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The map label for this gene is mtaD2

Identifier: 85859696

GI number: 85859696

Start: 1925619

End: 1926956

Strand: Direct

Name: mtaD2

Synonym: SYN_01991

Alternate gene names: 85859696

Gene position: 1925619-1926956 (Clockwise)

Preceding gene: 85859692

Following gene: 85859701

Centisome position: 60.57

GC content: 56.05

Gene sequence:

>1338_bases
ATGGCAAAAACAGAGCTTGATCTATTGATTCGCGGCAGCGTCCTGTTGACGATGCGCGAGGAGGAGGCTGTCATTGAAAA
CCCCGTCGTCGGCATACGGAACGGAAAAATCGTTCTGATCATGCAGAACGATCTCTTTACTGAGGAAGAATACACAGCCA
GAAAGGTCCTGGATAGAAGCAATACCCTGATCATGCCCGGACTCGTGAATACGCACACACACCTGGCCATGTCGTGCTTC
CGTGGACTGGCCGACGATCTCCCCCTGATGGCCTGGCTTCACGAATACATTTTCCCCGCAGAAGCGCGGCACGTCAATCC
GGAAATGGTTTACGCGGGTTCCCTGCTGGCCATGGCGGAAATGATTCTGTCCGGCACAACGACCTTCTGCGACGGCTACT
TCTTTGTCGATCAGGTCGCCCGGGCGGCAAAGGATGCCGGGATGCGGGCTGTTGTCTGCCAGGGATTCATCGATTTTCCC
ACGCCGGACACATCCGACCCGTCCCGGCAGATGGAAACCGCGGAACGGTTTATTGGAACGTGGAAAGACGCTTCACCTCT
GATTCAGCCTGCCCTCTTCTGTCATTCACCCTACACCTGCTCCCCGGAAACACTGGTCCGCATCAAAGAGGCGGCCCGAA
GGGAAAAAATCCTCTACGTTCTGCATCTTTCCGAAACCCGTGAGGAAGTTTCCCTGATCCAGGATTGTTATGGGAAACGG
CCTGCTTTACATCTCCACAACCTGGACGTTCTTGATCCGGATACCCTTGCCGTGCACTGCGTATGGCTCGACGAGGAAGA
GCAGGGCGTCCTGGCGGACTGCGGCGTCCGGGTTTCTCATACCCCGCAAAGCAACATGAAACTGGCGGCGGGCATCGCTC
CTGTCCCGGCCATGCAGGCCATGGGCATTTCCGTATCTCTGGGAACTGACGGCTCAGCCAGCAATAACGATCTGGACCTT
TTCCGGGAAATGGATTCGACGGCAAAGATCCACAAGGTCGCCACTGGAAACCCGGCCGTCATGGATGCCGCAAGGGTCGT
CCGGATGGCCACTTCCGAAGGGGCCGGAGCCCTGGGGTTGCAGGACCGGATTGGGTCTCTTGAAGTCGGCAAGGCTGCGG
ATCTCATCATCCTCGATCTGAATCAACCTCATCTCACGCCGATGTACCATCCCTTTTCTCATCTCGTCTACGCGGCCTCC
GGCGCGGATGTGCTCACCACCGTCATTGACGGCAACGTGGTCATGGAAAATCGGAAAATCCTCTCTTTCGACCTGGAGGC
AATCATGAGGGAAGTCGAGAAAATCGCGGAGAAGATAAGAAAAAGCTGCAGGAAATAA

Upstream 100 bases:

>100_bases
CAATAAAAAATCAGCAGAAAGACACGATTGACAAAAAAATTGAACCCATATTTTTAAGTGCAGGGGATATCTTCAGATTT
TCCCGACGAGGTCATTTTTC

Downstream 100 bases:

>100_bases
CACCATCATATCATGCCGCATTCCATAAAGAAAAAAGTGAACAGAGATGCGGCAATACACAGCACCGATGGATCGTGCGT
TGACATGCAGGCAATAAAGC

Product: chlorohydrolase/deaminase family protein

Products: NA

Alternate protein names: MTA/SAH deaminase 2

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MAKTELDLLIRGSVLLTMREEEAVIENPVVGIRNGKIVLIMQNDLFTEEEYTARKVLDRSNTLIMPGLVNTHTHLAMSCF
RGLADDLPLMAWLHEYIFPAEARHVNPEMVYAGSLLAMAEMILSGTTTFCDGYFFVDQVARAAKDAGMRAVVCQGFIDFP
TPDTSDPSRQMETAERFIGTWKDASPLIQPALFCHSPYTCSPETLVRIKEAARREKILYVLHLSETREEVSLIQDCYGKR
PALHLHNLDVLDPDTLAVHCVWLDEEEQGVLADCGVRVSHTPQSNMKLAAGIAPVPAMQAMGISVSLGTDGSASNNDLDL
FREMDSTAKIHKVATGNPAVMDAARVVRMATSEGAGALGLQDRIGSLEVGKAADLIILDLNQPHLTPMYHPFSHLVYAAS
GADVLTTVIDGNVVMENRKILSFDLEAIMREVEKIAEKIRKSCRK

Sequences:

>Translated_445_residues
MAKTELDLLIRGSVLLTMREEEAVIENPVVGIRNGKIVLIMQNDLFTEEEYTARKVLDRSNTLIMPGLVNTHTHLAMSCF
RGLADDLPLMAWLHEYIFPAEARHVNPEMVYAGSLLAMAEMILSGTTTFCDGYFFVDQVARAAKDAGMRAVVCQGFIDFP
TPDTSDPSRQMETAERFIGTWKDASPLIQPALFCHSPYTCSPETLVRIKEAARREKILYVLHLSETREEVSLIQDCYGKR
PALHLHNLDVLDPDTLAVHCVWLDEEEQGVLADCGVRVSHTPQSNMKLAAGIAPVPAMQAMGISVSLGTDGSASNNDLDL
FREMDSTAKIHKVATGNPAVMDAARVVRMATSEGAGALGLQDRIGSLEVGKAADLIILDLNQPHLTPMYHPFSHLVYAAS
GADVLTTVIDGNVVMENRKILSFDLEAIMREVEKIAEKIRKSCRK
>Mature_444_residues
AKTELDLLIRGSVLLTMREEEAVIENPVVGIRNGKIVLIMQNDLFTEEEYTARKVLDRSNTLIMPGLVNTHTHLAMSCFR
GLADDLPLMAWLHEYIFPAEARHVNPEMVYAGSLLAMAEMILSGTTTFCDGYFFVDQVARAAKDAGMRAVVCQGFIDFPT
PDTSDPSRQMETAERFIGTWKDASPLIQPALFCHSPYTCSPETLVRIKEAARREKILYVLHLSETREEVSLIQDCYGKRP
ALHLHNLDVLDPDTLAVHCVWLDEEEQGVLADCGVRVSHTPQSNMKLAAGIAPVPAMQAMGISVSLGTDGSASNNDLDLF
REMDSTAKIHKVATGNPAVMDAARVVRMATSEGAGALGLQDRIGSLEVGKAADLIILDLNQPHLTPMYHPFSHLVYAASG
ADVLTTVIDGNVVMENRKILSFDLEAIMREVEKIAEKIRKSCRK

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=382, Percent_Identity=28.5340314136126, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1789249, Length=442, Percent_Identity=25.1131221719457, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI87082177, Length=458, Percent_Identity=24.6724890829694, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17540282, Length=361, Percent_Identity=26.8698060941828, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319963, Length=392, Percent_Identity=25.5102040816327, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24643849, Length=352, Percent_Identity=28.4090909090909, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD2_SYNAS (Q2LUH4)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_461898.1
- ProteinModelPortal:   Q2LUH4
- SMR:   Q2LUH4
- STRING:   Q2LUH4
- GeneID:   3882630
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_01991
- NMPDR:   fig|56780.10.peg.1838
- eggNOG:   COG0402
- HOGENOM:   HBG668170
- OMA:   HTHIHET
- PhylomeDB:   Q2LUH4
- ProtClustDB:   CLSK771790
- BioCyc:   SACI56780:SYN_01991-MONOMER
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 49006; Mature: 48875

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: BINDING 101-101 BINDING 195-195 BINDING 225-225 BINDING 310-310

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTELDLLIRGSVLLTMREEEAVIENPVVGIRNGKIVLIMQNDLFTEEEYTARKVLDRS
CCCCCEEEEEECEEEEEEECCHHHHCCCCEEECCCEEEEEEECCCCCCHHHHHHHHHCCC
NTLIMPGLVNTHTHLAMSCFRGLADDLPLMAWLHEYIFPAEARHVNPEMVYAGSLLAMAE
CCEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHH
MILSGTTTFCDGYFFVDQVARAAKDAGMRAVVCQGFIDFPTPDTSDPSRQMETAERFIGT
HHHCCCCHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
WKDASPLIQPALFCHSPYTCSPETLVRIKEAARREKILYVLHLSETREEVSLIQDCYGKR
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEEEEEECHHHHHHHHHHHHHCCC
PALHLHNLDVLDPDTLAVHCVWLDEEEQGVLADCGVRVSHTPQSNMKLAAGIAPVPAMQA
CEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHCCEEEECCCCCCCEEEECCCCCCCHHH
MGISVSLGTDGSASNNDLDLFREMDSTAKIHKVATGNPAVMDAARVVRMATSEGAGALGL
CCEEEEECCCCCCCCCHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHHHHCCCCCCCCCH
QDRIGSLEVGKAADLIILDLNQPHLTPMYHPFSHLVYAASGADVLTTVIDGNVVMENRKI
HHCCCCEECCCCCCEEEEECCCCCCCCCCCCHHHHEEECCCCCEEEEEECCCEEEECCEE
LSFDLEAIMREVEKIAEKIRKSCRK
EEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKTELDLLIRGSVLLTMREEEAVIENPVVGIRNGKIVLIMQNDLFTEEEYTARKVLDRS
CCCCEEEEEECEEEEEEECCHHHHCCCCEEECCCEEEEEEECCCCCCHHHHHHHHHCCC
NTLIMPGLVNTHTHLAMSCFRGLADDLPLMAWLHEYIFPAEARHVNPEMVYAGSLLAMAE
CCEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHH
MILSGTTTFCDGYFFVDQVARAAKDAGMRAVVCQGFIDFPTPDTSDPSRQMETAERFIGT
HHHCCCCHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
WKDASPLIQPALFCHSPYTCSPETLVRIKEAARREKILYVLHLSETREEVSLIQDCYGKR
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEEEEEECHHHHHHHHHHHHHCCC
PALHLHNLDVLDPDTLAVHCVWLDEEEQGVLADCGVRVSHTPQSNMKLAAGIAPVPAMQA
CEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHCCEEEECCCCCCCEEEECCCCCCCHHH
MGISVSLGTDGSASNNDLDLFREMDSTAKIHKVATGNPAVMDAARVVRMATSEGAGALGL
CCEEEEECCCCCCCCCHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHHHHCCCCCCCCCH
QDRIGSLEVGKAADLIILDLNQPHLTPMYHPFSHLVYAASGADVLTTVIDGNVVMENRKI
HHCCCCEECCCCCCEEEEECCCCCCCCCCCCHHHHEEECCCCCEEEEEECCCEEEECCEE
LSFDLEAIMREVEKIAEKIRKSCRK
EEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA