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The map label for this gene is icd [H]

Identifier: 85859748

GI number: 85859748

Start: 1984516

End: 1985733

Strand: Direct

Name: icd [H]

Synonym: SYN_01410

Alternate gene names: 85859748

Gene position: 1984516-1985733 (Clockwise)

Preceding gene: 85859747

Following gene: 85859749

Centisome position: 62.42

GC content: 49.84

Gene sequence:

>1218_bases
ATGAAATCAAAAATTCGAGTCCATACACCCATTGTTGAAATGGACGGCGACGAAATGACCCGGGTGATGTGGCATATGGT
CAAGGAAAAACTTCTTCTGCCTTATCTGGATATACCTGTGGCTTATTACGATCTTCATGTCAGTCACCGCGACAAAACCG
ACGACCAGGTTACCGTCGACGCCTCAAAAGCTATTATGAAATACGGCGTCGGGGTGAAATGCGCCACAATTACGCCCAAT
GAAGATCGCGTTCGCGAATATGGACTTAAAAAAGCATGGAAAAGCCCGAATGCAACGATTCGGGCCCTGCTGGACGGGAC
CGTTTTCCGAAAGCCCATCCCGGTCAGGAATATCCGACCGGCGGTATCTTCCTGGAAGAAGCCCATCATCATTGGACGAC
ATGCCTATGGAGATGTCTATAATAATATCGAAATACGGGTGGATGGACCTGGAATGGCCGAGCTGGTTTTTACTCCCCTC
ATGGGAGAGCCCATCAGACAAACCATCCATTTTTTTAAAAATCCCGGCATTCTTCAGGGAATTCACAATACGGACGAATC
CATTGTCAGCTTCGCCCGTTCCTGCTTTGCCTTCGCGCTGGACCAGAAAATCGATCTCTGGTTCAGCACCAAAGACACGA
TCTCCAAAATCTATGATGGTCGATTTCGGGAGGTCTTCGCTCAGGAATATGAAACATCCTGGAGGGAAGCTTTTCAAAAC
GCCGGCATTGAGTATTTTTTCACTTTGATTGACGACGCCGTCGCACGGATCATGAAATCGGAGGGTGGCATCCTCTGGGC
GCTTAAGAATTATGACGGAGACGTCATGTCGGACATGATCGCATCGGCGAACGGCAGTCTGGCCATGATGACTTCCGTCC
TTGTTTCGCCATCCGGTTATTTCGAATATGAAGCGGCCCACGGCACAGTGCAGAAACATTATTACAAGCATCTCAAGGGT
GAGGAAACGTCCTCCAACTCCACGGCGCTGATTTTTGCCTGGTCCGGAGGTCTTCGAAAACGCGGGGAACTCGATGCAAC
CCCCGACGTCGTTTTCTTTGCCGATCAACTGGAGGCGGCCACACTGGAAACCATTGAATCAGGAATCATGACGGGAGATC
TCCTTCTTGTCGCCGACCCCAACCCGGACAATCGCAAGGTTAATACGGAAAGCTTTATCGAGGCGATTGCCCTCAATCTG
GACAGAAAACTGATTTAG

Upstream 100 bases:

>100_bases
AACATGATCTTTTGTACCCCATGATTTTATAAACACCGGTTCCGGCAGTCTGACATTGGAGGCCGCACTGAGAGGTGAAA
ACAACAGGAGGGTTATATCC

Downstream 100 bases:

>100_bases
CTTTCCGTTTCTGACAATCCTGCGGAAAAATTCAGGAAAGCAAAGGCAAATCGGCCCTTATGCCGTCGAGCGCCTTTTCA
CAATTTTTAAAGAAATTTGC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKSKIRVHTPIVEMDGDEMTRVMWHMVKEKLLLPYLDIPVAYYDLHVSHRDKTDDQVTVDASKAIMKYGVGVKCATITPN
EDRVREYGLKKAWKSPNATIRALLDGTVFRKPIPVRNIRPAVSSWKKPIIIGRHAYGDVYNNIEIRVDGPGMAELVFTPL
MGEPIRQTIHFFKNPGILQGIHNTDESIVSFARSCFAFALDQKIDLWFSTKDTISKIYDGRFREVFAQEYETSWREAFQN
AGIEYFFTLIDDAVARIMKSEGGILWALKNYDGDVMSDMIASANGSLAMMTSVLVSPSGYFEYEAAHGTVQKHYYKHLKG
EETSSNSTALIFAWSGGLRKRGELDATPDVVFFADQLEAATLETIESGIMTGDLLLVADPNPDNRKVNTESFIEAIALNL
DRKLI

Sequences:

>Translated_405_residues
MKSKIRVHTPIVEMDGDEMTRVMWHMVKEKLLLPYLDIPVAYYDLHVSHRDKTDDQVTVDASKAIMKYGVGVKCATITPN
EDRVREYGLKKAWKSPNATIRALLDGTVFRKPIPVRNIRPAVSSWKKPIIIGRHAYGDVYNNIEIRVDGPGMAELVFTPL
MGEPIRQTIHFFKNPGILQGIHNTDESIVSFARSCFAFALDQKIDLWFSTKDTISKIYDGRFREVFAQEYETSWREAFQN
AGIEYFFTLIDDAVARIMKSEGGILWALKNYDGDVMSDMIASANGSLAMMTSVLVSPSGYFEYEAAHGTVQKHYYKHLKG
EETSSNSTALIFAWSGGLRKRGELDATPDVVFFADQLEAATLETIESGIMTGDLLLVADPNPDNRKVNTESFIEAIALNL
DRKLI
>Mature_405_residues
MKSKIRVHTPIVEMDGDEMTRVMWHMVKEKLLLPYLDIPVAYYDLHVSHRDKTDDQVTVDASKAIMKYGVGVKCATITPN
EDRVREYGLKKAWKSPNATIRALLDGTVFRKPIPVRNIRPAVSSWKKPIIIGRHAYGDVYNNIEIRVDGPGMAELVFTPL
MGEPIRQTIHFFKNPGILQGIHNTDESIVSFARSCFAFALDQKIDLWFSTKDTISKIYDGRFREVFAQEYETSWREAFQN
AGIEYFFTLIDDAVARIMKSEGGILWALKNYDGDVMSDMIASANGSLAMMTSVLVSPSGYFEYEAAHGTVQKHYYKHLKG
EETSSNSTALIFAWSGGLRKRGELDATPDVVFFADQLEAATLETIESGIMTGDLLLVADPNPDNRKVNTESFIEAIALNL
DRKLI

Specific function: Catalyzes The Oxidation Of 3-Carboxy-2-Hydroxy-4- Methylpentanoate (3-Isopropylmalate) To 3-Carboxy-4-Methyl-2- Oxopentanoate. The Product Decarboxylates To 4-Methyl-2 Oxopentanoate. [C]

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=407, Percent_Identity=50.6142506142506, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI28178825, Length=400, Percent_Identity=50.75, Blast_Score=400, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17540874, Length=400, Percent_Identity=52, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17550822, Length=401, Percent_Identity=48.1296758104738, Blast_Score=386, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320137, Length=407, Percent_Identity=53.5626535626536, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6323203, Length=406, Percent_Identity=50.7389162561576, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=50.6142506142506, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24660856, Length=409, Percent_Identity=50.1222493887531, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI221330987, Length=409, Percent_Identity=50.1222493887531, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI221330985, Length=409, Percent_Identity=50.1222493887531, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI28574947, Length=409, Percent_Identity=50.1222493887531, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24660849, Length=409, Percent_Identity=50.1222493887531, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI21356561, Length=409, Percent_Identity=50.1222493887531, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI221330983, Length=409, Percent_Identity=50.1222493887531, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=50.1222493887531, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=50.1222493887531, Blast_Score=400, Evalue=1e-112,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45623; Mature: 45623

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKIRVHTPIVEMDGDEMTRVMWHMVKEKLLLPYLDIPVAYYDLHVSHRDKTDDQVTVD
CCCCEEEECCEEEECCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCEEEEH
ASKAIMKYGVGVKCATITPNEDRVREYGLKKAWKSPNATIRALLDGTVFRKPIPVRNIRP
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEHHHHCCHHHCCCCCCCCCCH
AVSSWKKPIIIGRHAYGDVYNNIEIRVDGPGMAELVFTPLMGEPIRQTIHFFKNPGILQG
HHHCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHCCCCCEEC
IHNTDESIVSFARSCFAFALDQKIDLWFSTKDTISKIYDGRFREVFAQEYETSWREAFQN
CCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
AGIEYFFTLIDDAVARIMKSEGGILWALKNYDGDVMSDMIASANGSLAMMTSVLVSPSGY
CCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHCCCCCC
FEYEAAHGTVQKHYYKHLKGEETSSNSTALIFAWSGGLRKRGELDATPDVVFFADQLEAA
EEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECHHHHH
TLETIESGIMTGDLLLVADPNPDNRKVNTESFIEAIALNLDRKLI
HHHHHHHCCEECCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKSKIRVHTPIVEMDGDEMTRVMWHMVKEKLLLPYLDIPVAYYDLHVSHRDKTDDQVTVD
CCCCEEEECCEEEECCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCEEEEH
ASKAIMKYGVGVKCATITPNEDRVREYGLKKAWKSPNATIRALLDGTVFRKPIPVRNIRP
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEHHHHCCHHHCCCCCCCCCCH
AVSSWKKPIIIGRHAYGDVYNNIEIRVDGPGMAELVFTPLMGEPIRQTIHFFKNPGILQG
HHHCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHCCCCCEEC
IHNTDESIVSFARSCFAFALDQKIDLWFSTKDTISKIYDGRFREVFAQEYETSWREAFQN
CCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
AGIEYFFTLIDDAVARIMKSEGGILWALKNYDGDVMSDMIASANGSLAMMTSVLVSPSGY
CCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHCCCCCC
FEYEAAHGTVQKHYYKHLKGEETSSNSTALIFAWSGGLRKRGELDATPDVVFFADQLEAA
EEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECHHHHH
TLETIESGIMTGDLLLVADPNPDNRKVNTESFIEAIALNLDRKLI
HHHHHHHCCEECCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]