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The map label for this gene is aldH [H]

Identifier: 86361263

GI number: 86361263

Start: 599925

End: 601448

Strand: Direct

Name: aldH [H]

Synonym: RHE_PF00534

Alternate gene names: 86361263

Gene position: 599925-601448 (Clockwise)

Preceding gene: 86361262

Following gene: 86361265

Centisome position: 93.37

GC content: 63.65

Gene sequence:

>1524_bases
ATGACAATCAACGGAAACCTGCTCGTTGCGGGAACGGAAAAACGTGGCCCAAACGGTGAGTTTCATGGCATCGAAGCGGC
CACCGGAAAGCCCCTTCCCATTTCCTTCGGTGGCGCTTCGCCCGAAGATGTCGAGCAGGCAGCCGAACAGGCATGGCAGG
CCTTTGCCACCTACCGCGAGACCGATCTGGAAGTCAGAGCAAAATTTCTGGAAAAGATTGCCGAGGAAATTGAAGCGATC
GGCGATGATCTCGTTGTCCGCGCGATGGCGGAAACCGGGCTCCCCCGGGGACGTCTCGAGGGGGAGCGGGCGCGCACGAC
CGGCCAGCTCCGCCTGTTCGCCAGGGAGGTCCGTGAAGGCCGCTTCCAGGAGCTGCGCTTCGATGCAGGCGATCCTTCCC
GCAAACCCGTTGCGAAGCCGGATCTCAGGCTCAGAAACGTCGCGCTCGGCCCCGTGGCAGTCTTTGGCGCCTCGAATTTT
CCGCTCGCCTTCTCCGTCGCCGGCGGCGACACGGCGTCCGCGCTGGCCGCGGGCTGCCCGGTCGTAGTAAAGGCCCATTC
GGCGCATCCGGGCACTTCGGAGCTCGTCGGCCGGGCGGTGCAGCGGGCAGTCTCAAGCACAGGTTTCCATCCAGGAACCT
TCTCGCTGCTGTTCGACACCGGCTTTGAAGTCGGTCAGAGGCTCGTGGCGGATTCCAGGATCCGGGCGGTCGGCTTTACC
GGCTCCCGCCGCGGGGGAACGGCACTGATGGAAATCGCCTCAAAGCGCAAACAACCCATCCCCGTCTATGCCGAAATGAG
CAGCATAAACCCTGTCATCCTTTTTCCCGGCGCCCTGAACGCCAGGGCAACCGATATTGCAGCCGGTTTCGTGACATCGC
TCGTCCTGGGCGCCGGCCAGTTCTGCACAAATCCCGGCCTGATCCTCGCCATCGACGGCGCCGCCCTTGACGCCTTTGTT
GCACGGACAGCCGAGCTGCTTCGGGATGTCGCGCCTCAGGCAATGCTGACGCCGTCGATCGCGAAGGCCTATTGCGATGG
CGTTGCCAAACTCAGGCAGCATTCCGAGGTGCGGGCAGTGGCATCGGGCAGGCCCGGCAGCGAATTTGAAGGCACGGCGG
CGCTGTTCGAGACGACGGCGGACGCCTTCCTCGCCAATCACCAGCTTCAGGACGAGGTCTTCGGCGCCGCCGGCCTCGTC
GTTCGTTGCCGGGATCTTCAGCAGCTCGAGGCGGTGCTCGACGAGCTGGAAGGCCAGCTCACCGTTGCGCTCCACATCGC
GGACGAGGACGAAGCCGCAGCACGCCGACTGGTTCCCAAGCTGGAGATGCTTGCAGGCCGGCTGCTCGTCAATGGTTTCG
GAACCGGGGTGGAAGTGTCTCCTGCCATGGTCCATGGCGGACCTTATCCGGCAACGGCGGACGGACGTTCTACATCCGTC
GGCACTCTGGCGATATATCGGTTCCTGCGGCCGGTATCTTATCAGGACTTCACGAAGGCCCTGTTGCCGGCAGCGCTTCG
ATAG

Upstream 100 bases:

>100_bases
CGGCCGTCAGTCGCGCGCCGCCGCGATCACGTACCGGCCATAGTGACAGAGACGGTTTCGGTTCCTATATCAGCCCCGAC
AGTTTGAAAGGAAATCGATC

Downstream 100 bases:

>100_bases
CGACAAGAGCGGCGGTCGCCGTCTGTCTCGACAGGCGACCGCCGCTCATTGGGTTCCGACAGAAGGCGGCGAAGCTCGTC
GCCATCGTCAATTCCATCCT

Product: aldehyde dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MTINGNLLVAGTEKRGPNGEFHGIEAATGKPLPISFGGASPEDVEQAAEQAWQAFATYRETDLEVRAKFLEKIAEEIEAI
GDDLVVRAMAETGLPRGRLEGERARTTGQLRLFAREVREGRFQELRFDAGDPSRKPVAKPDLRLRNVALGPVAVFGASNF
PLAFSVAGGDTASALAAGCPVVVKAHSAHPGTSELVGRAVQRAVSSTGFHPGTFSLLFDTGFEVGQRLVADSRIRAVGFT
GSRRGGTALMEIASKRKQPIPVYAEMSSINPVILFPGALNARATDIAAGFVTSLVLGAGQFCTNPGLILAIDGAALDAFV
ARTAELLRDVAPQAMLTPSIAKAYCDGVAKLRQHSEVRAVASGRPGSEFEGTAALFETTADAFLANHQLQDEVFGAAGLV
VRCRDLQQLEAVLDELEGQLTVALHIADEDEAAARRLVPKLEMLAGRLLVNGFGTGVEVSPAMVHGGPYPATADGRSTSV
GTLAIYRFLRPVSYQDFTKALLPAALR

Sequences:

>Translated_507_residues
MTINGNLLVAGTEKRGPNGEFHGIEAATGKPLPISFGGASPEDVEQAAEQAWQAFATYRETDLEVRAKFLEKIAEEIEAI
GDDLVVRAMAETGLPRGRLEGERARTTGQLRLFAREVREGRFQELRFDAGDPSRKPVAKPDLRLRNVALGPVAVFGASNF
PLAFSVAGGDTASALAAGCPVVVKAHSAHPGTSELVGRAVQRAVSSTGFHPGTFSLLFDTGFEVGQRLVADSRIRAVGFT
GSRRGGTALMEIASKRKQPIPVYAEMSSINPVILFPGALNARATDIAAGFVTSLVLGAGQFCTNPGLILAIDGAALDAFV
ARTAELLRDVAPQAMLTPSIAKAYCDGVAKLRQHSEVRAVASGRPGSEFEGTAALFETTADAFLANHQLQDEVFGAAGLV
VRCRDLQQLEAVLDELEGQLTVALHIADEDEAAARRLVPKLEMLAGRLLVNGFGTGVEVSPAMVHGGPYPATADGRSTSV
GTLAIYRFLRPVSYQDFTKALLPAALR
>Mature_506_residues
TINGNLLVAGTEKRGPNGEFHGIEAATGKPLPISFGGASPEDVEQAAEQAWQAFATYRETDLEVRAKFLEKIAEEIEAIG
DDLVVRAMAETGLPRGRLEGERARTTGQLRLFAREVREGRFQELRFDAGDPSRKPVAKPDLRLRNVALGPVAVFGASNFP
LAFSVAGGDTASALAAGCPVVVKAHSAHPGTSELVGRAVQRAVSSTGFHPGTFSLLFDTGFEVGQRLVADSRIRAVGFTG
SRRGGTALMEIASKRKQPIPVYAEMSSINPVILFPGALNARATDIAAGFVTSLVLGAGQFCTNPGLILAIDGAALDAFVA
RTAELLRDVAPQAMLTPSIAKAYCDGVAKLRQHSEVRAVASGRPGSEFEGTAALFETTADAFLANHQLQDEVFGAAGLVV
RCRDLQQLEAVLDELEGQLTVALHIADEDEAAARRLVPKLEMLAGRLLVNGFGTGVEVSPAMVHGGPYPATADGRSTSVG
TLAIYRFLRPVSYQDFTKALLPAALR

Specific function: Catalyzes the oxidation of long-chain aliphatic aldehydes to acids. May be implicated in controlling luminescence as it catalyzes the oxidation of the fatty aldehyde substrate for the light-emitting reaction [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507229, Length=277, Percent_Identity=26.7148014440433, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1787250, Length=415, Percent_Identity=27.2289156626506, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788042, Length=294, Percent_Identity=29.9319727891156, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081896, Length=433, Percent_Identity=23.7875288683603, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786504, Length=366, Percent_Identity=27.5956284153005, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787558, Length=508, Percent_Identity=24.0157480314961, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17551164, Length=280, Percent_Identity=27.1428571428571, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323822, Length=397, Percent_Identity=26.9521410579345, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319478, Length=330, Percent_Identity=24.5454545454545, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.4 [H]

Molecular weight: Translated: 53597; Mature: 53465

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00070 ALDEHYDE_DEHYDR_CYS ; PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTINGNLLVAGTEKRGPNGEFHGIEAATGKPLPISFGGASPEDVEQAAEQAWQAFATYRE
CEECCCEEEEECCCCCCCCCCCCEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
TDLEVRAKFLEKIAEEIEAIGDDLVVRAMAETGLPRGRLEGERARTTGQLRLFAREVREG
CCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCHHHCHHHHHHHHHHHHCC
RFQELRFDAGDPSRKPVAKPDLRLRNVALGPVAVFGASNFPLAFSVAGGDTASALAAGCP
HHHEEEECCCCCCCCCCCCCCCEEHEEEECCEEEECCCCCCEEEEECCCCHHHHHHCCCC
VVVKAHSAHPGTSELVGRAVQRAVSSTGFHPGTFSLLFDTGFEVGQRLVADSRIRAVGFT
EEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCEEEEECC
GSRRGGTALMEIASKRKQPIPVYAEMSSINPVILFPGALNARATDIAAGFVTSLVLGAGQ
CCCCCCHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCH
FCTNPGLILAIDGAALDAFVARTAELLRDVAPQAMLTPSIAKAYCDGVAKLRQHSEVRAV
HCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ASGRPGSEFEGTAALFETTADAFLANHQLQDEVFGAAGLVVRCRDLQQLEAVLDELEGQL
HCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCHHEEHHHHHHHHHHHHHCCCCE
TVALHIADEDEAAARRLVPKLEMLAGRLLVNGFGTGVEVSPAMVHGGPYPATADGRSTSV
EEEEEECCCHHHHHHHHHHHHHHHHHHHHEECCCCCEECCCEEEECCCCCCCCCCCCCCH
GTLAIYRFLRPVSYQDFTKALLPAALR
HHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TINGNLLVAGTEKRGPNGEFHGIEAATGKPLPISFGGASPEDVEQAAEQAWQAFATYRE
EECCCEEEEECCCCCCCCCCCCEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
TDLEVRAKFLEKIAEEIEAIGDDLVVRAMAETGLPRGRLEGERARTTGQLRLFAREVREG
CCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCHHHCHHHHHHHHHHHHCC
RFQELRFDAGDPSRKPVAKPDLRLRNVALGPVAVFGASNFPLAFSVAGGDTASALAAGCP
HHHEEEECCCCCCCCCCCCCCCEEHEEEECCEEEECCCCCCEEEEECCCCHHHHHHCCCC
VVVKAHSAHPGTSELVGRAVQRAVSSTGFHPGTFSLLFDTGFEVGQRLVADSRIRAVGFT
EEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCEEEEECC
GSRRGGTALMEIASKRKQPIPVYAEMSSINPVILFPGALNARATDIAAGFVTSLVLGAGQ
CCCCCCHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCH
FCTNPGLILAIDGAALDAFVARTAELLRDVAPQAMLTPSIAKAYCDGVAKLRQHSEVRAV
HCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ASGRPGSEFEGTAALFETTADAFLANHQLQDEVFGAAGLVVRCRDLQQLEAVLDELEGQL
HCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCHHEEHHHHHHHHHHHHHCCCCE
TVALHIADEDEAAARRLVPKLEMLAGRLLVNGFGTGVEVSPAMVHGGPYPATADGRSTSV
EEEEEECCCHHHHHHHHHHHHHHHHHHHHEECCCCCEECCCEEEECCCCCCCCCCCCCCH
GTLAIYRFLRPVSYQDFTKALLPAALR
HHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8527447; 10903148 [H]