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The map label for this gene is mltA [H]

Identifier: 85859155

GI number: 85859155

Start: 1330088

End: 1331515

Strand: Direct

Name: mltA [H]

Synonym: SYN_02860

Alternate gene names: 85859155

Gene position: 1330088-1331515 (Clockwise)

Preceding gene: 85859154

Following gene: 85859156

Centisome position: 41.84

GC content: 56.65

Gene sequence:

>1428_bases
ATGAAGATGACGATGAATAACTGGAAAAGGGGAACGGTTCCCATTGCCCTGGCATTTTTCCTTTCCATGGGGATGGCCGG
CTGCGCGGCGCGAAAAGGAGTGGATGAAGCTTACAGGCTGCCACCGCCGGCAGCAAAAGTGGAGCCGGCTCCGAAGACCG
TCCCTTCGCCGGCTCCGAAAACCGTTCCGCCTCCCTCTGTAAAACCAGCTCCGACGCCCGCACCGCCCCCCACACCGCCT
CCCGCTCCGAAACTGGAACCTCCGGAGCCTTATGAACCGACTCCGCTGACCTCGTCGCTGACGCCCATCAAACCTCAGGA
AGTGCCCCAGCTGCTGGATGATCTCGATACGGAATCCCTGCTGGCGGCTATCGAAAAAAGCCTGCTGTTCTACAGCCGAG
TTCCGGCGGACAGCCGCTACCCTCTGGGAGAATCAACCTGCACCGCCGGGGAATTGAAGGCAACCCTGCTGGCCTTGCGG
GAAATCCTTCAGACCTGCGGGTCCGATGAATGCAGAAGAACGAAAATCGCCGGGAACTTCGATTTTTATAAAGCCGCCGG
TCAGGATCAGAAAGGAACCGTCCTGTTTACCGGATATTTTGAACCGGTGATGAAGGGTTCGCTGGAAAAAACGGATTTCT
ATTCTTTTCCTCTGTATGGCCCTCCGGAAGAAACCGTCGTGATCAATCTGGGTAAGTTCAATTCGAAATATGAAGGAGAA
ACCCTGACCGGGCGGGTTCTTAACGGCGAAGTCGTTCCCCATTACAGCCGTGAGGAGATCGACGGGAAAGGAATTCTTCA
GGGACGGAATCTTGAAATCGCCTGGGCAGCGGACCCTGTGGAGCTGTTTTTTCTTCATATTCAGGGATCAGGCATCATGG
AACTGCCTGACGGCCGTAGAATCCGCGTCGGCTACGCCAGATCCAACGGGCGCCCTTTCCGCGGTCTGGCGAAGGTGCTT
CTGGATCGGGGAAAGATTACGGAACGGGAGATGTCTCATGAAGGCGTCAAAAACTGGCTTCTGGACAATCCGGAGGAACG
GGACGAAATGATGTACCGGAACCCGAGTTATGTCTTTTTCCGGATCATGGATGGTGAAAATGTCGGTTCCCACAATGTGC
CCCTGACTGCGGGGCGGTCCATCGCCACGGACGCAAAATTTTTCCCCAGGGGAGCGCCGGCCCTGATTCGACTGCGGAAG
CCTGTTTTTCCTGAAGAGGGCGGCGGGTTGGAGTGGGTCCCCTTCTCCCGCTTAGTTCTCAATCAGGACGCGGGCGGAGC
GATCAAGGGGACGGGGCGGGTTGACATTTACTGCGGCACGGGAAGAGAAGCGGAACGGGTTGCCGGAAGCCTCAAGGAAC
CGGGGGAACTGTATTTTCTGCTGAAGAAAAACAGTGTGACCGGCAAGGTGGCGTCCACGGTCTTTTGA

Upstream 100 bases:

>100_bases
GGTCGGACTGCTTCCGTTGCGCGAAATATCCCGACTACTGCGACGAAGTCGCCATGGACCTCGAACTTTGAGCAGGAACG
ACGAAAAAGGAAGATGAATT

Downstream 100 bases:

>100_bases
ACCTTACGGGAGTGTGAGATCCATGCATTGTGCGGTTTTTCATATTGCCACCCCGGCAAACCCCTATTTTTAATTGATAA
GGGGCATGTTTTATGTTAAA

Product: membrane-bound lytic murein transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKMTMNNWKRGTVPIALAFFLSMGMAGCAARKGVDEAYRLPPPAAKVEPAPKTVPSPAPKTVPPPSVKPAPTPAPPPTPP
PAPKLEPPEPYEPTPLTSSLTPIKPQEVPQLLDDLDTESLLAAIEKSLLFYSRVPADSRYPLGESTCTAGELKATLLALR
EILQTCGSDECRRTKIAGNFDFYKAAGQDQKGTVLFTGYFEPVMKGSLEKTDFYSFPLYGPPEETVVINLGKFNSKYEGE
TLTGRVLNGEVVPHYSREEIDGKGILQGRNLEIAWAADPVELFFLHIQGSGIMELPDGRRIRVGYARSNGRPFRGLAKVL
LDRGKITEREMSHEGVKNWLLDNPEERDEMMYRNPSYVFFRIMDGENVGSHNVPLTAGRSIATDAKFFPRGAPALIRLRK
PVFPEEGGGLEWVPFSRLVLNQDAGGAIKGTGRVDIYCGTGREAERVAGSLKEPGELYFLLKKNSVTGKVASTVF

Sequences:

>Translated_475_residues
MKMTMNNWKRGTVPIALAFFLSMGMAGCAARKGVDEAYRLPPPAAKVEPAPKTVPSPAPKTVPPPSVKPAPTPAPPPTPP
PAPKLEPPEPYEPTPLTSSLTPIKPQEVPQLLDDLDTESLLAAIEKSLLFYSRVPADSRYPLGESTCTAGELKATLLALR
EILQTCGSDECRRTKIAGNFDFYKAAGQDQKGTVLFTGYFEPVMKGSLEKTDFYSFPLYGPPEETVVINLGKFNSKYEGE
TLTGRVLNGEVVPHYSREEIDGKGILQGRNLEIAWAADPVELFFLHIQGSGIMELPDGRRIRVGYARSNGRPFRGLAKVL
LDRGKITEREMSHEGVKNWLLDNPEERDEMMYRNPSYVFFRIMDGENVGSHNVPLTAGRSIATDAKFFPRGAPALIRLRK
PVFPEEGGGLEWVPFSRLVLNQDAGGAIKGTGRVDIYCGTGREAERVAGSLKEPGELYFLLKKNSVTGKVASTVF
>Mature_475_residues
MKMTMNNWKRGTVPIALAFFLSMGMAGCAARKGVDEAYRLPPPAAKVEPAPKTVPSPAPKTVPPPSVKPAPTPAPPPTPP
PAPKLEPPEPYEPTPLTSSLTPIKPQEVPQLLDDLDTESLLAAIEKSLLFYSRVPADSRYPLGESTCTAGELKATLLALR
EILQTCGSDECRRTKIAGNFDFYKAAGQDQKGTVLFTGYFEPVMKGSLEKTDFYSFPLYGPPEETVVINLGKFNSKYEGE
TLTGRVLNGEVVPHYSREEIDGKGILQGRNLEIAWAADPVELFFLHIQGSGIMELPDGRRIRVGYARSNGRPFRGLAKVL
LDRGKITEREMSHEGVKNWLLDNPEERDEMMYRNPSYVFFRIMDGENVGSHNVPLTAGRSIATDAKFFPRGAPALIRLRK
PVFPEEGGGLEWVPFSRLVLNQDAGGAIKGTGRVDIYCGTGREAERVAGSLKEPGELYFLLKKNSVTGKVASTVF

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=309, Percent_Identity=29.7734627831715, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 52051; Mature: 52051

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMTMNNWKRGTVPIALAFFLSMGMAGCAARKGVDEAYRLPPPAAKVEPAPKTVPSPAPK
CCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCC
TVPPPSVKPAPTPAPPPTPPPAPKLEPPEPYEPTPLTSSLTPIKPQEVPQLLDDLDTESL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHH
LAAIEKSLLFYSRVPADSRYPLGESTCTAGELKATLLALREILQTCGSDECRRTKIAGNF
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHEEECCCC
DFYKAAGQDQKGTVLFTGYFEPVMKGSLEKTDFYSFPLYGPPEETVVINLGKFNSKYEGE
CHHHCCCCCCCCEEEEEECHHHHHCCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCCC
TLTGRVLNGEVVPHYSREEIDGKGILQGRNLEIAWAADPVELFFLHIQGSGIMELPDGRR
EEEEEEECCCCCCCCCHHCCCCCCEEECCCEEEEECCCCEEEEEEEEECCCEEECCCCCE
IRVGYARSNGRPFRGLAKVLLDRGKITEREMSHEGVKNWLLDNPEERDEMMYRNPSYVFF
EEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEE
RIMDGENVGSHNVPLTAGRSIATDAKFFPRGAPALIRLRKPVFPEEGGGLEWVPFSRLVL
EEECCCCCCCCCCCEECCCCCCCCCHHCCCCCHHHEEECCCCCCCCCCCEEECCCCEEEE
NQDAGGAIKGTGRVDIYCGTGREAERVAGSLKEPGELYFLLKKNSVTGKVASTVF
ECCCCCEEECCCEEEEEECCCCHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure
MKMTMNNWKRGTVPIALAFFLSMGMAGCAARKGVDEAYRLPPPAAKVEPAPKTVPSPAPK
CCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCC
TVPPPSVKPAPTPAPPPTPPPAPKLEPPEPYEPTPLTSSLTPIKPQEVPQLLDDLDTESL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHH
LAAIEKSLLFYSRVPADSRYPLGESTCTAGELKATLLALREILQTCGSDECRRTKIAGNF
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHEEECCCC
DFYKAAGQDQKGTVLFTGYFEPVMKGSLEKTDFYSFPLYGPPEETVVINLGKFNSKYEGE
CHHHCCCCCCCCEEEEEECHHHHHCCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCCC
TLTGRVLNGEVVPHYSREEIDGKGILQGRNLEIAWAADPVELFFLHIQGSGIMELPDGRR
EEEEEEECCCCCCCCCHHCCCCCCEEECCCEEEEECCCCEEEEEEEEECCCEEECCCCCE
IRVGYARSNGRPFRGLAKVLLDRGKITEREMSHEGVKNWLLDNPEERDEMMYRNPSYVFF
EEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEE
RIMDGENVGSHNVPLTAGRSIATDAKFFPRGAPALIRLRKPVFPEEGGGLEWVPFSRLVL
EEECCCCCCCCCCCEECCCCCCCCCHHCCCCCHHHEEECCCCCCCCCCCEEECCCCEEEE
NQDAGGAIKGTGRVDIYCGTGREAERVAGSLKEPGELYFLLKKNSVTGKVASTVF
ECCCCCEEECCCEEEEEECCCCHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]