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The map label for this gene is dxs

Identifier: 85859631

GI number: 85859631

Start: 1859757

End: 1861709

Strand: Direct

Name: dxs

Synonym: SYN_02456

Alternate gene names: 85859631

Gene position: 1859757-1861709 (Clockwise)

Preceding gene: 85859630

Following gene: 85859632

Centisome position: 58.5

GC content: 54.99

Gene sequence:

>1953_bases
ATGTTTATCTCTTCTATGAACCCGGTAAAAAAGAATAATTCCGGCGGCATTCTCAGTCGGATACAATTCCCCGAGGATAT
CCGGATGCTGGACATCGGCGACCTTACGCTTCTGGCGAGTGACATACGGTCGGCTATCATCGAAACGGTTTCCCGCACGG
GCGGACATCTGGCCTCATCCCTGGGAACCGTCGAGTTGACCCTGGCCGTACACAAGGTTTTCGATACACCGAAAGACCGT
GTGATCTGGGATGTGGGACACCAGGCTTACGCCCACAAACTGATCACAGGACGCAGGGATGTCTTCTCTACCCTCCGGCA
GAAAGGGGGAATCAGCGGCTTTCCTAAAAGGGAAGAAAGCCCCTATGATGTCTTCAACGTCGGCCACAGCAGCACCTCCA
TTTCCGCCGCTTCCGGCATCGCCGAGGCCCGGGATCTGAAGAAAGAGCGTTTCAAGGTCGTGGCCATAATCGGCGACGGG
TCCATGACGGCCGGCTTGGCTTTTGAAGGTTTGAACTGGTCAGGAGACCGGAAAAAAGACCTCGTCATTATTCTCAATGA
CAACGAGATGTCCATTTCACCCAATGTAGGCGCCCTGTCCTCCTACCTGAACCACATCATGACAGGTCAGACGGCGAATA
AAATTAGAAAGGACATCAGGAATTTTCTGAAAACGATCCCTTCCATCGGCGAGCAAGTGCTGGAATTCAGCAGAAGAGCG
GAGGAATCACTCAAGGCCCTCATTGTACCCGGGGCGCTCTTTGAAGACCTCGGGTTTACCTATGTGGGCCCCCTGGAAGG
CCATCGCCTCGATCACTTGATCCGGAATCTCGAGGACGTACGCAACATGGAAGGGCCTGTCCTGGTTCATGTCATTACAC
GGAAAGGCAAGGGGTACAAGTTCGCTGAAGCCGAACCCCTTCGTTTCCATGGAATCTGCCCTTTTTCGCCGGAGACTGGA
AAGCCGGCGGCTGCAAGCGAATCTCCAGTTCCCCCATCCTACACGCAGGTCTTCGGAAATACGATTGTAAAGCTTGCTCG
TCAAAATCCCCGACTCGTCGCTATTACCGCAGCCATGTGCGAGGGAACGGGACTGAACGCATTTGCTGAGGAGTTTCCGG
AACGCTTTTTCGATGTGGGCATTGCGGAACAGCACAGTGTGACCTTCGCCGCCGGACTGGCCACGGAAGGGATCCTGCCT
GTGGTGGCGATTTATTCGAGCTTTCTCCAACGGGCCTACGATCAGATCCTGCACGATGTCTGCCTGCAGAATCTTCCGGT
TGTTTTCGCTCTGGACCGGGCGGGTTTCGTCGGAGAAGACGGTCCGACTCATCACGGCCTCTTTGATCTTTCCTATCTGC
GGTCTATCCCGAACATGGTCGTCATGGCTCCCAAGGACGAAAACGAGCTGCAGCATATGCTGCACACTGCCGTCGCCTGC
GGAAAACCGGCAGCCGTACGCTACCCGCGAGGAAGCGGCGTCGGCGTGACAATGGACTCCCAGCCGTTTTCCCTGGAACT
CGGAAAAGGAGAAGTGCTTTGCGAAGGTGGGAGTCTGGCTATCCTGGCTGTCGGAGATCCGGTTCATCCAGCTCTAACCG
CCGCCGTCCAACTCAGGGAGGAAGGAATTTACGCCACGGTAGTCAACGCCCGGTTTGTCAAACCTCTGGACAGGGAACTC
CTTTTGAGAATCGTGCGGTCCTTCAAAAAAATCCTGACCGTGGAGGAAAATGTCCTCACGGGGGGATTCGGCAGCGCTAT
TCTGGAATTTCTTGAAGAAAACGATATCCATGGAATCCAGGTCAAACGGTTGGGAATCCGGGATGAATTTGCCGAACAGG
CCACACAGGCCGAGCAGCGCAGGCTTTACGGCATTGATGAACAGGGGATTGCTGCCGCTGTCCGGTCGATGATGAACATG
GGCAGATCGTCCCAGATGGAGGCCTGCCTTTGA

Upstream 100 bases:

>100_bases
GGGCGACTCCTCTGCGGCTGATGGCCAGATATTTTGTGGAGCGCCGACTTTAAGGGAAACGCACTGGCGCGACATCGTTA
TATAAATAAAATTATAATGG

Downstream 100 bases:

>100_bases
TATGTCTTCCGATTCGGATTTTCTGACCATTTACCATGGGAAGTAGAGAAGAAAAAATCCGTCTGGACCTGCTCCTGGTG
AACCGGGGTCTGTCGGCAAG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MFISSMNPVKKNNSGGILSRIQFPEDIRMLDIGDLTLLASDIRSAIIETVSRTGGHLASSLGTVELTLAVHKVFDTPKDR
VIWDVGHQAYAHKLITGRRDVFSTLRQKGGISGFPKREESPYDVFNVGHSSTSISAASGIAEARDLKKERFKVVAIIGDG
SMTAGLAFEGLNWSGDRKKDLVIILNDNEMSISPNVGALSSYLNHIMTGQTANKIRKDIRNFLKTIPSIGEQVLEFSRRA
EESLKALIVPGALFEDLGFTYVGPLEGHRLDHLIRNLEDVRNMEGPVLVHVITRKGKGYKFAEAEPLRFHGICPFSPETG
KPAAASESPVPPSYTQVFGNTIVKLARQNPRLVAITAAMCEGTGLNAFAEEFPERFFDVGIAEQHSVTFAAGLATEGILP
VVAIYSSFLQRAYDQILHDVCLQNLPVVFALDRAGFVGEDGPTHHGLFDLSYLRSIPNMVVMAPKDENELQHMLHTAVAC
GKPAAVRYPRGSGVGVTMDSQPFSLELGKGEVLCEGGSLAILAVGDPVHPALTAAVQLREEGIYATVVNARFVKPLDREL
LLRIVRSFKKILTVEENVLTGGFGSAILEFLEENDIHGIQVKRLGIRDEFAEQATQAEQRRLYGIDEQGIAAAVRSMMNM
GRSSQMEACL

Sequences:

>Translated_650_residues
MFISSMNPVKKNNSGGILSRIQFPEDIRMLDIGDLTLLASDIRSAIIETVSRTGGHLASSLGTVELTLAVHKVFDTPKDR
VIWDVGHQAYAHKLITGRRDVFSTLRQKGGISGFPKREESPYDVFNVGHSSTSISAASGIAEARDLKKERFKVVAIIGDG
SMTAGLAFEGLNWSGDRKKDLVIILNDNEMSISPNVGALSSYLNHIMTGQTANKIRKDIRNFLKTIPSIGEQVLEFSRRA
EESLKALIVPGALFEDLGFTYVGPLEGHRLDHLIRNLEDVRNMEGPVLVHVITRKGKGYKFAEAEPLRFHGICPFSPETG
KPAAASESPVPPSYTQVFGNTIVKLARQNPRLVAITAAMCEGTGLNAFAEEFPERFFDVGIAEQHSVTFAAGLATEGILP
VVAIYSSFLQRAYDQILHDVCLQNLPVVFALDRAGFVGEDGPTHHGLFDLSYLRSIPNMVVMAPKDENELQHMLHTAVAC
GKPAAVRYPRGSGVGVTMDSQPFSLELGKGEVLCEGGSLAILAVGDPVHPALTAAVQLREEGIYATVVNARFVKPLDREL
LLRIVRSFKKILTVEENVLTGGFGSAILEFLEENDIHGIQVKRLGIRDEFAEQATQAEQRRLYGIDEQGIAAAVRSMMNM
GRSSQMEACL
>Mature_650_residues
MFISSMNPVKKNNSGGILSRIQFPEDIRMLDIGDLTLLASDIRSAIIETVSRTGGHLASSLGTVELTLAVHKVFDTPKDR
VIWDVGHQAYAHKLITGRRDVFSTLRQKGGISGFPKREESPYDVFNVGHSSTSISAASGIAEARDLKKERFKVVAIIGDG
SMTAGLAFEGLNWSGDRKKDLVIILNDNEMSISPNVGALSSYLNHIMTGQTANKIRKDIRNFLKTIPSIGEQVLEFSRRA
EESLKALIVPGALFEDLGFTYVGPLEGHRLDHLIRNLEDVRNMEGPVLVHVITRKGKGYKFAEAEPLRFHGICPFSPETG
KPAAASESPVPPSYTQVFGNTIVKLARQNPRLVAITAAMCEGTGLNAFAEEFPERFFDVGIAEQHSVTFAAGLATEGILP
VVAIYSSFLQRAYDQILHDVCLQNLPVVFALDRAGFVGEDGPTHHGLFDLSYLRSIPNMVVMAPKDENELQHMLHTAVAC
GKPAAVRYPRGSGVGVTMDSQPFSLELGKGEVLCEGGSLAILAVGDPVHPALTAAVQLREEGIYATVVNARFVKPLDREL
LLRIVRSFKKILTVEENVLTGGFGSAILEFLEENDIHGIQVKRLGIRDEFAEQATQAEQRRLYGIDEQGIAAAVRSMMNM
GRSSQMEACL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=630, Percent_Identity=25.0793650793651, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI4507521, Length=630, Percent_Identity=25.0793650793651, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI225637463, Length=322, Percent_Identity=26.7080745341615, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI225637459, Length=322, Percent_Identity=26.7080745341615, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI225637461, Length=322, Percent_Identity=26.7080745341615, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI133778974, Length=378, Percent_Identity=27.2486772486773, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI4557353, Length=233, Percent_Identity=23.6051502145923, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI34101272, Length=233, Percent_Identity=23.6051502145923, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1786622, Length=623, Percent_Identity=47.9935794542536, Blast_Score=586, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI17539652, Length=662, Percent_Identity=25.0755287009063, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24666278, Length=555, Percent_Identity=26.1261261261261, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45551847, Length=604, Percent_Identity=24.5033112582781, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45550715, Length=604, Percent_Identity=24.5033112582781, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24645119, Length=561, Percent_Identity=24.4206773618538, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21358145, Length=235, Percent_Identity=25.531914893617, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650940, Length=235, Percent_Identity=25.531914893617, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_SYNAS (Q2LUA7)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_461833.1
- ProteinModelPortal:   Q2LUA7
- SMR:   Q2LUA7
- STRING:   Q2LUA7
- GeneID:   3883214
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_02456
- NMPDR:   fig|56780.10.peg.1771
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   VSNTGGH
- PhylomeDB:   Q2LUA7
- BioCyc:   SACI56780:SYN_02456-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 70931; Mature: 70931

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFISSMNPVKKNNSGGILSRIQFPEDIRMLDIGDLTLLASDIRSAIIETVSRTGGHLASS
CCCCCCCCCCCCCCCCEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHC
LGTVELTLAVHKVFDTPKDRVIWDVGHQAYAHKLITGRRDVFSTLRQKGGISGFPKREES
CCCEEEHHHHHHHHCCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCC
PYDVFNVGHSSTSISAASGIAEARDLKKERFKVVAIIGDGSMTAGLAFEGLNWSGDRKKD
CCCEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEECCCCCCCCCCC
LVIILNDNEMSISPNVGALSSYLNHIMTGQTANKIRKDIRNFLKTIPSIGEQVLEFSRRA
EEEEECCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EESLKALIVPGALFEDLGFTYVGPLEGHRLDHLIRNLEDVRNMEGPVLVHVITRKGKGYK
HHHHHEEECCCHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
FAEAEPLRFHGICPFSPETGKPAAASESPVPPSYTQVFGNTIVKLARQNPRLVAITAAMC
CCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEHH
EGTGLNAFAEEFPERFFDVGIAEQHSVTFAAGLATEGILPVVAIYSSFLQRAYDQILHDV
CCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHHH
CLQNLPVVFALDRAGFVGEDGPTHHGLFDLSYLRSIPNMVVMAPKDENELQHMLHTAVAC
HHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHC
GKPAAVRYPRGSGVGVTMDSQPFSLELGKGEVLCEGGSLAILAVGDPVHPALTAAVQLRE
CCCCEEECCCCCCCEEEECCCCCEEEECCCEEEECCCCEEEEEECCCCCHHHHHHHHHHH
EGIYATVVNARFVKPLDRELLLRIVRSFKKILTVEENVLTGGFGSAILEFLEENDIHGIQ
CCCEEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEE
VKRLGIRDEFAEQATQAEQRRLYGIDEQGIAAAVRSMMNMGRSSQMEACL
EEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHCC
>Mature Secondary Structure
MFISSMNPVKKNNSGGILSRIQFPEDIRMLDIGDLTLLASDIRSAIIETVSRTGGHLASS
CCCCCCCCCCCCCCCCEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHC
LGTVELTLAVHKVFDTPKDRVIWDVGHQAYAHKLITGRRDVFSTLRQKGGISGFPKREES
CCCEEEHHHHHHHHCCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCC
PYDVFNVGHSSTSISAASGIAEARDLKKERFKVVAIIGDGSMTAGLAFEGLNWSGDRKKD
CCCEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEECCCCCCCCCCC
LVIILNDNEMSISPNVGALSSYLNHIMTGQTANKIRKDIRNFLKTIPSIGEQVLEFSRRA
EEEEECCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EESLKALIVPGALFEDLGFTYVGPLEGHRLDHLIRNLEDVRNMEGPVLVHVITRKGKGYK
HHHHHEEECCCHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
FAEAEPLRFHGICPFSPETGKPAAASESPVPPSYTQVFGNTIVKLARQNPRLVAITAAMC
CCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEHH
EGTGLNAFAEEFPERFFDVGIAEQHSVTFAAGLATEGILPVVAIYSSFLQRAYDQILHDV
CCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHHH
CLQNLPVVFALDRAGFVGEDGPTHHGLFDLSYLRSIPNMVVMAPKDENELQHMLHTAVAC
HHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHC
GKPAAVRYPRGSGVGVTMDSQPFSLELGKGEVLCEGGSLAILAVGDPVHPALTAAVQLRE
CCCCEEECCCCCCCEEEECCCCCEEEECCCEEEECCCCEEEEEECCCCCHHHHHHHHHHH
EGIYATVVNARFVKPLDRELLLRIVRSFKKILTVEENVLTGGFGSAILEFLEENDIHGIQ
CCCEEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEE
VKRLGIRDEFAEQATQAEQRRLYGIDEQGIAAAVRSMMNMGRSSQMEACL
EEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA