTTCGAGCGGCTCAACGCCTTGGCCGGCAGCCACGGTGTCGGTCGCATCGACATGATCGAGGATCGGCTGGTGGG
GATCAAGTCGCGCGAGATCTACGAGTGCCCGGCCCTAACGGTGTTGATCCAGGCCCACCGCGAGCTGGAGAGCCTCACCC
TCACTCGCGAGGTCCTCCACTACAAGTACGGCATCGAGACCACCTACAGCCAGTTGGTCTACAACGGCCTCTGGTACTCG
CCGCTGCGGGAGGCCCTGGACGCCTTCATCCGCACCACCCAAAAAAGCGTTACCGGCGTGGTGCGGATGCGCCTGCACAA
GGGCCAGGCGGTCTGCGTGGGCCGCCGCTCCCCTTACTCCCTCTACAACGCGGAGCTGGCCACCTACGGGGAAGGGGATC
AATTCGACCACCGGGCTGCCGAAGGCTTCATCTACATCTGGGGCCTGCCTACCCGCACTTGGGCGCAGGTGCACCGCGGC
AGTGGTGCTTGA

Upstream 100 bases:

>100_bases
GTGATGTCTCCCCTTCGTCCGCTGCCACCCCCCGCCTCAAGATCCAAGCCACAGGGCATAATGGGCTAGCAACTTCTTTT
GAACAGGGATCCGCAGCAGC

Downstream 100 bases:

>100_bases
ACTCTACCGCCAGGCAATTTGTCCATCCGGGGTGCTGGTCAACCGGCTAGCCTGCTGGGGGGGAGGTGTCAAGCCGCTTG
CCTGCTGGCACGACGGCGCA

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MGRAKKVVLAYSGGVDTSVCIPYLKHEWGVESVVTLAVDLGQGAELEAIQAKALRAGAEQSLVREAVQTLIADYAFPAIQ
ANALYEQRYPLSTALARPLIAQLLVEVAEEVGADAVAHGCTGKGNDQVRFDLAIAALNPKLKVLAPAREWGMTREETIAY
GERYGIPMPVQKSSPYSIDLNILGRSVEAGILEDADQEPPEEVYALTRSIAQTPDEPAYVEIAFEEGIPVELDGQRLGPR
ALFERLNALAGSHGVGRIDMIEDRLVGIKSREIYECPALTVLIQAHRELESLTLTREVLHYKYGIETTYSQLVYNGLWYS
PLREALDAFIRTTQKSVTGVVRMRLHKGQAVCVGRRSPYSLYNAELATYGEGDQFDHRAAEGFIYIWGLPTRTWAQVHRG
SGA

Sequences:

>Translated_403_residues
MGRAKKVVLAYSGGVDTSVCIPYLKHEWGVESVVTLAVDLGQGAELEAIQAKALRAGAEQSLVREAVQTLIADYAFPAIQ
ANALYEQRYPLSTALARPLIAQLLVEVAEEVGADAVAHGCTGKGNDQVRFDLAIAALNPKLKVLAPAREWGMTREETIAY
GERYGIPMPVQKSSPYSIDLNILGRSVEAGILEDADQEPPEEVYALTRSIAQTPDEPAYVEIAFEEGIPVELDGQRLGPR
ALFERLNALAGSHGVGRIDMIEDRLVGIKSREIYECPALTVLIQAHRELESLTLTREVLHYKYGIETTYSQLVYNGLWYS
PLREALDAFIRTTQKSVTGVVRMRLHKGQAVCVGRRSPYSLYNAELATYGEGDQFDHRAAEGFIYIWGLPTRTWAQVHRG
SGA
>Mature_402_residues
GRAKKVVLAYSGGVDTSVCIPYLKHEWGVESVVTLAVDLGQGAELEAIQAKALRAGAEQSLVREAVQTLIADYAFPAIQA
NALYEQRYPLSTALARPLIAQLLVEVAEEVGADAVAHGCTGKGNDQVRFDLAIAALNPKLKVLAPAREWGMTREETIAYG
ERYGIPMPVQKSSPYSIDLNILGRSVEAGILEDADQEPPEEVYALTRSIAQTPDEPAYVEIAFEEGIPVELDGQRLGPRA
LFERLNALAGSHGVGRIDMIEDRLVGIKSREIYECPALTVLIQAHRELESLTLTREVLHYKYGIETTYSQLVYNGLWYSP
LREALDAFIRTTQKSVTGVVRMRLHKGQAVCVGRRSPYSLYNAELATYGEGDQFDHRAAEGFIYIWGLPTRTWAQVHRGS
GA

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=411, Percent_Identity=41.1192214111922, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI16950633, Length=411, Percent_Identity=41.1192214111922, Blast_Score=300, Evalue=2e-81,
Organism=Escherichia coli, GI1789563, Length=393, Percent_Identity=28.7531806615776, Blast_Score=115, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324514, Length=413, Percent_Identity=39.4673123486683, Blast_Score=278, Evalue=1e-75,
Organism=Drosophila melanogaster, GI21358151, Length=400, Percent_Identity=39.25, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_SYNJA (Q2JWE1)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_474185.1
- HSSP:   Q9X2A1
- ProteinModelPortal:   Q2JWE1
- SMR:   Q2JWE1
- STRING:   Q2JWE1
- GeneID:   3897213
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_0710
- TIGR:   CYA_0710
- eggNOG:   COG0137
- HOGENOM:   HBG335267
- OMA:   VAVDVGQ
- ProtClustDB:   PRK00509
- BioCyc:   SSP321327:CYA_0710-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 44316; Mature: 44185

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 89-89 BINDING 119-119 BINDING 121-121 BINDING 125-125 BINDING 125-125 BINDING 126-126 BINDING 129-129 BINDING 177-177 BINDING 186-186 BINDING 262-262 BINDING 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRAKKVVLAYSGGVDTSVCIPYLKHEWGVESVVTLAVDLGQGAELEAIQAKALRAGAEQ
CCCCEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHEECCCCCCHHHHHHHHHHCCHHH
SLVREAVQTLIADYAFPAIQANALYEQRYPLSTALARPLIAQLLVEVAEEVGADAVAHGC
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCC
TGKGNDQVRFDLAIAALNPKLKVLAPAREWGMTREETIAYGERYGIPMPVQKSSPYSIDL
CCCCCCEEEEEEEEEEECCCEEEEECHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEE
NILGRSVEAGILEDADQEPPEEVYALTRSIAQTPDEPAYVEIAFEEGIPVELDGQRLGPR
EEECCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCCCHH
ALFERLNALAGSHGVGRIDMIEDRLVGIKSREIYECPALTVLIQAHRELESLTLTREVLH
HHHHHHHHHHCCCCCCEEEEHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHH
YKYGIETTYSQLVYNGLWYSPLREALDAFIRTTQKSVTGVVRMRLHKGQAVCVGRRSPYS
HHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
LYNAELATYGEGDQFDHRAAEGFIYIWGLPTRTWAQVHRGSGA
CCCCCEEECCCCCCCCHHHHCCEEEEEECCCHHHHHHHCCCCC
>Mature Secondary Structure 
GRAKKVVLAYSGGVDTSVCIPYLKHEWGVESVVTLAVDLGQGAELEAIQAKALRAGAEQ
CCCEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHEECCCCCCHHHHHHHHHHCCHHH
SLVREAVQTLIADYAFPAIQANALYEQRYPLSTALARPLIAQLLVEVAEEVGADAVAHGC
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCC
TGKGNDQVRFDLAIAALNPKLKVLAPAREWGMTREETIAYGERYGIPMPVQKSSPYSIDL
CCCCCCEEEEEEEEEEECCCEEEEECHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEE
NILGRSVEAGILEDADQEPPEEVYALTRSIAQTPDEPAYVEIAFEEGIPVELDGQRLGPR
EEECCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCCCHH
ALFERLNALAGSHGVGRIDMIEDRLVGIKSREIYECPALTVLIQAHRELESLTLTREVLH
HHHHHHHHHHCCCCCCEEEEHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHH
YKYGIETTYSQLVYNGLWYSPLREALDAFIRTTQKSVTGVVRMRLHKGQAVCVGRRSPYS
HHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
LYNAELATYGEGDQFDHRAAEGFIYIWGLPTRTWAQVHRGSGA
CCCCCEEECCCCCCCCHHHHCCEEEEEECCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA