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The map label for this gene is tmk

Identifier: 85859637

GI number: 85859637

Start: 1865713

End: 1866372

Strand: Direct

Name: tmk

Synonym: SYN_03606

Alternate gene names: 85859637

Gene position: 1865713-1866372 (Clockwise)

Preceding gene: 85859636

Following gene: 85859638

Centisome position: 58.68

GC content: 55.3

Gene sequence:

>660_bases
ATGGCATATTTTATTTCCTTCGAAGGCATTGAAGGGTGCGGGAAAACAACCCAGCTCAAACTGGCGGCGCAATATCTCAG
GACGTTGAAAATTCCCGTTGGGACCACGGAAGAGCCAGGCGGCACACCGCTGGGCAAAAAGATTCGAAATATTCTTCTTA
ACCGGGGGCCCTTCGAGATCTGCGCTGAAGCGGAAACGCTGCTCTTCGTTGCCGCACGCGCTCAGCATGTCCGGGAGGTC
ATTCTGCCTTCCCTCGCCAGGGGCCAGTGGATCCTCTGTGACCGCTTTTCCGACGCCACTGCGGTTTATCAGGGTTGTGT
CCGGGGCATTGATGAGGCATGGATTCGTCAACTGGATTCCTTTGCCACGTCTTTCCTCAAGCCAAATCTCACCCTCCTGT
TTGATCTGCCGGCGGAAACGGGACTTCACCGGGCTATGCAGCGTATGACCGGCATTCCGGAAAACTCACGTGAAGATCGA
TTCGAGCAGGAAGGTCTGAACTTTCATGAGAAGATCCGCGAAGGCTATCTCGCTCTGGCACGACAGGAATCTGAGCGCTT
TCGAATCATTAACGCGGCAGCGGACATTCCTTCGATCCACCGCGAGGTGTGCCGTCACCTCGATGTCCTGAGACAGCAAC
CCGAAGCCGGCTTACCATAG

Upstream 100 bases:

>100_bases
TTACACTGTTGTCCCACGCAATCCCTGTCGAATCTTAGAATTTCCATTTCAATCGTCGAAAACAAATTCCAGGCAGCAGG
AAAAGGCAAGGCAATCGGTC

Downstream 100 bases:

>100_bases
AATCAGGAGTAGCTGGGAATCTCCGGTTTTTTTCAGGCCACTATTTTCATCTGCGCTTCATTTCCGGCCGCATCGCTGCA
TCAGGCAGCAAAGAAACCCG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MAYFISFEGIEGCGKTTQLKLAAQYLRTLKIPVGTTEEPGGTPLGKKIRNILLNRGPFEICAEAETLLFVAARAQHVREV
ILPSLARGQWILCDRFSDATAVYQGCVRGIDEAWIRQLDSFATSFLKPNLTLLFDLPAETGLHRAMQRMTGIPENSREDR
FEQEGLNFHEKIREGYLALARQESERFRIINAAADIPSIHREVCRHLDVLRQQPEAGLP

Sequences:

>Translated_219_residues
MAYFISFEGIEGCGKTTQLKLAAQYLRTLKIPVGTTEEPGGTPLGKKIRNILLNRGPFEICAEAETLLFVAARAQHVREV
ILPSLARGQWILCDRFSDATAVYQGCVRGIDEAWIRQLDSFATSFLKPNLTLLFDLPAETGLHRAMQRMTGIPENSREDR
FEQEGLNFHEKIREGYLALARQESERFRIINAAADIPSIHREVCRHLDVLRQQPEAGLP
>Mature_218_residues
AYFISFEGIEGCGKTTQLKLAAQYLRTLKIPVGTTEEPGGTPLGKKIRNILLNRGPFEICAEAETLLFVAARAQHVREVI
LPSLARGQWILCDRFSDATAVYQGCVRGIDEAWIRQLDSFATSFLKPNLTLLFDLPAETGLHRAMQRMTGIPENSREDRF
EQEGLNFHEKIREGYLALARQESERFRIINAAADIPSIHREVCRHLDVLRQQPEAGLP

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=184, Percent_Identity=40.2173913043478, Blast_Score=121, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_SYNAS (Q2LUB1)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_461839.1
- HSSP:   P65248
- ProteinModelPortal:   Q2LUB1
- SMR:   Q2LUB1
- STRING:   Q2LUB1
- GeneID:   3883220
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_03606
- NMPDR:   fig|56780.10.peg.1776
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q2LUB1
- BioCyc:   SACI56780:SYN_03606-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24692; Mature: 24561

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYFISFEGIEGCGKTTQLKLAAQYLRTLKIPVGTTEEPGGTPLGKKIRNILLNRGPFEI
CEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
CAEAETLLFVAARAQHVREVILPSLARGQWILCDRFSDATAVYQGCVRGIDEAWIRQLDS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCHHHHHHHHHHH
FATSFLKPNLTLLFDLPAETGLHRAMQRMTGIPENSREDRFEQEGLNFHEKIREGYLALA
HHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
RQESERFRIINAAADIPSIHREVCRHLDVLRQQPEAGLP
HHCCHHEEEEHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AYFISFEGIEGCGKTTQLKLAAQYLRTLKIPVGTTEEPGGTPLGKKIRNILLNRGPFEI
EEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
CAEAETLLFVAARAQHVREVILPSLARGQWILCDRFSDATAVYQGCVRGIDEAWIRQLDS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCHHHHHHHHHHH
FATSFLKPNLTLLFDLPAETGLHRAMQRMTGIPENSREDRFEQEGLNFHEKIREGYLALA
HHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
RQESERFRIINAAADIPSIHREVCRHLDVLRQQPEAGLP
HHCCHHEEEEHHHHCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA