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The map label for this gene is fabB [H]

Identifier: 85860834

GI number: 85860834

Start: 3000011

End: 3001288

Strand: Direct

Name: fabB [H]

Synonym: SYN_01694

Alternate gene names: 85860834

Gene position: 3000011-3001288 (Clockwise)

Preceding gene: 85860833

Following gene: 85860835

Centisome position: 94.36

GC content: 54.3

Gene sequence:

>1278_bases
ATGAAGCATAGAGTCGTTATTACAGGCATGGGTGTTGTGGCACCCAACGGTCATGGATTGCAGGAATTTGAAGCGGCCCT
TCGCGAGGGTCGGTCAGGCATCCGCTTTATTCAAGAGCTGAAGGATCTCAATTTCGCCTGTCAGGTAGGCGGCGTGCCTC
AAGGTGTTGAAGCGATTCGCGAACGTTATTTTTTACCCGAACAGCTTGTTTCAATGAATGAGAACATCGGTTACGCGGCG
ATTTCCGCCGTTGACGCCTGGAAGGATGCCGGGTTTACCGTACCTCCTTTCGACTCCGATGAGGTGGATTGGGATTCAGG
CATAATCGTGGGTTCCGGAATTGGAGGAATGGATACGATTGCCAATATCGTGGTTCCCATGGTCACTTCCGGTAAAGTGA
AACGGATGGGCAGCAGCATTGTCGAACAGGTCATGAACAGCGGAACCAGCGCACGCGTCGGCGGACTGCTGGCCCTCGGA
AACCAGGTGACCTCCAACTCCTCGGCATGCAGCACCGGAAATGAAGCCATATTTGAAGGCATGATGCGGATCCGGTTGGG
ATTAGCCAAGCGGATGCTTGCCGGCGGATGTGAGGGCTCATCACCATTCATCTGGGCGGGTTTTGACGCGATGAAAGTGC
TTGCCCGGAAATATAACGATTGTCCCGAAGAAGCATCCCGCCCCCTGAGCGGATCAGCGGCCGGATTTATTCCCGGCGCC
GGTGGGGCTCTTCTTCTTCTGGAGGATCTTGAAACAGCGCAAGCCAGGGGCGCCCGTATTTATGCGGAACTCCTCGGAGG
AAACGTCAACTGCGGCGGTCACCGGATGGGAGGGTCCATGACCGCTCCCAATCCGGAAGGAGTCAAACGATGCGTCCGCT
CAGCCATTGCCGATGCAGGCATTTCTTCAATGGACGTCGATGCGATTAATGGCCACCTGACGGCAACATTCGCTGATCCC
TACGAGGTCAGGAACTGGGCCGGGGCACTGGATCGGGAGCCGGATAATTTTCCCTATATCAATTCAACCAAATCCATGAT
CGGTCATTGTCTCGGTGCAGCAGGAGCCGTCGAGTGCGTTGCGGTTGTTCTGCAGCTCCATAAAGGGTTTCTCCATCCCT
CCGTGAACTGCACGGATGTTCATCCGGAGATTGAGTCATTCTCCAAGAGTATTCCGCATCAGGCCCTGGAATGTCCTGAT
GTGAAGATTATCGCCAAAGCCGGCTTCGGGTTCGGCGATGTTAACAGTTGCTTGATTTTCAAGAAATGGGAAGAGTAA

Upstream 100 bases:

>100_bases
TATTTCCGGAGGGGAAGCCTGAAAACAAGGGTGAGTATGGAACGGGAAAATGGTGAGAATATCTGTTTTGGTGTATTAGC
CGGGGCGGGGGTCATGTTAA

Downstream 100 bases:

>100_bases
AATCAAATTATTTATTAAGGAATAAAGGAGCATAAAAAATGGACGAAAAAAAGATTTTTGATGAGTTGATCAACATCCTG
AGGCTTTACGCCAAGGATCC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKHRVVITGMGVVAPNGHGLQEFEAALREGRSGIRFIQELKDLNFACQVGGVPQGVEAIRERYFLPEQLVSMNENIGYAA
ISAVDAWKDAGFTVPPFDSDEVDWDSGIIVGSGIGGMDTIANIVVPMVTSGKVKRMGSSIVEQVMNSGTSARVGGLLALG
NQVTSNSSACSTGNEAIFEGMMRIRLGLAKRMLAGGCEGSSPFIWAGFDAMKVLARKYNDCPEEASRPLSGSAAGFIPGA
GGALLLLEDLETAQARGARIYAELLGGNVNCGGHRMGGSMTAPNPEGVKRCVRSAIADAGISSMDVDAINGHLTATFADP
YEVRNWAGALDREPDNFPYINSTKSMIGHCLGAAGAVECVAVVLQLHKGFLHPSVNCTDVHPEIESFSKSIPHQALECPD
VKIIAKAGFGFGDVNSCLIFKKWEE

Sequences:

>Translated_425_residues
MKHRVVITGMGVVAPNGHGLQEFEAALREGRSGIRFIQELKDLNFACQVGGVPQGVEAIRERYFLPEQLVSMNENIGYAA
ISAVDAWKDAGFTVPPFDSDEVDWDSGIIVGSGIGGMDTIANIVVPMVTSGKVKRMGSSIVEQVMNSGTSARVGGLLALG
NQVTSNSSACSTGNEAIFEGMMRIRLGLAKRMLAGGCEGSSPFIWAGFDAMKVLARKYNDCPEEASRPLSGSAAGFIPGA
GGALLLLEDLETAQARGARIYAELLGGNVNCGGHRMGGSMTAPNPEGVKRCVRSAIADAGISSMDVDAINGHLTATFADP
YEVRNWAGALDREPDNFPYINSTKSMIGHCLGAAGAVECVAVVLQLHKGFLHPSVNCTDVHPEIESFSKSIPHQALECPD
VKIIAKAGFGFGDVNSCLIFKKWEE
>Mature_425_residues
MKHRVVITGMGVVAPNGHGLQEFEAALREGRSGIRFIQELKDLNFACQVGGVPQGVEAIRERYFLPEQLVSMNENIGYAA
ISAVDAWKDAGFTVPPFDSDEVDWDSGIIVGSGIGGMDTIANIVVPMVTSGKVKRMGSSIVEQVMNSGTSARVGGLLALG
NQVTSNSSACSTGNEAIFEGMMRIRLGLAKRMLAGGCEGSSPFIWAGFDAMKVLARKYNDCPEEASRPLSGSAAGFIPGA
GGALLLLEDLETAQARGARIYAELLGGNVNCGGHRMGGSMTAPNPEGVKRCVRSAIADAGISSMDVDAINGHLTATFADP
YEVRNWAGALDREPDNFPYINSTKSMIGHCLGAAGAVECVAVVLQLHKGFLHPSVNCTDVHPEIESFSKSIPHQALECPD
VKIIAKAGFGFGDVNSCLIFKKWEE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=429, Percent_Identity=31.002331002331, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI223972627, Length=163, Percent_Identity=31.9018404907975, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788663, Length=424, Percent_Identity=34.1981132075472, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1787337, Length=425, Percent_Identity=28.9411764705882, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71983541, Length=426, Percent_Identity=30.0469483568075, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=33.2075471698113, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320904, Length=453, Percent_Identity=30.0220750551876, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24644341, Length=432, Percent_Identity=30.5555555555556, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 44911; Mature: 44911

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHRVVITGMGVVAPNGHGLQEFEAALREGRSGIRFIQELKDLNFACQVGGVPQGVEAIR
CCCEEEEEECEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHH
ERYFLPEQLVSMNENIGYAAISAVDAWKDAGFTVPPFDSDEVDWDSGIIVGSGIGGMDTI
HHCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHH
ANIVVPMVTSGKVKRMGSSIVEQVMNSGTSARVGGLLALGNQVTSNSSACSTGNEAIFEG
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHCHHHEECCCCCCCCCCCCCCCHHHHHH
MMRIRLGLAKRMLAGGCEGSSPFIWAGFDAMKVLARKYNDCPEEASRPLSGSAAGFIPGA
HHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCC
GGALLLLEDLETAQARGARIYAELLGGNVNCGGHRMGGSMTAPNPEGVKRCVRSAIADAG
CCCEEEEEHHHHHHHCCCEEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
ISSMDVDAINGHLTATFADPYEVRNWAGALDREPDNFPYINSTKSMIGHCLGAAGAVECV
CCCCCHHCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
AVVLQLHKGFLHPSVNCTDVHPEIESFSKSIPHQALECPDVKIIAKAGFGFGDVNSCLIF
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCEEEEEECCCCCCCCCCEEEE
KKWEE
EECCC
>Mature Secondary Structure
MKHRVVITGMGVVAPNGHGLQEFEAALREGRSGIRFIQELKDLNFACQVGGVPQGVEAIR
CCCEEEEEECEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHH
ERYFLPEQLVSMNENIGYAAISAVDAWKDAGFTVPPFDSDEVDWDSGIIVGSGIGGMDTI
HHCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHH
ANIVVPMVTSGKVKRMGSSIVEQVMNSGTSARVGGLLALGNQVTSNSSACSTGNEAIFEG
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHCHHHEECCCCCCCCCCCCCCCHHHHHH
MMRIRLGLAKRMLAGGCEGSSPFIWAGFDAMKVLARKYNDCPEEASRPLSGSAAGFIPGA
HHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCC
GGALLLLEDLETAQARGARIYAELLGGNVNCGGHRMGGSMTAPNPEGVKRCVRSAIADAG
CCCEEEEEHHHHHHHCCCEEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
ISSMDVDAINGHLTATFADPYEVRNWAGALDREPDNFPYINSTKSMIGHCLGAAGAVECV
CCCCCHHCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
AVVLQLHKGFLHPSVNCTDVHPEIESFSKSIPHQALECPDVKIIAKAGFGFGDVNSCLIF
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCEEEEEECCCCCCCCCCEEEE
KKWEE
EECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]