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The map label for this gene is purM

Identifier: 85859465

GI number: 85859465

Start: 1670907

End: 1671950

Strand: Direct

Name: purM

Synonym: SYN_00889

Alternate gene names: 85859465

Gene position: 1670907-1671950 (Clockwise)

Preceding gene: 85859464

Following gene: 85859466

Centisome position: 52.56

GC content: 45.02

Gene sequence:

>1044_bases
ATGCGTGAGCAATCGTCATATAAGGATGCGGGCGTGGACATTGATAAGGCCAATCTCTTCATTAGCAGGATCATTCCTCT
TATCAAGATGACATCAAGAAAAGAGGTAATGAAGGGAATCGGAGGATTTGGAGGACTTTTCCACCTGGATCTCAAAAAAA
TCAAAGATCCTGTACTGGTTGCTGCAACAGATGGTGTGGGTACGAAGATCAAGATCGCCCAGATGATGAACAAACACGAT
ACGGTAGGCATCGATCTTGTTGCCATGTCCGTCAACGACATCATCGTTCAGGGAGCTGAACCCATATTTTTCCTTGATTA
TATCGCCATCGGACAGATGGATGTTGAACGCAACGTCAAGCTTATAGAGGGGATCGTCAAGGGTTGCCAGGAAGCTGGAT
GTGCCTTGATCGGTGGTGAAACGGCCGAAATGCCGGGCATTTATTCTGAAAACGAATATGATCTGGCCGGCTTCTGCATC
GGTGTTGTTGAAAACGGCAGAATCATCGACGGTTCGGACATTCGCGTCGGCGACCGTGTAATCGGAATTGCATCAAACGG
CATTCACAGCAACGGATATTCCCTGGTTCGCAAGGTTATATTTGACAAAGCAAAGTTAAATGTCGACGACACAATAGAGG
GTATCGAAAATTCCATTGGAGAAGAACTTCTGCGGCCAACACGAATCTATGTCAAACCCGTCCTTAATTTAATGAAGAGC
TTTAATATCAAAGGGATTGTTCATATTACGGGTGGAGGCTTTGTTGACAATATTCCCAGAATCGTTCCCAATCAATGCTG
CACTGTGATCCGAATGAACAGTTGGCAGATTCCGCCCATATTCAGTATTATCCAGGAGCTCGGTGATATTGACCAGATGG
AAATGGTCCGTGTATTCAATATGGGAATCGGAATGATCCTCATTGTTTCAGAAAAGGAAACCGATGATATTGTGGAACGC
CTCAACATGCTGGGGGAAAAGGCCTATATTATCGGATCTATCGAAAAAGCTGACGGCGAGAAAAGCGCTGTTTCTTTTAC
ATAG

Upstream 100 bases:

>100_bases
GCGCAAGGAAAGATTTGACTTTTGGAGCGATCTAAAATAGACAGTCTCTTTCAATCTGGCATCAGAGAAGTTTTTTAAAA
CGTTCATCAGGGGAGTCTAT

Downstream 100 bases:

>100_bases
CCTGATATATTGATTATGAACAGAAAGCTGCCTATTGGTGTCCTTGTCTCCGGAAGCGGTTCAAACCTGCAGTCCATCAT
TGATCACATTGAGCGGGGTC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MREQSSYKDAGVDIDKANLFISRIIPLIKMTSRKEVMKGIGGFGGLFHLDLKKIKDPVLVAATDGVGTKIKIAQMMNKHD
TVGIDLVAMSVNDIIVQGAEPIFFLDYIAIGQMDVERNVKLIEGIVKGCQEAGCALIGGETAEMPGIYSENEYDLAGFCI
GVVENGRIIDGSDIRVGDRVIGIASNGIHSNGYSLVRKVIFDKAKLNVDDTIEGIENSIGEELLRPTRIYVKPVLNLMKS
FNIKGIVHITGGGFVDNIPRIVPNQCCTVIRMNSWQIPPIFSIIQELGDIDQMEMVRVFNMGIGMILIVSEKETDDIVER
LNMLGEKAYIIGSIEKADGEKSAVSFT

Sequences:

>Translated_347_residues
MREQSSYKDAGVDIDKANLFISRIIPLIKMTSRKEVMKGIGGFGGLFHLDLKKIKDPVLVAATDGVGTKIKIAQMMNKHD
TVGIDLVAMSVNDIIVQGAEPIFFLDYIAIGQMDVERNVKLIEGIVKGCQEAGCALIGGETAEMPGIYSENEYDLAGFCI
GVVENGRIIDGSDIRVGDRVIGIASNGIHSNGYSLVRKVIFDKAKLNVDDTIEGIENSIGEELLRPTRIYVKPVLNLMKS
FNIKGIVHITGGGFVDNIPRIVPNQCCTVIRMNSWQIPPIFSIIQELGDIDQMEMVRVFNMGIGMILIVSEKETDDIVER
LNMLGEKAYIIGSIEKADGEKSAVSFT
>Mature_347_residues
MREQSSYKDAGVDIDKANLFISRIIPLIKMTSRKEVMKGIGGFGGLFHLDLKKIKDPVLVAATDGVGTKIKIAQMMNKHD
TVGIDLVAMSVNDIIVQGAEPIFFLDYIAIGQMDVERNVKLIEGIVKGCQEAGCALIGGETAEMPGIYSENEYDLAGFCI
GVVENGRIIDGSDIRVGDRVIGIASNGIHSNGYSLVRKVIFDKAKLNVDDTIEGIENSIGEELLRPTRIYVKPVLNLMKS
FNIKGIVHITGGGFVDNIPRIVPNQCCTVIRMNSWQIPPIFSIIQELGDIDQMEMVRVFNMGIGMILIVSEKETDDIVER
LNMLGEKAYIIGSIEKADGEKSAVSFT

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=46.5875370919881, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=46.5875370919881, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=46.5875370919881, Blast_Score=333, Evalue=2e-91,
Organism=Escherichia coli, GI1788845, Length=339, Percent_Identity=50.7374631268437, Blast_Score=353, Evalue=9e-99,
Organism=Caenorhabditis elegans, GI17567511, Length=350, Percent_Identity=42.2857142857143, Blast_Score=245, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6321203, Length=336, Percent_Identity=42.5595238095238, Blast_Score=287, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24582400, Length=294, Percent_Identity=40.4761904761905, Blast_Score=228, Evalue=4e-60,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_SYNAS (Q2LTT5)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_461667.1
- ProteinModelPortal:   Q2LTT5
- SMR:   Q2LTT5
- STRING:   Q2LTT5
- GeneID:   3883059
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_00889
- NMPDR:   fig|56780.10.peg.1609
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- PhylomeDB:   Q2LTT5
- ProtClustDB:   PRK05385
- BioCyc:   SACI56780:SYN_00889-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37970; Mature: 37970

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREQSSYKDAGVDIDKANLFISRIIPLIKMTSRKEVMKGIGGFGGLFHLDLKKIKDPVLV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEHHHCCCCEEE
AATDGVGTKIKIAQMMNKHDTVGIDLVAMSVNDIIVQGAEPIFFLDYIAIGQMDVERNVK
EEECCCCCEEEHHHHHCCCCCCCEEEEEEEHHHEEEECCCCEEEEHHHHHCCCCHHCCHH
LIEGIVKGCQEAGCALIGGETAEMPGIYSENEYDLAGFCIGVVENGRIIDGSDIRVGDRV
HHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCEECCEE
IGIASNGIHSNGYSLVRKVIFDKAKLNVDDTIEGIENSIGEELLRPTRIYVKPVLNLMKS
EEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
FNIKGIVHITGGGFVDNIPRIVPNQCCTVIRMNSWQIPPIFSIIQELGDIDQMEMVRVFN
CCCCEEEEEECCCCHHCCCHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHH
MGIGMILIVSEKETDDIVERLNMLGEKAYIIGSIEKADGEKSAVSFT
CCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MREQSSYKDAGVDIDKANLFISRIIPLIKMTSRKEVMKGIGGFGGLFHLDLKKIKDPVLV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEHHHCCCCEEE
AATDGVGTKIKIAQMMNKHDTVGIDLVAMSVNDIIVQGAEPIFFLDYIAIGQMDVERNVK
EEECCCCCEEEHHHHHCCCCCCCEEEEEEEHHHEEEECCCCEEEEHHHHHCCCCHHCCHH
LIEGIVKGCQEAGCALIGGETAEMPGIYSENEYDLAGFCIGVVENGRIIDGSDIRVGDRV
HHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCEECCEE
IGIASNGIHSNGYSLVRKVIFDKAKLNVDDTIEGIENSIGEELLRPTRIYVKPVLNLMKS
EEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
FNIKGIVHITGGGFVDNIPRIVPNQCCTVIRMNSWQIPPIFSIIQELGDIDQMEMVRVFN
CCCCEEEEEECCCCHHCCCHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHH
MGIGMILIVSEKETDDIVERLNMLGEKAYIIGSIEKADGEKSAVSFT
CCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA