Click here to switch to the map view.

The map label for this gene is relA [H]

Identifier: 86605385

GI number: 86605385

Start: 681136

End: 681759

Strand: Reverse

Name: relA [H]

Synonym: CYA_0673

Alternate gene names: 86605385

Gene position: 681759-681136 (Counterclockwise)

Preceding gene: 86605390

Following gene: 86605384

Centisome position: 23.25

GC content: 64.1

Gene sequence:

>624_bases
ATGTCTACCCAGTTGACGCCGCGGTTTGCCGAGGCCATGCGCTACGCCTACCGCTGGCATGCCGCTCAAACCCGCAAGGG
AACAAGGATCCCCTACCTCAGCCACCTGCTGGCGGTGGCGTCCATCGCCCTGGAGCATGGCGCCGACGAAGATGAGGCCA
TTGCTGCCCTCCTCCACGACAGCCTGGAGGATGGCCCCCGCTACAGCGGCGAGCCGCGGGCTCAGATTGAACGGGAGCTG
CGGGAGCACTTCGGAGAACGGGTGCTGCAGATCGTCCTGGGATGCACGGACACCGACAGCGATAGCTCCCTGGGCGAGCC
CAAAGAAGACTGGAAAGAGCGCAAAGTGGCCTATCTCAAGCACTTGGAAACCGCAGATGCCTCGGTTTTGCTGGTGGCCG
CCTCCGACAAGCTGCACAACGTCCGCTGCATCCTACGCGACTTTCGCCAACTGGGGGATCAGCTCTGGGAGCGCTTCTCC
GGCGGCAAAGAGGGATCCCTGTGGTACTACCGGTCGCTGGCGGAGATCCTGGGGCGACGGCTGCCTTCTAGGCTGGCAGT
GGAGTTCCAAGAGCTGGTGGTCGAGTTGCAACGGGCAGCCGGGTCGGGGCCGGCAACAGCTTGA

Upstream 100 bases:

>100_bases
GCAACCAGGTCAAAGCTTGGTTTGGAATAGAGGCTTTCTGGATACGATTTCCTACCAATACCAATCCCCTCAACTGCCAA
CCTCGACCGGAGAGATACCT

Downstream 100 bases:

>100_bases
CAGAGACGACCAGGGCTGAAGAAAATGCTGAGGGCAGCTTTCTCTCTTGCACTCTTCAGGTCACCTGTCTATGGTTCTCG
CTGTTGGCACCGTTGCTCCA

Product: HD domain-containing protein

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MSTQLTPRFAEAMRYAYRWHAAQTRKGTRIPYLSHLLAVASIALEHGADEDEAIAALLHDSLEDGPRYSGEPRAQIEREL
REHFGERVLQIVLGCTDTDSDSSLGEPKEDWKERKVAYLKHLETADASVLLVAASDKLHNVRCILRDFRQLGDQLWERFS
GGKEGSLWYYRSLAEILGRRLPSRLAVEFQELVVELQRAAGSGPATA

Sequences:

>Translated_207_residues
MSTQLTPRFAEAMRYAYRWHAAQTRKGTRIPYLSHLLAVASIALEHGADEDEAIAALLHDSLEDGPRYSGEPRAQIEREL
REHFGERVLQIVLGCTDTDSDSSLGEPKEDWKERKVAYLKHLETADASVLLVAASDKLHNVRCILRDFRQLGDQLWERFS
GGKEGSLWYYRSLAEILGRRLPSRLAVEFQELVVELQRAAGSGPATA
>Mature_206_residues
STQLTPRFAEAMRYAYRWHAAQTRKGTRIPYLSHLLAVASIALEHGADEDEAIAALLHDSLEDGPRYSGEPRAQIERELR
EHFGERVLQIVLGCTDTDSDSSLGEPKEDWKERKVAYLKHLETADASVLLVAASDKLHNVRCILRDFRQLGDQLWERFSG
GKEGSLWYYRSLAEILGRRLPSRLAVEFQELVVELQRAAGSGPATA

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 23332; Mature: 23200

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQLTPRFAEAMRYAYRWHAAQTRKGTRIPYLSHLLAVASIALEHGADEDEAIAALLHD
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SLEDGPRYSGEPRAQIERELREHFGERVLQIVLGCTDTDSDSSLGEPKEDWKERKVAYLK
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
HLETADASVLLVAASDKLHNVRCILRDFRQLGDQLWERFSGGKEGSLWYYRSLAEILGRR
HHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LPSRLAVEFQELVVELQRAAGSGPATA
CHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STQLTPRFAEAMRYAYRWHAAQTRKGTRIPYLSHLLAVASIALEHGADEDEAIAALLHD
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SLEDGPRYSGEPRAQIERELREHFGERVLQIVLGCTDTDSDSSLGEPKEDWKERKVAYLK
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
HLETADASVLLVAASDKLHNVRCILRDFRQLGDQLWERFSGGKEGSLWYYRSLAEILGRR
HHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LPSRLAVEFQELVVELQRAAGSGPATA
CHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8825780; 8631867; 12000953 [H]