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The map label for this gene is proI [H]

Identifier: 86361160

GI number: 86361160

Start: 482866

End: 483648

Strand: Direct

Name: proI [H]

Synonym: RHE_PF00430

Alternate gene names: 86361160

Gene position: 482866-483648 (Clockwise)

Preceding gene: 86361159

Following gene: 86361161

Centisome position: 75.15

GC content: 64.75

Gene sequence:

>783_bases
ATGATCAACAGCATTGGATTCGTCGGCACCGGCGCGATCACCGAAGCGATGGTTCGCGGGCTTCTGGCCGCACCGGCCTA
CGCCTCCGAGATCCACGTATCGCCGCGGAGCGCACACATTGCCGCGACATTGGCCCAGGAGTTCGCCGCCGTCAGGATTG
CCGGGGACAACCAGACTGTCGTCGATCGCAGCGACATGGTGTTCCTGGCGATCCGGCCGCAGATCGCCGAGGAGGTCGTA
CGGGCGCTTTCGTTCAGAACCGGCCAGGTGGTCGTCAGCCTCGTAGCCGCGACCGAGCGCCAGGCTCTTCTCGATTGGAT
CGGCACCGACGTGCACCTCGTCCAGGCCATCCCCCTGCCTTTCGTTGCGCAGCGGCAAGGCGTCACCGCCATCCTCCCGC
CGGATGCCGCCGTCGCGGCGCTGTTCGATACGCTCGGAACCGCCGTCCAGTGCCAGTCGAGAAAGGAATATGATCTGCTC
GCGGCGGCGAGCGCACTGATGTCGACCTATTTCGGCATCATGGAAACCACAGCCGTCTGGCTGGAAAAAAGCGGCCTGGA
AAGGCCGAAAGCAAATGCCTACATCGCGCCGCTTTTCGCAAGCCTGGCGCAGAAGGCCAACAGCCCAGGCACCGAGCCGT
TCAGCGCGCTAAGCCGCGAATTCGCCACCAAGGGCGGATTGAACGAGCAGGTTCTCTCCGACGTTGACAAGAAGGGCGGC
CTCGCTGCGCTGACCGCGGCACTCGACGGTGTGCTCGCCCGCATCGAGGGCCGCAGCGACTGA

Upstream 100 bases:

>100_bases
CATACGCGCCAGTTCCAGGATAATTTCATCAACTTCATGCGCGAGAACTACACGACGGATGTCGCGCTGGGACCGCTGCG
AGCTGCGGAGTAACGACGTG

Downstream 100 bases:

>100_bases
AGCGCATGCACCCTAAGCGAATATCCCTTACCGTCCTTTTCACAGTCGCCGCGATTTTGGGCCAGGCGATTTTAGCCCGC
GCCGAACCGGTGGAGCGACC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase 2; P5CR 2 [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MINSIGFVGTGAITEAMVRGLLAAPAYASEIHVSPRSAHIAATLAQEFAAVRIAGDNQTVVDRSDMVFLAIRPQIAEEVV
RALSFRTGQVVVSLVAATERQALLDWIGTDVHLVQAIPLPFVAQRQGVTAILPPDAAVAALFDTLGTAVQCQSRKEYDLL
AAASALMSTYFGIMETTAVWLEKSGLERPKANAYIAPLFASLAQKANSPGTEPFSALSREFATKGGLNEQVLSDVDKKGG
LAALTAALDGVLARIEGRSD

Sequences:

>Translated_260_residues
MINSIGFVGTGAITEAMVRGLLAAPAYASEIHVSPRSAHIAATLAQEFAAVRIAGDNQTVVDRSDMVFLAIRPQIAEEVV
RALSFRTGQVVVSLVAATERQALLDWIGTDVHLVQAIPLPFVAQRQGVTAILPPDAAVAALFDTLGTAVQCQSRKEYDLL
AAASALMSTYFGIMETTAVWLEKSGLERPKANAYIAPLFASLAQKANSPGTEPFSALSREFATKGGLNEQVLSDVDKKGG
LAALTAALDGVLARIEGRSD
>Mature_260_residues
MINSIGFVGTGAITEAMVRGLLAAPAYASEIHVSPRSAHIAATLAQEFAAVRIAGDNQTVVDRSDMVFLAIRPQIAEEVV
RALSFRTGQVVVSLVAATERQALLDWIGTDVHLVQAIPLPFVAQRQGVTAILPPDAAVAALFDTLGTAVQCQSRKEYDLL
AAASALMSTYFGIMETTAVWLEKSGLERPKANAYIAPLFASLAQKANSPGTEPFSALSREFATKGGLNEQVLSDVDKKGG
LAALTAALDGVLARIEGRSD

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27378; Mature: 27378

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSIGFVGTGAITEAMVRGLLAAPAYASEIHVSPRSAHIAATLAQEFAAVRIAGDNQTV
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHEECCCCHHHHHHHHHHHHHEEEECCCCCEE
VDRSDMVFLAIRPQIAEEVVRALSFRTGQVVVSLVAATERQALLDWIGTDVHLVQAIPLP
EECCCEEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCCCC
FVAQRQGVTAILPPDAAVAALFDTLGTAVQCQSRKEYDLLAAASALMSTYFGIMETTAVW
HHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEKSGLERPKANAYIAPLFASLAQKANSPGTEPFSALSREFATKGGLNEQVLSDVDKKGG
HHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCC
LAALTAALDGVLARIEGRSD
HHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MINSIGFVGTGAITEAMVRGLLAAPAYASEIHVSPRSAHIAATLAQEFAAVRIAGDNQTV
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHEECCCCHHHHHHHHHHHHHEEEECCCCCEE
VDRSDMVFLAIRPQIAEEVVRALSFRTGQVVVSLVAATERQALLDWIGTDVHLVQAIPLP
EECCCEEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCCCC
FVAQRQGVTAILPPDAAVAALFDTLGTAVQCQSRKEYDLLAAASALMSTYFGIMETTAVW
HHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEKSGLERPKANAYIAPLFASLAQKANSPGTEPFSALSREFATKGGLNEQVLSDVDKKGG
HHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCC
LAALTAALDGVLARIEGRSD
HHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 11418582 [H]