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The map label for this gene is degP [H]

Identifier: 85860823

GI number: 85860823

Start: 2988630

End: 2990114

Strand: Direct

Name: degP [H]

Synonym: SYN_01706

Alternate gene names: 85860823

Gene position: 2988630-2990114 (Clockwise)

Preceding gene: 85860822

Following gene: 85860825

Centisome position: 94.0

GC content: 51.92

Gene sequence:

>1485_bases
ATGAAAAAGGAAAGTAAGAACAGAAATACGTTCATTATGTTTCTGTTAGCTTTTCTCGTAGCATTTTTTGTCGTATCCGT
GATTGAAGTCCTGCGTTCCTCCTTTGCACCGGTTGCGCCCGATGTCCAGGTCGCATCGGCGATATCTCCCATAGACCCGA
GAACTCCCGGATCCTTTGCGGACTTGGTCGACCGTTTAAAACCGGCTGTCGTGAATATCAGCACCACCAAGACCATCCGC
TCCGGATCCAATCCTTTTTCCTCGCCTTTCAGCGGCGAAGGATCGCCTTTTGAACGGTATTTCTGGGGGGATGAATTCTT
TGACCGGTTCTTTGGCGATGTTCCCAAGCGTGAGTTCAAGAAGAAAAGCCTCGGGTCCGGTTTCATCATCAGTCATGACG
GTTACATTTTCACCAATAACCATGTCGTGGAGCAGGCAGACAAGATTCTGGTGAAGCTTTCGGACGGCAAGGAATTCGAG
GCGCGCGTCATCGGAAAAGATGCCAAGACAGACATCGCCCTGATCAAGATCAAGCCAACTGTCAGTTTGCCCGTTGTTGA
AATAGGCGATTCCGATAAGTTGCGGGTGGGGGAATGGGTCCTGGCGATCGGCAATCCTTTCGGACTCGAGCAGACAGTCA
CGGCTGGAATTGTCAGTGCGAAAGGTCGGGTGATCGGCGCGGGCCCCTATGATAATTTCATTCAGACGGATGCCTCCATC
AATCCGGGAAACAGCGGCGGCCCTCTGTTCAGCATGGATGGACAAGTCATCGGGATTAATACCGCCATTGTCGCCCAGGG
ACAGGGGATCGGATTTGCAATCCCTGTAAATATGGCCAAAAATATTCTGCCCGACCTGAAAACAAAGGGAAAGGTTTCAC
GCGGCTGGCTTGGGGTTTCCGTTCAGGACATCACCGAGGATATCGCCAAGAGCATGAAGCAGAAAGACAGGCAGGGCGCC
CTGGTGGCTGAGGTTTTCAAAGGCGATCCGGCCAGCAACGCGGGAATCAAGCCGGGGGATATCATTACGGAAATCAACGG
CAAGACAGTCATCAACTCGCACGAACTGCTGCTGATGATTGCCAACTTTCACGTGGGGGATCGCATCAATATCACATTAC
TGCGAGGCAACCGCCCCATGAACGTGAATGTTCTCGTTGCGGAGCGAACAGACCGCGGCGAGTATGCGGCAAGAAAAACC
TCCCGGGATGATTACGGCATGGTGGTGCACGACATCACGCCTGAGATCGCACAATATCTGGGATTGTCCAGTCGTACGGG
AGTGATCGTGACGGACGTTCGCGAGGGAAGTCCAGCTGATGATGTGGGCATTCAACCCCAGGATGTCATCCTGCAGGTCA
ATCGCGCAAAAATTGCTTCCAAAAAAGACTATCTCAAAGAATTGTCCCGAAAAGAGGCAAAACAGAATCTCCTTCTGCTG
GTCAAGCGAGGTCAATCCACCTTCTTTGTTGCCCTGCAACAGTAA

Upstream 100 bases:

>100_bases
CTGGTCATCCCGGGGGAAAAATAAAACATTAGCAACATCATTACATTTATGTTAGAGAAACCGATCAAATAAGAATCAGA
TTTGATATCGGGAGGTTTCA

Downstream 100 bases:

>100_bases
ATATTCAGGTCGTTCCGTCATGAAATCGAAGACAGAATCCTGCGAGCTGTCCGTTATATACAGCAGGCTCAACAGTCACT
TTGGCGATCTTCACTGGTGG

Product: endopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MKKESKNRNTFIMFLLAFLVAFFVVSVIEVLRSSFAPVAPDVQVASAISPIDPRTPGSFADLVDRLKPAVVNISTTKTIR
SGSNPFSSPFSGEGSPFERYFWGDEFFDRFFGDVPKREFKKKSLGSGFIISHDGYIFTNNHVVEQADKILVKLSDGKEFE
ARVIGKDAKTDIALIKIKPTVSLPVVEIGDSDKLRVGEWVLAIGNPFGLEQTVTAGIVSAKGRVIGAGPYDNFIQTDASI
NPGNSGGPLFSMDGQVIGINTAIVAQGQGIGFAIPVNMAKNILPDLKTKGKVSRGWLGVSVQDITEDIAKSMKQKDRQGA
LVAEVFKGDPASNAGIKPGDIITEINGKTVINSHELLLMIANFHVGDRINITLLRGNRPMNVNVLVAERTDRGEYAARKT
SRDDYGMVVHDITPEIAQYLGLSSRTGVIVTDVREGSPADDVGIQPQDVILQVNRAKIASKKDYLKELSRKEAKQNLLLL
VKRGQSTFFVALQQ

Sequences:

>Translated_494_residues
MKKESKNRNTFIMFLLAFLVAFFVVSVIEVLRSSFAPVAPDVQVASAISPIDPRTPGSFADLVDRLKPAVVNISTTKTIR
SGSNPFSSPFSGEGSPFERYFWGDEFFDRFFGDVPKREFKKKSLGSGFIISHDGYIFTNNHVVEQADKILVKLSDGKEFE
ARVIGKDAKTDIALIKIKPTVSLPVVEIGDSDKLRVGEWVLAIGNPFGLEQTVTAGIVSAKGRVIGAGPYDNFIQTDASI
NPGNSGGPLFSMDGQVIGINTAIVAQGQGIGFAIPVNMAKNILPDLKTKGKVSRGWLGVSVQDITEDIAKSMKQKDRQGA
LVAEVFKGDPASNAGIKPGDIITEINGKTVINSHELLLMIANFHVGDRINITLLRGNRPMNVNVLVAERTDRGEYAARKT
SRDDYGMVVHDITPEIAQYLGLSSRTGVIVTDVREGSPADDVGIQPQDVILQVNRAKIASKKDYLKELSRKEAKQNLLLL
VKRGQSTFFVALQQ
>Mature_494_residues
MKKESKNRNTFIMFLLAFLVAFFVVSVIEVLRSSFAPVAPDVQVASAISPIDPRTPGSFADLVDRLKPAVVNISTTKTIR
SGSNPFSSPFSGEGSPFERYFWGDEFFDRFFGDVPKREFKKKSLGSGFIISHDGYIFTNNHVVEQADKILVKLSDGKEFE
ARVIGKDAKTDIALIKIKPTVSLPVVEIGDSDKLRVGEWVLAIGNPFGLEQTVTAGIVSAKGRVIGAGPYDNFIQTDASI
NPGNSGGPLFSMDGQVIGINTAIVAQGQGIGFAIPVNMAKNILPDLKTKGKVSRGWLGVSVQDITEDIAKSMKQKDRQGA
LVAEVFKGDPASNAGIKPGDIITEINGKTVINSHELLLMIANFHVGDRINITLLRGNRPMNVNVLVAERTDRGEYAARKT
SRDDYGMVVHDITPEIAQYLGLSSRTGVIVTDVREGSPADDVGIQPQDVILQVNRAKIASKKDYLKELSRKEAKQNLLLL
VKRGQSTFFVALQQ

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=345, Percent_Identity=37.9710144927536, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI22129776, Length=323, Percent_Identity=37.7708978328173, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI24308541, Length=267, Percent_Identity=38.2022471910112, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI7019477, Length=272, Percent_Identity=37.8676470588235, Blast_Score=149, Evalue=9e-36,
Organism=Escherichia coli, GI1786356, Length=451, Percent_Identity=39.0243902439024, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI1789629, Length=481, Percent_Identity=38.2536382536383, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1789630, Length=343, Percent_Identity=36.1516034985423, Blast_Score=198, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24646839, Length=284, Percent_Identity=37.6760563380282, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 53749; Mature: 53749

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKESKNRNTFIMFLLAFLVAFFVVSVIEVLRSSFAPVAPDVQVASAISPIDPRTPGSFA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCHH
DLVDRLKPAVVNISTTKTIRSGSNPFSSPFSGEGSPFERYFWGDEFFDRFFGDVPKREFK
HHHHHCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCHHHHH
KKSLGSGFIISHDGYIFTNNHVVEQADKILVKLSDGKEFEARVIGKDAKTDIALIKIKPT
HHCCCCCEEEECCCEEEECCCHHHCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEECC
VSLPVVEIGDSDKLRVGEWVLAIGNPFGLEQTVTAGIVSAKGRVIGAGPYDNFIQTDASI
CCCEEEEECCCCCEEECEEEEEECCCCCCHHHHHHHEEECCCEEEECCCCCCHHCCCCCC
NPGNSGGPLFSMDGQVIGINTAIVAQGQGIGFAIPVNMAKNILPDLKTKGKVSRGWLGVS
CCCCCCCCEEEECCEEEEEEEEEEECCCCCEEEEEHHHHHHHCCCCCCCCCCCCCEEECC
VQDITEDIAKSMKQKDRQGALVAEVFKGDPASNAGIKPGDIITEINGKTVINSHELLLMI
HHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCCCCCCCEEEECCCCEEECCCEEEEEE
ANFHVGDRINITLLRGNRPMNVNVLVAERTDRGEYAARKTSRDDYGMVVHDITPEIAQYL
ECCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCHHHHCCCCCCCCEEEECCCHHHHHHH
GLSSRTGVIVTDVREGSPADDVGIQPQDVILQVNRAKIASKKDYLKELSRKEAKQNLLLL
CCCCCCCEEEEECCCCCCCCCCCCCCHHHEEEECHHHHHHHHHHHHHHHHHHHHCCEEEE
VKRGQSTFFVALQQ
EECCCCEEEEEEEC
>Mature Secondary Structure
MKKESKNRNTFIMFLLAFLVAFFVVSVIEVLRSSFAPVAPDVQVASAISPIDPRTPGSFA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCHH
DLVDRLKPAVVNISTTKTIRSGSNPFSSPFSGEGSPFERYFWGDEFFDRFFGDVPKREFK
HHHHHCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCHHHHH
KKSLGSGFIISHDGYIFTNNHVVEQADKILVKLSDGKEFEARVIGKDAKTDIALIKIKPT
HHCCCCCEEEECCCEEEECCCHHHCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEECC
VSLPVVEIGDSDKLRVGEWVLAIGNPFGLEQTVTAGIVSAKGRVIGAGPYDNFIQTDASI
CCCEEEEECCCCCEEECEEEEEECCCCCCHHHHHHHEEECCCEEEECCCCCCHHCCCCCC
NPGNSGGPLFSMDGQVIGINTAIVAQGQGIGFAIPVNMAKNILPDLKTKGKVSRGWLGVS
CCCCCCCCEEEECCEEEEEEEEEEECCCCCEEEEEHHHHHHHCCCCCCCCCCCCCEEECC
VQDITEDIAKSMKQKDRQGALVAEVFKGDPASNAGIKPGDIITEINGKTVINSHELLLMI
HHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCCCCCCCEEEECCCCEEECCCEEEEEE
ANFHVGDRINITLLRGNRPMNVNVLVAERTDRGEYAARKTSRDDYGMVVHDITPEIAQYL
ECCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCHHHHCCCCCCCCEEEECCCHHHHHHH
GLSSRTGVIVTDVREGSPADDVGIQPQDVILQVNRAKIASKKDYLKELSRKEAKQNLLLL
CCCCCCCEEEEECCCCCCCCCCCCCCHHHEEEECHHHHHHHHHHHHHHHHHHHHCCEEEE
VKRGQSTFFVALQQ
EECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]