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The map label for this gene is thiD

Identifier: 86605008

GI number: 86605008

Start: 295483

End: 296295

Strand: Reverse

Name: thiD

Synonym: CYA_0287

Alternate gene names: 86605008

Gene position: 296295-295483 (Counterclockwise)

Preceding gene: 86605009

Following gene: 86605004

Centisome position: 10.1

GC content: 65.68

Gene sequence:

>813_bases
ATGTTGGCCGAGCAGCATCCCCCTGTTGCCCTCACCATTGCCGGATCCGATAGCGGCGGCGGAGCGGGCATTCAAGCGGA
TCTGCGCACCTTTGCCTTCCAGCGCGTCCACGGCACTTCCGCCCTCACCTGCGTAACTGCCCAAAACACCCTCGGGGTCA
ACCGCGTGGATGCGCTGCCGCCGGAGGCGGTGGCCGCCCAGATTGAGGCGGTGGTGCAGGATATCGGGGTGCAAGGGATC
AAAACCGGCATGTTGCTCAATGTCGAGATCGTGCGGGAGGTGGCCCGCCAAGTGGAGCGGTGGGCCCTGCAGCCGCTGGT
GGTGGATCCGGTGATGGTCTCCCGCACCGGGGCCAAGCTGCTGGCAGAAGACGCCATCCAGGCCATCCGCGAGCGGCTGA
TCCCGCTGGCCCAGGTCGTTACCCCCAACCGCTACGAGGCCCAGATTTTGGCAGGGATGGAGCTGCAGTCATTGGCGGAT
ATGGAGGAGGCGGGCCGCCGCATCTACGCCCTGGGCTGTAAGGCGGTTTTGGTCAAGGGGGGAGGTATGCCAGGGGAACT
GCAGGGGGTGGATGTGTGGTTTGACGGCGAGCGGCTGGAGATCCTCAAAAGCGAGCGCATCCCCACCCGCCACACCCACG
GCACCGGCTGTACCCTCTCGGCAGCCATTGCGGCGCAACTGGCTTGGGGCAAGGATCCCTTGGCGGCGACGCTAGCAGCC
AAGGCCTATGTTACCGAAGCCCTGCGGCATCCTCTGGCCATCGGCGCAGGACAAGGGCCGGTGGGGCACTTCTACCCGCT
TCTCCAGTCTTAG

Upstream 100 bases:

>100_bases
TCGTTGCTACGCTGAAGGACAGAAATGGCTAGCGGTACCCTCGGCAGTTTTTGTCCTTTGGCCAATGTCTGTCCCCACAT
CTGAACCAATGTCGGCTCCA

Downstream 100 bases:

>100_bases
CCCCCTTCTTCGCAGCCGGCAGCCGCTCAGGCTGCCGGGGGAGGTTGAACGGCCCCGCTGGCTAGAGCAGTTCCCGCACG
TCCACCACTTTGCCGCTCAC

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MLAEQHPPVALTIAGSDSGGGAGIQADLRTFAFQRVHGTSALTCVTAQNTLGVNRVDALPPEAVAAQIEAVVQDIGVQGI
KTGMLLNVEIVREVARQVERWALQPLVVDPVMVSRTGAKLLAEDAIQAIRERLIPLAQVVTPNRYEAQILAGMELQSLAD
MEEAGRRIYALGCKAVLVKGGGMPGELQGVDVWFDGERLEILKSERIPTRHTHGTGCTLSAAIAAQLAWGKDPLAATLAA
KAYVTEALRHPLAIGAGQGPVGHFYPLLQS

Sequences:

>Translated_270_residues
MLAEQHPPVALTIAGSDSGGGAGIQADLRTFAFQRVHGTSALTCVTAQNTLGVNRVDALPPEAVAAQIEAVVQDIGVQGI
KTGMLLNVEIVREVARQVERWALQPLVVDPVMVSRTGAKLLAEDAIQAIRERLIPLAQVVTPNRYEAQILAGMELQSLAD
MEEAGRRIYALGCKAVLVKGGGMPGELQGVDVWFDGERLEILKSERIPTRHTHGTGCTLSAAIAAQLAWGKDPLAATLAA
KAYVTEALRHPLAIGAGQGPVGHFYPLLQS
>Mature_270_residues
MLAEQHPPVALTIAGSDSGGGAGIQADLRTFAFQRVHGTSALTCVTAQNTLGVNRVDALPPEAVAAQIEAVVQDIGVQGI
KTGMLLNVEIVREVARQVERWALQPLVVDPVMVSRTGAKLLAEDAIQAIRERLIPLAQVVTPNRYEAQILAGMELQSLAD
MEEAGRRIYALGCKAVLVKGGGMPGELQGVDVWFDGERLEILKSERIPTRHTHGTGCTLSAAIAAQLAWGKDPLAATLAA
KAYVTEALRHPLAIGAGQGPVGHFYPLLQS

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=259, Percent_Identity=42.0849420849421, Blast_Score=186, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6325378, Length=276, Percent_Identity=32.2463768115942, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324517, Length=277, Percent_Identity=34.6570397111913, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6324997, Length=277, Percent_Identity=34.6570397111913, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28570; Mature: 28570

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAEQHPPVALTIAGSDSGGGAGIQADLRTFAFQRVHGTSALTCVTAQNTLGVNRVDALP
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCC
PEAVAAQIEAVVQDIGVQGIKTGMLLNVEIVREVARQVERWALQPLVVDPVMVSRTGAKL
HHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCEEECCCHHCCCCHHH
LAEDAIQAIRERLIPLAQVVTPNRYEAQILAGMELQSLADMEEAGRRIYALGCKAVLVKG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCHHHHHHHHHHHCCEEEEECCEEEEEEC
GGMPGELQGVDVWFDGERLEILKSERIPTRHTHGTGCTLSAAIAAQLAWGKDPLAATLAA
CCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHH
KAYVTEALRHPLAIGAGQGPVGHFYPLLQS
HHHHHHHHHCCEEEECCCCCCHHHHHHHCC
>Mature Secondary Structure
MLAEQHPPVALTIAGSDSGGGAGIQADLRTFAFQRVHGTSALTCVTAQNTLGVNRVDALP
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCC
PEAVAAQIEAVVQDIGVQGIKTGMLLNVEIVREVARQVERWALQPLVVDPVMVSRTGAKL
HHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCEEECCCHHCCCCHHH
LAEDAIQAIRERLIPLAQVVTPNRYEAQILAGMELQSLADMEEAGRRIYALGCKAVLVKG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCHHHHHHHHHHHCCEEEEECCEEEEEEC
GGMPGELQGVDVWFDGERLEILKSERIPTRHTHGTGCTLSAAIAAQLAWGKDPLAATLAA
CCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHH
KAYVTEALRHPLAIGAGQGPVGHFYPLLQS
HHHHHHHHHCCEEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA