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The map label for this gene is fixL

Identifier: 86361238

GI number: 86361238

Start: 573231

End: 575102

Strand: Direct

Name: fixL

Synonym: RHE_PF00509

Alternate gene names: 86361238

Gene position: 573231-575102 (Clockwise)

Preceding gene: 86361237

Following gene: 86361239

Centisome position: 89.22

GC content: 62.23

Gene sequence:

>1872_bases
ATGGTGCACGTGCTCGACGGCGCAGATATCCTGGTTCATCGCTTCGACGGGACGATCACGCACTGGTCGATCGGCTGCGA
GAACATGTATGGCTGGGCAAGAGAGGAAGCCGTCGGCGAAAAGGTCTATGACCTGCTGGCGACGAAGTTTCACGAACCGG
CTGAAAACATCCGCGACCAGCTGAGGTCGCGCGGCTTCTGGCAGGGCGAGATCATTCACCGCCATAAGAGCGGGCACGAG
ATTCATGTCGCGTCCCGCTGCGTGCTGGTCAAACTGCCGGATGGAGAGTTTGCCGTCATCCAGACGAATAGCGACGTCAG
CGCCCTGAGGGGCGCGCAGGAGGCGGTCAAGGCCCGCGAGGCGCACCTCAGTTCGATCCTCGACACCGTACCCGATGCGA
TGGTGGTGATCGACCACAAAGGGACGGTGCTGTCGTTCAGCAAGGCTGCCGAAAAACTGTTCGGAATGCCTTCGGATCAG
ATTTGCGGCCGCAACGTCAGCAACCTGATGCCGAACCCCTACCGCGACGCTCACGACGGCTATATCGACCATTATATCGA
AACCGGCGAGAAGCGCATCATCGGCTATGGGCGCGTTGTCACAGGACAGCGGGCGGACGGCTCGCAATTCCCGATGGAAC
TCCATGTCGGCGAGGCAACGGCGAACGGCGAGCGGATCTTCACAGGTTTCGTCCGCGACTTGACGAGCCGCTTCAAGATC
GAGGAGGACCTTCGTCAGGCACAGAAGATGGAGGCGATCGGACAGCTGACCGGCGGTCTCGCGCATGACTTCAACAACCT
CCTTACCGTCATCAGCGGCAACCTCGAAATGATCGAGGACAAGCTGCCGCCCGGCAGCCTTCGCGATATCCTCAGGGAGG
CGCAGGCCGCCGCGCAGGACGGAGCTATCCTGACGGGCCAGCTGCTGGCATTCGGCCGGCGCCAGCCGTTGAATCCCAAG
CATGCGGATCTCGGGCAGCTCGTCACCGGCTTTGCCGATCTGCTGCGGCGAACACTTGGTGAAGATATCAAGCTGTCGAC
CATTATCGACGGGTCGGACCTCAGCGTTCTGGTCGACAGCTCGCAGCTTCAGAACGCCATCCTGAACATCGCCCTGAACG
CGAGGGATGCCATGCCGAAGGGCGGCAGTCTGACGACGACGATTTCGCGTGTCCATCTCGATGCCGATTATGCAAAAATG
TATCCGGAAGTGCGCAGCGGCAACTTCGTCCTCGTCACCATGACGGATACCGGCATGGGCATGACCGAGGAGGTCAGGAA
GCGGGCGATAGAACCGTTTTTCACAACGAAGGAAGTCGGCTCGGGCACGGGTCTCGGGCTCAGCATGGTCTATGGTTTCG
TCAAGCAATCGGGCGGGCATCTCCAGCTCTACAGCGAGGTGGGACGCGGCACGACGGTTCGGATATATCTGCCGGCCGTC
GCCGGCGCAAAGCCCCGCGAGCCGGCGCCGGATCATGGCGTCGTCGAGAGCCAGCTGCCGCGCGGGGACGAAACGGTGCT
GGTCGTCGAGGATGACGCCCGCGTCCGCCGCGTCGCCGTCGCAAGACTCGCTTCGATGGGCTACACGGTGCTTGAAGCCG
AAAACGGCCGCCGCGCACTCGATCTCCTCAGGGAAAATCCCGACATCGCGCTCCTGTTCACCGACATCGTGATGCCGGGC
GGGATCACCGGCGACGAACTCGCGCGGGAGGTGCGCCTCTTGCGGCCCGACATCGCCGTTCTGTTCACCTCGGGATATTC
CGAGCCGGGCCTTGCGGGCAAGGGTATCGTTCCCGGCGCACAGTGGCTGCGCAAGCCCTACACAGCAAGGGAGCTGGCGT
TGAAGATCCGCGAGCTTCTCGACACGAAGTGA

Upstream 100 bases:

>100_bases
TCATAGGGTCAACCTGCATTGATGCAACAAGCCAGGATCGACGTTCATGCCCCATCGCCTCGTGTCACCGAGAACCGCAT
CGCCGCAGGAGCTGGATGCC

Downstream 100 bases:

>100_bases
GCTCCAGGCTCGCGGCCGTCAGGACCATATTGTCGGGCTGACGTTCGCCAAGGAGCGTCTTTCCGGCCGTTCGCATTGCC
GATGGCTTCCGCCGATTAGG

Product: two-component sensor histidine kinase protein

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MVHVLDGADILVHRFDGTITHWSIGCENMYGWAREEAVGEKVYDLLATKFHEPAENIRDQLRSRGFWQGEIIHRHKSGHE
IHVASRCVLVKLPDGEFAVIQTNSDVSALRGAQEAVKAREAHLSSILDTVPDAMVVIDHKGTVLSFSKAAEKLFGMPSDQ
ICGRNVSNLMPNPYRDAHDGYIDHYIETGEKRIIGYGRVVTGQRADGSQFPMELHVGEATANGERIFTGFVRDLTSRFKI
EEDLRQAQKMEAIGQLTGGLAHDFNNLLTVISGNLEMIEDKLPPGSLRDILREAQAAAQDGAILTGQLLAFGRRQPLNPK
HADLGQLVTGFADLLRRTLGEDIKLSTIIDGSDLSVLVDSSQLQNAILNIALNARDAMPKGGSLTTTISRVHLDADYAKM
YPEVRSGNFVLVTMTDTGMGMTEEVRKRAIEPFFTTKEVGSGTGLGLSMVYGFVKQSGGHLQLYSEVGRGTTVRIYLPAV
AGAKPREPAPDHGVVESQLPRGDETVLVVEDDARVRRVAVARLASMGYTVLEAENGRRALDLLRENPDIALLFTDIVMPG
GITGDELAREVRLLRPDIAVLFTSGYSEPGLAGKGIVPGAQWLRKPYTARELALKIRELLDTK

Sequences:

>Translated_623_residues
MVHVLDGADILVHRFDGTITHWSIGCENMYGWAREEAVGEKVYDLLATKFHEPAENIRDQLRSRGFWQGEIIHRHKSGHE
IHVASRCVLVKLPDGEFAVIQTNSDVSALRGAQEAVKAREAHLSSILDTVPDAMVVIDHKGTVLSFSKAAEKLFGMPSDQ
ICGRNVSNLMPNPYRDAHDGYIDHYIETGEKRIIGYGRVVTGQRADGSQFPMELHVGEATANGERIFTGFVRDLTSRFKI
EEDLRQAQKMEAIGQLTGGLAHDFNNLLTVISGNLEMIEDKLPPGSLRDILREAQAAAQDGAILTGQLLAFGRRQPLNPK
HADLGQLVTGFADLLRRTLGEDIKLSTIIDGSDLSVLVDSSQLQNAILNIALNARDAMPKGGSLTTTISRVHLDADYAKM
YPEVRSGNFVLVTMTDTGMGMTEEVRKRAIEPFFTTKEVGSGTGLGLSMVYGFVKQSGGHLQLYSEVGRGTTVRIYLPAV
AGAKPREPAPDHGVVESQLPRGDETVLVVEDDARVRRVAVARLASMGYTVLEAENGRRALDLLRENPDIALLFTDIVMPG
GITGDELAREVRLLRPDIAVLFTSGYSEPGLAGKGIVPGAQWLRKPYTARELALKIRELLDTK
>Mature_623_residues
MVHVLDGADILVHRFDGTITHWSIGCENMYGWAREEAVGEKVYDLLATKFHEPAENIRDQLRSRGFWQGEIIHRHKSGHE
IHVASRCVLVKLPDGEFAVIQTNSDVSALRGAQEAVKAREAHLSSILDTVPDAMVVIDHKGTVLSFSKAAEKLFGMPSDQ
ICGRNVSNLMPNPYRDAHDGYIDHYIETGEKRIIGYGRVVTGQRADGSQFPMELHVGEATANGERIFTGFVRDLTSRFKI
EEDLRQAQKMEAIGQLTGGLAHDFNNLLTVISGNLEMIEDKLPPGSLRDILREAQAAAQDGAILTGQLLAFGRRQPLNPK
HADLGQLVTGFADLLRRTLGEDIKLSTIIDGSDLSVLVDSSQLQNAILNIALNARDAMPKGGSLTTTISRVHLDADYAKM
YPEVRSGNFVLVTMTDTGMGMTEEVRKRAIEPFFTTKEVGSGTGLGLSMVYGFVKQSGGHLQLYSEVGRGTTVRIYLPAV
AGAKPREPAPDHGVVESQLPRGDETVLVVEDDARVRRVAVARLASMGYTVLEAENGRRALDLLRENPDIALLFTDIVMPG
GITGDELAREVRLLRPDIAVLFTSGYSEPGLAGKGIVPGAQWLRKPYTARELALKIRELLDTK

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=254, Percent_Identity=27.9527559055118, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788549, Length=367, Percent_Identity=25.3405994550409, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1788713, Length=516, Percent_Identity=23.2558139534884, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081921, Length=112, Percent_Identity=32.1428571428571, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 68228; Mature: 68228

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHVLDGADILVHRFDGTITHWSIGCENMYGWAREEAVGEKVYDLLATKFHEPAENIRDQ
CEEEECCCEEEEEECCCCEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LRSRGFWQGEIIHRHKSGHEIHVASRCVLVKLPDGEFAVIQTNSDVSALRGAQEAVKARE
HHHCCCCCCHHEEECCCCCEEEEECEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHH
AHLSSILDTVPDAMVVIDHKGTVLSFSKAAEKLFGMPSDQICGRNVSNLMPNPYRDAHDG
HHHHHHHHHCCCEEEEEECCCCEEEHHHHHHHHHCCCCHHHCCCCHHHCCCCCCCCCCCC
YIDHYIETGEKRIIGYGRVVTGQRADGSQFPMELHVGEATANGERIFTGFVRDLTSRFKI
HHHHHHHCCCEEEEEECEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCH
EEDLRQAQKMEAIGQLTGGLAHDFNNLLTVISGNLEMIEDKLPPGSLRDILREAQAAAQD
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHCC
GAILTGQLLAFGRRQPLNPKHADLGQLVTGFADLLRRTLGEDIKLSTIIDGSDLSVLVDS
CCEEEHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECC
SQLQNAILNIALNARDAMPKGGSLTTTISRVHLDADYAKMYPEVRSGNFVLVTMTDTGMG
HHHHHHHHHEEECCCCCCCCCCCEEEEEEEEEECCHHHHHCCHHCCCCEEEEEEECCCCC
MTEEVRKRAIEPFFTTKEVGSGTGLGLSMVYGFVKQSGGHLQLYSEVGRGTTVRIYLPAV
CHHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHHHHCCCCCEEEEHHHCCCCEEEEEEEEC
AGAKPREPAPDHGVVESQLPRGDETVLVVEDDARVRRVAVARLASMGYTVLEAENGRRAL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCHHHH
DLLRENPDIALLFTDIVMPGGITGDELAREVRLLRPDIAVLFTSGYSEPGLAGKGIVPGA
HHHHCCCCEEEEEEEHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCH
QWLRKPYTARELALKIRELLDTK
HHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVHVLDGADILVHRFDGTITHWSIGCENMYGWAREEAVGEKVYDLLATKFHEPAENIRDQ
CEEEECCCEEEEEECCCCEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LRSRGFWQGEIIHRHKSGHEIHVASRCVLVKLPDGEFAVIQTNSDVSALRGAQEAVKARE
HHHCCCCCCHHEEECCCCCEEEEECEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHH
AHLSSILDTVPDAMVVIDHKGTVLSFSKAAEKLFGMPSDQICGRNVSNLMPNPYRDAHDG
HHHHHHHHHCCCEEEEEECCCCEEEHHHHHHHHHCCCCHHHCCCCHHHCCCCCCCCCCCC
YIDHYIETGEKRIIGYGRVVTGQRADGSQFPMELHVGEATANGERIFTGFVRDLTSRFKI
HHHHHHHCCCEEEEEECEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCH
EEDLRQAQKMEAIGQLTGGLAHDFNNLLTVISGNLEMIEDKLPPGSLRDILREAQAAAQD
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHCC
GAILTGQLLAFGRRQPLNPKHADLGQLVTGFADLLRRTLGEDIKLSTIIDGSDLSVLVDS
CCEEEHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECC
SQLQNAILNIALNARDAMPKGGSLTTTISRVHLDADYAKMYPEVRSGNFVLVTMTDTGMG
HHHHHHHHHEEECCCCCCCCCCCEEEEEEEEEECCHHHHHCCHHCCCCEEEEEEECCCCC
MTEEVRKRAIEPFFTTKEVGSGTGLGLSMVYGFVKQSGGHLQLYSEVGRGTTVRIYLPAV
CHHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHHHHCCCCCEEEEHHHCCCCEEEEEEEEC
AGAKPREPAPDHGVVESQLPRGDETVLVVEDDARVRRVAVARLASMGYTVLEAENGRRAL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCHHHH
DLLRENPDIALLFTDIVMPGGITGDELAREVRLLRPDIAVLFTSGYSEPGLAGKGIVPGA
HHHHCCCCEEEEEEEHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCH
QWLRKPYTARELALKIRELLDTK
HHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA