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The map label for this gene is norD

Identifier: 86361247

GI number: 86361247

Start: 582915

End: 584801

Strand: Direct

Name: norD

Synonym: RHE_PF00518

Alternate gene names: 86361247

Gene position: 582915-584801 (Clockwise)

Preceding gene: 86361246

Following gene: 86361249

Centisome position: 90.72

GC content: 63.75

Gene sequence:

>1887_bases
ATGCTCGAATTCCTGGAACTCGAAGAAACGGTCGGACGCGCGTGGCACCGCCTTGTCGGCGACACCCGCTCCTGGCCCCG
CCATCCGCAGCATGAGGTCAAACTGGCCGACATCAGATCGCAGCTGTCGGTCTGCTTCCGCGCCTTCGGCGGCGAGCCGA
CGTTGCAGATCCAGAAATCGCGCCAGCAGAGCTCGTCGCACCGGCTGCGTTTCCGGCAGGTCGTCGGCCTCGGCGAGGAG
AGAAGCGATCATCCGACCTGGGACGGCAGCGCAATCCATCTGCCTGCATCGATCGAAATCTTCGATGACGAACGGCTGAA
CCGGGATCTCTATTTCTGGCTCGCGGCCTACATTGCGGTGGCTTCCACGCCCGATCGCAGGGCAGACGACGCCATGCTTT
CCGACATCGCCCGGATCGAAGCGGGGCGCAGAAACGCCGCGCGAGTGGTCGCGACCTTTCCTGGCATGCATGCTCGGTAC
CTTCGCCTGAGCGAGGCCATTCTCGCATGCCGAACCCGCGGCAGGCTGCCCAAGGCCGAGAGGCAGGTCGAGGATTATCT
GCGCTTCGCCCTGGCATTTCCATTGGGGGACCGGCTGGCCAACCTTATCCGGCCGACGGCAGCCAAGGCGCCCCCAGGTT
ATCTGCCGATGCTGCCTGTCCCGATCTGGCCAGACTTCACCGGACGCGCGGAAGCTGAAAAATCCGACCGCGAGGACCTT
CCCTCCGAGGGTGGCGAGGCAGGCCCTGCCCGCTCTTCGCATCAGGCCGTCCGCAAGAAGGACGCCTACGACCGCCGGCG
CGATCCCTTCATCCTCAACCGCTTCGAAAAGATCCTCGCCATGGCCGAGATGGTCAACGTCGACCGTCCGACGGATGACC
GGGACGACGACGATGCCGGCGCAGCCGATGAACTTGACGAGATCAGCTTGAGCGAAACACGTGAGCGGCCGAAGTCGAAG
TTCCGTTTCGACCTGGATCTCTCCCCGGAAGCCTCGGACGTCTCGCAAATCCACGGCGCATTCACCTATCCCGAATGGGA
TTACCGCAGAAAGCAATATATGGAGGATCACTGCCGCGTCCTCCTCGGCACCGTCCCGGCCCCGCAGCAGGCGACCGTCG
CGACCGATCAGGCCATCGTGCGCAAGATCAGACGGCAATTCGAGACGCTCCGGCCGAAGCGGGAGATCCGGAAGGCGCAG
CTCGACGGCAACGACCTCGACCTCGAGGCGCTGATACGGGCGCGCGCCGATCTGCTTGCAACCGGCCAGCCGGATGACCG
CATTTATGAATGCGCCCGTCCTGCCTCACACGAACTTGCTACGTCGATCCTCGTCGACGTCTCGTTGTCGACGGATTCCT
GGGTGGATAACCGCAGGGTCCTCGATCTCGAGAAACAGGCGCTCGACGTCTTCGCGCGCGGCCTGGATGCCTGCGGCGAC
AGTTTCTCCATTCACACTTTCACGTCGAGACGCCGCAACTGGGTGCGTATCGACAGCATCAAGGAGTTCGAGGAGACGTT
CTCGCCGACGACCGCGAGGCGGATCGCCGATCTGAAGCCCGGCTATTACACGCGTATGGGGGCGGCCCTCCGGCATGTGT
CGGGGCAGTTGCACCAGCACGGCGCGCGGAAAAAGCTGCTCCTCATCCTGACGGACGGCAAGCCGAATGACGTCGATCAT
TACGAAGGACGATTTGCCCTGGAGGACAGCCGAAAAGCGGTCGCCGAAGCCCGCGCCCTCGGCCAGGCCGTCTTTGCCGT
CACCGTCGACCGCAACGCCGGCGACTATCTGCCGGCAATCTTCGGAAGGGCGGGCTTTGCCGTGATCTCGGAGCTTTCGA
AACTGCCGAGCGCACTGCCGGCGATCTATCGAAACCTCACCGCCTGA

Upstream 100 bases:

>100_bases
CGAGGCGGTCAGAGCCGCGATCATCGAGCCGCTGACGGACGAAGCCGATGTGAAGGCCGCCCTTGTCGAAGTGGCCGCAG
CGACGCTCGGCAGGTGAGCG

Downstream 100 bases:

>100_bases
GCGCATCCACGAACAGGCCGGAGCCGCTCGACTGGCGCCTCCCACCTGGCTTGATGTTCTTTGTTTTCACAACGCGTTTT
AGCTTTGTTCTTATACGTGT

Product: nitric oxide reductase protein

Products: nitric oxide; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MLEFLELEETVGRAWHRLVGDTRSWPRHPQHEVKLADIRSQLSVCFRAFGGEPTLQIQKSRQQSSSHRLRFRQVVGLGEE
RSDHPTWDGSAIHLPASIEIFDDERLNRDLYFWLAAYIAVASTPDRRADDAMLSDIARIEAGRRNAARVVATFPGMHARY
LRLSEAILACRTRGRLPKAERQVEDYLRFALAFPLGDRLANLIRPTAAKAPPGYLPMLPVPIWPDFTGRAEAEKSDREDL
PSEGGEAGPARSSHQAVRKKDAYDRRRDPFILNRFEKILAMAEMVNVDRPTDDRDDDDAGAADELDEISLSETRERPKSK
FRFDLDLSPEASDVSQIHGAFTYPEWDYRRKQYMEDHCRVLLGTVPAPQQATVATDQAIVRKIRRQFETLRPKREIRKAQ
LDGNDLDLEALIRARADLLATGQPDDRIYECARPASHELATSILVDVSLSTDSWVDNRRVLDLEKQALDVFARGLDACGD
SFSIHTFTSRRRNWVRIDSIKEFEETFSPTTARRIADLKPGYYTRMGAALRHVSGQLHQHGARKKLLLILTDGKPNDVDH
YEGRFALEDSRKAVAEARALGQAVFAVTVDRNAGDYLPAIFGRAGFAVISELSKLPSALPAIYRNLTA

Sequences:

>Translated_628_residues
MLEFLELEETVGRAWHRLVGDTRSWPRHPQHEVKLADIRSQLSVCFRAFGGEPTLQIQKSRQQSSSHRLRFRQVVGLGEE
RSDHPTWDGSAIHLPASIEIFDDERLNRDLYFWLAAYIAVASTPDRRADDAMLSDIARIEAGRRNAARVVATFPGMHARY
LRLSEAILACRTRGRLPKAERQVEDYLRFALAFPLGDRLANLIRPTAAKAPPGYLPMLPVPIWPDFTGRAEAEKSDREDL
PSEGGEAGPARSSHQAVRKKDAYDRRRDPFILNRFEKILAMAEMVNVDRPTDDRDDDDAGAADELDEISLSETRERPKSK
FRFDLDLSPEASDVSQIHGAFTYPEWDYRRKQYMEDHCRVLLGTVPAPQQATVATDQAIVRKIRRQFETLRPKREIRKAQ
LDGNDLDLEALIRARADLLATGQPDDRIYECARPASHELATSILVDVSLSTDSWVDNRRVLDLEKQALDVFARGLDACGD
SFSIHTFTSRRRNWVRIDSIKEFEETFSPTTARRIADLKPGYYTRMGAALRHVSGQLHQHGARKKLLLILTDGKPNDVDH
YEGRFALEDSRKAVAEARALGQAVFAVTVDRNAGDYLPAIFGRAGFAVISELSKLPSALPAIYRNLTA
>Mature_628_residues
MLEFLELEETVGRAWHRLVGDTRSWPRHPQHEVKLADIRSQLSVCFRAFGGEPTLQIQKSRQQSSSHRLRFRQVVGLGEE
RSDHPTWDGSAIHLPASIEIFDDERLNRDLYFWLAAYIAVASTPDRRADDAMLSDIARIEAGRRNAARVVATFPGMHARY
LRLSEAILACRTRGRLPKAERQVEDYLRFALAFPLGDRLANLIRPTAAKAPPGYLPMLPVPIWPDFTGRAEAEKSDREDL
PSEGGEAGPARSSHQAVRKKDAYDRRRDPFILNRFEKILAMAEMVNVDRPTDDRDDDDAGAADELDEISLSETRERPKSK
FRFDLDLSPEASDVSQIHGAFTYPEWDYRRKQYMEDHCRVLLGTVPAPQQATVATDQAIVRKIRRQFETLRPKREIRKAQ
LDGNDLDLEALIRARADLLATGQPDDRIYECARPASHELATSILVDVSLSTDSWVDNRRVLDLEKQALDVFARGLDACGD
SFSIHTFTSRRRNWVRIDSIKEFEETFSPTTARRIADLKPGYYTRMGAALRHVSGQLHQHGARKKLLLILTDGKPNDVDH
YEGRFALEDSRKAVAEARALGQAVFAVTVDRNAGDYLPAIFGRAGFAVISELSKLPSALPAIYRNLTA

Specific function: Part of the operon norEFCBQD encoding nitric oxide reductase. Essential virulence factor, probably involved in the detoxification of nitric oxide (NO) produced in the macrophages during the innate response against infection [H]

COG id: COG4548

COG function: function code P; Nitric oxide reductase activation protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 VWFA domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002035 [H]

Pfam domain/function: PF00092 VWA [H]

EC number: 1.7.99.7

Molecular weight: Translated: 71013; Mature: 71013

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50234 VWFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEFLELEETVGRAWHRLVGDTRSWPRHPQHEVKLADIRSQLSVCFRAFGGEPTLQIQKS
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHH
RQQSSSHRLRFRQVVGLGEERSDHPTWDGSAIHLPASIEIFDDERLNRDLYFWLAAYIAV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCEEEEECCHHCCHHHHHHHHHHHHH
ASTPDRRADDAMLSDIARIEAGRRNAARVVATFPGMHARYLRLSEAILACRTRGRLPKAE
CCCCCCCHHHHHHHHHHHHHCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHH
RQVEDYLRFALAFPLGDRLANLIRPTAAKAPPGYLPMLPVPIWPDFTGRAEAEKSDREDL
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCC
PSEGGEAGPARSSHQAVRKKDAYDRRRDPFILNRFEKILAMAEMVNVDRPTDDRDDDDAG
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AADELDEISLSETRERPKSKFRFDLDLSPEASDVSQIHGAFTYPEWDYRRKQYMEDHCRV
CHHHHHHCCHHHHHHCCHHHEEEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHE
LLGTVPAPQQATVATDQAIVRKIRRQFETLRPKREIRKAQLDGNDLDLEALIRARADLLA
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHC
TGQPDDRIYECARPASHELATSILVDVSLSTDSWVDNRRVLDLEKQALDVFARGLDACGD
CCCCHHHHHHHCCCCHHHHHHHHHEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCC
SFSIHTFTSRRRNWVRIDSIKEFEETFSPTTARRIADLKPGYYTRMGAALRHVSGQLHQH
CCEEEEEHHCCCCEEEEHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
GARKKLLLILTDGKPNDVDHYEGRFALEDSRKAVAEARALGQAVFAVTVDRNAGDYLPAI
CCCCEEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHH
FGRAGFAVISELSKLPSALPAIYRNLTA
HCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLEFLELEETVGRAWHRLVGDTRSWPRHPQHEVKLADIRSQLSVCFRAFGGEPTLQIQKS
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHH
RQQSSSHRLRFRQVVGLGEERSDHPTWDGSAIHLPASIEIFDDERLNRDLYFWLAAYIAV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCEEEEECCHHCCHHHHHHHHHHHHH
ASTPDRRADDAMLSDIARIEAGRRNAARVVATFPGMHARYLRLSEAILACRTRGRLPKAE
CCCCCCCHHHHHHHHHHHHHCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHH
RQVEDYLRFALAFPLGDRLANLIRPTAAKAPPGYLPMLPVPIWPDFTGRAEAEKSDREDL
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCC
PSEGGEAGPARSSHQAVRKKDAYDRRRDPFILNRFEKILAMAEMVNVDRPTDDRDDDDAG
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AADELDEISLSETRERPKSKFRFDLDLSPEASDVSQIHGAFTYPEWDYRRKQYMEDHCRV
CHHHHHHCCHHHHHHCCHHHEEEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHE
LLGTVPAPQQATVATDQAIVRKIRRQFETLRPKREIRKAQLDGNDLDLEALIRARADLLA
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHC
TGQPDDRIYECARPASHELATSILVDVSLSTDSWVDNRRVLDLEKQALDVFARGLDACGD
CCCCHHHHHHHCCCCHHHHHHHHHEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCC
SFSIHTFTSRRRNWVRIDSIKEFEETFSPTTARRIADLKPGYYTRMGAALRHVSGQLHQH
CCEEEEEHHCCCCEEEEHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
GARKKLLLILTDGKPNDVDHYEGRFALEDSRKAVAEARALGQAVFAVTVDRNAGDYLPAI
CCCCEEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHH
FGRAGFAVISELSKLPSALPAIYRNLTA
HCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: nitrous oxide; acceptor; H2O

Specific reaction: nitrous oxide + acceptor + H2O = 2 nitric oxide + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA