Click here to switch to the map view.

The map label for this gene is etfAf

Identifier: 86361134

GI number: 86361134

Start: 456632

End: 457561

Strand: Reverse

Name: etfAf

Synonym: RHE_PF00404

Alternate gene names: 86361134

Gene position: 457561-456632 (Counterclockwise)

Preceding gene: 86361135

Following gene: 86361133

Centisome position: 71.21

GC content: 66.24

Gene sequence:

>930_bases
ATGACCATTCTTCTTCTGGCCGACCATGACGGCAATCATCTCTCCGACCAGACCGCCAAGGCGCTGACGGCAGCCTCGCA
GATCGGCTCCGATGTGCATGTGCTGGTTGCCGGCAAGGGCGCCAGGGCTGCGGCCGATCAGGCGGCAAAACTCTCCGGCG
TCTCCAAGGTGCTGCTGGCCGAAAGCGAGGCGCTTGCCAACAATCTCGCCGAGCCGCTGGCCGACCTGATCGTCTCGCTC
GCCGGCTCCTACGACACCATCGTCTCGGCCGCCACCTCGGTCGGCAAGACGGTGCTGCCGCGCGTCGCCGCCCTGCTCGA
TGTCGCCCAGGTCTCGGAGATCATCGAAGTCGTCAGCCCCGATACCTTCAAGCGGCCGATCTATGCCGGCAACGCCATCC
AGACGGTGCAGGCCAGCGACGCCAAGAAGGTGATCACCGTGCGAACCGCCTCGTTTGCCTCTGCGGCTGAAGGCGGCTCT
GCCTCTGTCGAGGCGATCCCGGCCGTCTCCGATCCGGGTCTGTCGCGGTTCGTCTCCGATGCGCTGTCGGCGTCGGAACG
TCCGGAACTGACCTCGGCCAAGGTCATCATCTCCGGCGGCCGGGCGCTCGGCTCGGCCGAGAAGTTCAGGGAGGTCATCC
TGCCGGTTGCCGACAAGCTCGGTGCCGCCGTCGGCGCCAGCCGTGCGGCCGTCGATGCCGGTTATGCCCCGAACGACTGG
CAGGTCGGCCAGACCGGCAAAGTGGTGGCGCCCGACCTCTATATCGCCTGCGGCATCTCCGGCGCCATCCAGCATCTGGC
CGGCATGAAGGATTCGAAGGTGATCGTCGCCATCAACAAGGATGAGGAGGCGCCGATCTTCCAGGTCGCCGACTATGGCC
TCGTCGCCGACCTCTTCGACGCCCTGCCGGAACTGCAAAAGGCGCTCTGA

Upstream 100 bases:

>100_bases
CGCAAGGCCGGCGTCAAGGTCAAGTCGGTCGCCGAACTGGTCGACAAGCTGAAGAACGAAGCCGGCGTGCTGTAATCGGG
TTGGAACAGGAGCAACTATC

Downstream 100 bases:

>100_bases
GCGAGGAGACCAAACGTGGCGCGTGGGGTGGGACGTCCAATCAGACCTGGTGCCGACCTTCTCCTGAACGATGAGGAAAA
GCCGGCCTATATCAGGCTGC

Product: electron-transport flavoprotein, alpha-subunit

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTILLLADHDGNHLSDQTAKALTAASQIGSDVHVLVAGKGARAAADQAAKLSGVSKVLLAESEALANNLAEPLADLIVSL
AGSYDTIVSAATSVGKTVLPRVAALLDVAQVSEIIEVVSPDTFKRPIYAGNAIQTVQASDAKKVITVRTASFASAAEGGS
ASVEAIPAVSDPGLSRFVSDALSASERPELTSAKVIISGGRALGSAEKFREVILPVADKLGAAVGASRAAVDAGYAPNDW
QVGQTGKVVAPDLYIACGISGAIQHLAGMKDSKVIVAINKDEEAPIFQVADYGLVADLFDALPELQKAL

Sequences:

>Translated_309_residues
MTILLLADHDGNHLSDQTAKALTAASQIGSDVHVLVAGKGARAAADQAAKLSGVSKVLLAESEALANNLAEPLADLIVSL
AGSYDTIVSAATSVGKTVLPRVAALLDVAQVSEIIEVVSPDTFKRPIYAGNAIQTVQASDAKKVITVRTASFASAAEGGS
ASVEAIPAVSDPGLSRFVSDALSASERPELTSAKVIISGGRALGSAEKFREVILPVADKLGAAVGASRAAVDAGYAPNDW
QVGQTGKVVAPDLYIACGISGAIQHLAGMKDSKVIVAINKDEEAPIFQVADYGLVADLFDALPELQKAL
>Mature_308_residues
TILLLADHDGNHLSDQTAKALTAASQIGSDVHVLVAGKGARAAADQAAKLSGVSKVLLAESEALANNLAEPLADLIVSLA
GSYDTIVSAATSVGKTVLPRVAALLDVAQVSEIIEVVSPDTFKRPIYAGNAIQTVQASDAKKVITVRTASFASAAEGGSA
SVEAIPAVSDPGLSRFVSDALSASERPELTSAKVIISGGRALGSAEKFREVILPVADKLGAAVGASRAAVDAGYAPNDWQ
VGQTGKVVAPDLYIACGISGAIQHLAGMKDSKVIVAINKDEEAPIFQVADYGLVADLFDALPELQKAL

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=311, Percent_Identity=53.3762057877814, Blast_Score=308, Evalue=5e-84,
Organism=Homo sapiens, GI189181759, Length=275, Percent_Identity=56.3636363636364, Blast_Score=287, Evalue=7e-78,
Organism=Escherichia coli, GI1786226, Length=199, Percent_Identity=35.678391959799, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787990, Length=301, Percent_Identity=29.5681063122924, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87082157, Length=220, Percent_Identity=30.4545454545455, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17506929, Length=311, Percent_Identity=55.3054662379421, Blast_Score=324, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6325261, Length=291, Percent_Identity=47.0790378006873, Blast_Score=253, Evalue=3e-68,
Organism=Drosophila melanogaster, GI17136898, Length=313, Percent_Identity=57.1884984025559, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24652801, Length=313, Percent_Identity=57.1884984025559, Blast_Score=319, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 31490; Mature: 31359

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILLLADHDGNHLSDQTAKALTAASQIGSDVHVLVAGKGARAAADQAAKLSGVSKVLLA
CEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ESEALANNLAEPLADLIVSLAGSYDTIVSAATSVGKTVLPRVAALLDVAQVSEIIEVVSP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DTFKRPIYAGNAIQTVQASDAKKVITVRTASFASAAEGGSASVEAIPAVSDPGLSRFVSD
CCCCCCEECCCCEEEEECCCCCEEEEEEECHHHHHCCCCCCCEEEECCCCCCHHHHHHHH
ALSASERPELTSAKVIISGGRALGSAEKFREVILPVADKLGAAVGASRAAVDAGYAPNDW
HHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
QVGQTGKVVAPDLYIACGISGAIQHLAGMKDSKVIVAINKDEEAPIFQVADYGLVADLFD
CCCCCCCEECCCEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCHHHHHHHH
ALPELQKAL
HHHHHHHCC
>Mature Secondary Structure 
TILLLADHDGNHLSDQTAKALTAASQIGSDVHVLVAGKGARAAADQAAKLSGVSKVLLA
EEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ESEALANNLAEPLADLIVSLAGSYDTIVSAATSVGKTVLPRVAALLDVAQVSEIIEVVSP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DTFKRPIYAGNAIQTVQASDAKKVITVRTASFASAAEGGSASVEAIPAVSDPGLSRFVSD
CCCCCCEECCCCEEEEECCCCCEEEEEEECHHHHHCCCCCCCEEEECCCCCCHHHHHHHH
ALSASERPELTSAKVIISGGRALGSAEKFREVILPVADKLGAAVGASRAAVDAGYAPNDW
HHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
QVGQTGKVVAPDLYIACGISGAIQHLAGMKDSKVIVAINKDEEAPIFQVADYGLVADLFD
CCCCCCCEECCCEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCHHHHHHHH
ALPELQKAL
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8599534; 12597275 [H]