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The map label for this gene is mepA [H]

Identifier: 85859927

GI number: 85859927

Start: 2161721

End: 2163082

Strand: Direct

Name: mepA [H]

Synonym: SYN_00672

Alternate gene names: 85859927

Gene position: 2161721-2163082 (Clockwise)

Preceding gene: 85859926

Following gene: 85859928

Centisome position: 67.99

GC content: 52.42

Gene sequence:

>1362_bases
ATGACTGACAAGGCTCTTAACCTGGGGAAAGGTCCCATTCTGCCTCTTCTGCTGAAGATGAGCGGGCCGTCTATCGCCAC
GGTTCTGGTTGTAAATCTTTATAGCCTCATAGATGCCTTCTGGCTTGCCAGACTCAGCCCGAATGCCCTTGCCGCCTTAA
CCATTATTTTCCCCATACAGTTGATTTTAGGTGGTGTCGGCGTGGGAACCGGGCTGGGAGCAGGCTCATACGCCGCCAGG
ATGTTCGGCGCAGGAGAGAACAGGAAAGCCCGACAGACGGCTGGACAGGTTTTTTTTCTTTCGGCTGTCCTCGGAACGCT
GTTCATTGGAGCAGTCCTTACGGGACCTGAACATATTCTGAGGTTTCTCGGCGCGACAACGGAGATTATTCCACTATCAC
GCCAGTATCTCCTAACCTTACTCCCCGGTGTGCCTTTTCTGTTTCTAATCATGATGACCAGCAATCTCCTCCGGGCAGAG
GGCAGGCCGCATCTCGTCATGTATTCCGCTCTTCTCTTCTCAGCCGTCAGCTGTATCCTCGATCCTTTTCTCATCTTCGG
CTGGGGCCCCTTCCCACGGCTGGAAATCCGGGGGGCTGCCGCGGCAGCCGTAATTTCCCAGATAGCGGGAGCATTGCTTG
CCGCTTACTACCTGCAGCAGAAAAGCTCGAAGTATAAACTTAAATGGCATTATCTCCGCCCTGATTACCGGATTATCTGG
TCCATTTATCAGACGGGATTTCCCTCCATCATCATCAATCTCGCGGTCAGTCTGGGAATGCTTCTTCACAACCATATCCT
CGGGGGGTACAGCTACCTTGCCGTTGCGACTCTGGGCATTGTCTCCCGGGTGAATGGTCTGGTCATGATAGCTTTATACG
GCATCGGTCATGGCCTGATGCCGATGGTCGCTTACAGTGAAGGGGCGAATCTTCGTTCAAGATTGAAGGAAACCGTGAAG
ATTGCTGTAAAAATTTCTTTTGGAATTGCGCTGTTGTGTCTTCTGATCGTGGAAGTCTTCGCGCCGGCCATTGCGGCGCT
TTTTTCCGATGGCTCTGAGCTGCGGAATTTAACGGCAACAGCCCTGCGCATTAATATTTTGATCCTGATTACAGCCGCTC
CCAGCCTGATGTGGATCAACATGTTCATCGGTCTCGGACAGGGGAAAACCGCCATGGTTCTGCTTGTCGGCCGCGAAACC
CTTATTCTGATCCCTCTTTTGTGGCTGCTTCCTTCCTCGTTCGGCATCAACGGCGTCTGGATGGCGCAGCCGCTTGCCAA
CGCCCTTTCATTTCTATTCATCCTTTACTGGACGAAGCGTCAGTTTCGAATCTTTGACTCTCAGATAAGCGGTGAGGCAT
AA

Upstream 100 bases:

>100_bases
AAATTATCATCAGAATTCACAAACTGAGCAATGTCTTTGACTACCTTGATGAAAAGAAAACTCCATAGTAAAGAACAGTG
GCCATATCAACCAATAAGTC

Downstream 100 bases:

>100_bases
TCAAGCCTTGTTCTCCGAAACGCTGGATGCCCGTCAATATGGTTGGATCGATGAAAATTGTAATTCCTCCGCGATCGGCT
TGATTACTTTGGCTGAAATG

Product: Na+ driven multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTDKALNLGKGPILPLLLKMSGPSIATVLVVNLYSLIDAFWLARLSPNALAALTIIFPIQLILGGVGVGTGLGAGSYAAR
MFGAGENRKARQTAGQVFFLSAVLGTLFIGAVLTGPEHILRFLGATTEIIPLSRQYLLTLLPGVPFLFLIMMTSNLLRAE
GRPHLVMYSALLFSAVSCILDPFLIFGWGPFPRLEIRGAAAAAVISQIAGALLAAYYLQQKSSKYKLKWHYLRPDYRIIW
SIYQTGFPSIIINLAVSLGMLLHNHILGGYSYLAVATLGIVSRVNGLVMIALYGIGHGLMPMVAYSEGANLRSRLKETVK
IAVKISFGIALLCLLIVEVFAPAIAALFSDGSELRNLTATALRINILILITAAPSLMWINMFIGLGQGKTAMVLLVGRET
LILIPLLWLLPSSFGINGVWMAQPLANALSFLFILYWTKRQFRIFDSQISGEA

Sequences:

>Translated_453_residues
MTDKALNLGKGPILPLLLKMSGPSIATVLVVNLYSLIDAFWLARLSPNALAALTIIFPIQLILGGVGVGTGLGAGSYAAR
MFGAGENRKARQTAGQVFFLSAVLGTLFIGAVLTGPEHILRFLGATTEIIPLSRQYLLTLLPGVPFLFLIMMTSNLLRAE
GRPHLVMYSALLFSAVSCILDPFLIFGWGPFPRLEIRGAAAAAVISQIAGALLAAYYLQQKSSKYKLKWHYLRPDYRIIW
SIYQTGFPSIIINLAVSLGMLLHNHILGGYSYLAVATLGIVSRVNGLVMIALYGIGHGLMPMVAYSEGANLRSRLKETVK
IAVKISFGIALLCLLIVEVFAPAIAALFSDGSELRNLTATALRINILILITAAPSLMWINMFIGLGQGKTAMVLLVGRET
LILIPLLWLLPSSFGINGVWMAQPLANALSFLFILYWTKRQFRIFDSQISGEA
>Mature_452_residues
TDKALNLGKGPILPLLLKMSGPSIATVLVVNLYSLIDAFWLARLSPNALAALTIIFPIQLILGGVGVGTGLGAGSYAARM
FGAGENRKARQTAGQVFFLSAVLGTLFIGAVLTGPEHILRFLGATTEIIPLSRQYLLTLLPGVPFLFLIMMTSNLLRAEG
RPHLVMYSALLFSAVSCILDPFLIFGWGPFPRLEIRGAAAAAVISQIAGALLAAYYLQQKSSKYKLKWHYLRPDYRIIWS
IYQTGFPSIIINLAVSLGMLLHNHILGGYSYLAVATLGIVSRVNGLVMIALYGIGHGLMPMVAYSEGANLRSRLKETVKI
AVKISFGIALLCLLIVEVFAPAIAALFSDGSELRNLTATALRINILILITAAPSLMWINMFIGLGQGKTAMVLLVGRETL
ILIPLLWLLPSSFGINGVWMAQPLANALSFLFILYWTKRQFRIFDSQISGEA

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49080; Mature: 48948

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKALNLGKGPILPLLLKMSGPSIATVLVVNLYSLIDAFWLARLSPNALAALTIIFPIQ
CCCCCCCCCCCCHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LILGGVGVGTGLGAGSYAARMFGAGENRKARQTAGQVFFLSAVLGTLFIGAVLTGPEHIL
HHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RFLGATTEIIPLSRQYLLTLLPGVPFLFLIMMTSNLLRAEGRPHLVMYSALLFSAVSCIL
HHHCCCCCEECCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DPFLIFGWGPFPRLEIRGAAAAAVISQIAGALLAAYYLQQKSSKYKLKWHYLRPDYRIIW
HHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHH
SIYQTGFPSIIINLAVSLGMLLHNHILGGYSYLAVATLGIVSRVNGLVMIALYGIGHGLM
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHEEEEEHHCCCCHH
PMVAYSEGANLRSRLKETVKIAVKISFGIALLCLLIVEVFAPAIAALFSDGSELRNLTAT
HHHEECCCCCHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ALRINILILITAAPSLMWINMFIGLGQGKTAMVLLVGRETLILIPLLWLLPSSFGINGVW
HHEEEEEEEEECCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCEEE
MAQPLANALSFLFILYWTKRQFRIFDSQISGEA
HHHHHHHHHHHHHHHHHHCHHHEEECCCCCCCC
>Mature Secondary Structure 
TDKALNLGKGPILPLLLKMSGPSIATVLVVNLYSLIDAFWLARLSPNALAALTIIFPIQ
CCCCCCCCCCCHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LILGGVGVGTGLGAGSYAARMFGAGENRKARQTAGQVFFLSAVLGTLFIGAVLTGPEHIL
HHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RFLGATTEIIPLSRQYLLTLLPGVPFLFLIMMTSNLLRAEGRPHLVMYSALLFSAVSCIL
HHHCCCCCEECCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DPFLIFGWGPFPRLEIRGAAAAAVISQIAGALLAAYYLQQKSSKYKLKWHYLRPDYRIIW
HHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHH
SIYQTGFPSIIINLAVSLGMLLHNHILGGYSYLAVATLGIVSRVNGLVMIALYGIGHGLM
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHEEEEEHHCCCCHH
PMVAYSEGANLRSRLKETVKIAVKISFGIALLCLLIVEVFAPAIAALFSDGSELRNLTAT
HHHEECCCCCHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ALRINILILITAAPSLMWINMFIGLGQGKTAMVLLVGRETLILIPLLWLLPSSFGINGVW
HHEEEEEEEEECCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCEEE
MAQPLANALSFLFILYWTKRQFRIFDSQISGEA
HHHHHHHHHHHHHHHHHHCHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA