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The map label for this gene is folP

Identifier: 86604755

GI number: 86604755

Start: 20577

End: 21446

Strand: Reverse

Name: folP

Synonym: CYA_0022

Alternate gene names: 86604755

Gene position: 21446-20577 (Counterclockwise)

Preceding gene: 86604756

Following gene: 86604754

Centisome position: 0.73

GC content: 63.68

Gene sequence:

>870_bases
ATGGGCGTTACCAGCTTGCTCTCTCGCCGTCCCCTGCCTGGGGCAGAACAAACACCGGAGGGGTACTGCCTTTCCTGGCG
GGGTGTGGCGGTGATGGGGGTACTCAATGTAACCCCCGATAGCTTCAGCGACGGCGGCCAGTGGGGATCCGTGGAAGCTG
CCGTGCAGGCAGCCAGAGCCATGGCAGCGGCGGGGGCCTTGATTGTGGATATCGGCGGCGAGTCCACCCGTCCGGGGGCA
GAGCCGGTGCCGGTAGAGGTGGAGTGCGACCGGGTTTTGCCTGTAATTCGGGCTCTAGAAGGATCCGGCATTCTCATCAG
CGTCGATACGCGCCGAACGGAGGTGGCAGCGGCAGCTCTGGCGGCTGGAGCGCACATGATTAATGACGTCACCGGCCTGC
GCGATCCGCAGATGATGCAGCTGTGTGCCGAGAAGGGGGTGCCGGCAATCATCATGCACATGCGGGGAGAGCCCCGCACC
ATGCAGCAGCTTACCCACTACGAGGATCTGGAGGGAGAAGTTTTTGGGTTTCTCAAGGATCAAGCGGAACGGGCCCTGGC
AGCCGGTGTTCCCAGCGTGGTTTTGGATCCCGGCCTGGGCTTTGCCAAAACCGCCGAGCAGAACATTGCCCTCCTCAGAG
CGCTGCCGCGGCTGGTGGCCTATGGCTACCCGGTGCTGGTGGGAGCCTCGCGCAAAAGTTTTGTTGGCCAGCTTTCCGGC
ATTGCTGTGCCCAAAGAGCGGGATAGCGCCAGCGTAGCCGTGCACCTCTTTGCCGCCAGCCGGGGCGCTACCCTGGTGCG
GGCGCACAACGTCCCTGCTCATGTCTCCGCTCTAGCGGCTTGGGAAGGGCTGCACTGTGAGCCAAACTAG

Upstream 100 bases:

>100_bases
ATTACTGCCCCCTGCGCTTCCCTACTTCTAGAATTCAGCTAGGCACGCGCTGGTCCTATCTGGGGCGGCTGCTCTGACAG
CGAATTAGCTTGCAGGAGTT

Downstream 100 bases:

>100_bases
GCTGGTGCTGCGGGGTCTTAGCTTCCATGCCCACCACGGCTATCGTCCTGAGGAGGCCCTGTTGGGGGCGCGCTTTGTAG
TGGATGTGGAGCTGCAGCTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MGVTSLLSRRPLPGAEQTPEGYCLSWRGVAVMGVLNVTPDSFSDGGQWGSVEAAVQAARAMAAAGALIVDIGGESTRPGA
EPVPVEVECDRVLPVIRALEGSGILISVDTRRTEVAAAALAAGAHMINDVTGLRDPQMMQLCAEKGVPAIIMHMRGEPRT
MQQLTHYEDLEGEVFGFLKDQAERALAAGVPSVVLDPGLGFAKTAEQNIALLRALPRLVAYGYPVLVGASRKSFVGQLSG
IAVPKERDSASVAVHLFAASRGATLVRAHNVPAHVSALAAWEGLHCEPN

Sequences:

>Translated_289_residues
MGVTSLLSRRPLPGAEQTPEGYCLSWRGVAVMGVLNVTPDSFSDGGQWGSVEAAVQAARAMAAAGALIVDIGGESTRPGA
EPVPVEVECDRVLPVIRALEGSGILISVDTRRTEVAAAALAAGAHMINDVTGLRDPQMMQLCAEKGVPAIIMHMRGEPRT
MQQLTHYEDLEGEVFGFLKDQAERALAAGVPSVVLDPGLGFAKTAEQNIALLRALPRLVAYGYPVLVGASRKSFVGQLSG
IAVPKERDSASVAVHLFAASRGATLVRAHNVPAHVSALAAWEGLHCEPN
>Mature_288_residues
GVTSLLSRRPLPGAEQTPEGYCLSWRGVAVMGVLNVTPDSFSDGGQWGSVEAAVQAARAMAAAGALIVDIGGESTRPGAE
PVPVEVECDRVLPVIRALEGSGILISVDTRRTEVAAAALAAGAHMINDVTGLRDPQMMQLCAEKGVPAIIMHMRGEPRTM
QQLTHYEDLEGEVFGFLKDQAERALAAGVPSVVLDPGLGFAKTAEQNIALLRALPRLVAYGYPVLVGASRKSFVGQLSGI
AVPKERDSASVAVHLFAASRGATLVRAHNVPAHVSALAAWEGLHCEPN

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=266, Percent_Identity=44.3609022556391, Blast_Score=214, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6324073, Length=301, Percent_Identity=32.5581395348837, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30270; Mature: 30139

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVTSLLSRRPLPGAEQTPEGYCLSWRGVAVMGVLNVTPDSFSDGGQWGSVEAAVQAARA
CCHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
MAAAGALIVDIGGESTRPGAEPVPVEVECDRVLPVIRALEGSGILISVDTRRTEVAAAAL
HHHCCEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
AAGAHMINDVTGLRDPQMMQLCAEKGVPAIIMHMRGEPRTMQQLTHYEDLEGEVFGFLKD
HHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHH
QAERALAAGVPSVVLDPGLGFAKTAEQNIALLRALPRLVAYGYPVLVGASRKSFVGQLSG
HHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHC
IAVPKERDSASVAVHLFAASRGATLVRAHNVPAHVSALAAWEGLHCEPN
CCCCCCCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GVTSLLSRRPLPGAEQTPEGYCLSWRGVAVMGVLNVTPDSFSDGGQWGSVEAAVQAARA
CHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
MAAAGALIVDIGGESTRPGAEPVPVEVECDRVLPVIRALEGSGILISVDTRRTEVAAAAL
HHHCCEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
AAGAHMINDVTGLRDPQMMQLCAEKGVPAIIMHMRGEPRTMQQLTHYEDLEGEVFGFLKD
HHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHH
QAERALAAGVPSVVLDPGLGFAKTAEQNIALLRALPRLVAYGYPVLVGASRKSFVGQLSG
HHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHC
IAVPKERDSASVAVHLFAASRGATLVRAHNVPAHVSALAAWEGLHCEPN
CCCCCCCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]