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The map label for this gene is guaA

Identifier: 85860898

GI number: 85860898

Start: 3068649

End: 3070181

Strand: Direct

Name: guaA

Synonym: SYN_01626

Alternate gene names: 85860898

Gene position: 3068649-3070181 (Clockwise)

Preceding gene: 85860897

Following gene: 85860899

Centisome position: 96.52

GC content: 57.99

Gene sequence:

>1533_bases
TTGATTCTTATTATTGATTTCGGTTCTCAATACAACCAGCTGATCGCCCGGCGCGTGCGGGAGCTGGAGGTGTACTGCCA
GATTGAACCCCCGGAAATTGCGCTGGAAACGATCAAGGCTCTGCAGCCGGAAGGGATTATTCTCTCCGGAGGTCCGGCGA
GCATCTACGAACCCAAAAGTCCGAAGGTGGACAAGGGGATTTTCGACTTGAACATCCCGATCCTGGGCATCTGTTACGGC
CTGCAGTACATGGTTGACTCCCTGGGTGGCAAAGTGATCCGGTCGGCAAAGCGGGAATACGGGTTTGCCCAGCTCCACAT
TGTTCGGGAGGGAAAGGGAATCTTTGCGGGGGTAACGGAAAACACCCGCTGCTGGATGAGTCATGGCGATACGATCGACC
AGTTGCCCGCAGGCTTCGCGATCACGGCCTCTACGGCCAATACCCCCGCCGCGGCGATGGAAGATCCGGTTCGGCGGCTT
TACGGCCTGCAGTTCCACCCCGAAGTGGTTCATACGCCGGAAGGGAAAAAGATGCTGGAAAATTTCCTCTTTTCCGTCTG
CGGCTGCCGGAAGAGCTGGACCATGGCGTCCTTCATCCGGGATTCCGTGGAAGAGATCCGGTCAACCGTTGGAGACCGGA
AGGTCGTCCTTGGTCTGAGCGGCGGCGTGGATTCTTCCGTGGCGGCGCTGCTTCTTCATCAGGCCATCGGCAATCAGTTG
ACCTGTGTTTTTGTCGATAACGGCCTCCTGCGGCAGGGAGAGGCGGAAAAGGTCCGATCGCTCTTCAAACAGCATTTTCA
CATGAATGTCCGCTTCGCCCGGGCCAAGGCCCAGTTTCTCGATGCCCTGAAAGGCATCGTGGATCCTGAACGGAAGCGCA
AGATCATTGGCCGAGTCTTTGTCGAAGTCTTTGATCAGGAAGCGCGAAAAATCCGGGATGTGGATTATCTGGCACAGGGG
ACCCTCTATCCCGACGTGATCGAATCCCGTTCCGCCTTCGGCGGTCCAAGTGCGGTGATCAAGTCCCACCATAACGTGGG
CGGACTCCCCCGGCGGATGAAACTGAAGCTGATCGAGCCGCTGAAACACCTTTTCAAGGATGAGGTGCGCCTCCTCGGCA
GGGAGCTGGGACTCTCCGACGACATGATCTGGCGGCACCCCTTCCCCGGCCCCGGTCTGGGCATCCGGATCATCGGCGAG
GTGACGGACAAACGGCTGTCCCTCCTCCGCAAGGCCGATGCCATCCTGCTGGAGGAGATCAAGGCCGCCGATTACTATGG
CCGGCTCTGGCAGTCATTCGTCGTCCTGCTTCCCCTGAAAAGCGTCGGGATTATGGGCGATCAGCGAACCTATGAACATA
TCGCGGCCATCCGGGCCGTCACCAGCGATGACGCCATGACGGCGGACTGGGCGCGGCTTCCTCATGATCTGCTGGGAAAG
ATTGCCAATCGGATCATCAACGAGGTCCGGGGAATCAATCGCGTGGTCTACGATATCAGCTCCAAACCACCCAGCACGAT
TGAATGGGAATAA

Upstream 100 bases:

>100_bases
CGCAGGATGCATCCTATCTTTTCAAACAGTTTGTAAAACTAATCACATCAGAGAAGGGAAACAAGCTTAGGACCCCTTCC
TGAGACATGAGAGGCTTATC

Downstream 100 bases:

>100_bases
AGAAGATATTTTATGCCGAAGCGGAAAGACCTTAAGAAGATCCTGATTATCGGCTCGGGACCGATTATCATCAGCCAGGC
ATGCGAATTCGACTATTCCG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MILIIDFGSQYNQLIARRVRELEVYCQIEPPEIALETIKALQPEGIILSGGPASIYEPKSPKVDKGIFDLNIPILGICYG
LQYMVDSLGGKVIRSAKREYGFAQLHIVREGKGIFAGVTENTRCWMSHGDTIDQLPAGFAITASTANTPAAAMEDPVRRL
YGLQFHPEVVHTPEGKKMLENFLFSVCGCRKSWTMASFIRDSVEEIRSTVGDRKVVLGLSGGVDSSVAALLLHQAIGNQL
TCVFVDNGLLRQGEAEKVRSLFKQHFHMNVRFARAKAQFLDALKGIVDPERKRKIIGRVFVEVFDQEARKIRDVDYLAQG
TLYPDVIESRSAFGGPSAVIKSHHNVGGLPRRMKLKLIEPLKHLFKDEVRLLGRELGLSDDMIWRHPFPGPGLGIRIIGE
VTDKRLSLLRKADAILLEEIKAADYYGRLWQSFVVLLPLKSVGIMGDQRTYEHIAAIRAVTSDDAMTADWARLPHDLLGK
IANRIINEVRGINRVVYDISSKPPSTIEWE

Sequences:

>Translated_510_residues
MILIIDFGSQYNQLIARRVRELEVYCQIEPPEIALETIKALQPEGIILSGGPASIYEPKSPKVDKGIFDLNIPILGICYG
LQYMVDSLGGKVIRSAKREYGFAQLHIVREGKGIFAGVTENTRCWMSHGDTIDQLPAGFAITASTANTPAAAMEDPVRRL
YGLQFHPEVVHTPEGKKMLENFLFSVCGCRKSWTMASFIRDSVEEIRSTVGDRKVVLGLSGGVDSSVAALLLHQAIGNQL
TCVFVDNGLLRQGEAEKVRSLFKQHFHMNVRFARAKAQFLDALKGIVDPERKRKIIGRVFVEVFDQEARKIRDVDYLAQG
TLYPDVIESRSAFGGPSAVIKSHHNVGGLPRRMKLKLIEPLKHLFKDEVRLLGRELGLSDDMIWRHPFPGPGLGIRIIGE
VTDKRLSLLRKADAILLEEIKAADYYGRLWQSFVVLLPLKSVGIMGDQRTYEHIAAIRAVTSDDAMTADWARLPHDLLGK
IANRIINEVRGINRVVYDISSKPPSTIEWE
>Mature_510_residues
MILIIDFGSQYNQLIARRVRELEVYCQIEPPEIALETIKALQPEGIILSGGPASIYEPKSPKVDKGIFDLNIPILGICYG
LQYMVDSLGGKVIRSAKREYGFAQLHIVREGKGIFAGVTENTRCWMSHGDTIDQLPAGFAITASTANTPAAAMEDPVRRL
YGLQFHPEVVHTPEGKKMLENFLFSVCGCRKSWTMASFIRDSVEEIRSTVGDRKVVLGLSGGVDSSVAALLLHQAIGNQL
TCVFVDNGLLRQGEAEKVRSLFKQHFHMNVRFARAKAQFLDALKGIVDPERKRKIIGRVFVEVFDQEARKIRDVDYLAQG
TLYPDVIESRSAFGGPSAVIKSHHNVGGLPRRMKLKLIEPLKHLFKDEVRLLGRELGLSDDMIWRHPFPGPGLGIRIIGE
VTDKRLSLLRKADAILLEEIKAADYYGRLWQSFVVLLPLKSVGIMGDQRTYEHIAAIRAVTSDDAMTADWARLPHDLLGK
IANRIINEVRGINRVVYDISSKPPSTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=549, Percent_Identity=36.976320582878, Blast_Score=304, Evalue=1e-82,
Organism=Escherichia coli, GI1788854, Length=516, Percent_Identity=56.3953488372093, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1789760, Length=189, Percent_Identity=30.6878306878307, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787517, Length=186, Percent_Identity=27.9569892473118, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=567, Percent_Identity=36.68430335097, Blast_Score=317, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI133901714, Length=567, Percent_Identity=36.68430335097, Blast_Score=316, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI71992710, Length=567, Percent_Identity=36.68430335097, Blast_Score=316, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6323873, Length=515, Percent_Identity=50.2912621359223, Blast_Score=544, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6322638, Length=161, Percent_Identity=34.1614906832298, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281365319, Length=544, Percent_Identity=36.5808823529412, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56961; Mature: 56961

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIIDFGSQYNQLIARRVRELEVYCQIEPPEIALETIKALQPEGIILSGGPASIYEPKS
CEEEEECCCHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHCCCCCEEEECCCCCCCCCCC
PKVDKGIFDLNIPILGICYGLQYMVDSLGGKVIRSAKREYGFAQLHIVREGKGIFAGVTE
CCCCCCEEEECCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEEEEEECCCCEEEECCC
NTRCWMSHGDTIDQLPAGFAITASTANTPAAAMEDPVRRLYGLQFHPEVVHTPEGKKMLE
CCEEEECCCCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEECCCHHHHHH
NFLFSVCGCRKSWTMASFIRDSVEEIRSTVGDRKVVLGLSGGVDSSVAALLLHQAIGNQL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCE
TCVFVDNGLLRQGEAEKVRSLFKQHFHMNVRFARAKAQFLDALKGIVDPERKRKIIGRVF
EEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VEVFDQEARKIRDVDYLAQGTLYPDVIESRSAFGGPSAVIKSHHNVGGLPRRMKLKLIEP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHH
LKHLFKDEVRLLGRELGLSDDMIWRHPFPGPGLGIRIIGEVTDKRLSLLRKADAILLEEI
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
KAADYYGRLWQSFVVLLPLKSVGIMGDQRTYEHIAAIRAVTSDDAMTADWARLPHDLLGK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHH
IANRIINEVRGINRVVYDISSKPPSTIEWE
HHHHHHHHHHHHHHHEEECCCCCCCCCCCC
>Mature Secondary Structure
MILIIDFGSQYNQLIARRVRELEVYCQIEPPEIALETIKALQPEGIILSGGPASIYEPKS
CEEEEECCCHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHCCCCCEEEECCCCCCCCCCC
PKVDKGIFDLNIPILGICYGLQYMVDSLGGKVIRSAKREYGFAQLHIVREGKGIFAGVTE
CCCCCCEEEECCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEEEEEECCCCEEEECCC
NTRCWMSHGDTIDQLPAGFAITASTANTPAAAMEDPVRRLYGLQFHPEVVHTPEGKKMLE
CCEEEECCCCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEECCCHHHHHH
NFLFSVCGCRKSWTMASFIRDSVEEIRSTVGDRKVVLGLSGGVDSSVAALLLHQAIGNQL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCE
TCVFVDNGLLRQGEAEKVRSLFKQHFHMNVRFARAKAQFLDALKGIVDPERKRKIIGRVF
EEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VEVFDQEARKIRDVDYLAQGTLYPDVIESRSAFGGPSAVIKSHHNVGGLPRRMKLKLIEP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHH
LKHLFKDEVRLLGRELGLSDDMIWRHPFPGPGLGIRIIGEVTDKRLSLLRKADAILLEEI
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
KAADYYGRLWQSFVVLLPLKSVGIMGDQRTYEHIAAIRAVTSDDAMTADWARLPHDLLGK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHH
IANRIINEVRGINRVVYDISSKPPSTIEWE
HHHHHHHHHHHHHHHEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA