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The map label for this gene is glcD [H]

Identifier: 85860394

GI number: 85860394

Start: 2564289

End: 2565719

Strand: Direct

Name: glcD [H]

Synonym: SYN_01167

Alternate gene names: 85860394

Gene position: 2564289-2565719 (Clockwise)

Preceding gene: 85860393

Following gene: 85860395

Centisome position: 80.66

GC content: 56.67

Gene sequence:

>1431_bases
GTGCCGGATGGCCATCGGCGAGAAACCGGATATGGAGTCATGAAAATGGAAAACATCACGCAAGAACTTGCTGAAATCGT
CGGAAAGACTTATGTTTCCTGGCAGGCGGAAGAGCGCTGGTTCTATGGAAGAGACTCGGGGCTGATGCCCGCCCATCAGC
CGGATTATGTCGTTCTTCCCCGAACCGTCGAGGAAATTCAGGCGATTGTCAGATTCGCCGGCCGGGAAGACATCCCCGTG
GTTCCCATGGGAGCCGGGATGTCCCTGAGCGGTCTTGTCATTCCGCAGAAGGGCGGCATCGTCGTCGACATGAAGCGCAT
GGACAGAATCCTGAAAGTCAACGAAACCGCCCGGTATGCCGTTGTCGAAGGCGGAACATCCACCGGGGCGCTTCACGCCC
ATCTGAATCGATATTATCCCCGTCTGCGGTTCAGCATCCCGGACTCGCCCGCAACGACCACCATTGCCGCCAATGTCATG
ATCCACGGCCAGGGGCGGTTGACCCAGCAGTACGGCTTCAACTCCGACATGGTTTCCGGCCTGGAGGTCGTCCTTCCTTC
GGGAGAGCTCTGCCGGATCGGTTCCTGCGCCCTGTCCGACGACTGGTTTTCCAAGGGTCCTCCCCTGCCCGATCTCTCCG
GCCTTTTCCTCGGCTGGTTCGGCGCGACGGGAATTCTCACCAAGGTGGGCCTCAAGCTTTATCCACGGAAAAAAATGCGG
GATGTGGAAATCTTCATCACCGACAGCCCTGACTTCGTTCCCGGGATCCTCTACGAGATCACCCATACGGAGATGGCGGA
GGACATCAACATCTTCGCCCAACCCCTGCCCCTTATATTCAAAGACAATCACCACATCGTCGTCTACTTTACCGGAGAGG
ATCTTGAAGAGCTGGATTTCAAAAAGAAGAAAATTTTCCATGCCCTTGACGGATTCATTCGCAACAAGGACGGCGGGTTT
ATGACCATCGGCGAAGGGATGAGGAAAACCCTCCTGGACATGCCCCAGCGCAGCGCCACGACATTCGCGGACGTAACCAG
GGGGGGCGGTTTCGAATACTCCGGACCGATCATTCCCATCGACCGCTACCCCCAGTGTTCCCGGAAGCTCGATGAACTTG
CGGTAAAGTATGATCTCAAGTATCACGCGACGGCCAGGGTCATCGGCAGAGGACACGCCATGATGTTCGCCTTTTCCTTT
ACATTCAACCGGGCGGACGTGGACATGATGGAGCGGACGCGGAAGGCGCTCCATGAAGCGAGCGAATATGCCCTTTCCAT
CGGCGGCCTTTTCTGGAAACCGACGCTGGATGAACAGCGGATCGCCCTGGCGAAGATGGACCCGCAAACCGCAAAACTCA
TGAAGATGATCAAGGAGAATCTGGACCCGCAGGGGATCATGAATCCCGGAAACTGGGAGGTTGCTGAATGA

Upstream 100 bases:

>100_bases
GCGGCGCTGAAGCCTGCATCTTCAACTGCCATGGGTGCATGAACGCCCTGAGCGCCCTGGTCGCCTCGCGGGGGATCAAA
CCTCTTCACATGATCGATCT

Downstream 100 bases:

>100_bases
AATACGCCGATATCGCCCATCGCTGTTTTCGCTGCGGCTACTGCAAATTCACCAGCGACTACGAAAATTTCAACTGTCCC
TCCTACCGGAAATACCGTTT

Product: (s)-2-hydroxy-acid oxidase chain D

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MPDGHRRETGYGVMKMENITQELAEIVGKTYVSWQAEERWFYGRDSGLMPAHQPDYVVLPRTVEEIQAIVRFAGREDIPV
VPMGAGMSLSGLVIPQKGGIVVDMKRMDRILKVNETARYAVVEGGTSTGALHAHLNRYYPRLRFSIPDSPATTTIAANVM
IHGQGRLTQQYGFNSDMVSGLEVVLPSGELCRIGSCALSDDWFSKGPPLPDLSGLFLGWFGATGILTKVGLKLYPRKKMR
DVEIFITDSPDFVPGILYEITHTEMAEDINIFAQPLPLIFKDNHHIVVYFTGEDLEELDFKKKKIFHALDGFIRNKDGGF
MTIGEGMRKTLLDMPQRSATTFADVTRGGGFEYSGPIIPIDRYPQCSRKLDELAVKYDLKYHATARVIGRGHAMMFAFSF
TFNRADVDMMERTRKALHEASEYALSIGGLFWKPTLDEQRIALAKMDPQTAKLMKMIKENLDPQGIMNPGNWEVAE

Sequences:

>Translated_476_residues
MPDGHRRETGYGVMKMENITQELAEIVGKTYVSWQAEERWFYGRDSGLMPAHQPDYVVLPRTVEEIQAIVRFAGREDIPV
VPMGAGMSLSGLVIPQKGGIVVDMKRMDRILKVNETARYAVVEGGTSTGALHAHLNRYYPRLRFSIPDSPATTTIAANVM
IHGQGRLTQQYGFNSDMVSGLEVVLPSGELCRIGSCALSDDWFSKGPPLPDLSGLFLGWFGATGILTKVGLKLYPRKKMR
DVEIFITDSPDFVPGILYEITHTEMAEDINIFAQPLPLIFKDNHHIVVYFTGEDLEELDFKKKKIFHALDGFIRNKDGGF
MTIGEGMRKTLLDMPQRSATTFADVTRGGGFEYSGPIIPIDRYPQCSRKLDELAVKYDLKYHATARVIGRGHAMMFAFSF
TFNRADVDMMERTRKALHEASEYALSIGGLFWKPTLDEQRIALAKMDPQTAKLMKMIKENLDPQGIMNPGNWEVAE
>Mature_475_residues
PDGHRRETGYGVMKMENITQELAEIVGKTYVSWQAEERWFYGRDSGLMPAHQPDYVVLPRTVEEIQAIVRFAGREDIPVV
PMGAGMSLSGLVIPQKGGIVVDMKRMDRILKVNETARYAVVEGGTSTGALHAHLNRYYPRLRFSIPDSPATTTIAANVMI
HGQGRLTQQYGFNSDMVSGLEVVLPSGELCRIGSCALSDDWFSKGPPLPDLSGLFLGWFGATGILTKVGLKLYPRKKMRD
VEIFITDSPDFVPGILYEITHTEMAEDINIFAQPLPLIFKDNHHIVVYFTGEDLEELDFKKKKIFHALDGFIRNKDGGFM
TIGEGMRKTLLDMPQRSATTFADVTRGGGFEYSGPIIPIDRYPQCSRKLDELAVKYDLKYHATARVIGRGHAMMFAFSFT
FNRADVDMMERTRKALHEASEYALSIGGLFWKPTLDEQRIALAKMDPQTAKLMKMIKENLDPQGIMNPGNWEVAE

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=472, Percent_Identity=26.271186440678, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI37595754, Length=492, Percent_Identity=25.609756097561, Blast_Score=125, Evalue=8e-29,
Organism=Escherichia coli, GI1789351, Length=200, Percent_Identity=33, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71992373, Length=229, Percent_Identity=27.5109170305677, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320027, Length=203, Percent_Identity=25.1231527093596, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320023, Length=241, Percent_Identity=22.8215767634855, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24653753, Length=472, Percent_Identity=25.2118644067797, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 53401; Mature: 53270

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDGHRRETGYGVMKMENITQELAEIVGKTYVSWQAEERWFYGRDSGLMPAHQPDYVVLP
CCCCCCCCCCCCEEEHHHHHHHHHHHHCCHHEEEECCCCEEEECCCCCCCCCCCCEEEEC
RTVEEIQAIVRFAGREDIPVVPMGAGMSLSGLVIPQKGGIVVDMKRMDRILKVNETARYA
CCHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEEECCCCEEEEHHHHHHHHCCCCCEEEE
VVEGGTSTGALHAHLNRYYPRLRFSIPDSPATTTIAANVMIHGQGRLTQQYGFNSDMVSG
EEECCCCCCHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEEECCCCEEHHCCCCCHHHCC
LEVVLPSGELCRIGSCALSDDWFSKGPPLPDLSGLFLGWFGATGILTKVGLKLYPRKKMR
EEEEECCCCEEECCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEECCCCCCC
DVEIFITDSPDFVPGILYEITHTEMAEDINIFAQPLPLIFKDNHHIVVYFTGEDLEELDF
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCHHHHHH
KKKKIFHALDGFIRNKDGGFMTIGEGMRKTLLDMPQRSATTFADVTRGGGFEYSGPIIPI
HHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCEEEC
DRYPQCSRKLDELAVKYDLKYHATARVIGRGHAMMFAFSFTFNRADVDMMERTRKALHEA
CCCCHHHHHHHHHHEEECEEEEEEEEEEECCCEEEEEEEEEECCCCHHHHHHHHHHHHHH
SEYALSIGGLFWKPTLDEQRIALAKMDPQTAKLMKMIKENLDPQGIMNPGNWEVAE
HHHHEEECCEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PDGHRRETGYGVMKMENITQELAEIVGKTYVSWQAEERWFYGRDSGLMPAHQPDYVVLP
CCCCCCCCCCCEEEHHHHHHHHHHHHCCHHEEEECCCCEEEECCCCCCCCCCCCEEEEC
RTVEEIQAIVRFAGREDIPVVPMGAGMSLSGLVIPQKGGIVVDMKRMDRILKVNETARYA
CCHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEEECCCCEEEEHHHHHHHHCCCCCEEEE
VVEGGTSTGALHAHLNRYYPRLRFSIPDSPATTTIAANVMIHGQGRLTQQYGFNSDMVSG
EEECCCCCCHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEEECCCCEEHHCCCCCHHHCC
LEVVLPSGELCRIGSCALSDDWFSKGPPLPDLSGLFLGWFGATGILTKVGLKLYPRKKMR
EEEEECCCCEEECCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEECCCCCCC
DVEIFITDSPDFVPGILYEITHTEMAEDINIFAQPLPLIFKDNHHIVVYFTGEDLEELDF
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCHHHHHH
KKKKIFHALDGFIRNKDGGFMTIGEGMRKTLLDMPQRSATTFADVTRGGGFEYSGPIIPI
HHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCEEEC
DRYPQCSRKLDELAVKYDLKYHATARVIGRGHAMMFAFSFTFNRADVDMMERTRKALHEA
CCCCHHHHHHHHHHEEECEEEEEEEEEEECCCEEEEEEEEEECCCCHHHHHHHHHHHHHH
SEYALSIGGLFWKPTLDEQRIALAKMDPQTAKLMKMIKENLDPQGIMNPGNWEVAE
HHHHEEECCEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]