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The map label for this gene is gyrA [H]

Identifier: 86604741

GI number: 86604741

Start: 7057

End: 9606

Strand: Reverse

Name: gyrA [H]

Synonym: CYA_0008

Alternate gene names: 86604741

Gene position: 9606-7057 (Counterclockwise)

Preceding gene: 86604743

Following gene: 86604738

Centisome position: 0.33

GC content: 64.82

Gene sequence:

>2550_bases
ATGACTCAGCAACTGACTCTCGACGGACTGGGATCTGGATCGGGTGGGGGATCCCGTCTAGGGCGAGTAATCGTAACCGA
TTTGCAGGGGGAGATGCAGCGCTCCTACCTGGAATATGCCATGAGCGTGATCGTGGGGCGGGCCTTGCCGGATGTGCGGG
ATGGCCTCAAGCCGGTGCATCGCCGCATCCTCTACGCCATGCACGAGCTGGGCCTGACGCCGGATCGCCCCTACCGCAAG
TGCGCGCGCGTCGTGGGGGACGTGCTGGGGAAATATCACCCCCACGGGGATCAGGCGGTCTATGACGCGCTGGTGCGCAT
GGCACAAGACTTTTCCAGCCGCTACCCCCTGGTGGCGGGGCACGGCAACTTCGGCTCGGTGGACGACGACCCGCCGGCGG
CCATGCGCTACACGGAGTGTCGGCTGGCGGAGCTGAGCCACACAGCCCTTCTGCAGGGGATCTCCGAAGCAATTGTGGAC
TTTATGCCCAATTTCGACGGCTCCCAGGCGGAGCCCACCGTCCTGCCGGCCCGCCTGCCCATCTTGCTGCTCAACGGCTC
TGCTGGCATTGCCGTGGGCATGGCCACCAACATCCCGCCCCACAACCTGGGGGAAGTGGTGGACGGCCTGCTGGCTTTGA
TCGACGAGCCCGATCTCAGCCCTGAGGAGCTGTTGCGCTGGATCCCGGGGCCGGACTTTCCCACCGGCGGCCAAATTGTC
GATGGCCAGGGGATCCGCGAGGCCTACCTCACCGGCCGCGGCTCCATCACCCTGCGGGGAGTGGCCCGCTTTGAGGAGAT
CCAGCCGGGCAGAGGACGCCACCGCCGGCCCGCCCTGATCATCAGCGAGTTTCCCTATCAGGTGAACAAGGCTGCCTGGC
TCGAGAAGGTGGCCGAGCTGGTCGCCCAAGACCGTCTCAGCGGCATCGCAGATTTGCGGGATGAGTCGGATCGCAGCGGC
ATGCGCGTGGTGGTGGAGCTGAAGCGGGAGGCCAACCCGCAGGCGGTTTTGCAGCAGTTGTACAAGCTCACCCCCTTGCA
GAGCACCTTTGGGGTGATCCTGTTGGCCTTGGTGGAGGGAAAACCCCAGCAGCTCAGCTTGAAGCAGATTTTGCAGCACT
TTTTGCAATTTCGCGAGGCCACTCTCAAGCGGATGTTTCGCGCCGAACTGCAGCAGGTACAGCGCAAAGCCGAAGAGGTG
GCGGGGATGGTGCTGGCCCTGGCCGATCTGGAAGGGGTAATCGACCTGCTGCGGCAAGCGCCCGATAGCGCCACGGCCAA
AGCCCAGCTGCAAACCCGCTTGGGCTGCACCTCCCAGCAGGCGGAGACGATCTTGGCCATGCCCCTGCGCCGCCTGACAA
CCTTGGAGCGGGAGCGCCTCTATCAAGAGCAAGCCGAGCTGCAGGCCCGCATCGCCGAGCTGCAGGGACTGCTGCAAGAT
CGCCGCAAGCTCTTGAATTACCTGAAAAAAGAGCTGCGACACTTGAAAAAAACCTTTGCGGATCCCCGGCGCACCCAGAT
TCTCTCGGCCTCGGAACTGGAAGCGGAGGCGGCCCAGATCCCCGGCGGCGAAGCCGGCGAAGACAGCCGCTTTCTGCTGC
AACTCACCCGCAAAGGCTACGTGCGCCGCCTGCCTCTGCCTGGGCCTCGCTCCCGCAGCAACCCGGCGCAGCGGGAATTG
GGAGAAGATACCCTGGTCAGCCTGGAATGCGTGACCCCAGAGCAGGCAATCTTGGTGCTCACCGCCAGCGGCAGGGCTTT
CACCGTGCCCATCGAAGGGATCCCCCTCAGCACCGGCTCCTCGCGGGGGGTGCCTCTGGTCACCCTTCTCCCCAACCCCG
AGCCGATTGTTGCCGCCTTCCCGTTGGATCCCGTTCGCGTCAGCGGTGCGGAGCACTCTCCCGGCGAGGCCAGCTTGGTG
GTGCTCAGCCGGCAGGGGCGGATCAAGCGGGTGGCCTTGGCGGAGCTGGTGGGCCTCAGCCAACGGGGAGCCGCCGTCTT
GAAGCTCAAAGAAGGAGACGAGCTGGGCTGGGCGGCCCTTTGGCATCCCGGCCACCAAGGCTACAGCGTTGTCCTGGCCA
CCTCCGGCGGGCGGGTGCTGCGGCTGGACGCCGAACAGATCCCCTTGATGGGTCGGGCAGCTATGGGATCCCCAGCTCTA
CGTTTGGGGCGCACAGAACAGATCGTCGGTATGGCGCTGCTGCCCCCGCAAGGGATCTTAGTTTTGGCCAGCCGGTCGGG
GTATTTGAAGCGGCTACCCCTGGGCGAGATCCCCATCCTGGAGCAGGGTAAAGTGGGCGTGTCGGCCTTTCACTTCTCCA
ACAAAGGGGATGGCTTGGTGGGCTTGGTGGGTTTTCCCCCCGATCTGGCGGCGCACCCCCATCTGCAAGTGGATGTGATC
GCGGAGTCCGAGCGGGTACACTCCTTCTCTCCTGAGGAAATTCCCCTGCAAGGCCGGTCCGGCGGCGGATCCCTGTTGGT
CAAGGGGGAGCAGGTTAGGGAGTTGCGCCTGTTTTGGCCGCAGTGGCTGCCGGAGGGCGGGATTGGATAG

Upstream 100 bases:

>100_bases
ATTGAGATGGGATGTGAGATGGGATGAGATGGGATCCCACCTCGCAAGAACCAGAGAAACGGCTACAGTAACCTGGAAAG
CGTTCCGCTCCTAATGAGCC

Downstream 100 bases:

>100_bases
CTCTGGAGCTTTTGGGGGAAAGCAGAAGTCTGGATCGCTAGGACAGAGAGCCATCCCCAGGCGAGGCAGAATCAGGCGGC
TGGGAGCCGGGATCCGGCGC

Product: type II DNA topoisomerase, A subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 849; Mature: 848

Protein sequence:

>849_residues
MTQQLTLDGLGSGSGGGSRLGRVIVTDLQGEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDRPYRK
CARVVGDVLGKYHPHGDQAVYDALVRMAQDFSSRYPLVAGHGNFGSVDDDPPAAMRYTECRLAELSHTALLQGISEAIVD
FMPNFDGSQAEPTVLPARLPILLLNGSAGIAVGMATNIPPHNLGEVVDGLLALIDEPDLSPEELLRWIPGPDFPTGGQIV
DGQGIREAYLTGRGSITLRGVARFEEIQPGRGRHRRPALIISEFPYQVNKAAWLEKVAELVAQDRLSGIADLRDESDRSG
MRVVVELKREANPQAVLQQLYKLTPLQSTFGVILLALVEGKPQQLSLKQILQHFLQFREATLKRMFRAELQQVQRKAEEV
AGMVLALADLEGVIDLLRQAPDSATAKAQLQTRLGCTSQQAETILAMPLRRLTTLERERLYQEQAELQARIAELQGLLQD
RRKLLNYLKKELRHLKKTFADPRRTQILSASELEAEAAQIPGGEAGEDSRFLLQLTRKGYVRRLPLPGPRSRSNPAQREL
GEDTLVSLECVTPEQAILVLTASGRAFTVPIEGIPLSTGSSRGVPLVTLLPNPEPIVAAFPLDPVRVSGAEHSPGEASLV
VLSRQGRIKRVALAELVGLSQRGAAVLKLKEGDELGWAALWHPGHQGYSVVLATSGGRVLRLDAEQIPLMGRAAMGSPAL
RLGRTEQIVGMALLPPQGILVLASRSGYLKRLPLGEIPILEQGKVGVSAFHFSNKGDGLVGLVGFPPDLAAHPHLQVDVI
AESERVHSFSPEEIPLQGRSGGGSLLVKGEQVRELRLFWPQWLPEGGIG

Sequences:

>Translated_849_residues
MTQQLTLDGLGSGSGGGSRLGRVIVTDLQGEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDRPYRK
CARVVGDVLGKYHPHGDQAVYDALVRMAQDFSSRYPLVAGHGNFGSVDDDPPAAMRYTECRLAELSHTALLQGISEAIVD
FMPNFDGSQAEPTVLPARLPILLLNGSAGIAVGMATNIPPHNLGEVVDGLLALIDEPDLSPEELLRWIPGPDFPTGGQIV
DGQGIREAYLTGRGSITLRGVARFEEIQPGRGRHRRPALIISEFPYQVNKAAWLEKVAELVAQDRLSGIADLRDESDRSG
MRVVVELKREANPQAVLQQLYKLTPLQSTFGVILLALVEGKPQQLSLKQILQHFLQFREATLKRMFRAELQQVQRKAEEV
AGMVLALADLEGVIDLLRQAPDSATAKAQLQTRLGCTSQQAETILAMPLRRLTTLERERLYQEQAELQARIAELQGLLQD
RRKLLNYLKKELRHLKKTFADPRRTQILSASELEAEAAQIPGGEAGEDSRFLLQLTRKGYVRRLPLPGPRSRSNPAQREL
GEDTLVSLECVTPEQAILVLTASGRAFTVPIEGIPLSTGSSRGVPLVTLLPNPEPIVAAFPLDPVRVSGAEHSPGEASLV
VLSRQGRIKRVALAELVGLSQRGAAVLKLKEGDELGWAALWHPGHQGYSVVLATSGGRVLRLDAEQIPLMGRAAMGSPAL
RLGRTEQIVGMALLPPQGILVLASRSGYLKRLPLGEIPILEQGKVGVSAFHFSNKGDGLVGLVGFPPDLAAHPHLQVDVI
AESERVHSFSPEEIPLQGRSGGGSLLVKGEQVRELRLFWPQWLPEGGIG
>Mature_848_residues
TQQLTLDGLGSGSGGGSRLGRVIVTDLQGEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDRPYRKC
ARVVGDVLGKYHPHGDQAVYDALVRMAQDFSSRYPLVAGHGNFGSVDDDPPAAMRYTECRLAELSHTALLQGISEAIVDF
MPNFDGSQAEPTVLPARLPILLLNGSAGIAVGMATNIPPHNLGEVVDGLLALIDEPDLSPEELLRWIPGPDFPTGGQIVD
GQGIREAYLTGRGSITLRGVARFEEIQPGRGRHRRPALIISEFPYQVNKAAWLEKVAELVAQDRLSGIADLRDESDRSGM
RVVVELKREANPQAVLQQLYKLTPLQSTFGVILLALVEGKPQQLSLKQILQHFLQFREATLKRMFRAELQQVQRKAEEVA
GMVLALADLEGVIDLLRQAPDSATAKAQLQTRLGCTSQQAETILAMPLRRLTTLERERLYQEQAELQARIAELQGLLQDR
RKLLNYLKKELRHLKKTFADPRRTQILSASELEAEAAQIPGGEAGEDSRFLLQLTRKGYVRRLPLPGPRSRSNPAQRELG
EDTLVSLECVTPEQAILVLTASGRAFTVPIEGIPLSTGSSRGVPLVTLLPNPEPIVAAFPLDPVRVSGAEHSPGEASLVV
LSRQGRIKRVALAELVGLSQRGAAVLKLKEGDELGWAALWHPGHQGYSVVLATSGGRVLRLDAEQIPLMGRAAMGSPALR
LGRTEQIVGMALLPPQGILVLASRSGYLKRLPLGEIPILEQGKVGVSAFHFSNKGDGLVGLVGFPPDLAAHPHLQVDVIA
ESERVHSFSPEEIPLQGRSGGGSLLVKGEQVRELRLFWPQWLPEGGIG

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=344, Percent_Identity=23.8372093023256, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI19913406, Length=355, Percent_Identity=23.943661971831, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788562, Length=853, Percent_Identity=38.8042203985932, Blast_Score=550, Evalue=1e-157,
Organism=Escherichia coli, GI1789396, Length=729, Percent_Identity=34.9794238683128, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI212645845, Length=205, Percent_Identity=28.780487804878, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17535065, Length=398, Percent_Identity=25.3768844221106, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=188, Percent_Identity=28.7234042553192, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92490; Mature: 92359

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQLTLDGLGSGSGGGSRLGRVIVTDLQGEMQRSYLEYAMSVIVGRALPDVRDGLKPVH
CCCEEEECCCCCCCCCHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RRILYAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQAVYDALVRMAQDFSSRYPLVAG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEE
HGNFGSVDDDPPAAMRYTECRLAELSHTALLQGISEAIVDFMPNFDGSQAEPTVLPARLP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCC
ILLLNGSAGIAVGMATNIPPHNLGEVVDGLLALIDEPDLSPEELLRWIPGPDFPTGGQIV
EEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEE
DGQGIREAYLTGRGSITLRGVARFEEIQPGRGRHRRPALIISEFPYQVNKAAWLEKVAEL
CCCCCHHHHHCCCCCEEEEEHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHH
VAQDRLSGIADLRDESDRSGMRVVVELKREANPQAVLQQLYKLTPLQSTFGVILLALVEG
HHHHHHHHHHHHCCCCCCCCCEEEEEEHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
KPQQLSLKQILQHFLQFREATLKRMFRAELQQVQRKAEEVAGMVLALADLEGVIDLLRQA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDSATAKAQLQTRLGCTSQQAETILAMPLRRLTTLERERLYQEQAELQARIAELQGLLQD
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRKLLNYLKKELRHLKKTFADPRRTQILSASELEAEAAQIPGGEAGEDSRFLLQLTRKGY
HHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCC
VRRLPLPGPRSRSNPAQRELGEDTLVSLECVTPEQAILVLTASGRAFTVPIEGIPLSTGS
EEECCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCEEEEEEECCCEEEEEECCEECCCCC
SRGVPLVTLLPNPEPIVAAFPLDPVRVSGAEHSPGEASLVVLSRQGRIKRVALAELVGLS
CCCCEEEEECCCCCCEEEECCCCCEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCC
QRGAAVLKLKEGDELGWAALWHPGHQGYSVVLATSGGRVLRLDAEQIPLMGRAAMGSPAL
CCCCEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCEEEEECHHHCCCCCCCCCCCCHH
RLGRTEQIVGMALLPPQGILVLASRSGYLKRLPLGEIPILEQGKVGVSAFHFSNKGDGLV
HCCCCHHHHEEEECCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCEE
GLVGFPPDLAAHPHLQVDVIAESERVHSFSPEEIPLQGRSGGGSLLVKGEQVRELRLFWP
EEECCCCCCCCCCCEEEEEEECCCHHCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHH
QWLPEGGIG
HHCCCCCCC
>Mature Secondary Structure 
TQQLTLDGLGSGSGGGSRLGRVIVTDLQGEMQRSYLEYAMSVIVGRALPDVRDGLKPVH
CCEEEECCCCCCCCCHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RRILYAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQAVYDALVRMAQDFSSRYPLVAG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEE
HGNFGSVDDDPPAAMRYTECRLAELSHTALLQGISEAIVDFMPNFDGSQAEPTVLPARLP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCC
ILLLNGSAGIAVGMATNIPPHNLGEVVDGLLALIDEPDLSPEELLRWIPGPDFPTGGQIV
EEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEE
DGQGIREAYLTGRGSITLRGVARFEEIQPGRGRHRRPALIISEFPYQVNKAAWLEKVAEL
CCCCCHHHHHCCCCCEEEEEHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHH
VAQDRLSGIADLRDESDRSGMRVVVELKREANPQAVLQQLYKLTPLQSTFGVILLALVEG
HHHHHHHHHHHHCCCCCCCCCEEEEEEHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
KPQQLSLKQILQHFLQFREATLKRMFRAELQQVQRKAEEVAGMVLALADLEGVIDLLRQA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDSATAKAQLQTRLGCTSQQAETILAMPLRRLTTLERERLYQEQAELQARIAELQGLLQD
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRKLLNYLKKELRHLKKTFADPRRTQILSASELEAEAAQIPGGEAGEDSRFLLQLTRKGY
HHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCC
VRRLPLPGPRSRSNPAQRELGEDTLVSLECVTPEQAILVLTASGRAFTVPIEGIPLSTGS
EEECCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCEEEEEEECCCEEEEEECCEECCCCC
SRGVPLVTLLPNPEPIVAAFPLDPVRVSGAEHSPGEASLVVLSRQGRIKRVALAELVGLS
CCCCEEEEECCCCCCEEEECCCCCEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCC
QRGAAVLKLKEGDELGWAALWHPGHQGYSVVLATSGGRVLRLDAEQIPLMGRAAMGSPAL
CCCCEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCEEEEECHHHCCCCCCCCCCCCHH
RLGRTEQIVGMALLPPQGILVLASRSGYLKRLPLGEIPILEQGKVGVSAFHFSNKGDGLV
HCCCCHHHHEEEECCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCEE
GLVGFPPDLAAHPHLQVDVIAESERVHSFSPEEIPLQGRSGGGSLLVKGEQVRELRLFWP
EEECCCCCCCCCCCEEEEEEECCCHHCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHH
QWLPEGGIG
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]