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The map label for this gene is zam

Identifier: 86604907

GI number: 86604907

Start: 179593

End: 181878

Strand: Reverse

Name: zam

Synonym: CYA_0181

Alternate gene names: 86604907

Gene position: 181878-179593 (Counterclockwise)

Preceding gene: 86604908

Following gene: 86604906

Centisome position: 6.2

GC content: 62.16

Gene sequence:

>2286_bases
ATGGATTTCTCTCGGATTTTTCATCACTTTTTCTCTCAACCTGCCGAGCAATGGACCGATAAAGACGCGCTGCTTGCCCT
CCTGCCAGCCTCAGACCCAGAAGCGCCGGAAATGCTCGAGATTGCCCTCGATGGTCTGGTACGGGCGGGGTTTCTCGAAC
GGACAGGGGATCCGCCCCGCTATCGGCGTAAGCCGGATGAATCCTTGGTGGTGGGGCGTTTGCGCTGTTCCAGCAAGGGT
TTTTGCTTTGCCGTGCGGGATGAACCGGGGGCAGAGGATGTGTATATCCACGGCAGCAACCTTAGCGGCGCTTGGAACGG
CGACCAAGTGATAGCCCGGATTACCAAAGAAGGCAATCGCCGCCGCAGCCCAGAGGGAGAGGTGGTAGCTGTTGTGGAAC
GGGCCAATCCCACTCTCGTGGGCCGCCTCAAACAGACGGAAGAGGGTTTCCGGGTGGTGCCTCTGGATGACCGGCTGCTG
TTCGAGCTGGCCTTGACCGAGGGATCCCCTGCCGAGCTGGCGGAAGGTCGGGTGGCCTATGTGGAAGTGGAGCGCTACCC
GCTGGGCAACTTGCCCCCCGTGGGCACGATTCGCAAGATCTTGGGCAATGGCCCGGAGGCGTCCATCGATGCGGATCTGG
TCTGCTGCAAGTACGACCTGCCCCAGGAGTTTCCCCCGGCGGTGCTGGAGGCTGCGGCAACTCTGCCCAAAAAGCTGAGC
CGCTCCGACCAAAAGAACCGTCGCGATCTGCGGGACTGGTTTTGCGTCACGCTGGAGCCGCTGGACTTGCAGCACCCCCA
CGGCCTCGAGCCCAACGTGGCCGTCTCCCTGCAGCGGCAAGAAGAGGGCCACTGGCTGCTGGGGGTGCACATTGCCGATG
TAGCCCACTGGCTGGATCCGGATCACCCCCTGGAGCGGGAGGCGCAGCGGCGCACCGCCACGGTTTACCTGGATAGCGTG
GTGCTGCCCCTTTTCCCGCCGGAAGTGCACAGCCGCCTGGCTCTGTTGCCGCAGCAGGAGCGTCTGGCCTACTCGCTGCT
GCTGACCATTGACCCCGAAGGGGTGGTGCGCAACTTCGAGATCCACCCCAGCCTGGTGCAATCGCGGGCTCACCTGTCCT
ATGGTCAGGTGCAGGCTCTCTTGGCCACCGCCGCGGATCTGGGCCCCGATGAGGAGGTGCCGGAGTTGATGGCCCTGCTG
CAAAACCTGCTCCGTCTCAGCCAAGTCCTGCGAGTCAAGCGCCACCAGGCAGGCGGGTTCGATCTGCCCCTGTTGGATTT
GCTCACCCCCTACTCTGCCGATGAAAGCGGCTATGGGCCCCTGCTGGTCAGCGATCGCCTCGGCGCCCACGCCCTGATGA
CCGAAATTCTGCTGCTGGCCAACCAAATCCTGGGCCACCATTTGCGCCGGCTGGGGATCCCTTCGTTGGCCCGCGTGCAG
AAGCCCCCCACCGCTGAGGCCCTGCAGAACTTTTTGCGTCTGGCCAACGCCATGAAGCTGGATCTGAACTTGCAGGATCC
AGAAGCTGTGACGTTAGCCGATTGGCAGCGGATCTGTGCCCGCATCACCGCCCCCGATGTCTTGGCCGCAGGGACTAGCC
CAGCCTTGGTGGCCCAGTTGTTGGCTACTCTGCCCCCCGTCGAGTATTGCCTGCAGCCGCTGCAGGAGCCGCTCGGCCAT
TTTGGCCTTGGCCTCAAAGAGCCCTACGCCTCTTTTACTGCCCCTTTGCGCCGCTATGCCGATTTGCTGAATTTGCGGGC
TCTGCACCTAGCCTTGAGCAAAGGACGGGATCGCCGCAGCCCGCGCTCCAAAACCGTGGTGGATCTGCATGGCCCCGGCA
GCTACGACCAAATTGATTGGCAGGTGCTGCCGCCAAAAGTGCATGAGGAGTGGCAGGCCTTTCTCCAAGCGCAACTGCCC
AAAATCCAGGCGGGATATCAGCTCCATCAACAGGCAGAGCGGGAGCTGATGGGCTTGAAGCGGTGCGAGTTCATGCAAAA
ACACCTGGGGGAGACGTTCCCCGGCCTGATCGTCAGCGTCCAGAACTACGGCTTTTTTGTGCAGGTGGATCCCATCTTGG
CGGAAGGCTTGGTGCGGGTCAGCACCCTGAAAAACGACTGGTACGAATACCGCAGCCGCCAGCAGGCCCTGGTAGGGCGC
AAAAGCCGGCGCCAGTTCCGCCTGGGGGATCGGGTGGAGGTGCAGATTAAAAACGTAGACTACTACCGCCAACAAATTGA
CCTGGCGGTGATCGGCGAGGGACGGCCCTACGAAGAAGAGGAATAA

Upstream 100 bases:

>100_bases
CGGTCAGCGAGTAGCCTTTATCGTCACCGGCCACCGCGACTAATCCAAGTGGCTGCGCCTGTCCCTTAATCGCGGCTCTC
ATTCCCCCTGGATACCCGCA

Downstream 100 bases:

>100_bases
GGCGGGGATCCGTCCATCAATCGCGGTAGGAGGGGACGGTTGTTGCGAACTCCGGCTTTGGCAAAATAGGCGATACCTGG
ATCGTAGGATGCCAGCAGCG

Product: acetazolamide conferring resistance protein Zam

Products: tetrahydrofolate; N-formylmethionyl-tRNA(fMet)

Alternate protein names: NA

Number of amino acids: Translated: 761; Mature: 761

Protein sequence:

>761_residues
MDFSRIFHHFFSQPAEQWTDKDALLALLPASDPEAPEMLEIALDGLVRAGFLERTGDPPRYRRKPDESLVVGRLRCSSKG
FCFAVRDEPGAEDVYIHGSNLSGAWNGDQVIARITKEGNRRRSPEGEVVAVVERANPTLVGRLKQTEEGFRVVPLDDRLL
FELALTEGSPAELAEGRVAYVEVERYPLGNLPPVGTIRKILGNGPEASIDADLVCCKYDLPQEFPPAVLEAAATLPKKLS
RSDQKNRRDLRDWFCVTLEPLDLQHPHGLEPNVAVSLQRQEEGHWLLGVHIADVAHWLDPDHPLEREAQRRTATVYLDSV
VLPLFPPEVHSRLALLPQQERLAYSLLLTIDPEGVVRNFEIHPSLVQSRAHLSYGQVQALLATAADLGPDEEVPELMALL
QNLLRLSQVLRVKRHQAGGFDLPLLDLLTPYSADESGYGPLLVSDRLGAHALMTEILLLANQILGHHLRRLGIPSLARVQ
KPPTAEALQNFLRLANAMKLDLNLQDPEAVTLADWQRICARITAPDVLAAGTSPALVAQLLATLPPVEYCLQPLQEPLGH
FGLGLKEPYASFTAPLRRYADLLNLRALHLALSKGRDRRSPRSKTVVDLHGPGSYDQIDWQVLPPKVHEEWQAFLQAQLP
KIQAGYQLHQQAERELMGLKRCEFMQKHLGETFPGLIVSVQNYGFFVQVDPILAEGLVRVSTLKNDWYEYRSRQQALVGR
KSRRQFRLGDRVEVQIKNVDYYRQQIDLAVIGEGRPYEEEE

Sequences:

>Translated_761_residues
MDFSRIFHHFFSQPAEQWTDKDALLALLPASDPEAPEMLEIALDGLVRAGFLERTGDPPRYRRKPDESLVVGRLRCSSKG
FCFAVRDEPGAEDVYIHGSNLSGAWNGDQVIARITKEGNRRRSPEGEVVAVVERANPTLVGRLKQTEEGFRVVPLDDRLL
FELALTEGSPAELAEGRVAYVEVERYPLGNLPPVGTIRKILGNGPEASIDADLVCCKYDLPQEFPPAVLEAAATLPKKLS
RSDQKNRRDLRDWFCVTLEPLDLQHPHGLEPNVAVSLQRQEEGHWLLGVHIADVAHWLDPDHPLEREAQRRTATVYLDSV
VLPLFPPEVHSRLALLPQQERLAYSLLLTIDPEGVVRNFEIHPSLVQSRAHLSYGQVQALLATAADLGPDEEVPELMALL
QNLLRLSQVLRVKRHQAGGFDLPLLDLLTPYSADESGYGPLLVSDRLGAHALMTEILLLANQILGHHLRRLGIPSLARVQ
KPPTAEALQNFLRLANAMKLDLNLQDPEAVTLADWQRICARITAPDVLAAGTSPALVAQLLATLPPVEYCLQPLQEPLGH
FGLGLKEPYASFTAPLRRYADLLNLRALHLALSKGRDRRSPRSKTVVDLHGPGSYDQIDWQVLPPKVHEEWQAFLQAQLP
KIQAGYQLHQQAERELMGLKRCEFMQKHLGETFPGLIVSVQNYGFFVQVDPILAEGLVRVSTLKNDWYEYRSRQQALVGR
KSRRQFRLGDRVEVQIKNVDYYRQQIDLAVIGEGRPYEEEE
>Mature_761_residues
MDFSRIFHHFFSQPAEQWTDKDALLALLPASDPEAPEMLEIALDGLVRAGFLERTGDPPRYRRKPDESLVVGRLRCSSKG
FCFAVRDEPGAEDVYIHGSNLSGAWNGDQVIARITKEGNRRRSPEGEVVAVVERANPTLVGRLKQTEEGFRVVPLDDRLL
FELALTEGSPAELAEGRVAYVEVERYPLGNLPPVGTIRKILGNGPEASIDADLVCCKYDLPQEFPPAVLEAAATLPKKLS
RSDQKNRRDLRDWFCVTLEPLDLQHPHGLEPNVAVSLQRQEEGHWLLGVHIADVAHWLDPDHPLEREAQRRTATVYLDSV
VLPLFPPEVHSRLALLPQQERLAYSLLLTIDPEGVVRNFEIHPSLVQSRAHLSYGQVQALLATAADLGPDEEVPELMALL
QNLLRLSQVLRVKRHQAGGFDLPLLDLLTPYSADESGYGPLLVSDRLGAHALMTEILLLANQILGHHLRRLGIPSLARVQ
KPPTAEALQNFLRLANAMKLDLNLQDPEAVTLADWQRICARITAPDVLAAGTSPALVAQLLATLPPVEYCLQPLQEPLGH
FGLGLKEPYASFTAPLRRYADLLNLRALHLALSKGRDRRSPRSKTVVDLHGPGSYDQIDWQVLPPKVHEEWQAFLQAQLP
KIQAGYQLHQQAERELMGLKRCEFMQKHLGETFPGLIVSVQNYGFFVQVDPILAEGLVRVSTLKNDWYEYRSRQQALVGR
KSRRQFRLGDRVEVQIKNVDYYRQQIDLAVIGEGRPYEEEE

Specific function: Not known; control resistance to the carbonic anhydrase inhibitor acetazolamide [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=483, Percent_Identity=25.879917184265, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI190014623, Length=483, Percent_Identity=25.879917184265, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI134288890, Length=420, Percent_Identity=25.952380952381, Blast_Score=109, Evalue=1e-23,
Organism=Homo sapiens, GI19115966, Length=380, Percent_Identity=25.7894736842105, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI219521928, Length=380, Percent_Identity=25.7894736842105, Blast_Score=87, Evalue=7e-17,
Organism=Escherichia coli, GI87082383, Length=690, Percent_Identity=29.4202898550725, Blast_Score=250, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI212645896, Length=496, Percent_Identity=23.991935483871, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17553506, Length=462, Percent_Identity=24.025974025974, Blast_Score=84, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324552, Length=671, Percent_Identity=23.6959761549926, Blast_Score=118, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320499, Length=453, Percent_Identity=23.1788079470199, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24649634, Length=492, Percent_Identity=25.609756097561, Blast_Score=121, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24654592, Length=393, Percent_Identity=24.9363867684478, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922976, Length=393, Percent_Identity=24.9363867684478, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24654597, Length=393, Percent_Identity=24.9363867684478, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 2.1.2.9

Molecular weight: Translated: 85383; Mature: 85383

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSRIFHHFFSQPAEQWTDKDALLALLPASDPEAPEMLEIALDGLVRAGFLERTGDPPR
CCHHHHHHHHHCCHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
YRRKPDESLVVGRLRCSSKGFCFAVRDEPGAEDVYIHGSNLSGAWNGDQVIARITKEGNR
HCCCCCCHHEEEEEEECCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCC
RRSPEGEVVAVVERANPTLVGRLKQTEEGFRVVPLDDRLLFELALTEGSPAELAEGRVAY
CCCCCCCEEEEEECCCCCEEEEHHHCCCCCEEEECCCCEEEEEEECCCCCHHHHCCCEEE
VEVERYPLGNLPPVGTIRKILGNGPEASIDADLVCCKYDLPQEFPPAVLEAAATLPKKLS
EEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
RSDQKNRRDLRDWFCVTLEPLDLQHPHGLEPNVAVSLQRQEEGHWLLGVHIADVAHWLDP
HCHHHHHHHHHHHEEEEECCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHCCC
DHPLEREAQRRTATVYLDSVVLPLFPPEVHSRLALLPQQERLAYSLLLTIDPEGVVRNFE
CCCHHHHHHHHEEEEEEEEEECCCCCHHHHHHHHCCCCHHHEEEEEEEEECCCCCEEEEE
IHPSLVQSRAHLSYGQVQALLATAADLGPDEEVPELMALLQNLLRLSQVLRVKRHQAGGF
CCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DLPLLDLLTPYSADESGYGPLLVSDRLGAHALMTEILLLANQILGHHLRRLGIPSLARVQ
CCCHHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
KPPTAEALQNFLRLANAMKLDLNLQDPEAVTLADWQRICARITAPDVLAAGTSPALVAQL
CCCCHHHHHHHHHHHHHEEEEEECCCCCEEEHHHHHHHHHHCCCCHHHCCCCCHHHHHHH
LATLPPVEYCLQPLQEPLGHFGLGLKEPYASFTAPLRRYADLLNLRALHLALSKGRDRRS
HHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PRSKTVVDLHGPGSYDQIDWQVLPPKVHEEWQAFLQAQLPKIQAGYQLHQQAERELMGLK
CCCCCEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RCEFMQKHLGETFPGLIVSVQNYGFFVQVDPILAEGLVRVSTLKNDWYEYRSRQQALVGR
HHHHHHHHCCCCCCCEEEEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSRRQFRLGDRVEVQIKNVDYYRQQIDLAVIGEGRPYEEEE
HHHHHCCCCCEEEEEEECCHHHHHHCCEEEEECCCCCCCCC
>Mature Secondary Structure
MDFSRIFHHFFSQPAEQWTDKDALLALLPASDPEAPEMLEIALDGLVRAGFLERTGDPPR
CCHHHHHHHHHCCHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
YRRKPDESLVVGRLRCSSKGFCFAVRDEPGAEDVYIHGSNLSGAWNGDQVIARITKEGNR
HCCCCCCHHEEEEEEECCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCC
RRSPEGEVVAVVERANPTLVGRLKQTEEGFRVVPLDDRLLFELALTEGSPAELAEGRVAY
CCCCCCCEEEEEECCCCCEEEEHHHCCCCCEEEECCCCEEEEEEECCCCCHHHHCCCEEE
VEVERYPLGNLPPVGTIRKILGNGPEASIDADLVCCKYDLPQEFPPAVLEAAATLPKKLS
EEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
RSDQKNRRDLRDWFCVTLEPLDLQHPHGLEPNVAVSLQRQEEGHWLLGVHIADVAHWLDP
HCHHHHHHHHHHHEEEEECCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHCCC
DHPLEREAQRRTATVYLDSVVLPLFPPEVHSRLALLPQQERLAYSLLLTIDPEGVVRNFE
CCCHHHHHHHHEEEEEEEEEECCCCCHHHHHHHHCCCCHHHEEEEEEEEECCCCCEEEEE
IHPSLVQSRAHLSYGQVQALLATAADLGPDEEVPELMALLQNLLRLSQVLRVKRHQAGGF
CCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DLPLLDLLTPYSADESGYGPLLVSDRLGAHALMTEILLLANQILGHHLRRLGIPSLARVQ
CCCHHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
KPPTAEALQNFLRLANAMKLDLNLQDPEAVTLADWQRICARITAPDVLAAGTSPALVAQL
CCCCHHHHHHHHHHHHHEEEEEECCCCCEEEHHHHHHHHHHCCCCHHHCCCCCHHHHHHH
LATLPPVEYCLQPLQEPLGHFGLGLKEPYASFTAPLRRYADLLNLRALHLALSKGRDRRS
HHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PRSKTVVDLHGPGSYDQIDWQVLPPKVHEEWQAFLQAQLPKIQAGYQLHQQAERELMGLK
CCCCCEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RCEFMQKHLGETFPGLIVSVQNYGFFVQVDPILAEGLVRVSTLKNDWYEYRSRQQALVGR
HHHHHHHHCCCCCCCEEEEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSRRQFRLGDRVEVQIKNVDYYRQQIDLAVIGEGRPYEEEE
HHHHHCCCCCEEEEEEECCHHHHHHCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 10-formyltetrahydrofolate; L-methionyl-tRNA(fMet); H2O

Specific reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) + H2O = tetrahydrofolate + N-formylmethionyl-tRNA(fMet)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7727754; 8905231 [H]